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41. 发明授权

US08117907B2 Caliper logging using circumferentially spaced and/or angled transducer elements 有权
标题翻译：使用圆周间隔和/或成角度的换能器元件进行卡尺测井
公开(公告)号：US08117907B2
公开(公告)日：2012-02-21
申请号：US12339229
申请日：2008-12-19
申请人： Wei Han , Tsili Wang
发明人： Wei Han , Tsili Wang
IPC分类号： E21B47/00
CPC分类号： E21B47/082
摘要： A downhole tool includes circumferentially spaced and/or angled transducer elements. In one embodiment a standoff sensor has at least three piezoelectric transducer elements, at least a first element of which is configured to both transmit and receive ultrasonic energy. At least second and third of the elements are configured to receive ultrasonic energy transmitted by the first element in pitch catch mode. An electronic controller is configured to calculate a standoff distance from the ultrasonic waveforms received at the first, the second, and the third piezoelectric transducer elements. The controller may further be configured to estimate the eccentricity of a measurement tool in the borehole. Exemplary embodiments of the invention may improve borehole coverage and data quality and reliability in LWD caliper logging. In particular, the invention may advantageously reduce or even eliminate blind spots when logging eccentric bore holes.
摘要翻译：井下工具包括周向间隔开和/或成角度的换能器元件。在一个实施例中，间隔传感器具有至少三个压电换能器元件，其至少第一元件被配置为发送和接收超声波能量。至少第二和第三元件构造成在俯仰模式下接收由第一元件传递的超声波能量。电子控制器被配置为计算从在第一，第二和第三压电换能器元件处接收的超声波波形的间隔距离。控制器还可以被配置为估计钻孔中的测量工具的偏心度。本发明的示例性实施例可以改进LWD卡尺测井中的井眼覆盖和数据质量和可靠性。特别地，当记录偏心孔时，本发明可有利地减少甚至消除盲点。

42. 发明授权

US07943131B2 Methods for protecting and regenerating bone marrow using CXCR3 agonists and antagonists 有权
标题翻译：使用CXCR3激动剂和拮抗剂保护和再生骨髓的方法
公开(公告)号：US07943131B2
公开(公告)日：2011-05-17
申请号：US12565300
申请日：2009-09-23
申请人： Wei Han , Huili Lu , Di Xiang
发明人： Wei Han , Huili Lu , Di Xiang
IPC分类号： A61K39/395 , A61K38/44 , A61K38/17 , A61K38/19
CPC分类号： A61K31/255 , A61K31/00 , A61K31/437 , A61K31/505 , A61K31/519 , A61K31/675 , A61K31/704 , A61K33/24 , A61K38/193 , A61K38/2006 , A61K38/2073 , A61K41/00 , A61K45/06 , A61K2300/00
摘要： CXCR3 agonists, including natural CXCR3 ligands, promote bone marrow regeneration, increase peripheral white blood cells, and increase survival if administered prior to treatment of a subject with chemotherapy or radiotherapy. Similar effects are obtained by administering an CXCR3 antagonists following chemotherapy radiotherapy. Compositions and methods are presented for the treatment of cancer and bone marrow diseases.
摘要翻译： CXCR3激动剂，包括天然CXCR3配体，促进骨髓再生，增加外周白细胞，如果在化疗或放疗治疗受试者之前进行治疗，则可增加其存活率。通过在化疗放疗后施用CXCR3拮抗剂可获得类似的作用。提供了治疗癌症和骨髓疾病的组合物和方法。

