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41. 发明授权

US08414880B2 PDT treatment method for cellulites and cosmetic use 失效
标题翻译：用于脂肪团和化妆品使用的PDT处理方法
公开(公告)号：US08414880B2
公开(公告)日：2013-04-09
申请号：US12899003
申请日：2010-10-06
申请人： Danilo Castro , Wolfgang Neuberger
发明人： Danilo Castro , Wolfgang Neuberger
IPC分类号： A01N63/00
CPC分类号： A61K31/555 , A61K8/494 , A61K31/409 , A61K2800/81 , A61Q19/06
摘要： Photosensitizer mixtures and method of treating cellulites by light illumination are presented. Photosensitizer is combined with cellular products, e.g. adipose cells, collagen, previously removed by liposuction. Concentrations used depend on treatment area, cellulite stage and whether cellulites are in depressed or elevated skin areas. The cosmetic treatment reduces/removes localized lipodystrophies, flaccidity, cellulite using localized laser, LED, etc emissions. Applied light energy destroys “fat” cells by a combination of chemical reactions primarily, and temperature, wherein cell walls break releasing cell fluid. Transmission devices guide radiation to the treatment site. One or more light sources like laser diodes or LEDs may be coupled into one or more optical fibers to increase the covered area and increase the amount of radiation in that area. Optical fibers can be introduced percutaneously or interstitially. Cell fluid in the treatment area is removed by a combination of techniques.
摘要翻译：提出了光敏剂混合物和通过光照照治疗脂肪团的方法。光敏剂与蜂窝产品结合，例如脂肪细胞，胶原蛋白，预先通过吸脂除去。使用的浓度取决于治疗区域，脂肪团阶段以及是否在脂肪团处于抑郁或升高的皮肤区域。化妆处理减少/消除了使用局部激光，LED等排放的局部脂肪营养不良，松弛，脂肪团。应用光能主要通过化学反应的组合和温度破坏脂肪细胞，其中细胞壁破坏释放细胞液体。传输装置将辐射引导到治疗部位。诸如激光二极管或LED的一个或多个光源可以耦合到一个或多个光纤中，以增加覆盖面积并增加该区域中的辐射量。光纤可经皮或间质引入。通过技术的组合来去除处理区域中的细胞液。

42. 发明授权

US08409176B2 Method and device for laser lithotripsy 失效
标题翻译：激光碎石术的方法和装置
公开(公告)号：US08409176B2
公开(公告)日：2013-04-02
申请号：US12628634
申请日：2009-12-01
申请人： Walter Cecchetti , Wolfgang Neuberger , Leonardo Cecchetti
发明人： Walter Cecchetti , Wolfgang Neuberger , Leonardo Cecchetti
IPC分类号： A61B17/22
CPC分类号： A61B18/26 , A61B18/24 , A61B2017/2215 , A61B2018/00029 , A61B2018/263
摘要： A system/method for destruction/ablation of stones, calculi or other hard substances using laser is disclosed. Lithotripsy is particularly benefitted. The system comprises a diode laser source, one or more optical fibers and a liquid delivery system creating a liquid environment around stones (calculi). At least one emitted wavelength is highly absorbed in surrounding/covering medium, causing evaporation and cavitation effects that lead to stone/calculi destruction. Different radiation configurations may be used. in one embodiment continuous radiation is used to create sparkler-less plasma bubbles to destroy hard substances. In another embodiment high peak power pulsed radiation is used. Wavelengths of 1470 nm, 1940 nm, or 1550 nm are preferred. Additionally device/method is used with another wavelength having absorption in water e.g. 980 nm. Safer/improved methods/system provide enhanced lithotripsy treatments with shorter treatment times to destroy a wider range of stones with less tissue damage risk.
摘要翻译：公开了使用激光破坏/消融石块，结石或其他硬物质的系统/方法。碎石术特别受益。该系统包括二极管激光源，一个或多个光纤以及在石头（结石）周围产生液体环境的液体输送系统。至少一个发射波长在周围/覆盖介质中被高度吸收，导致导致石头/结石破坏的蒸发和气蚀效应。可以使用不同的辐射配置。在一个实施例中，连续辐射用于产生无闪蒸的等离子体气泡以破坏硬物质。在另一个实施例中，使用高峰值功率脉冲辐射。优选1470nm，1940nm或1550nm的波长。另外装置/方法用于在水中具有吸收的另一种波长。 980nm。更安全/改进的方法/系统提供增强的碎石治疗，治疗时间更短，以破坏更广泛的石块，减少组织损伤风险。

