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41. 发明授权

US06506609B1 Focusing of microparticles in microfluidic systems 有权
标题翻译：将微粒聚焦在微流体系统中
公开(公告)号：US06506609B1
公开(公告)日：2003-01-14
申请号：US09569747
申请日：2000-05-11
申请人： H. Garrett Wada , Anne R. Kopf-Sill , Marja Liisa Alajoki , J. Wallace Parce , Benjamin N. Wang , Andrea W. Chow , Robert S. Dubrow
发明人： H. Garrett Wada , Anne R. Kopf-Sill , Marja Liisa Alajoki , J. Wallace Parce , Benjamin N. Wang , Andrea W. Chow , Robert S. Dubrow
IPC分类号： G01N700
CPC分类号： B01F13/0062 , B01J19/0093 , B01J2219/00889 , B01J2219/00891 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0652 , B01L2400/0406 , B01L2400/0487 , G01N15/1404 , G01N27/44704 , G01N27/44791 , G01N2015/1409 , G01N2015/149 , G01N2333/4718 , Y10T436/117497 , Y10T436/2575
摘要： Methods and systems for particle focusing to increase assay throughput in microscale systems are provided. The invention includes methods for providing substantially uniform flow velocity to flowing particles in microfluidic devices. Methods of sorting members of particle populations, such as cells and various subcellular components are also provided. Integrated systems in which particles are focused and/or sorted are additionally included.
摘要翻译：提供了用于增加微尺度系统中测定通过量的粒子聚焦的方法和系统。本发明包括为微流体装置中的流动颗粒提供基本均匀的流速的方法。还提供了分选颗粒群体成员的方法，例如细胞和各种亚细胞组分。另外包括其中聚焦和/或分选颗粒的集成系统。

42. 发明授权

US06488897B2 Microfluidic devices and systems incorporating cover layers 失效
标题翻译：微流体装置和包含覆盖层的系统
公开(公告)号：US06488897B2
公开(公告)日：2002-12-03
申请号：US09846694
申请日：2001-05-01
申请人： Robert S. Dubrow , Colin B. Kennedy , Robert Nagle
发明人： Robert S. Dubrow , Colin B. Kennedy , Robert Nagle
IPC分类号： B01L300
CPC分类号： B01L3/502715 , B01L3/5085 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/0689 , B01L2300/0681 , B01L2300/0887 , B01L2300/16 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , G01N27/44791 , G01N2035/00148 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： The present invention provides microfluidic devices that comprise a body structure comprising at least a first microscale channel network disposed therein. The body structure has a plurality of ports disposed in the body structure, where each port is in fluid communication with one or more channels in the first channel network. The devices also include a cover layer comprising a plurality of apertures disposed through the cover layer. The cover layer is mated with the body structure whereby each of the apertures is aligned with a separate one of the plurality of ports.
摘要翻译：本发明提供了包括主体结构的微流体装置，其包括至少设置在其中的第一微量通道网络。身体结构具有设置在身体结构中的多个端口，其中每个端口与第一通道网络中的一个或多个通道流体连通。这些装置还包括覆盖层，其包括穿过覆盖层设置的多个孔。覆盖层与主体结构配合，由此每个孔与多个端口中的单独一个对准。

43. 发明授权

US6149787A External material accession systems and methods 有权
公开(公告)号：US6149787A
公开(公告)日：2000-11-21
申请号：US173469
申请日：1998-10-14
申请人： Andrea W. Chow , Robert S. Dubrow , J. Wallace Parce , Steven A. Sundberg , Jeffrey A. Wolk
发明人： Andrea W. Chow , Robert S. Dubrow , J. Wallace Parce , Steven A. Sundberg , Jeffrey A. Wolk
IPC分类号： B01L3/00 , G01N35/00 , G01N35/10 , G01N27/26
CPC分类号： B01L3/502715 , B01L3/502746 , B01L2200/027 , B01L2300/0816 , B01L2300/0838 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , B01L3/50273 , G01N2035/00237 , G01N2035/1062 , Y10S366/02 , Y10T436/2575
摘要： Methods, apparatus and systems are provided for introducing large numbers of different materials into a microfluidic analytical device rapidly, efficiently and reproducibly. In particular, improved integrated pipettor chip configurations, e.g. sippers or electropipettors, are described which are capable of sampling extremely small amounts of material for which analysis is desired, transporting material into a microfluidic analytical channel network, and performing the desired analysis on the material.

