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41. 发明授权

US4963536A Diphosphonic acid compounds, and pharmaceutical composition comprising the same useful for treating bone diseases 失效
标题翻译：二膦酸化合物，以及包含可用于治疗骨疾病的药物组合物
公开(公告)号：US4963536A
公开(公告)日：1990-10-16
申请号：US333953
申请日：1989-04-06
申请人： Teruo Oku , Eishiro Todo , Chiyoshi Kasahara , Katsuya Nakamura , Hiroshi Kayakiri , Masashi Hashimoto
发明人： Teruo Oku , Eishiro Todo , Chiyoshi Kasahara , Katsuya Nakamura , Hiroshi Kayakiri , Masashi Hashimoto
IPC分类号： C07F9/38 , C07F9/58 , C07F9/60 , C07F9/6506 , C07F9/6553
CPC分类号： C07F9/588 , C07F9/3873 , C07F9/60 , C07F9/65067 , C07F9/655354
摘要： A compound of the formula: ##STR1## wherein R.sup.1 -A- is a group of the formula: ##STR2## in which R.sup.1 is aryl or a heterocyclic group, each of which may be substituted with substituent(s) selected from the group consisting of lower alkyl, lower alkoxy, lower alkylthio, halo(lower)alkyl, acyl, acylamino and halogen, or lower alkyl which may be substituted with a heterocyclic group optionally substituted with acyl, andX is O or S, andR.sup.2 is hydrogen or lower alkyl, provided that when R.sup.1 is lower alkyl, thenR.sup.1 -A- is a group of the formula: ##STR3## in which R.sup.1 and X are each as defined above, processes for the preparation thereof and pharmaceutical composition comprising the same.

42. 发明授权

US4954496A Cyclohexane derivatives and pharmaceutical compositions 失效
标题翻译：环己烷衍生物和药物组合物
公开(公告)号：US4954496A
公开(公告)日：1990-09-04
申请号：US386232
申请日：1989-07-28
申请人： Teruo Oku , Ciyoshi Kasahara , Takehiko Ohkawa , Masashi Hashimoto
发明人： Teruo Oku , Ciyoshi Kasahara , Takehiko Ohkawa , Masashi Hashimoto
IPC分类号： C07D303/26 , A61K31/335 , A61K31/336 , A61K31/535 , A61P9/00 , C07D303/22 , C07D303/34
CPC分类号： C07D303/22 , C07D303/34 , Y10S514/825 , Y10S514/863 , Y10S514/866
摘要： The invention relates to a cyclohexane derivative, useful as an angiogenesis inhibitor, of the formula: ##STR1## wherein R.sup.1 is halomethyl; or arylthiomethyl which may have amino, lower alkoxy or acylamino,R.sup.2 is lower alkoxy,R.sup.3 is ##STR2## or ##STR3## and R.sup.4 is hydrogen, lower alkylcarbamoyl, lower alkylcarbamoyloxy(lower)alkylcarbamoyl, heterocyclic carbonyl or heterocyclic carbamoyl, or salt thereof.

43. 发明授权

US4941127A Method for operating semiconductor memory system in the storage and readout of video signal data 失效
标题翻译：在存储和读出视频信号数据时操作半导体存储器系统的方法
公开(公告)号：US4941127A
公开(公告)日：1990-07-10
申请号：US158173
申请日：1988-02-19
申请人： Masashi Hashimoto
发明人： Masashi Hashimoto
IPC分类号： G11C11/401 , G06F5/16 , G06T1/60 , G09G5/00 , G09G5/14 , G09G5/42 , G11C7/00 , G11C7/10 , H01L27/10 , H04N5/907 , H04N7/01
CPC分类号： G06F5/16 , G11C7/1006
摘要： A method of employing a semiconductor memory system in the storage and readout of video signal data, wherein first and second FIFO memories are utilized in a tandem manner to perform video-related operations in a plurality of functional modes, such as a flicker free mode, picture-in-picture mode, teletext mode, multi-picture mode, stroboscopic mode and still picture mode.
摘要翻译：一种在存储和读出视频信号数据中采用半导体存储器系统的方法，其中以串联的方式利用第一和第二FIFO存储器来执行诸如无闪烁模式的多个功能模式中的视频相关操作，画中画模式，图文电视模式，多画面模式，频闪模式和静态图片模式。

