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41. 发明申请

US20070105829A1 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THEIR PREPARATION 失效
标题翻译： 5-氨基-2-羟基苯甲酰胺衍生物，含有它们的药物组合物及其制备中间体
公开(公告)号：US20070105829A1
公开(公告)日：2007-05-10
申请号：US11553573
申请日：2006-10-27
申请人： Kosuke OKAZAKI , Masahiko Uchida , Harunobu Mukaiyama , Hiroaki Kobayashi , Yuichiro Kai , Hideki Takeuchi , Kenji Yokoyama , Yoshihiro Terao , Yuji Hoyano , Hiroaki Shiohara , Norihiko Kikuchi
发明人： Kosuke OKAZAKI , Masahiko Uchida , Harunobu Mukaiyama , Hiroaki Kobayashi , Yuichiro Kai , Hideki Takeuchi , Kenji Yokoyama , Yoshihiro Terao , Yuji Hoyano , Hiroaki Shiohara , Norihiko Kikuchi
IPC分类号： A61K31/553 , A61K31/55 , A61K31/5377 , A61K31/445 , A61K31/421 , A61K31/40 , A61K31/18
CPC分类号： A61K31/18 , A61K31/40 , A61K31/421 , A61K31/445 , A61K31/5377 , A61K31/55 , A61K31/553 , C07C311/29 , C07C311/37 , C07C317/32 , C07C2601/14
摘要： The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; R2 is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, an optionally substituted aryl group, an optionally substituted heterocycloalkyl group, or an optionally substituted aromatic heterocyclic group; T is an oxygen atom, a sulfur atom, a sulfonyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof.
摘要翻译：本发明涉及由以下通式表示的5-脒基-2-羟基苯磺酰胺衍生物：其中R 1是氢原子或任选取代的低级烷基; R 2是二（低级烷基）氨基，低级烷基，环烷基，任选取代的芳基，任选取代的杂环烷基或任选取代的芳族杂环基; T是氧原子，硫原子，磺酰基等; Q是氢原子或任意取代的低级烷基; Z是氢原子，羟基等，或其药学上可接受的盐，其具有有效和选择性的活化凝血因子X抑制活性，并且可用作预防或治疗疾病的药剂，活化凝血因子X，包含其的药物组合物，其药物用途及其中间体。

42. 发明申请

US20060205812A1 5-Amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation 失效
标题翻译： 5-脒基-2-羟基苯磺酰胺衍生物，含有它们的药物组合物及其制备中间体
公开(公告)号：US20060205812A1
公开(公告)日：2006-09-14
申请号：US11359430
申请日：2006-02-23
申请人： Kosuke Okazaki , Masahiko Uchida , Harunobu Mukaiyama , Hiroaki Kobayashi , Yuichiro Kai , Hideki Takeuchi , Kenji Yokoyama , Yoshihiro Terao , Yuji Hoyano , Hiroaki Shiohara , Norihiko Kikuchi
发明人： Kosuke Okazaki , Masahiko Uchida , Harunobu Mukaiyama , Hiroaki Kobayashi , Yuichiro Kai , Hideki Takeuchi , Kenji Yokoyama , Yoshihiro Terao , Yuji Hoyano , Hiroaki Shiohara , Norihiko Kikuchi
IPC分类号： A61K31/24 , A61K31/195 , C07C311/47
CPC分类号： A61K31/18 , A61K31/40 , A61K31/421 , A61K31/445 , A61K31/5377 , A61K31/55 , A61K31/553 , C07C311/29 , C07C311/37 , C07C317/32 , C07C2601/14
摘要： The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; R2 is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, an optionally substituted aryl group, an optionally substituted heterocycloalkyl group, or an optionally substituted aromatic heterocyclic group; T is an oxygen atom, a sulfur atom, a sulfonyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof.
摘要翻译：本发明涉及由以下通式表示的5-脒基-2-羟基苯磺酰胺衍生物：其中R 1是氢原子或任选取代的低级烷基; R 2是二（低级烷基）氨基，低级烷基，环烷基，任选取代的芳基，任选取代的杂环烷基或任选取代的芳族杂环基; T是氧原子，硫原子，磺酰基等; Q是氢原子或任意取代的低级烷基; Z是氢原子，羟基等，或其药学上可接受的盐，其具有有效和选择性的活化凝血因子X抑制活性，并且可用作预防或治疗疾病，活化凝血因子X，包含其的药物组合物，其药物用途及其中间体。