44. 发明授权

US6123798A Methods of fabricating polymeric structures incorporating microscale fluidic elements 失效
公开(公告)号：US6123798A
公开(公告)日：2000-09-26
申请号：US73710
申请日：1998-05-06
申请人： Khushroo Gandhi , Robert S. Dubrow , Luc J. Bousse
发明人： Khushroo Gandhi , Robert S. Dubrow , Luc J. Bousse
IPC分类号： B01L3/00 , B29C65/00 , B29C65/02 , B32B38/04 , B32B38/06 , G01N27/447 , B32B31/20
CPC分类号： G01N27/44791 , B01L3/502707 , B07C5/342 , B29C65/02 , B29C65/08 , B29C66/30223 , B29C66/54 , B29C66/712 , B29C66/73115 , B29C66/73365 , B29C66/8322 , B32B37/0023 , B32B38/06 , B01L2200/12 , B29C66/71 , B29C66/73343 , B29L2031/756 , B32B2037/0092 , B32B2310/028 , B32B2310/0843 , Y10T156/10 , Y10T428/2495 , Y10T428/266
摘要： The present invention generally provides improved methods of fabricating polymeric microfluidic devices that incorporate microscale fluidic structures, whereby the fabrication process does not substantially distort or deform such structures. The methods of the invention generally provide enhanced bonding processes for mating and bonding substrate layers to define the microscale channel networks therebetween.

45. 发明授权

US4859715A Microporous poly (arylether ketone) article 失效
标题翻译：微孔聚（芳基醚酮）制品
公开(公告)号：US4859715A
公开(公告)日：1989-08-22
申请号：US119140
申请日：1987-11-10
申请人： Robert S. Dubrow , Michael F. Froix
发明人： Robert S. Dubrow , Michael F. Froix
IPC分类号： B29C61/00 , C08J9/26
CPC分类号： B29C61/003 , C08J9/26 , B29K2105/04 , Y10S525/928
摘要： This invention provides a method for the preparation of an article from a blend of at least two molecularly compatible polymers by treating the blend with a solvent which is a solvent for one of the polymers and a non-solvent for the other. The solvent can be removed while the article is restrained from undergoing substantial shrinkage, in which case a microporous article is obtained. Alternatively, the solvent can be removed while the article is permitted to shrink. In this case high shrinkage force (also referred to as recovery force) results which can be utilized to apply the article to a substrate. The final and intermediate articles are novel. In a preferred embodiment, the invention provides a microporous article having an average pore size of about 0.005 microns to about 1 micron.
摘要翻译：本发明提供了一种由至少两种分子相容的聚合物的共混物制备制品的方法，其通过用作为聚合物之一的溶剂的溶剂和另一种的非溶剂处理该共混物。可以在制品被抑制发生大量收缩的同时除去溶剂，在这种情况下获得微孔制品。或者，可以在允许制品收缩的同时除去溶剂。在这种情况下，可以将该物品应用于基材的高收缩力（也称为恢复力）。最后和中间的文章是新颖的。在优选的实施方案中，本发明提供了具有约0.005微米至约1微米的平均孔径的微孔制品。

46. 发明授权

US4690831A Protective article 失效
标题翻译：防护用品
公开(公告)号：US4690831A
公开(公告)日：1987-09-01
申请号：US875802
申请日：1986-06-18
申请人： William D. Uken , Robert S. Dubrow , Carib Nelson , Catherine A. Dittmer
发明人： William D. Uken , Robert S. Dubrow , Carib Nelson , Catherine A. Dittmer
IPC分类号： F16L58/18 , G02B6/44 , H01B17/60 , H01R4/22 , H01R4/70 , H01R4/72 , H01R13/52 , H01R43/00 , H02G15/10 , H05K3/28 , B05D3/06
CPC分类号： H02G15/10 , F16L58/18 , G02B6/4447 , H01B17/60 , H01R13/5216 , H01R4/70 , H01R43/005 , H01R4/22 , H01R4/72 , H05K3/284 , Y10T156/1048
摘要： An article for protecting a substrate includes a preshaped member having a shape similar to that of the substrate being protected, the article having a thin layer of gel disposed in intimate contact with an inner surface of the member such that the gel is disposed in intimate contact with the substrate when the member is disposed therearound. Preferably, the gel comprises an open looped three-dimensional network, the gel being relatively soft, elastic, and having an ultimate elongation in excess of 100%.
摘要翻译：用于保护基材的制品包括具有与被保护的基材的形状类似的形状的预成型构件，所述制品具有薄的凝胶层，其与构件的内表面紧密接触，使得凝胶以紧密接触的方式设置当该构件被布置在其周围时与该衬底。优选地，凝胶包含开环三维网络，凝胶相对柔软，弹性，并具有超过100％的极限伸长率。