43. 发明申请

US20110275979A1 METHOD/DEVICE FOR TRANSDERMAL VASCULAR TREATMENT 有权
标题翻译：用于超声波血管治疗的方法/装置
公开(公告)号：US20110275979A1
公开(公告)日：2011-11-10
申请号：US12992533
申请日：2009-05-15
申请人： Jorge O. López D'Ambola , Jorge E. Soracco , Wolfgang Neuberger
发明人： Jorge O. López D'Ambola , Jorge E. Soracco , Wolfgang Neuberger
IPC分类号： A61M37/00 , A61N5/067
CPC分类号： A61B18/203 , A61B18/20 , A61B18/22 , A61B2017/00765 , A61B2018/00452 , A61B2018/00458 , A61B2018/202 , A61B2018/2065 , A61N5/062 , A61N2005/007 , A61N2005/0651 , A61N2005/0659
摘要： Devices and transdermal methods are provided for safe and effective therapeutic treatment of the venous system, such as varicose veins. Present invention provides non-invasive and minimally invasive transdermal methods for treating varicose and spider veins, comprising the use of a radiation source in combination with a chemical fluid/composition to safely and more effectively close or shrink vein walls, providing a transdermal therapeutic method for varicose veins until now only treated with surgery or endovascular laser treatments. In a preferred embodiment a device comprises a radiation source, preferably of wavelength between about 980 and 1940 nm, being effective in causing shrinkage of the vein treated. In other preferred embodiments methods comprise the transdermal delivery of a chemical composition through a patch or gel or the injection of a chemical fluid, preferably a hypertonic solution, to the vein under treatment; and simultaneously or after a dwell time, irradiating with a radiation source transdermally. The treatment performed with the present invention results in blood vessel wall damaged, eventually closing the vein, in lesser time with practically no pain or discomfort to the patient during and after the therapy.
摘要翻译：提供装置和透皮方法用于对静脉系统进行安全和有效的治疗，例如静脉曲张。本发明提供用于治疗静脉曲张和蜘蛛静脉的非侵入性和微创透皮方法，其包括使用辐射源与化学液体/组合物组合以安全且更有效地闭合或收缩静脉壁，提供透皮治疗方法静脉曲张直到目前为止只用手术或血管内激光治疗。在优选实施例中，装置包括辐射源，优选波长在约980和1940nm之间，有效地引起所治疗静脉的收缩。在其它优选实施方案中，方法包括通过贴剂或凝胶透皮递送化学组合物或将化学流体（优选高渗溶液）注射到处理的静脉中; 并且在停留时间之后或之后，经皮肤照射辐射源。用本发明进行的治疗导致血管壁受损，最终在较短的时间内关闭静脉，实际上在治疗期间和之后患者没有疼痛或不适。