43. 发明申请

US20050207066A1 Recording disk drive and ramp member therefor 审中-公开
标题翻译：记录磁盘驱动器和斜坡部件
公开(公告)号：US20050207066A1
公开(公告)日：2005-09-22
申请号：US11128377
申请日：2005-05-13
申请人： Hiroaki Kobayashi , Kazunori Akama
发明人： Hiroaki Kobayashi , Kazunori Akama
IPC分类号： G11B5/54 , G11B21/12 , G11B21/22
CPC分类号： G11B21/22 , G11B5/54 , G11B21/12
摘要： A recording disk drive includes a restriction member located within an enclosure at a location opposed to a slant. The slant is defined on a ramp member so as to get closer to a recording disk at a location closer to the center of the recording disk. The slant is designed to receive the tip end of a head actuator supporting a head slider. If an impact acts on the recording disk drive during the movement of the head slider toward the recording disk or off the recording disk, the tip end of the head actuator tends to jump up from the slant. Here, the tip end of the head actuator is received on the restriction member. The restriction member thus serves to reliably prevent the head slider from jumping up. The head slider is prevented from colliding against the enclosure.
摘要翻译：记录盘驱动器包括位于与倾斜相对的位置处的外壳内的限制构件。斜面被限定在斜坡构件上，以便在靠近记录盘的中心的位置处更靠近记录盘。斜面被设计成接收支撑头部滑块的头部致动器的末端。如果在磁头滑动器朝向记录盘移动或记录盘移动期间冲击作用在记录磁盘驱动器上，则磁头致动器的尖端倾向于从倾斜向上跳起。这里，头部致动器的末端接收在限制部件上。因此，限制构件用于可靠地防止磁头滑块跳跃。防止头部滑块与外壳碰撞。

44. 发明授权

US06899793B2 Method of manufacturing pulp mold formed body 有权
标题翻译：制造纸浆成型体的方法
公开(公告)号：US06899793B2
公开(公告)日：2005-05-31
申请号：US10182743
申请日：2001-02-16
申请人： Akira Nonomura , Yasushi Yamada , Tokuo Tsuura , Hiroaki Kobayashi , Kenichi Otani
发明人： Akira Nonomura , Yasushi Yamada , Tokuo Tsuura , Hiroaki Kobayashi , Kenichi Otani
IPC分类号： D21J3/10 , D21J7/00
CPC分类号： D21J7/00 , D21J3/10
摘要： A method of producing a pulp molded article. The method feeds a pulp slurry to a cavity of a papermaking mold having a prescribed cavity shape to form a pulp preform including a main part having an opening and a separable part having a flange and connected to an edge of the opening. A pressing member is inserted into the preform, the pressing member is expanded to press the preform toward the papermaking surface, the preform is removed from the papermaking mold, and then the preform is cut at a joint between the separable part and the main part.
摘要翻译：制造纸浆模制品的方法。该方法将纸浆浆料送入具有规定腔体形状的造纸模具的空腔，以形成纸浆预制件，该纸浆预制件包括具有开口的主要部分和具有凸缘的可分离部分并与开口的边缘连接。将压紧构件插入预制件中，将加压构件膨胀以将预制件推向造纸表面，将预成型件从造纸模具中取出，然后在可分离部分和主要部分之间的接头处切割预成型件。

45. 发明授权

US06431770B1 Automatic processing apparatus for photosensitive material 失效
公开(公告)号：US06431770B1
公开(公告)日：2002-08-13
申请号：US09941404
申请日：2001-08-28
申请人： Masayuki Kurematsu , Hiroyuki Hashimoto , Hiroaki Kobayashi
发明人： Masayuki Kurematsu , Hiroyuki Hashimoto , Hiroaki Kobayashi
IPC分类号： G03D302
CPC分类号： G03D3/00
摘要： An automatic processing apparatus for processing an exposed photographic light-sensitive material by coating a processing solution on the photographic material, comprising: a conveying device having a conveying path for conveying the photographic material in a conveying direction while inclining the photographic material downward in the conveying direction; and a coating device for coating the processing solution on an inclined portion of the photographic material in a line form in a direction perpendicular to the conveying direction.

