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41. 发明授权

US5771325A Modular laser system 失效
标题翻译：模块化激光系统
公开(公告)号：US5771325A
公开(公告)日：1998-06-23
申请号：US724082
申请日：1996-09-30
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： H01S3/0941 , H01S5/068 , H01S5/40 , C02B6/36
CPC分类号： H01S3/09415 , H01S5/06825 , H01S5/4025
摘要： In a modular laser system, a plurality of laser modules are interchangeably mounted on a support rack with each laser module transmitting an output beam to a respective optical pump fiber, and the plurality of pump fibers are optically coupled to a laser rod for generating a combined output beam. A laser diode array is mounted within a sealed chamber of each module, and an output wave-guide of each module is coupled through a plurality of optical fibers to the diode array to receive the laser emissions. The other end of each output wave-guide has a first connector, and each pump fiber has a corresponding second connector permitting the output wave-guides to be interchangeably connected to the pump fibers. A control circuit of each laser module monitors the status of its laser diodes, the voltage and current supplied thereto, and the temperature conditions, and generates signals indicative of these parameters for detecting and replacing failed or defective laser modules. During replacement of a laser module, the other modules may continue to operate and generate a system output beam (albeit at a lower power level) thus permitting virtually continuous system operation.
摘要翻译：在模块化激光系统中，多个激光模块可互换地安装在支撑架上，每个激光模块将输出光束传输到相应的光泵浦光纤，并且多个泵浦光纤光学耦合到激光棒，以产生组合输出光束。激光二极管阵列安装在每个模块的密封室中，并且每个模块的输出波导通过多根光纤耦合到二极管阵列以接收激光发射。每个输出波导的另一端具有第一连接器，并且每个泵浦光纤具有相应的第二连接器，允许输出波导可互换地连接到泵浦光纤。每个激光模块的控制电路监视其激光二极管的状态，供给的激光二极管的电压和电流以及温度条件，并产生指示这些参数的信号，用于检测和更换失效或有缺陷的激光模块。在更换激光模块期间，其他模块可以继续操作并产生系统输出光束（尽管处于较低功率水平），从而允许实际上连续的系统操作。

42. 发明申请

US20210378741A1 ENCLOSED LASER MEDICAL DEVICE/SYSTEM 有权
公开(公告)号：US20210378741A1
公开(公告)日：2021-12-09
申请号：US16891656
申请日：2020-06-03
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/22 , A61B90/98
摘要： A fiber optic medical device/system is presented, comprising means to connect and enclose a laser source to ensure sterility and safe operation. Device includes a low cost, single use system enclosed and sterilized including laser source and with the fiber attached in a sterile tube. Another embodiment comprises hermetically sealed laser unit with simple connection system to a properly shaped fiber optic, after joining, unit comprises a hand piece and fiber for direct insertion to treat target tissue. Laser handle is aseptically packaged. In other embodiments, fiber is proximally terminated in solid funnel-shaped end to provide unique directional keyed junction with laser module. In another embodiment, unit includes fiber proximally joined to it, where a laser module can be added away from the fiber end, so that laser does not need to be sterilized but entire unit is safe for medical use in sterile fields. Enclosure also serves as a grip for pulling and/or manipulating device. In another preferred embodiment, laser unit is attached to a rigid delivery system for laparoscopic procedures.

43. 发明授权

US09693826B2 Endoluminal laser ablation device and method for treating veins 有权
公开(公告)号：US09693826B2
公开(公告)日：2017-07-04
申请号：US12395455
申请日：2009-02-27
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/18 , A61B18/24 , A61B17/22 , A61B18/22
CPC分类号： A61B18/24 , A61B17/22012 , A61B2018/2272
摘要： An improved method and device is provided for safe and efficient low power density endoluminal treatment of venous insufficiency. One such device emits pulsed or continuous energy radially through an optical fiber end with a conical shaped tip for 360° radial emission. In some embodiments, a conical reflective surface is distally spaced opposite to and faces the emitting tip for enhancing radial emission efficiency by reflecting out any designed or remnant forwardly transmitted energy in radial directions. Other devices include flat emitting faces sealed within protective, radiation transparent covers. Laser radiation is transmitted at a wavelength and power such that is it substantially entirely absorbed within the blood vessel wall to sufficiently damage the intravascular endothelium and, in turn, achieve blood vessel closure. Because the energy is substantially entirely absorbed within the blood vessel wall, the need for a local anesthetic along the treatment area of the blood vessel may be substantially avoided.