44. 发明申请

US20110196356A1 ABLATIVE/COAGULATIVE UROLOGICAL TREATMENT DEVICE AND METHOD 审中-公开
标题翻译：摘要/凝血治疗装置及方法
公开(公告)号：US20110196356A1
公开(公告)日：2011-08-11
申请号：US12882758
申请日：2010-09-15
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/22
CPC分类号： A61B18/22 , A61B18/18 , A61B18/1815 , A61B2017/00274 , A61B2018/00547 , A61B2018/00577 , A61B2018/00589 , A61B2018/1861 , A61N5/02
摘要： A device/system and a method of treating enlarged prostate and other urologic abnormalities are presented. A combined treatment is performed with several interstitial coagulating probes and an ablating fiber. Tissue vaporization is minimized by the denaturalizing effect of interstitial coagulative fibers. In a single device, multiple delivery systems achieve optimal tissue ablation/coagulation; a non-laser source like microwave energy coagulates tissue and a laser source ablates tissue. Another device comprises two or more laser sources with adjustable wavelengths controllable by physician as to ablative, coagulative, and tissue penetration needs. Continuous, semi-continuous, pulsed wave, or combinations are useful. In another embodiment, optical fiber has a central core for transmitting laser radiation, and a cladding layer about the core that may further transmit other laser radiation of a different or a same wavelength as the core. Fibers may have a side-firing distal end, a radial firing end, or an off-axis firing end. Feedback controls can be used. In general coagulative irradiation can use a radiofrequency or other radiant thermal source.
摘要翻译：提出了一种治疗放大的前列腺和其他泌尿系统异常的装置/系统和方法。用几个间质凝结探针和消融纤维进行联合治疗。组织蒸发通过间质凝固纤维的变性作用最小化。在单个装置中，多个递送系统实现最佳的组织消融/凝血; 诸如微波能量的非激光源凝结组织，激光源消融组织。另一个装置包括两个或更多个具有可调波长的激光源，可由医师控制，以消融，凝固和组织穿透需要。连续，半连续，脉冲波或组合是有用的。在另一个实施例中，光纤具有用于传输激光辐射的中心芯和围绕芯的包覆层，其可以进一步透射与芯不同或相同波长的其他激光辐射。纤维可以具有侧发射远端，径向射击端或离轴射击端。可以使用反馈控制。一般来说，凝结照射可以使用射频或其他辐射热源。

45. 发明申请

US20110172652A1 METHOD AND DEVICE FOR UNDERSKIN RADIATION TREATMENT OF ADIPOSE TISSUE 有权
公开(公告)号：US20110172652A1
公开(公告)日：2011-07-14
申请号：US12987416
申请日：2011-01-10
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/22
CPC分类号： A61B18/22 , A61B2018/0019 , A61B2018/00994 , A61B2018/2005 , A61B2018/2272
摘要： A method and device for underskin treatment and removal of adipose tissue by means of a radiation energy source is disclosed. The method disclosed of radiation-assisted tissue improvement consists of inserting a device or part of a device below the skin into areas to be treated, emitting radiation and moving the device within tissue area to reach all parts. The method is characterized by emitting radiation at intensity levels low enough to practically avoid or minimize carbonization in the main tissue components such as fat and connective tissue but at sufficient intensity to enable coagulation of smaller blood vessels thus preventing from bleeding at the spectrum emitted. Thus, in preferred embodiments, power density is kept at up to about 2 W/mm. This allows for use of small diameter fibers such as 400 μm or less. The device for carrying out underskin radiation treatment consists of a handpiece that allows easy manipulation by physicians, with a part that can be inserted below the skin and a part that can be held and manipulated outside the body. The part inserted below the skin can be vibrated or oscillated by means of suitable transducers to aid in distributing the radiation. Simultaneously or immediately afterwards, liquefied tissue is aspirated. If convenient, fluid irrigation of the area to be treated can be done. In a preferred embodiment, handpiece consists in a hollow cannula incorporating at least one channel for suction and/or irrigation and a light guiding means in its body/wall section for the purpose of the treatment and liquefaction of adipose tissue. Due to handpiece's special configuration, a wide variety of fiber tip configurations can be used, i.e. side emitting, conical, radial emitting, drop shaped, reflective caps, but not limited thereto. Each fiber tip configuration allows for optimally performing different specific treatments. The device further comprises at least one radiation source, included in device part affixed to the handpiece either in a permanent or detachable manner.

