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41. 发明授权

US09343494B2 Light guided pixel configured for emissions detection and comprising a guide layer with a wavelength selective filter material and a light detector layer 有权
标题翻译：配置用于发射检测的光引导像素，并且包括具有波长选择滤光器材料和光检测器层的引导层
公开(公告)号：US09343494B2
公开(公告)日：2016-05-17
申请号：US13411103
申请日：2012-03-02
申请人： Seung Ah Lee , Guoan Zheng , Benjamin Judkewitz , Shuo Pang , Jigang Wu , Changhuei Yang
发明人： Seung Ah Lee , Guoan Zheng , Benjamin Judkewitz , Shuo Pang , Jigang Wu , Changhuei Yang
IPC分类号： H01L27/146
CPC分类号： H01L27/14629 , H01L27/14621
摘要： A light guided pixel having a guide layer and a light detector layer. The guide layer has a light guide. The light detector layer has a light detecting element that receives light channeled by the light guide. The light guide may include a filter for channeling emissions to the light detecting element.
摘要翻译：具有引导层和光检测器层的光引导像素。引导层具有光导。光检测器层具有接收光导通路的光检测元件。光导可以包括用于将发射引导到光检测元件的滤光器。

42. 发明授权

US08970671B2 Nondiffracting beam detection devices for three-dimensional imaging 有权
$Nondiffracting beam detection devices for three-dimensional imaging$
标题翻译：用于三维成像的非衍射光束检测装置
公开(公告)号：US08970671B2
公开(公告)日：2015-03-03
申请号：US13032449
申请日：2011-02-22
申请人： Sri Rama Prasanna Pavani , Changhuei Yang
发明人： Sri Rama Prasanna Pavani , Changhuei Yang
IPC分类号： H04N13/02 , G02B21/16 , G02B21/36 , G02B27/22
CPC分类号： H04N13/207 , G02B21/16 , G02B21/361 , G02B27/2242 , G02B27/2285 , H04N13/221 , H04N13/254
摘要： Embodiments of the present invention relate a nondiffracting beam detection module for generating three-dimensional image data that has a surface layer having a first surface and a light transmissive region, a microaxicon, and a light detector. The microaxicon receives light through the light transmissive region from outside the first surface and generates one or more detection nondiffracting beams based on the received light. The light detector receives the nondiffracting beams and generates three-dimensional image data associated with an object located outside the first surface based on the one or more detection nondiffracting beams received. In some cases, the light detector can localize a three-dimensional position on the object associated with each detection nondiffracting beam received. In other cases, the light detector can determine perspective projections based on the detection nondiffracting beams received and generates the three-dimensional image data, using tomography, based on the determined perspective projections.
摘要翻译：本发明的实施例涉及一种用于产生具有具有第一表面和透光区域的表面层的三维图像数据的非衍射光束检测模块，微型透镜和光检测器。微轴通过第一表面外部的透光区域接收光，并基于接收的光产生一个或多个检测非衍射光束。光检测器基于接收的一个或多个检测非衍射光束接收非衍射光束并产生与位于第一表面外部的物体相关联的三维图像数据。在某些情况下，光检测器可以定位与所接收的每个检测非衍射光束相关联的物体上的三维位置。在其他情况下，光检测器可以基于所接收的检测非衍射光束来确定透视投影，并且基于所确定的透视投影，使用断层摄影产生三维图像数据。