44. 发明授权

US09149335B2 Contact free and perforation safe endoluminal laser treatment device and method 有权
标题翻译：接触自由和穿孔安全腔内激光治疗装置及方法
公开(公告)号：US09149335B2
公开(公告)日：2015-10-06
申请号：US12951617
申请日：2010-11-22
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/18 , A61B18/24
CPC分类号： A61B18/24
摘要： A device and method for endovascular radiation therapy that prevents unwanted damage to blood vessels during treatment is described. The device is adapted to prevent the emission end of an energy delivery device from coming into contact with the wall of a blood vessel. The device is also adapted to sense the inputted radiation power and prevent irradiation above a preselected power or energy level. Both features serve to prevent radiation, having an overly high intensity or power density, from impacting the vessel wall and causing a puncture.
摘要翻译：描述了用于在治疗期间防止对血管的不期望的损伤的血管内放射治疗的装置和方法。该装置适于防止能量输送装置的排放端与血管的壁接触。该装置还适于感测输入的辐射功率并防止辐射高于预选的功率或能量水平。这两个特征都用于防止具有过高的强度或功率密度的辐射影响血管壁并引起穿刺。

45. 发明授权

US08815931B2 Oral formulations for tetrapyrrole derivatives 有权
标题翻译：四吡咯衍生物的口服制剂
公开(公告)号：US08815931B2
公开(公告)日：2014-08-26
申请号：US12768244
申请日：2010-04-27
申请人： Susanna Gräfe , Nikolay Nifantiev , Albrecht Volker , Wolfgang Neuberger , Gerhard Wieland , Dietrich Scheglmann , Alfred Fahr , Arno Wiehe
发明人： Susanna Gräfe , Nikolay Nifantiev , Albrecht Volker , Wolfgang Neuberger , Gerhard Wieland , Dietrich Scheglmann , Alfred Fahr , Arno Wiehe
IPC分类号： A61K31/40 , A61K9/127 , A61K31/498 , A61K9/00 , A61K31/409
CPC分类号： A61K31/409 , A61K9/0065 , A61K9/127 , A61K9/1271 , A61K31/498
摘要： Oral formulations and method of formulating photosensitive agents for oral administration during photodynamic therapy (PDT) and Antimicrobial photodynamic therapy (APDT) treatment are presented. The oral formulated photosensitizers show increased solubility and permeability, thus improving the bioavailability of photosensitizers at the treatment site. An orally administered photosensitizer is suitably formulated for mucosal adhesion and absorption via gastrointestinal mucosal membranes. Oral formulation provided herein use lipids and known proteins as carriers for photosensitizers by oral route. Carriers for encapsulating preselected photosensitizers include conventional liposomes, pegylated liposomes, nanoemulsions, nanocrystrals, nanoparticles, fatty emulsions, lipidic formulations, hydrosols, SMEDDS, Alpha-Feto protein (AFP), and Bovine-Serum-Albumin (BSA), fatty emulsions, hot-melt-extrudates and nanoparticles. The oral formulation, in case of a hydrophobic photosensitizer in the present invention, is stabilized using suitable surfactants/solubilizers thus preventing aggregation of the drug in the stomach and until it is absorbed in the duodenum and the small intestine. Oral formulations can be administered in the form of liquid, capsule, tablet, powder, paste or gel. Formulated drugs can be administered orally as one single dose or in multiple doses before administering PDT. In one embodiment Temoporfin (m-THPC) is used as a photosensitizer in the oral formulations. Temoporfin like many hydrophobic photosensitizers are especially suitable to be administered orally because there is no known enzyme system in the mammalian body which can metabolize Temoporfin or similar photosensitizers. Temoporfin can reach the blood system unchanged and fully active after absorption of the formulation in the gastrointestinal tract.
摘要翻译：提出了在光动力治疗（PDT）和抗微生物光动力疗法（APDT）治疗中配制口服光敏剂的口服制剂和方法。口服配制的光敏剂显示增加的溶解度和渗透性，从而提高光敏剂在治疗部位的生物利用度。口服给药的光敏剂适于配制用于通过胃肠粘膜进行粘膜粘附和吸收。本文提供的口服制剂通过口服途径使用脂质和已知蛋白质作为光敏剂的载体。用于封装预选光敏剂的载体包括常规脂质体，聚乙二醇化脂质体，纳米乳剂，纳米胶体，纳米颗粒，脂肪乳剂，脂质制剂，水溶胶，SMEDDS，α-铁蛋白（AFP）和牛血清白蛋白（BSA），脂肪乳剂，热熔融挤出物和纳米颗粒。在本发明的疏水性光敏剂的情况下，使用合适的表面活性剂/增溶剂稳定口服制剂，从而防止药物在胃中的聚集，直到其被吸收到十二指肠和小肠中。口服制剂可以以液体，胶囊，片剂，粉末，糊剂或凝胶的形式施用。配制药物可以在给予PDT之前以一次剂量或多次剂量口服给药。在一个实施方案中，Temoporfin（m-THPC）用作口服制剂中的光敏剂。类似于许多疏水性光敏剂的Temoporfin特别适合于口服给药，因为哺乳动物体内没有已知的可以代谢Temoporfin或类似光敏剂的酶系统。 Temoporfin可以在胃肠道吸收制剂后达到血液系统不变和充分活性。