43. 发明授权

US07579865B1 Selective loading of configuration data into configuration memory cells 有权
标题翻译：将配置数据选择性地加载到配置存储单元中
公开(公告)号：US07579865B1
公开(公告)日：2009-08-25
申请号：US12186027
申请日：2008-08-05
申请人： David L. Rutledge , Wei Han , Yoshita Yerramilli
发明人： David L. Rutledge , Wei Han , Yoshita Yerramilli
IPC分类号： H03K19/173
CPC分类号： H03K19/1776 , H03K19/17764
摘要： In one embodiment, a programmable logic device (PLD) such as a field programmable gate array (FPGA) includes a non-volatile memory adapted to store a first bit, a second bit, and a plurality of configuration data. A plurality of configuration memory cells within the PLD is adapted to receive configuration data transferred from the non-volatile memory. The PLD further includes control logic adapted to determine based on the logic states of the first and second bits stored in the non-volatile memory and prior to any transfer of the configuration data whether to transfer the configuration data from the non-volatile memory to the configuration memory cells.
摘要翻译：在一个实施例中，诸如现场可编程门阵列（FPGA）的可编程逻辑器件（PLD）包括适于存储第一位，第二位和多个配置数据的非易失性存储器。 PLD内的多个配置存储器单元适于接收从非易失性存储器传送的配置数据。 PLD还包括控制逻辑，其适于基于存储在非易失性存储器中的第一和第二位的逻辑状态确定并且在配置数据的任何传送之前是否将配置数据从非易失性存储器传送到配置存储单元。

44. 发明申请

US20090176758A1 LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS 有权
标题翻译：含有LACTAM的化合物及其作为因子XA抑制剂的衍生物
公开(公告)号：US20090176758A1
公开(公告)日：2009-07-09
申请号：US12401401
申请日：2009-03-10
申请人： Donald J.P. Pinto , Mimi L. Quan , Michael J. Orwat , Yun-Long Li , Wei Han , Jennifer X. Qiao , Patrick Y.S. Lam , Stephanie L. Koch
发明人： Donald J.P. Pinto , Mimi L. Quan , Michael J. Orwat , Yun-Long Li , Wei Han , Jennifer X. Qiao , Patrick Y.S. Lam , Stephanie L. Koch
IPC分类号： A61K31/55 , C07D401/14 , A61P9/10
CPC分类号： C07D471/04 , A61J1/00 , A61J1/03 , A61J1/05 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/513 , A61K31/55 , A61K45/06 , B65D81/3216 , C07D213/75 , C07D213/81 , C07D213/82 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/14 , C07D417/14
摘要： The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4—P-M-M4 I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
摘要翻译：本申请描述了含有酰胺的化合物及其式I的衍生物：<？in-line-formula description =“In-line Formulas”end =“lead”？> P4-PM-M4 I <βin-line-formula 描述=“内联式”末端=“尾”→其药学上可接受的盐形式，其中环P（如果存在）为5-7元碳环或杂环，并且环M为5-7元碳环或杂环。本发明的化合物可用作胰蛋白酶样丝氨酸蛋白酶的抑制剂，特别是因子Xa。

45. 发明授权

US07446679B1 Compression and decompression of configuration data for programmable logic devices 有权
标题翻译：压缩和解压缩可编程逻辑器件的配置数据
公开(公告)号：US07446679B1
公开(公告)日：2008-11-04
申请号：US11779246
申请日：2007-07-17
申请人： Wei Han
发明人： Wei Han
IPC分类号： H03M7/38 , H03M7/34
CPC分类号： H03M7/3086 , H03M7/3088 , H03M7/40
摘要： Various approaches are disclosed to provide improved compression and decompression of configuration data for use with programmable logic devices (PLDs). Uncompressed configuration data may comprise a plurality of rows. In accordance with one embodiment, a method of converting the uncompressed configuration data into compressed configuration data includes encoding a row of configuration data comprising only bulk erase bytes into a first bit pattern within a fixed length header. The method also includes encoding a number of continuous bulk erase bytes of configuration data in a row that includes more than bulk erase bytes into a second bit pattern within the fixed length header. The method further includes encoding at least a portion of a row of configuration data according to a Lempel-Ziv (LZ) compression process into a third bit pattern within the fixed length header.
摘要翻译：公开了各种方法来提供用于与可编程逻辑器件（PLD）一起使用的配置数据的改进的压缩和解压缩。未压缩的配置数据可以包括多行。根据一个实施例，将未压缩配置数据转换成压缩配置数据的方法包括将仅包括批量擦除字节的配置数据行编码为固定长度报头内的第一位模式。该方法还包括将包括多于批量擦除字节的行中的多个配置数据的连续批量擦除字节编码为固定长度报头内的第二位模式。该方法还包括根据Lempel-Ziv（LZ）压缩过程将一行配置数据的至少一部分编码为固定长度报头内的第三位模式。