43. 发明授权

US08525998B2 Optical phase processing in a scattering medium 有权
标题翻译：散射介质中的光学相位处理
公开(公告)号：US08525998B2
公开(公告)日：2013-09-03
申请号：US12886320
申请日：2010-09-20
申请人： Zahid Yaqoob , Emily McDowell , Changhuei Yang
发明人： Zahid Yaqoob , Emily McDowell , Changhuei Yang
IPC分类号： G01B9/021
CPC分类号： G03H1/0005 , G03H2001/0083 , G03H2001/0268 , G03H2001/0413 , G03H2001/0415 , G03H2210/63 , G03H2222/56
摘要： An optical phase processing system for a scattering medium. A first beam has a direction and a wavefront and the first beam is configured to enter a holographic recording medium. A scattering medium is illuminated by a signal beam generating at least one scattered beam. An interference pattern is recorded from the at least one scattered beam and the first beam. A second beam is generated in a direction opposite to the direction of the first beam, the second beam having a wavefront and a phase substantially opposite to a phase of the wavefront of the first beam, and the second beam is configured to enter the holographic recording medium. The second beam and the interference pattern interact to generate at least one reconstructed beam having a phase substantially opposite to a phase of the at least one scattered beam, and the at least one reconstructed beam is configured to be viewable through the scattering medium.
摘要翻译：一种用于散射介质的光学相位处理系统。第一光束具有方向和波前，并且第一光束被配置为进入全息记录介质。散射介质由产生至少一个散射光束的信号光束照射。从至少一个散射光束和第一光束记录干涉图案。在与第一光束的方向相反的方向上产生第二光束，第二光束具有波前和与第一光束的波阵面的相位基本相反的相位，第二光束被配置为进入全息记录中。所述第二光束和所述干涉图案相互作用以产生具有与所述至少一个散射光束的相位基本相反的相位的至少一个重建光束，并且所述至少一个重建光束被配置为通过所述散射介质可观看。

44. 发明申请

US20110234757A1 SUPER RESOLUTION OPTOFLUIDIC MICROSCOPES FOR 2D AND 3D IMAGING 有权
标题翻译：超分辨率光学显微镜2D和3D成像
公开(公告)号：US20110234757A1
公开(公告)日：2011-09-29
申请号：US13069651
申请日：2011-03-23
申请人： Guoan Zheng , Changhuei Yang , Samuel Yang , Seung Ah Lee
发明人： Guoan Zheng , Changhuei Yang , Samuel Yang , Seung Ah Lee
IPC分类号： H04N13/02 , H04N7/18
CPC分类号： H04N5/349 , G01N15/147 , G01N15/1484 , G02B21/0008 , G02B21/36 , G06T3/4053
摘要： A super resolution optofluidic microscope device comprises a body defining a fluid channel having a longitudinal axis and includes a surface layer proximal the fluid channel. The surface layer has a two-dimensional light detector array configured to receive light passing through the fluid channel and sample a sequence of subpixel shifted projection frames as an object moves through the fluid channel. The super resolution optofluidic microscope device further comprises a processor in electronic communication with the two-dimensional light detector array. The processor is configured to generate a high resolution image of the object using a super resolution algorithm, and based on the sequence of subpixel shifted projection frames and a motion vector of the object.
摘要翻译：超分辨率光流体显微镜装置包括限定具有纵向轴线的流体通道的主体并且包括靠近流体通道的表面层。表面层具有二维光检测器阵列，其构造成当物体移动通过流体通道时，接收通过流体通道的光并采样一系列子像素偏移的投影框。超分辨率光流体显微镜装置还包括与二维光检测器阵列电子通信的处理器。处理器被配置为使用超分辨率算法，并且基于子像素偏移的投影帧的序列和对象的运动矢量来生成对象的高分辨率图像。