46. 发明授权

US08801764B2 Cosmetic laser treatment device and method for localized lipodystrophies and flaccidity 有权
标题翻译：化妆品激光治疗装置及局部脂肪营养不良及易感性的方法
公开(公告)号：US08801764B2
公开(公告)日：2014-08-12
申请号：US11415782
申请日：2006-05-02
申请人： Danilo Castro Suarez , Wolfgang Neuberger
发明人： Danilo Castro Suarez , Wolfgang Neuberger
IPC分类号： A61N5/06 , A61B18/20 , A61B18/24 , A61B18/00 , A61B18/22 , A61B17/00
CPC分类号： A61B18/22 , A61B18/20 , A61B18/24 , A61B2017/00792 , A61B2018/00464 , A61B2018/0047 , A61B2018/00577 , A61B2018/2272
摘要： A method and device for cosmetic surgery, especially fat reduction and collagen reformation, by means of a high power laser operating at about 980 nm is presented. The cosmetic surgery method substantially reduces or removes localized lipodystrophies, and essentially reduces flaccidity by localized laser heating of adipose tissue using an optical fiber inserted into a treatment area. The method and device are particularly well suited for treating Lipodystrophies with flaccidity High power laser energy is applied to “fat” cells to breakdown the cell walls releasing the cell fluid. The laser radiation is applied through an optical fiber which may be held within a catheter-like device having a single lumen. The optical fiber may have a diffuser mounted on the tip to further apply heating to tissues surrounding the whole tip. A saline solution may also be inserted into the treatment site to aid in the heating of the fat cells and their eventual destruction as well as their removal. The pool of cell fluid in the area of treatment is removed by a combination of techniques including allowing the body to remove it by absorption and drainage from the entry sites thus minimizing trauma to the area of treatment and hastening recovery. Additional techniques to remove the cell fluid include direct force application by means of elastic bandages and external suction applied to the entry sites. Quick and lasting cosmetic changes, even in areas having prior untreatable fat tissues, are achieved while minimizing trauma to the treatment areas.
摘要翻译：提出了一种用于整容手术的方法和装置，特别是通过在约980nm下操作的高功率激光来减脂和胶原蛋白重整。整容手术方法基本上减少或去除局部的脂肪营养不良，并且通过使用插入到治疗区域中的光纤对脂肪组织的局部激光加热来基本上减少松弛。该方法和装置特别适合用于治疗具有松弛性的脂肪营养不良。大功率激光能量被施加到“脂肪”细胞上以破坏释放细胞液的细胞壁。激光辐射通过可以保持在具有单个管腔的导管状装置内的光纤施加。光纤可以具有安装在尖端上的扩散器，以进一步对整个尖端周围的组织施加加热。也可以将盐水溶液插入治疗部位，以帮助加热脂肪细胞及其最终的破坏以及其去除。治疗区域中的细胞液池通过技术的组合来去除，包括允许身体通过进入部位的吸收和排出而将其去除，从而最小化对治疗区域和加速恢复的创伤。除去细胞液的附加技术包括通过弹性绷带施加的直接力施加和施加到入口部位的外部吸力。即使在具有先前不可治愈的脂肪组织的区域中也能实现快速和持久的化妆品变化，同时最小化治疗区域的创伤。