44. 发明授权

US4893281A Semiconductor memory system with programmable address decoder 失效
标题翻译：具有可编程地址解码器的半导体存储器系统
公开(公告)号：US4893281A
公开(公告)日：1990-01-09
申请号：US911926
申请日：1986-09-25
申请人： Masashi Hashimoto
发明人： Masashi Hashimoto
IPC分类号： G11C17/00 , G11C8/10 , G11C16/06
CPC分类号： G11C8/10
摘要： A semiconductor memory system using address signals each consisting of a first predetermined number of logic bits, comprising a memory array having a number of memory cells and access lines along which the memory cells are arranged in rows or columns, and a programmable address decoder responsive to a second number of logic bits of each of the address signals, the second predetermined number being not larger than the first predetermined number. The address decoder comprises a plurality of address generation networks commonly connected to the address bus and respectively associated with the access lines and is operative to generate a predetermined sequence of address bits representing a desired address for one of the access lines in the memory array in response to the second predetermined number of address bits of each of the address signals. Each of the address generation networks comprises a plurality of programmable memory cells and a switching circuit for selecting memory cells out of all the programmable memory cells of each of the address generation networks in response to the predetermined sequence of the address bits generated in the address decoder.
摘要翻译：一种半导体存储器系统，其使用每个由第一预定数量的逻辑位组成的地址信号，所述地址信号包括存储器阵列，所述存储器阵列具有多个存储单元和存储器单元以行或列排列的存取线，以及响应于每个地址信号的第二数量的逻辑位，第二预定数不大于第一预定数。地址解码器包括通常连接到地址总线并且分别与接入线相关联的多个地址生成网络，并且可操作地响应地产生表示存储器阵列中的一个接入线的期望地址的预定顺序的地址位到每个地址信号的第二预定数量的地址位。每个地址生成网络包括多个可编程存储器单元和切换电路，用于响应于在地址解码器中产生的地址位的预定顺序，从每个地址生成网络的所有可编程存储器单元中选择存储单元。

45. 发明授权

US4883800A Quinazoline derivatives and process for their production 失效
标题翻译：喹唑啉衍生物及其生产工艺
公开(公告)号：US4883800A
公开(公告)日：1989-11-28
申请号：US130297
申请日：1987-12-08
申请人： Masashi Hashimoto , Teruo Oku , Yoshikuni Ito , Takayuki Namiki , Kozo Sawada , Chiyoshi Kasahara , Yukihisa Baba
发明人： Masashi Hashimoto , Teruo Oku , Yoshikuni Ito , Takayuki Namiki , Kozo Sawada , Chiyoshi Kasahara , Yukihisa Baba
IPC分类号： C12N9/99 , A61K31/505 , A61K31/517 , A61K31/54 , A61K31/5415 , A61P1/16 , A61P3/08 , A61P3/10 , A61P13/02 , A61P15/00 , A61P25/00 , A61P27/02 , A61P27/12 , A61P43/00 , C07D239/80 , C07D239/91 , C07D239/93 , C07D239/95 , C07D239/96 , C07D265/26 , C07D285/24 , C07D401/06 , C07D409/06 , C07D521/00
CPC分类号： C07D401/06 , C07D239/95 , C07D239/96 , C07D285/24 , C07D409/06
摘要： The invention relates to compounds having aldose reductase-inhibitory activity of the formula: ##STR1## in which R.sup.1 and R.sup.2 are each hydrogen, halogen, lower alkoxy or halo(lower)alkyl,R.sup.3 is phenyl(lower)alkyl which may have one or more substituent(s) selected from the group consisting of halogen, lower alkoxy, halo(lower)alkyl and lower alkyl,R.sup.4 is carboxy or protected carboxy,A is sulfur atom,Y is carbonyl, thiocarbonyl or sulfonyl andZ is lower alkylene,and pharmaceutically acceptable salts thereof, useful in treating diabetic complications.