45. 发明申请

US20110109962A1 OPTICAL PHASE CONJUGATION 4 PI MICROSCOPE 有权
标题翻译：光学相位4 PI显微镜
公开(公告)号：US20110109962A1
公开(公告)日：2011-05-12
申请号：US12943818
申请日：2010-11-10
申请人： Meng Cui , Changhuei Yang
发明人： Meng Cui , Changhuei Yang
IPC分类号： G02B21/06 , G01B9/021
CPC分类号： G02B21/0056 , A61B5/0059 , A61B5/0066 , G01N21/1717 , G01N21/4795 , G01N21/6456 , G01N2021/1708 , G01N2021/1727 , G02B21/00 , G02B21/0004 , G02B21/0068 , G02B21/0092 , Y10T29/49826
摘要： A 4-Pi microscope for imaging a sample, comprising a first objective for focusing a first light beam on the sample at a spatial point one or more Digital Optical Phase Conjugation (DOPC) devices, wherein the DOPC devices include a sensor for detecting the first light beam that has been transmitted through the sample and inputted on the sensor; and a spatial light modulator (SLM) for outputting, in response to the first light beam detected by the sensor, a second light beam that is an optical phase conjugate of the first light beam; and a second objective positioned to transmit the first light beam to the sensor and focus the second light beam on the sample at the spatial point, so that the first light beam and the second light beam are counter-propagating and both focused to the spatial point.
摘要翻译：一种用于对样本进行成像的4-Pi显微镜，包括用于在空间点上将第一光束聚焦在一个或多个数字光相位共轭（DOPC）装置上的第一物镜，其中所述DOPC装置包括用于检测所述第一通过样品传输并输入到传感器上的光束; 以及空间光调制器（SLM），用于响应于由传感器检测到的第一光束，输出作为第一光束的光学相位共轭的第二光束; 以及第二目的，其定位为将第一光束传输到传感器并将第二光束聚焦在空间点处的样本上，使得第一光束和第二光束相反传播并且两者都聚焦到空间点。

46. 发明申请

US20100290049A1 OPTOFLUIDIC MICROSCOPE DEVICE 审中-公开
标题翻译：光学显微镜装置
公开(公告)号：US20100290049A1
公开(公告)日：2010-11-18
申请号：US12797132
申请日：2010-06-09
申请人： Changhuei Yang , Demetri Psaltis
发明人： Changhuei Yang , Demetri Psaltis
IPC分类号： G01N21/00
CPC分类号： G01N21/6458 , B82Y10/00 , B82Y20/00
摘要： An optofluidic microscope device is disclosed. The device includes a fluid channel having a surface and an object such as a bacterium or virus may flow through the fluid channel. Light imaging elements in the bottom of the fluid channel may be used to image the object.
摘要翻译：公开了一种光流体显微镜装置。该装置包括具有表面的流体通道，诸如细菌或病毒的物体可以流过流体通道。流体通道底部的光成像元件可用于成像物体。

47. 发明申请

US20090009834A1 OPTICAL PHASE PROCESSING IN A SCATTERING MEDIUM 审中-公开
标题翻译：散射介质中的光相处理
公开(公告)号：US20090009834A1
公开(公告)日：2009-01-08
申请号：US11868394
申请日：2007-10-05
申请人： Zahid Yaqoob , Emily McDowell , Changhuei Yang
发明人： Zahid Yaqoob , Emily McDowell , Changhuei Yang
IPC分类号： G03H1/08
CPC分类号： G03H1/0005 , G03H2001/0083 , G03H2001/0268 , G03H2001/0413 , G03H2001/0415 , G03H2210/63 , G03H2222/56
摘要： An optical phase processing system for a scattering medium. A first beam has a direction and a wavefront and the first beam is configured to enter a holographic recording medium. A scattering medium is illuminated by a signal beam generating at least one scattered beam. An interference pattern is recorded from the at least one scattered beam and the first beam. A second beam is generated in a direction opposite to the direction of the first beam, the second beam having a wavefront and a phase substantially opposite to a phase of the wavefront of the first beam, and the second beam is configured to enter the holographic recording medium. The second beam and the interference pattern interact to generate at least one reconstructed beam having a phase substantially opposite to a phase of the at least one scattered beam, and the at least one reconstructed beam is configured to be viewable through the scattering medium.
摘要翻译：一种用于散射介质的光学相位处理系统。第一光束具有方向和波前，并且第一光束被配置为进入全息记录介质。散射介质由产生至少一个散射光束的信号光束照射。从至少一个散射光束和第一光束记录干涉图案。在与第一光束的方向相反的方向上产生第二光束，第二光束具有波前和与第一光束的波阵面的相位基本相反的相位，第二光束被配置为进入全息记录中。所述第二光束和所述干涉图案相互作用以产生具有与所述至少一个散射光束的相位基本相反的相位的至少一个重建光束，并且所述至少一个重建光束被配置为通过所述散射介质可观看。

