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41. 发明专利

AU2014201605B2 N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS 未知
公开(公告)号：AU2014201605B2
公开(公告)日：2016-05-12
申请号：AU2014201605
申请日：2014-03-15
申请人： CARDIOXYL PHARMACEUTICALS INC , UNIV JOHNS HOPKINS
发明人： COHEN ANDREW D , BROOKFIELD FREDERICK ARTHUR , KALISH VINCENT JACOB , FROST LISA MARIE , COURTNEY STEPHEN MARTIN , TOSCANO JOHN P
IPC分类号： C07C311/48 , A61K31/18 , A61K31/192 , A61K31/235 , A61K31/5377 , A61P9/04 , A61P9/10 , C07D295/192 , C07D333/34 , C07D333/38
摘要： [0172] The invention relates to N-hydroxylsulfonamide derivatives for formula (I), (II), or (III), in which the variables are as defined in the claims, that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. N-hydroxylsulfonamide derivatives release HNO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of the functional groups on the N-hydroxylsulfonamide derivatives.

42. 发明专利

ES2448807T3 Derivados de N-hidroxilsulfonamida como nuevos donantes de nitroxilo fisiológicamente útiles 未知
公开(公告)号：ES2448807T3
公开(公告)日：2014-03-17
申请号：ES12155608
申请日：2007-03-16
申请人： CARDIOXYL PHARMACEUTICALS INC , UNIV JOHNS HOPKINS MED
发明人： TOSCANO JOHN P , BROOKFIELD FREDERICK ARTHUR , COHEN ANDREW D , COURTNEY STEPHEN MARTIN , FROST LISA MARIE , KALISH VINCENT JACOB
IPC分类号： A61K31/18 , A61P9/04 , C07D207/36 , C07D213/71 , C07D213/74 , C07D231/18 , C07D233/84 , C07D239/38 , C07D241/18 , C07D249/12 , C07D261/10 , C07D263/58 , C07D277/36 , C07D285/12 , C07D285/125 , C07D295/096 , C07D307/64 , C07D307/82 , C07D333/34 , C07D333/62
摘要： Un compuesto de fórmula (III):**Fórmula** o una sal farmacéuticamente aceptable del mismo, donde: R1 es H; R2 es H, aralquilo o heterociclilo; n es un número entero de 0 a 2; b es un número entero de 0 a 4; cada R8 está seleccionado, de manera independiente, de entre halo, alquilsulfonilo, N-hidroxilsulfonamidilo,perhaloalquilo, nitro, arilo, ciano, alcoxi, perhaloalcoxi, alquilo, ariloxi sustituido, alquilsulfanilo, alquilsulfinilo,heterocicloalquilo, heterocicloalquilo sustituido, dialquilamino, NH2, OH, C(O)OH, C(O)Oalquilo,NHC(O)alquilC(O)OH, C(O)NH2, NHC(O)alquilC(O)alquilo, NHC(O)alquenilC(O)OH, NHC(O)NH2,OalquilC(O)Oalquilo, NHC(O)alquilo, C(>=N-OH)NH2, cicloalcoxi, cicloalquilsulfanilo, arilsulfanilo y arilsulfinilo;donde dicho ariloxi sustituido es un grupo arilo conectado a la estructura precursora a través de un átomo deoxígeno, cuyo grupo arilo está sustituido con 1 a 3 grupos seleccionados de entre halo, nitro, ciano, oxo, arilo,alcoxi, alquilo, acilo, acilamino, amino, hidroxilo, carboxilo, carboxilalquilo, tiol, tioalquilo, heterociclilo y -OS(O)2-alquilo; y donde dicho heterocicloalquilo sustituido es un grupo heterociclilo sustituido con de 1 a 5 grupos seleccionadosde entre halo, nitro, ciano, oxo, arilo, alcoxi, alquilo, acilo, acilamino, amino, hidroxilo, carboxilo, carboxilalquilo,tiol, tioalquilo, heterociclilo y -OS(O)2-alquilo; C es un anillo heteroaromático que contiene restos anulares Q9, Q10, Q11, Q12, Q13 y Q14, que estánseleccionados, de manera independiente, del grupo que consiste en C, CH, N, NR10, O y S, con la condición deque al menos uno de Q9, Q10, Q11, Q12, Q13 y Q14 sea N, NR10, O y S; y R10 es H, alquilo, acilo o sulfonilo; para su uso en un método de modulación in vivo de los niveles de nitroxilo, de tratamiento de una enfermedad oafección que es sensible a la terapia con nitroxilo, de tratamiento de una enfermedad o afección cardiovascular, o detratamiento de la insuficiencia cardiaca.