46. 发明申请

US20110160713A1 TWISTER FIBER OPTIC SYSTEMS AND THEIR USE IN MEDICAL APPLICATIONS 有权
公开(公告)号：US20110160713A1
公开(公告)日：2011-06-30
申请号：US12714155
申请日：2010-02-26
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/22
CPC分类号： A61B18/22 , A61B2018/0019 , A61B2018/1861 , A61B2018/2211 , A61B2018/2272 , A61B2018/2288
摘要： An improved device and method for safe, accurate and efficient surgical procedures are disclosed. The disclosed device is an optical fiber set with an asymmetric distal end configuration, comprising a bent tip fiber with a fused sleeve as an integral part of it, placed at the fiber's distal (output) end and with a rotatable connector at the proximal (input) side. Fiber tip and tissue-contacting surface located at the distal end of the tip may be constructed with different shape configurations, such as convex tip to improve focusing characteristics, concave tip to achieve diverging irradiation or an expanded beam tip to achieve an effect similar to that obtained by electrosurgical tools. A grip guarantees and enhances the ability to twist and rotate it easily. In another preferred embodiment, twisting maneuvers are enhanced through a special configuration. Both special features (bent tip and rotatable connector), allow for improved and enhanced treatment of diverse pathologies, making possible to efficiently and easily reach and treat specific tissues. Optical fiber's steerability, twistability and rotation lead to a more precise and improved effect on tissues. Due to this, easier, faster and more precise and efficient treatments can be performed by its means. For instance, it may be inserted into a cystoscope to perforin high power ablation of prostatic tissue for BPH treatments, or steered into one of the prostatic lobes, which can be excavated from the inside in order to relieve pressure on the urethra while maintaining the urethra's integrity. Other uses might be the removal of tumorous, hyperplasic or other unwanted tissue in the body. Optical fiber set disclosed can be used with laser sources of various wavelengths, including dual laser sources, but also higher power LED devices or very bright light sources can be used to generate the radiation to be transmitted as well. Due to this novel design, described fiber is easy to put in place, also easy to maintain in contact with tissue and highly durable. The feel to the doctor is greatly improved too. This results in more effective power transfer into tissue and therefore procedures are more reliable and procedure times are cut by up to 30%.

47. 发明申请

US20110160642A1 PEGYLATED LIPOSOMAL FORMULATIONS FOR PHOTODYNAMIC TREATMENT OF INFLAMMATORY DISEASES 审中-公开
标题翻译：用于荧光动力治疗炎性疾病的聚乙二醇脂质体制剂
公开(公告)号：US20110160642A1
公开(公告)日：2011-06-30
申请号：US12742336
申请日：2008-11-14
申请人： Wolfgang Neuberger , Volker Albrecht
发明人： Wolfgang Neuberger , Volker Albrecht
IPC分类号： A61M37/00 , A61K9/127 , A61K31/409 , A61P29/00 , A61P19/02
CPC分类号： A61K9/1271 , A61K41/0071 , A61K47/6911
摘要： A PDT treatment system designed to treat all types of human inflammatory disorders. A suitable drug delivery system is developed to target proliferating cells, at inflamed sites, populated with macrophages and other inflammatory mediators. The hydrophobic photosensitizer is loaded into the liposomal bilayer formed of synthetic phospholipids; at least one of the synthetic phospholipids is conjugated to polyethylene glycol (PEG) molecules, to prevent accumulation in the liver and spleen. Further, (PEG) formulated photosensitizer increases the circulatory half-life of the drug, enhances solubility, and modifies pharmacokinetic and pharmacodynamic properties. The formulation, thus, leads to a higher amount of delivered drug to the diseased target synovial tissue, increasing clinical effectiveness. In one embodiment, pegylated liposomes loaded with mTHPC are administered to diseased synovial joints, followed by light irradiation. Activated photosensitizer induces cytotoxic effect in the diseased synovial cells, thus preventing further inflammation and joint erosion and minimizing joint damage.
摘要翻译：设计用于治疗所有类型的人类炎症性疾病的PDT治疗系统。开发合适的药物递送系统以靶向增殖细胞，在发炎部位，富含巨噬细胞和其他炎症介质。将疏水性光敏剂加载到由合成磷脂形成的脂质体双层中; 至少一种合成磷脂与聚乙二醇（PEG）分子缀合，以防止在肝脏和脾脏中积累。此外，（PEG）配制的光敏剂可增加药物的循环半衰期，增强溶解性，并改变药代动力学和药效学性质。因此，该制剂导致更高量的递送药物到患病的目标滑液组织，增加临床有效性。在一个实施方案中，将装载有mTHPC的聚乙二醇化脂质体施用于患病的滑膜关节，随后进行光照射。活化的光敏剂在患病的滑膜细胞中诱导细胞毒性作用，从而防止进一步的炎症和关节侵蚀并最小化关节损伤。