46. 发明申请

US20080186805A1 Apparatus and method for determining drilling fluid acoustic properties 有权
标题翻译：用于确定钻井液声学特性的装置和方法
公开(公告)号：US20080186805A1
公开(公告)日：2008-08-07
申请号：US11701260
申请日：2007-02-01
申请人： Wei Han
发明人： Wei Han
IPC分类号： G01V1/40
CPC分类号： E21B47/01 , E21B47/082
摘要： Aspects of this invention include a downhole tool having first and second radially offset ultrasonic standoff sensors and a controller including instructions to determine at least one of a drilling fluid acoustic velocity and a drilling fluid attenuation coefficient from the reflected waveforms received at the standoff sensors. The drilling fluid acoustic velocity may be determined via processing the time delay between arrivals of a predetermined wellbore reflection component at the first and second sensors. The drilling fluid attenuation coefficient may be determined via processing amplitudes of the predetermined wellbore reflection coefficients. The invention advantageously enables the acoustic velocity and attenuation coefficient of drilling fluid in the borehole annulus to be determined in substantially real-time.
摘要翻译：本发明的方面包括具有第一和第二径向偏移的超声波支架传感器的井下工具和包括用于根据在支座传感器处接收的反射波形来确定钻井液声速和钻井液衰减系数中的至少一个的指令的控制器。可以通过处理在第一和第二传感器处的预定井筒反射部件的到达之间的时间延迟来确定钻井液声速。钻井液衰减系数可以通过预定的井筒反射系数的处理振幅来确定。本发明有利地使得能够基本上实时地确定钻孔环中的钻井液的声速和衰减系数。

47. 发明授权

US07312214B2 1, 1-disubstituted cycloalkyl derivatives as factor Xa inhibitors 有权
标题翻译： 1,1-二取代的环烷基衍生物作为因子Xa抑制剂
公开(公告)号：US07312214B2
公开(公告)日：2007-12-25
申请号：US10430024
申请日：2003-05-05
申请人： Jennifer X. Qiao , Donald J. Pinto , Michael J. Orwat , Sarah R. Friedrich , Wei Han
发明人： Jennifer X. Qiao , Donald J. Pinto , Michael J. Orwat , Sarah R. Friedrich , Wei Han
IPC分类号： A61K31/535 , A61K31/50 , A61K31/495 , A01N43/58 , A01N43/60
CPC分类号： C07D213/75 , C07D209/30 , C07D333/38 , C07D401/04 , C07D409/12 , C07D471/04
摘要： The present application describes 1,1-disubstituted cycloalkyl compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
摘要翻译：本申请描述了可用作因子Xa抑制剂的1,1-二取代的环烷基化合物及其衍生物或其药学上可接受的盐形式。

48. 发明申请

US20060181960A1 Acoustic stimulation method with axial driver actuating moment arms on tines 有权
标题翻译：声刺激方法与轴向驱动器致动力矩臂在齿上
公开(公告)号：US20060181960A1
公开(公告)日：2006-08-17
申请号：US11059215
申请日：2005-02-16
申请人： James Birchak , Thomas Ritter , Ali Mese , Diederik Batenburg , William Trainor , Wei Han , Kwang Yoo , Daniel Kusmer , Mark Proett , Ferdinand Bas , Peter Sman , Jeroen Groenenboom , Pedro Zuiderwijk
发明人： James Birchak , Thomas Ritter , Ali Mese , Diederik Batenburg , William Trainor , Wei Han , Kwang Yoo , Daniel Kusmer , Mark Proett , Ferdinand Bas , Peter Sman , Jeroen Groenenboom , Pedro Zuiderwijk
IPC分类号： H04R17/00
CPC分类号： G10K9/121
摘要： A method for generating acoustic waves, the method having the steps of: extending a tine from a support structure so that a proximal end of the tine is attached to the support structure and a distal end of the tine is uninhibited; positioning an oscillator so as to be supported by the support structure and to mechanically communicate with the tine; and oscillating the tine with the oscillator.
摘要翻译：一种用于产生声波的方法，所述方法具有以下步骤：从支撑结构延伸齿，使得齿的近端附接到支撑结构，并且尖齿的远端不被抑制; 定位振荡器以便由支撑结构支撑并与齿机械连通; 并用振荡器振荡齿。