43. 发明专利

AU2008304200B2 N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors 未知
公开(公告)号：AU2008304200B2
公开(公告)日：2013-12-19
申请号：AU2008304200
申请日：2008-09-26
申请人： CARDIOXYL PHARMACEUTICALS INC , UNIV JOHNS HOPKINS
发明人： BROOKFIELD FREDERICK ARTHUR , TOSCANO JOHN P , COHEN ANDREW D , FROST LISA MARIE , KALISH VINCENT JACOB , COURTNEY STEPHEN MARTIN
IPC分类号： C07C311/48 , A61K31/18 , A61K31/192 , A61K31/235 , A61K31/5377 , A61P9/04 , A61P9/10 , C07D295/192 , C07D333/34 , C07D333/38
摘要： The invention relates to

44. 发明专利

SG185255A1 N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS 未知
公开(公告)号：SG185255A1
公开(公告)日：2012-11-29
申请号：SG2012071627
申请日：2008-09-26
申请人： UNIV JOHNS HOPKINS , CARDIOXYL PHARMACEUTICALS INC
发明人： TOSCANO JOHN P , BROOKFIELD FREDERICK ARTHUR , COHEN ANDREW D , COURTNEY STEPHEN MARTIN , FROST LISA MARIE , KALISH VINCENT JACOB
摘要： The invention relates to N-hydroxylsulfonamide derivatives for formula (I), (II) or (III), in which the variables are as defined in the claims, that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. N-hydroxylsulfonamide derivatives release HNO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of the functional groups on the N-hydroxylsulfonamide derivatives.No suitable figure

45. 发明专利

NZ584036A N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors 未知
公开(公告)号：NZ584036A
公开(公告)日：2012-06-29
申请号：NZ58403608
申请日：2008-09-26
申请人： UNIV JOHNS HOPKINS , CARDIOXYL PHARMACEUTICALS INC
发明人： TOSCANO JOHN P , BROOKFIELD FREDERICK ARTHUR , COHEN ANDREW D , COURTNEY STEPHEN MARTIN , FROST LISA MARIE , KALISH VINCENT JACOB
IPC分类号： C07D333/34 , A61K31/18 , A61K31/192 , A61K31/235 , A61K31/5377 , A61P9/04 , A61P9/10 , C07C311/48 , C07D295/192 , C07D333/38
摘要： The disclosure relates to N-hydroxylsulfonamide derivatives for formula (I), (II) or (III), wherein the variables are as defined in the specification, that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury, wherein the variables shown in these structural formulae are as defined in the specification. These N-hydroxylsulfonamide derivatives release HNO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of the functional groups on the N-hydroxylsulfonamide derivatives.

46. 发明专利

TR200807066T1 未知
公开(公告)号：TR200807066T1
公开(公告)日：2009-11-23
申请号：TR200807066
申请日：2007-03-16
申请人： UNIV JOHNS HOPKINS MED , CARDIOXYL PHARMACEUTICALS INC
发明人： TOSCANO JOHN P , BROOKFIELD FREDERICK ARTHUR , KALISH VINCENT JACOB , COURTNEY STEPHEN MARTIN , FROST LISA MARIE , COHEN ANDREW D
IPC分类号： A61K31/18 , A61P9/04 , C07C311/48 , C07C317/14 , C07C323/67 , C07D207/36 , C07D213/71 , C07D213/74 , C07D215/06 , C07D215/28 , C07D231/18 , C07D233/84 , C07D239/38 , C07D241/18 , C07D249/12
摘要： The invention relates toN-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. NovelN-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on theN-hydroxysulfonamide derivatives.