46. 发明授权

US4882710A FIFO memory including dynamic memory elements 失效
标题翻译： FIFO存储器包括动态存储器元件
公开(公告)号：US4882710A
公开(公告)日：1989-11-21
申请号：US94943
申请日：1987-09-09
申请人： Masashi Hashimoto , Sasaki Kenji , Masayoshi Nomura
发明人： Masashi Hashimoto , Sasaki Kenji , Masayoshi Nomura
IPC分类号： G11C11/401 , G06F5/10 , G11C7/00
CPC分类号： G06F5/10 , G11C7/00
摘要： A FIFO memory is provided with individual arrays of dynamic memory cells and includes a dedicated write line buffer memory and a dedicated read line buffer memory operably connected thereto. First and second line buffer memories are also provided in conjunction with the write line buffer memory and the read line buffer memory so as to permit a faster response to the input and output of data with respect to the FIFO memory. Data may be alternately written into either one of the line buffer memories as a lead-in to the subsequent writing of data in the dynamic memory arrays via the write line buffer memory. Data read out from the other line buffer memory may occur simultaneously. The FIFO memory may serve as a video data frame memory for storing a frame of a video screen image. Where video data is continuously written into the FIFO memory, either the preceding video data frame or the current video data frame that is being written is subject to read out depending on the timing of a read reset signal relative to the last write reset signal. The write line buffer memory and the read line buffer memory are operable independently of each other, and may have simultaneous cycle times without any synchronization therebetween. The first and second line buffer memories preferably comprise static type memory elements to facilitate rapid data read out therefrom in response to a read reset signal.
摘要翻译： FIFO存储器具有单独的动态存储器单元阵列，并且包括可操作地连接到其上的专用写行缓冲存储器和专用读行缓冲存储器。第一和第二行缓冲存储器还与写行缓冲存储器和读行缓冲存储器一起提供，以便允许对FIFO存储器的数据的输入和输出的更快的响应。可以将数据交替地写入行缓冲存储器中的任何一个作为通过写行缓冲存储器在动态存储器阵列中随后写入数据的导入。从其他行缓冲存储器读出的数据可能同时发生。 FIFO存储器可以用作存储视频屏幕图像的帧的视频数据帧存储器。在视频数据被连续地写入FIFO存储器的情况下，根据读取复位信号相对于最后写入复位信号的定时，前面的视频数据帧或正被写入的当前视频数据帧被读出。写行缓冲存储器和读行缓冲存储器可彼此独立地操作，并且可以具有同时的周期时间，而在它们之间没有任何同步。第一行缓冲存储器和第二行缓冲存储器优选地包括静态型存储器元件，以便响应读取的复位信号便于从其读出数据。

47. 发明授权

US4862413A Semiconductor ROM with reduced supply voltage requirement 失效
标题翻译：半导体ROM具有降低的电源电压要求
公开(公告)号：US4862413A
公开(公告)日：1989-08-29
申请号：US180648
申请日：1988-04-04
申请人： Masashi Hashimoto , Tadashi Tachibana
发明人： Masashi Hashimoto , Tadashi Tachibana
IPC分类号： G11C17/18 , G11C5/14 , G11C17/12
CPC分类号： G11C5/147 , G11C17/12
摘要： A memory device including a voltage stepdown circuit is proposed in which a reduced reference voltage is produced from a supplied reference voltage and is passed to the selected one of the row lines of the memory array after all the row lines are discharged to ground potential, while the supplied reference voltage is fed directly, viz., without reduction, to all the control circuits of the device. The voltage stepdown circuit provided in the memory device is thus relieved from the burden to supply current to the control circuits and has only to feed the selected one of the row lines so that the field-effect transistors forming the voltage stepdown circuit can be fabricated to have channel regions with significantly reduced widths.
摘要翻译：提出了包括降压电路的存储器件，其中从所提供的参考电压产生降低的参考电压，并且在所有行线被放电到地电位之后被传递到存储器阵列的选定行之一行，同时所提供的参考电压直接馈送到设备的所有控制电路，即不减少。因此，设置在存储装置中的降压电路免除了向控制电路提供电流的负担，并且仅供给所选择的一行行线，使得形成降压电路的场效应晶体管可以制造成具有显着减小宽度的通道区域。