48. 发明申请

US20100273803A1 Oral Formulations for Tetrapyrrole Derivatives 有权
标题翻译：四吡咯衍生物的口服制剂
公开(公告)号：US20100273803A1
公开(公告)日：2010-10-28
申请号：US12768244
申请日：2010-04-27
申请人： Susanna Gräfe , Nikolay Nifantiev , Albrecht Volker , Wolfgang Neuberger , Gerhard Wieland , Dietrich Scheglmann , Alfred Fahr , Arno Wiehe
发明人： Susanna Gräfe , Nikolay Nifantiev , Albrecht Volker , Wolfgang Neuberger , Gerhard Wieland , Dietrich Scheglmann , Alfred Fahr , Arno Wiehe
IPC分类号： A61K31/498 , C07D241/46 , A61K31/409 , C07D487/22 , A61P35/00 , A61P31/00 , A61K8/49 , A61Q19/00 , A61Q9/00
CPC分类号： A61K31/409 , A61K9/0065 , A61K9/127 , A61K9/1271 , A61K31/498
摘要： Oral formulations and method of formulating photosensitive agents for oral administration during photodynamic therapy (PDT) and Antimicrobial photodynamic therapy (APDT) treatment are presented. The oral formulated photosensitizers show increased solubility and permeability, thus improving the bioavailability of photosensitizers at the treatment site. An orally administered photosensitizer is suitably formulated for mucosal adhesion and absorption via gastrointestinal mucosal membranes. Oral formulation provided herein use lipids and known proteins as carriers for photosensitizers by oral route. Carriers for encapsulating preselected photosensitizers include conventional liposomes, pegylated liposomes, nanoemulsions, nanocrystrals, nanoparticles, fatty emulsions, lipidic formulations, hydrosols, SMEDDS, Alpha-Feto protein (AFP), and Bovine-Serum-Albumin (BSA), fatty emulsions, hot-melt-extrudates and nanoparticles. The oral formulation, in case of a hydrophobic photosensitizer in the present invention, is stabilized using suitable surfactants/solubilizers thus preventing aggregation of the drug in the stomach and until it is absorbed in the duodenum and the small intestine. Oral formulations can be administered in the form of liquid, capsule, tablet, powder, paste or gel. Formulated drugs can be administered orally as one single dose or in multiple doses before administering PDT. In one embodiment Temoporfin (m-THPC) is used as a photosensitizer in the oral formulations. Temoporfin like many hydrophobic photosensitizers are especially suitable to be administered orally because there is no known enzyme system in the mammalian body which can metabolize Temoporfin or similar photosensitizers. Temoporfin can reach the blood system unchanged and fully active after absorption of the formulation in the gastrointestinal tract.
摘要翻译：提出了在光动力治疗（PDT）和抗微生物光动力疗法（APDT）治疗中配制口服光敏剂的口服制剂和方法。口服配制的光敏剂显示增加的溶解度和渗透性，从而提高光敏剂在治疗部位的生物利用度。口服给药的光敏剂适于配制用于通过胃肠粘膜进行粘膜粘附和吸收。本文提供的口服制剂通过口服途径使用脂质和已知蛋白质作为光敏剂的载体。用于封装预选光敏剂的载体包括常规脂质体，聚乙二醇化脂质体，纳米乳剂，纳米胶体，纳米颗粒，脂肪乳剂，脂质制剂，水溶胶，SMEDDS，α-铁蛋白（AFP）和牛血清白蛋白（BSA），脂肪乳剂，热熔融挤出物和纳米颗粒。在本发明的疏水性光敏剂的情况下，使用合适的表面活性剂/增溶剂稳定口服制剂，从而防止药物在胃中的聚集，直到其被吸收到十二指肠和小肠中。口服制剂可以以液体，胶囊，片剂，粉末，糊剂或凝胶的形式施用。配制药物可以在给予PDT之前以一次剂量或多次剂量口服给药。在一个实施方案中，Temoporfin（m-THPC）用作口服制剂中的光敏剂。类似于许多疏水性光敏剂的Temoporfin特别适合于口服给药，因为哺乳动物体内没有已知的可以代谢Temoporfin或类似光敏剂的酶系统。 Temoporfin可以在胃肠道吸收制剂后达到血液系统不变和充分活性。