48. 发明专利

ES2719101T3 Derivados de hidroxilamina N-acilados y derivados de hidroxilamina o-acilados 未知
公开(公告)号：ES2719101T3
公开(公告)日：2019-07-08
申请号：ES10793381
申请日：2010-12-07
申请人： UNIV JOHNS HOPKINS , CARDIOXYL PHARMACEUTICALS INC
发明人： TOSCANO JOHN P , SUTTON ART , KALISH VINCENT J , BROOKFIELD FREDERICK ARTHUR , COURTNEY STEPHEN MARTIN , FROST LISA MARIE
IPC分类号： C07C311/48 , A61K31/18 , A61P9/04 , C07C317/14 , C07D265/00
摘要： Un compuesto de formula (I)**Fórmula** o una sal, un hidrato o un solvato del mismo farmaceuticamente aceptables en donde: R es hidrogeno, alquilo, heterocicloalquilo, arilo, bencilo, alcoxi, heterocicloalcoxi, ariloxi, benciloxi, -NR3R4 o - N(OR3)R4, en donde dichos alquilo, heterocicloalquilo, arilo, bencilo, alcoxi, heterocicloalcoxi, ariloxi y benciloxi estan sin sustituir o sustituidos con uno o mas sustituyentes; R3 y R4 son independientemente alquilo, heterocicloalquilo o arilo, en donde dicho alquilo, heterocicloalquilo y arilo estan sin sustituir o sustituidos con uno o mas sustituyentes; L es SO2, Y es arilo y dicho arilo esta sin sustituir o sustituido con uno o mas sustituyentes seleccionados independientemente entre W, y W es halo, -OH, -CN, -NO2, -COR1, -COOR1, -CONR1R2, -CH(C(O)R1)2, -SO2R1 o -COX, en donde X es halo y R1 y R2 son independientemente alquilo o arilo, o R1 y R2 se toman juntos para formar a cicloalquilo o heterocicloalquilo, en donde dichos cicloalquilo y heterocicloalquilo estan sin sustituir o sustituidos con uno o mas sustituyentes; y en donde los sustituyentes, que pueden estar presentes cuando los grupos anteriores incluyen dichos uno o mas sustituyentes, son iguales o diferentes y se seleccionan entre halo, hidroxilo, amino, alquilamino, arilamino, dialquilamino, diarilamino, ciano, nitro, mercapto, oxo, carbonilo, tio, imino, formilo, carbamido, carbamilo, carboxilo, tioureido, tiocianato, sulfoamido, sulfonilalquilo, sulfonilarilo, alquilo, alquenilo, alcoxi, mercaptoalcoxi, arilo, heteroarilo, ciclilo, heterociclilo, en donde alquilo, alquenilo, alquiloxi, arilo, heteroarilo, ciclilo y heterociclilo estan opcionalmente sustituidos con alquilo, arilo, heteroarilo, halogeno, hidroxilo, amino, mercapto, ciano, nitro, oxo, tioxo o imino; dichos compuesto, sal, hidrato o solvato para uso en un metodo de tratamiento de una enfermedad o una afeccion seleccionadas de enfermedades cardiovasculares, isquemia, lesion por reperfusion, enfermedad cancerosa e hipertension pulmonar.

49. 发明专利

HUE030920T2 N-hidroxil-szulfonamid származékok mint új fiziológiailag hasznos nitroxil donorok 未知
公开(公告)号：HUE030920T2
公开(公告)日：2017-06-28
申请号：HUE12195124
申请日：2007-03-16
申请人： UNIV JOHNS HOPKINS , CARDIOXYL PHARMACEUTICALS INC
发明人： TOSCANO JOHN P , COHEN ANDREW D , COURTNEY STEPHEN MARTIN , FROST LISA MARIE , KALISH VINCENT JACOB , BROOKFIELD FREDERICK ARTHUR
IPC分类号： A61K31/18 , A61P9/04

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