47. 发明授权

US08623288B1 Apparatus and methods for high density nanowire growth 有权
标题翻译：高密度纳米线生长的装置和方法
公开(公告)号：US08623288B1
公开(公告)日：2014-01-07
申请号：US12824485
申请日：2010-06-28
申请人： Robert S. Dubrow , Carlos Casillas
发明人： Robert S. Dubrow , Carlos Casillas
IPC分类号： B01J8/02 , B01J35/02 , B01J19/00 , B01J8/00 , C01B31/00 , C01B31/02 , D01F9/00
CPC分类号： C30B29/06 , B01J19/006 , B01J19/2415 , B01J19/2495 , B01J19/32 , B01J21/08 , B01J21/185 , B01J23/52 , B01J35/0013 , B01J35/0026 , B01J35/04 , B01J35/06 , B01J37/0207 , B01J37/0211 , B01J37/0217 , B01J37/0225 , B01J2219/00772 , B01J2219/32466 , B01J2219/32491 , B82Y30/00 , B82Y40/00 , C01B32/15 , C30B11/12 , C30B29/602 , D01F9/00
摘要： Methods and apparatus for high density nanowire growth are presented. Methods of making a nanowire growth cartridge assembly are also provided, as are nanowire growth cartridge assemblies.
摘要翻译：提出了高密度纳米线生长的方法和装置。还提供了制备纳米线生长盒组件的方法，纳米线生长盒组件也是如此。

48. 发明授权

US07723123B1 Western blot by incorporating an affinity purification zone 有权
标题翻译：通过掺入亲和纯化区的蛋白质印迹
公开(公告)号：US07723123B1
公开(公告)日：2010-05-25
申请号：US10159605
申请日：2002-05-31
申请人： Matthew B. Murphy , Robert S. Dubrow
发明人： Matthew B. Murphy , Robert S. Dubrow
IPC分类号： G01N33/558
CPC分类号： G01N33/54366
摘要： An upstream affinity purification region is used to bind one or more component of interest in a mixture of components prior to separating the mixture of components. Detection of the separated components and a released component of interest provide identification of the component of interest. In addition, post separation dilution is optionally used to improve detection of the mixture of components and the released component of interest. Microfluidic devices and systems suitable for performing such analyses are also provided.
摘要翻译：在分离组分混合物之前，使用上游亲和纯化区域将组分混合物中的一种或多种感兴趣组分结合。检测分离的组分和释放的感兴趣组分提供了感兴趣组分的鉴定。此外，可以使用后分离稀释来改进组分混合物和所释放的感兴趣组分的检测。还提供了适于执行这种分析的微流体装置和系统。

49. 发明申请

US20090124025A1 Nanowire-based sensor configurations 有权
标题翻译：基于纳米线的传感器配置
公开(公告)号：US20090124025A1
公开(公告)日：2009-05-14
申请号：US11399218
申请日：2006-04-06
申请人： James M. Hamilton , Robert S. Dubrow , Calvin Y.H. Chow
发明人： James M. Hamilton , Robert S. Dubrow , Calvin Y.H. Chow
IPC分类号： G01N33/551 , G01N33/543 , G01N33/53
CPC分类号： G01N33/54313 , B82Y15/00 , G01N27/127 , G01N27/4146
摘要： This invention provides nanowire based molecular sensors and methods for detecting analytes in a microfluidic system. Methods for sensing analytes include detecting changed electrical parameters associated with contact of a nanowire with the analyte in a microfluidic system. Sensors of the invention include nanowires mounted in microchambers of a microfluidic system in electrical contact with the detector, whereby electrical parameter changes induced in the nanowire by the analyte can be monitored by the detector.
摘要翻译：本发明提供了基于纳米线的分子传感器和用于检测微流体系统中的分析物的方法。感测分析物的方法包括检测与微流体系统中的纳米线与分析物的接触相关联的改变的电参数。本发明的传感器包括安装在与检测器电接触的微流体系统的微室中的纳米线，由分析物在纳米线中诱发的电参数变化可由检测器监测。

50. 发明申请

US20080237540A1 Methods for encapsulating nanocrystals 审中-公开
标题翻译：封装纳米晶体的方法
公开(公告)号：US20080237540A1
公开(公告)日：2008-10-02
申请号：US12076530
申请日：2008-03-19
申请人： Robert S. Dubrow
发明人： Robert S. Dubrow
IPC分类号： C23C14/34 , B29C65/08 , C09K11/54
CPC分类号： C09K11/025 , C09K11/08 , Y10T156/10
摘要： The present invention provides methods for hermetically sealing luminescent nanocrystals, as well as compositions and containers comprising hermetically sealed luminescent nanocrystals. By hermetically sealing the luminescent nanocrystals, enhanced lifetime and luminescence can be achieved.
摘要翻译：本发明提供了用于气密密封发光纳米晶体的方法，以及包括密封的发光纳米晶体的组合物和容器。通过气密密封发光纳米晶体，可以实现寿命延长和发光。

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