49. 发明申请

US20050273547A1 Method for balancing data access to non-volatile memory 审中-公开
标题翻译：用于平衡数据访问到非易失性存储器的方法
公开(公告)号：US20050273547A1
公开(公告)日：2005-12-08
申请号：US10859223
申请日：2004-06-03
申请人： Tony Tsai , David Ho , Wei Han
发明人： Tony Tsai , David Ho , Wei Han
IPC分类号： G06F12/00 , G11C16/10 , G11C16/34
CPC分类号： G11C16/102 , G11C16/349
摘要： The present invention discloses a method for balancing the data access to a non-volatile memory by sorting a block number of an unwritten memory block of a non-volatile memory with a queue structure. If the data in any memory block of the non-volatile memory is erased, the block number of the memory block in which the data is erased will be appended to the tail of the queue. If a data is written into the non-volatile memory, a block number of the memory block is obtained from the head of the queue and the desired data is written into the memory block with the corresponding block number, and in the meanwhile the block number is deleted from the queue.
摘要翻译：本发明公开了一种通过使用队列结构对非易失性存储器的未写入存储块的块数进行排序来平衡对非易失性存储器的数据访问的方法。如果非易失性存储器的任何存储器块中的数据被擦除，则擦除数据的存储器块的块号将附加到队列的尾部。如果将数据写入非易失性存储器，则从队列的头部获取存储块的块号，并将所需数据写入具有相应块号的存储块中，同时块号从队列中删除。

50. 发明申请

US20050176955A1 N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as hiv integrase inhibitors 失效
标题翻译：可用作hiv整合酶抑制剂的N-（取代的苄基）-8-羟基-1,6-萘啶-7-甲酰胺
公开(公告)号：US20050176955A1
公开(公告)日：2005-08-11
申请号：US10508094
申请日：2003-03-12
申请人： Melissa Egbertson , H. Marie Langford , Jeffrey Melamed , John Wai , Wei Han , Debbie Perlow , Linghang Zhuang , Mark Embrey , Steven Young
发明人： Melissa Egbertson , H. Marie Langford , Jeffrey Melamed , John Wai , Wei Han , Debbie Perlow , Linghang Zhuang , Mark Embrey , Steven Young
IPC分类号： A61K31/4375 , A61K31/541 , A61K31/549 , A61K45/00 , A61P31/18 , A61P43/00 , C07D471/02 , C07D471/04
CPC分类号： C07D471/04
摘要： N-(Substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides are inhibitors of HIV integrase and inhibitors of HIV replication. The naphthyridine carboxamides are of Formula (I): wherein R1′, R2′ and R3′ are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are described.
摘要翻译： N-（取代的苄基）-8-羟基-1,6-萘啶-7-甲酰胺是HIV整合酶和HIV复制抑制剂的抑制剂。萘啶甲酰胺具有式（I）：其中R 1，R 2和R 3'在本文中定义。这些化合物可用于预防和治疗艾滋病毒感染以及预防，延迟艾滋病的发病和治疗。这些化合物用作抗感染和艾滋病作为化合物本身或以药学上可接受的盐的形式。化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。描述了预防，治疗或延缓AIDS发病的方法以及预防或治疗HIV感染的方法。

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