48. 再颁专利

USRE32992E Peptide process for preparation thereof and use thereof 失效
标题翻译：其制备方法及其用途
公开(公告)号：USRE32992E
公开(公告)日：1989-07-18
申请号：US611733
申请日：1984-05-18
申请人： Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka , Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto
发明人： Yoshio Kuroda , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka , Yoshihiko Kitaura , Osamu Nakaguchi , Keiji Hemmi , Matsuhiko Aratani , Hidekazu Takeno , Satoshi Okada , Hirokazu Tanaka , Masashi Hashimoto
IPC分类号： A61K38/00 , C07K5/02 , C07K5/06 , C07K5/062 , C07K5/072 , C07K9/00
CPC分类号： C07C243/00 , C07K5/0215 , C07K5/06026 , C07K5/06052 , C07K5/06069 , C07K5/06078 , C07K9/005 , C12R1/465 , A61K38/00 , Y02P20/55
摘要： The invention deals with novel peptides useful for the therapeutic treatment of infectious diseases caused by pathogenic microorganisms. Included is the peptide FR900156 having the structure: ##STR1## as well as the peptides of the structure ##STR2## wherein R.sup.1 is acyl;R.sub.b.sup.1 is hydrogen, methyl, isopropyl, hydroxymethyl, protected hydroxymethyl or benzyl;R.sup.2 is hydrogen, carboxy, protected carboxy, or a group of the formula: ##STR3## wherein R.sub.a.sup.2 is mono- or di-carboxy lower alkyl or ar(carboxy) lower alkyl whose aryl moiety may be substituted by hydroxy,R.sub.b.sup.2 is hydrogen or lower alkyl;R.sup.p and R.sup.q are each hydrogen, carboxy, protected carboxy, with proviso that when one of R.sup.2 and R.sup.q is hydrogen, then the other is carboxy or protected carboxy;R.sup.r is hydrogen or amino protective group; m is an integer 1 to 3, and n is 1 .Iadd.provided that when R.sup.1 is benzyloxycarbonyl R.sub.5.sup.1 is methyl, m is an integer 2 and n is an integer 1, then R.sup.2 is not protected carboxy, and .Iaddend.provided that when R.sup.1 is .[.hydrogen,.]. t-butoxycarbonyl or N-acetylmuramyl, R.sub.b.sup.1 is methyl, m is an integer 2 and n is an integer 1, then R.sup.2 is hydrogen, protected carboxy or a group of the formula: ##STR4## wherein R.sub.a.sup.2 is mono- or di-carboxy lower alkyl having 1 and 3 to 6, carbon atoms, .[..alpha.-carboxyethyl,.]. .Iadd.--CH.sub.2 --CH.sub.2 --COOH, .Iaddend.ar(carboxy) lower alkyl whose aryl moiety may be substituted by hydroxy and R.sub.b.sup.2 is as defined above, or its pharmaceutically acceptable salt.

49. 发明授权

US4849248A Ion implantation method for making silicon-rich silicon dioxide film 失效
标题翻译：用于制造富硅二氧化硅膜的离子注入方法
公开(公告)号：US4849248A
公开(公告)日：1989-07-18
申请号：US935483
申请日：1986-11-26
申请人： Masashi Hashimoto
发明人： Masashi Hashimoto
IPC分类号： C01B33/113 , C23C14/08 , C23C14/48 , H01L21/265 , H01L21/28 , H01L21/3115 , H01L21/316 , H01L21/36
CPC分类号： H01L21/28185 , H01L21/31155
摘要： A silicon dioxide film containing additional silicon in the form of segregates having controlled grain sizs is fabricated by forming a silicon dioxide, injecting silicon ions into the silicon dioxide film by ion implantation with a predetermined ion acceleration energy and a predetermined ion dose, and annealing the resultant silicon dioxide film for causing the additional silicon atoms in the silicon dioxide film to segregate therein to form segregates of silicon having grain sizes which are substantially predominated by the predetermined ion acceleration energy and the predetermined ion dose.
摘要翻译：通过形成二氧化硅，以预定的离子加速能量和预定的离子剂量通过离子注入将硅离子注入到二氧化硅膜中，制造含有具有受控晶粒尺寸的分离形式的附加硅的二氧化硅膜，所得的二氧化硅膜用于使二氧化硅膜中的另外的硅原子分离在其中以形成具有基本上以预定离子加速能量和预定离子剂量为主的晶粒尺寸的硅分离体。