49. 发明申请

US20090240242A1 Endoluminal Laser Ablation Device and Method for Treating Veins 有权
标题翻译：腔内激光消融装置及其治疗方法
公开(公告)号：US20090240242A1
公开(公告)日：2009-09-24
申请号：US12395455
申请日：2009-02-27
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/20
CPC分类号： A61B18/24 , A61B17/22012 , A61B2018/2272
摘要： An improved method and device is provided for safe and efficient low power density endoluminal treatment of venous insufficiency. One such device emits pulsed or continuous energy radially through an optical fiber end with a conical shaped tip for 360° radial emission. In some embodiments, a conical reflective surface is distally spaced opposite to and faces the emitting tip for enhancing radial emission efficiency by reflecting out any designed or remnant forwardly transmitted energy in radial directions. Other devices include flat emitting faces sealed within protective, radiation transparent covers. Laser radiation is transmitted at a wavelength and power such that is it substantially entirely absorbed within the blood vessel wall to sufficiently damage the intravascular endothelium and, in turn, achieve blood vessel closure. Because the energy is substantially entirely absorbed within the blood vessel wall, the need for a local anesthetic along the treatment area of the blood vessel may be substantially avoided.
摘要翻译：提供了一种改进的方法和装置，用于安全有效的低功率密度腔内治疗静脉功能不全。一个这样的装置通过具有锥形尖端的光纤端部径向地发射脉冲或连续的能量，用于360°径向发射。在一些实施例中，锥形反射表面与发射尖端相对并面对发射尖端，以通过反射径向方向上任何设计或残余的向前传输的能量来增强径向发射效率。其他设备包括密封在保护性辐射透明盖内的平坦发射面。激光辐射以波长和功率传输，使得其基本上完全被血管壁吸收，以充分损伤血管内皮，从而实现血管闭合。因为能量基本上完全被吸收在血管壁内，所以可以基本上避免沿着血管治疗区域的局部麻醉剂的需要。

50. 发明申请

US20080281308A1 Device and method for improved vascular laser treatment 审中-公开
标题翻译：改善血管激光治疗的装置和方法
公开(公告)号：US20080281308A1
公开(公告)日：2008-11-13
申请号：US11800865
申请日：2007-05-07
申请人： Wolfgang Neuberger , Marc Richly
发明人： Wolfgang Neuberger , Marc Richly
IPC分类号： A61B18/20
CPC分类号： A61B18/24
摘要： An improved treatment set and an improved method for endovascular laser treatments are described. The treatment set comprises an introducer sheath or tip and an optical waveguide for allowing the treatment set to be guided within a blood vessel. The s introducer sheath itself acts as the guide wire in one embodiment of the procedure. The introducer includes a means for protecting the tip of the optical fiber while the set is being positioned within the vessel and protecting the introducer tip from damaging the vessel. The method includes the steps of inserting the introducer/optical waveguide combination into a blood vessel to be treated, positioning the distal end of the introducer at a proper position in the blood vessel; advancing the optical fiber through a protective cap and/or means, and irradiating the blood vessel, preferably while withdrawing the treatment set toward the point of insertion. In another embodiment, the introducer/optical fiber combination includes a monorail groove within which a guidewire resides, wherein the optical fiber resides within the introducer and is advanced along the guidewire prior to treatment. The invention is advantageous in that it is quicker, as it requires fewer parts and fewer steps for effective treatment than do prior art devices and methods.
摘要翻译：描述了改进的治疗组和改善的血管内激光治疗方法。治疗组包括导引鞘或尖端和用于允许治疗组在血管内引导的光波导。在该过程的一个实施例中，导引鞘本身用作导丝。引导器包括用于在组件定位在容器内时保护光纤的尖端的装置，并且保护引导器尖端免于损坏容器。该方法包括以下步骤：将导引器/光波导组合插入待处理的血管中，将引导器的远端定位在血管中的适当位置; 通过保护盖和/或装置推进光纤，并且优选地在将治疗组朝向插入点撤回时照射血管。在另一个实施例中，导引器/光纤组合包括单轨槽，引导线所在的单轨槽，其中光纤位于导引器内，并且在处理之前沿导丝前进。本发明的优点在于它比现有技术的装置和方法更快，因为其需要更少的部件和更少的有效治疗步骤。

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