47. 发明授权

US08709004B2 Method and device for vascular treatment 有权
标题翻译：用于血管治疗的方法和装置
公开(公告)号：US08709004B2
公开(公告)日：2014-04-29
申请号：US12755948
申请日：2010-04-07
申请人： Julio H. G. Ferreira , Jorge O. Löpez D'Ambola , Wolfgang Neuberger , Antonio C. Reichelt , Jorge E. Soracco
发明人： Julio H. G. Ferreira , Jorge O. Löpez D'Ambola , Wolfgang Neuberger , Antonio C. Reichelt , Jorge E. Soracco
IPC分类号： A61B18/18
CPC分类号： A61B18/00 , A61B18/06 , A61B18/08 , A61B18/1492 , A61B18/24 , A61B2018/00023 , A61B2018/00029 , A61B2018/00404 , A61B2218/002
摘要： A method and device for improved minimally invasive vascular treatments. The method comprises introducing a catheter into a vein to be treated. The catheter is adapted to introduce an energy transmitting member and a fluid into the vein to be treated. The fluid introduced via the catheter can include, but is not limited to: saline solutions, cooled saline solutions, liquids for vapor generation, vasoconstricting agents, anesthetic agents and/or a formulation containing an ingredient which can be activated by the applied energy.
摘要翻译：用于改善微创血管治疗的方法和装置。该方法包括将导管引入待治疗的静脉中。导管适于将能量传递构件和流体引入待治疗的静脉中。通过导管引入的流体可以包括但不限于：盐水溶液，冷却的盐水溶液，用于蒸气产生的液体，血管收缩剂，麻醉剂和/或含有可被施加的能量活化的成分的制剂。

48. 发明授权

US08414880B2 PDT treatment method for cellulites and cosmetic use 失效
标题翻译：用于脂肪团和化妆品使用的PDT处理方法
公开(公告)号：US08414880B2
公开(公告)日：2013-04-09
申请号：US12899003
申请日：2010-10-06
申请人： Danilo Castro , Wolfgang Neuberger
发明人： Danilo Castro , Wolfgang Neuberger
IPC分类号： A01N63/00
CPC分类号： A61K31/555 , A61K8/494 , A61K31/409 , A61K2800/81 , A61Q19/06
摘要： Photosensitizer mixtures and method of treating cellulites by light illumination are presented. Photosensitizer is combined with cellular products, e.g. adipose cells, collagen, previously removed by liposuction. Concentrations used depend on treatment area, cellulite stage and whether cellulites are in depressed or elevated skin areas. The cosmetic treatment reduces/removes localized lipodystrophies, flaccidity, cellulite using localized laser, LED, etc emissions. Applied light energy destroys “fat” cells by a combination of chemical reactions primarily, and temperature, wherein cell walls break releasing cell fluid. Transmission devices guide radiation to the treatment site. One or more light sources like laser diodes or LEDs may be coupled into one or more optical fibers to increase the covered area and increase the amount of radiation in that area. Optical fibers can be introduced percutaneously or interstitially. Cell fluid in the treatment area is removed by a combination of techniques.
摘要翻译：提出了光敏剂混合物和通过光照照治疗脂肪团的方法。光敏剂与蜂窝产品结合，例如脂肪细胞，胶原蛋白，预先通过吸脂除去。使用的浓度取决于治疗区域，脂肪团阶段以及是否在脂肪团处于抑郁或升高的皮肤区域。化妆处理减少/消除了使用局部激光，LED等排放的局部脂肪营养不良，松弛，脂肪团。应用光能主要通过化学反应的组合和温度破坏脂肪细胞，其中细胞壁破坏释放细胞液体。传输装置将辐射引导到治疗部位。诸如激光二极管或LED的一个或多个光源可以耦合到一个或多个光纤中，以增加覆盖面积并增加该区域中的辐射量。光纤可经皮或间质引入。通过技术的组合来去除处理区域中的细胞液。