50. 发明授权

US4725608A Semicarbazide derivatives, processes for preparation thereof and pharmaceutical composition comprising the same 失效
标题翻译：氨基脲衍生物，其制备方法和包含其的药物组合物
公开(公告)号：US4725608A
公开(公告)日：1988-02-16
申请号：US673845
申请日：1984-11-21
申请人： Osamu Nakaguchi , Norihiko Shimazaki , Yoshio Kawai , Masashi Hashimoto , Michie Nakatuka
发明人： Osamu Nakaguchi , Norihiko Shimazaki , Yoshio Kawai , Masashi Hashimoto , Michie Nakatuka
IPC分类号： C07D203/26 , C07D211/70 , C07D213/89 , C07D237/04 , C07D295/28 , A61K31/435 , C07D211/98
CPC分类号： C07D213/89 , C07D203/26 , C07D211/70 , C07D237/04 , C07D295/32
摘要： New semicarbazide derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen,R.sup.2 is hydrogen, lower alkyl, ar(lower)alkyl, lower alkenyl or aryl,R.sup.3 is lower alkyl, ar(lower)alkyl, lower alkenyl or aryl, orR.sup.2 and R.sup.3 are taken together to form (C.sub.2 -C.sub.6)alkylidene group optionally substituted with aryl or taken together with the adjacent nitrogen atom to form a saturated or unsaturated, 5- or 6-membered heterocyclic group optionally substituted with aryl; orR.sup.1 and R.sup.2 are taken together with the adjacent nitrogen atoms to form a saturated or unsaturated, 5- or 6-membered heterocyclic group or 1,2-diazaspiroalkane-1,2-diyl group,R.sup.3 is hydrogen, lower alkyl, ar(lower)alkyl, lower alkenyl or aryl;R.sup.4 is aryl which may have substituent(s) selected from lower alkyl, halogen, lower alkoxy, lower alkylamino, halo(lower)alkyl, hydroxy, lower alkanoyl, esterified carboxy and carboxy,R.sup.5 is hydrogen or lower alkyl, andX is O or S, provided that the lower alkyl group for R.sup.3 is (C.sub.3 -C.sub.6)alkyl, when R.sup.2 is hydrogen or (C.sub.1 -C.sub.2) alkyl and R.sup.4 is aryl optionally having substituent(s) selected from groups consisting of halogen, lower alkyl, lower alkoxy and halo(lower)alkyl, and pharmaceutically acceptable salts thereof, and processes for preparation thereof and pharmaceutical composition comprising the same.These derivatives and salts thereof are useful as antiinflammatory and analgesic agents.
摘要翻译：新的下式的氨基脲衍生物：其中R1是氢，R2是氢，低级烷基，芳基（低级）烷基，低级烯基或芳基，R3是低级烷基，芳基（低级）烷基，低级烯基或芳基，或 R2和R3一起形成任选被芳基取代的（C 2 -C 6）亚烷基或与相邻的氮原子一起形成任选被芳基取代的饱和或不饱和的5或6元杂环基; 或者R1和R2与相邻的氮原子一起形成饱和或不饱和的5或6元杂环基或1,2-二氮杂环烷-1,2-二基，R3是氢，低级烷基，ar（低级）烷基，低级烯基或芳基; R4是可以具有选自低级烷基，卤素，低级烷氧基，低级烷基氨基，卤代（低级）烷基，羟基，低级烷酰基，酯化羧基和羧基的取代基的芳基，R 5是氢或低级烷基，X是O 或者当R 2为氢或（C 1 -C 2）烷基，且R 4为任选具有选自以下的取代基的芳基时，R 3的低级烷基为（C 3 -C 6）烷基：（C 3 -C 6）烷基，低级烷基，低级烷氧基和卤代（低级）烷基及其药学上可接受的盐，及其制备方法和包含其的药物组合物。这些衍生物和其盐可用作抗炎和止痛剂。

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