48. 发明授权

US07385460B1 Combined electrostatic and optical waveguide based microfluidic chip systems and methods 有权
标题翻译：基于静电和光波导的微流控芯片系统和方法
公开(公告)号：US07385460B1
公开(公告)日：2008-06-10
申请号：US11264980
申请日：2005-11-01
申请人： Fei Wang , David Erickson , Changhuei Yang
发明人： Fei Wang , David Erickson , Changhuei Yang
IPC分类号： H01P5/00
CPC分类号： H01P5/00
摘要： A system for detecting interactions between charged targets and analytes. The system includes a fluid channel, and a waveguide associated with the fluid channel. A detection region is associated with the waveguide, and a biasing element is operatively coupled to the detection region. The biasing element is adapted to electrically bias a portion of the waveguide at the detection region, and the charged targets are electrostatically bound to the detection region when the portion of the waveguide is electrically biased. An optical detector is adapted to detect optical changes from the detection region.
摘要翻译：用于检测带电目标和分析物之间相互作用的系统。该系统包括流体通道和与流体通道相关联的波导。检测区域与波导相关联，并且偏置元件可操作地耦合到检测区域。偏置元件适于在检测区域电偏置波导的一部分，并且当波导的部分被电偏置时，带电目标被静电地结合到检测区域。光学检测器适于检测来自检测区域的光学变化。

49. 发明授权

US07075658B2 Method for optical coherence tomography imaging with molecular contrast 有权
标题翻译：光学相干层析成像与分子对比的方法
公开(公告)号：US07075658B2
公开(公告)日：2006-07-11
申请号：US10765010
申请日：2004-01-26
申请人： Joseph A. Izatt , Divakar K. Rao , Changhuei Yang , Michael A. Choma , Siavash Yazdanfar , Andrew M. Rollins , Brian E. Applegate
发明人： Joseph A. Izatt , Divakar K. Rao , Changhuei Yang , Michael A. Choma , Siavash Yazdanfar , Andrew M. Rollins , Brian E. Applegate
IPC分类号： G01B9/02
CPC分类号： G01B9/02004 , G01B9/02002 , G01B9/02007 , G01B9/02014 , G01B9/02044 , G01B9/02069 , G01B9/02091 , G01B2290/70
摘要： Spatial information, such as concentration and displacement, about a specific molecular contrast agent, may be determined by stimulating a sample containing the agent, thereby altering an optical property of the agent. A plurality of optical coherence tomography (OCT) images may be acquired, at least some of which are acquired at different stimulus intensities. The acquired images are used to profile the molecular contrast agent concentration distribution of the sample.
摘要翻译：关于特定分子造影剂的空间信息，例如浓度和位移可以通过刺激含有试剂的样品来确定，从而改变试剂的光学性质。可以获取多个光学相干断层摄影（OCT）图像，其中至少一些在不同的刺激强度下被获取。采集的图像用于分析样品的分子造影剂浓度分布。

50. 发明申请

US20050271548A1 Optofluidic microscope device 有权
标题翻译：光电显微镜装置
公开(公告)号：US20050271548A1
公开(公告)日：2005-12-08
申请号：US11125718
申请日：2005-05-09
申请人： Changhuei Yang , Demetri Psaltis
发明人： Changhuei Yang , Demetri Psaltis
IPC分类号： G01N21/00 , G01N21/64
CPC分类号： G01N21/6458 , B82Y10/00 , B82Y20/00
摘要： An optofluidic microscope device is disclosed. The device includes a fluid channel having a surface and an object such as a bacterium or virus may flow through the fluid channel. Light imaging elements in the bottom of the fluid channel may be used to image the object.
摘要翻译：公开了一种光流体显微镜装置。该装置包括具有表面的流体通道，诸如细菌或病毒的物体可以流过流体通道。流体通道底部的光成像元件可用于成像物体。

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