49. 发明授权

US08409176B2 Method and device for laser lithotripsy 失效
标题翻译：激光碎石术的方法和装置
公开(公告)号：US08409176B2
公开(公告)日：2013-04-02
申请号：US12628634
申请日：2009-12-01
申请人： Walter Cecchetti , Wolfgang Neuberger , Leonardo Cecchetti
发明人： Walter Cecchetti , Wolfgang Neuberger , Leonardo Cecchetti
IPC分类号： A61B17/22
CPC分类号： A61B18/26 , A61B18/24 , A61B2017/2215 , A61B2018/00029 , A61B2018/263
摘要： A system/method for destruction/ablation of stones, calculi or other hard substances using laser is disclosed. Lithotripsy is particularly benefitted. The system comprises a diode laser source, one or more optical fibers and a liquid delivery system creating a liquid environment around stones (calculi). At least one emitted wavelength is highly absorbed in surrounding/covering medium, causing evaporation and cavitation effects that lead to stone/calculi destruction. Different radiation configurations may be used. in one embodiment continuous radiation is used to create sparkler-less plasma bubbles to destroy hard substances. In another embodiment high peak power pulsed radiation is used. Wavelengths of 1470 nm, 1940 nm, or 1550 nm are preferred. Additionally device/method is used with another wavelength having absorption in water e.g. 980 nm. Safer/improved methods/system provide enhanced lithotripsy treatments with shorter treatment times to destroy a wider range of stones with less tissue damage risk.
摘要翻译：公开了使用激光破坏/消融石块，结石或其他硬物质的系统/方法。碎石术特别受益。该系统包括二极管激光源，一个或多个光纤以及在石头（结石）周围产生液体环境的液体输送系统。至少一个发射波长在周围/覆盖介质中被高度吸收，导致导致石头/结石破坏的蒸发和气蚀效应。可以使用不同的辐射配置。在一个实施例中，连续辐射用于产生无闪蒸的等离子体气泡以破坏硬物质。在另一个实施例中，使用高峰值功率脉冲辐射。优选1470nm，1940nm或1550nm的波长。另外装置/方法用于在水中具有吸收的另一种波长。 980nm。更安全/改进的方法/系统提供增强的碎石治疗，治疗时间更短，以破坏更广泛的石块，减少组织损伤风险。

50. 发明申请

US20110275979A1 METHOD/DEVICE FOR TRANSDERMAL VASCULAR TREATMENT 有权
标题翻译：用于超声波血管治疗的方法/装置
公开(公告)号：US20110275979A1
公开(公告)日：2011-11-10
申请号：US12992533
申请日：2009-05-15
申请人： Jorge O. López D'Ambola , Jorge E. Soracco , Wolfgang Neuberger
发明人： Jorge O. López D'Ambola , Jorge E. Soracco , Wolfgang Neuberger
IPC分类号： A61M37/00 , A61N5/067
CPC分类号： A61B18/203 , A61B18/20 , A61B18/22 , A61B2017/00765 , A61B2018/00452 , A61B2018/00458 , A61B2018/202 , A61B2018/2065 , A61N5/062 , A61N2005/007 , A61N2005/0651 , A61N2005/0659
摘要： Devices and transdermal methods are provided for safe and effective therapeutic treatment of the venous system, such as varicose veins. Present invention provides non-invasive and minimally invasive transdermal methods for treating varicose and spider veins, comprising the use of a radiation source in combination with a chemical fluid/composition to safely and more effectively close or shrink vein walls, providing a transdermal therapeutic method for varicose veins until now only treated with surgery or endovascular laser treatments. In a preferred embodiment a device comprises a radiation source, preferably of wavelength between about 980 and 1940 nm, being effective in causing shrinkage of the vein treated. In other preferred embodiments methods comprise the transdermal delivery of a chemical composition through a patch or gel or the injection of a chemical fluid, preferably a hypertonic solution, to the vein under treatment; and simultaneously or after a dwell time, irradiating with a radiation source transdermally. The treatment performed with the present invention results in blood vessel wall damaged, eventually closing the vein, in lesser time with practically no pain or discomfort to the patient during and after the therapy.
摘要翻译：提供装置和透皮方法用于对静脉系统进行安全和有效的治疗，例如静脉曲张。本发明提供用于治疗静脉曲张和蜘蛛静脉的非侵入性和微创透皮方法，其包括使用辐射源与化学液体/组合物组合以安全且更有效地闭合或收缩静脉壁，提供透皮治疗方法静脉曲张直到目前为止只用手术或血管内激光治疗。在优选实施例中，装置包括辐射源，优选波长在约980和1940nm之间，有效地引起所治疗静脉的收缩。在其它优选实施方案中，方法包括通过贴剂或凝胶透皮递送化学组合物或将化学流体（优选高渗溶液）注射到处理的静脉中; 并且在停留时间之后或之后，经皮肤照射辐射源。用本发明进行的治疗导致血管壁受损，最终在较短的时间内关闭静脉，实际上在治疗期间和之后患者没有疼痛或不适。

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