46. 发明授权

US06213657B1 Automatic processor for silver halide light-sensitive photographic material 失效
标题翻译：卤化银感光感光材料自动处理器
公开(公告)号：US06213657B1
公开(公告)日：2001-04-10
申请号：US09149137
申请日：1998-09-08
申请人： Hiroaki Kobayashi
发明人： Hiroaki Kobayashi
IPC分类号： G03D500
CPC分类号： G03C5/26 , G03C5/261 , G03C7/407 , G03C2200/21
摘要： An automatic processor for a silver halide light sensitive photographic material is disclosed. The automatic processor comprises at least two reservoirs storing partial processing compositions separately, and a supply means to supply each of said partial compositions to said silver halide light-sensitive photographic material after mixing said partial compositions.
摘要翻译：公开了一种用于卤化银感光照相材料的自动处理器。所述自动处理器包括至少两个储存部分处理组合物的储存器，以及在混合所述部分组合物之后，将所述部分组合物供应给所述卤化银感光照相材料的供给装置。

47. 发明授权

US6136852A 3,4-disubstituted phenylethanolaminotetralincarboxylic acid derivatives 有权
标题翻译： 3,4-二取代苯乙醇氨基四氢萘羧酸衍生物
公开(公告)号：US6136852A
公开(公告)日：2000-10-24
申请号：US155345
申请日：1999-03-08
申请人： Makio Kitazawa , Kosuke Okazaki , Tetsuro Tamai , Masaru Saito , Nobuyuki Tanaka , Hiroaki Kobayashi , Ken Kikuchi , Hideyuki Muranaka
发明人： Makio Kitazawa , Kosuke Okazaki , Tetsuro Tamai , Masaru Saito , Nobuyuki Tanaka , Hiroaki Kobayashi , Ken Kikuchi , Hideyuki Muranaka
IPC分类号： C07C217/74 , C07C229/46 , C07C229/50 , A61K31/215 , A61K31/19 , C07C62/06 , C07C69/76
CPC分类号： C07C229/50 , C07C217/74 , C07C2102/10 , Y02P20/55
摘要： The present invention relates to 3,4-disubstituted phenylethanolaminotetralincarboxylic acid derivatives represented by the general formula: ##STR1## [wherein Q represents a vinylene group or a group represented by the general formula:-A-(CH.sub.2).sub.m --(wherein A represents an oxygen atom or a methylene group; and m is an integer of from 1 to 6); R represents a hydrogen atom or a lower alkyl group; n is an integer of 1 or 2; the carbon atom marked with * represents a carbon atom in R configuration, S configuration or a mixture thereof; and the carbon atom marked with (S) represents a carbon atom in S configuration] and pharmaceutically acceptable salts thereof, which have a selective .beta..sub.2 -adrenergic receptor stimulating effect with relieved burdens on the heart such as tachycardia and are useful as an agent for the prevention of threatened abortion and premature labor, a bronchodilator and an agent for pain remission and promoting stone removal in urolithiasis.
摘要翻译： PCT No.PCT / JP97 / 01008 Sec。 371日期1999年3月8日 102（e）1999年3月8日PCT 1997年3月26日PCT公布。公开号WO97 / 35835 日期：1997年10月2日本发明涉及由以下通式表示的3,4-二取代苯乙醇氨基四氢萘羧酸衍生物：[其中Q表示亚乙烯基或由通式-A-（CH 2）m - 表示的基团 A表示氧原子或亚甲基; m表示1〜6的整数）; R表示氢原子或低级烷基; n为1或2的整数; 标有*的碳原子表示R构型，S构型或其混合物中的碳原子; 标记有（S）的碳原子表示S构型的碳原子及其药学上可接受的盐，其具有选择性β2-肾上腺素能受体刺激作用，并且在心脏上缓解负担，例如心动过速，并且可用作防止威胁堕胎和早产，支气管扩张剂和止痛剂，促进尿石症中的除石。

48. 发明授权

US6126339A Automatic processor for silver halide photosensitive photographic material 失效
标题翻译：自动处理器用于卤化银感光感光材料
公开(公告)号：US6126339A
公开(公告)日：2000-10-03
申请号：US385618
申请日：1999-08-30
申请人： Hiroaki Kobayashi
发明人： Hiroaki Kobayashi
IPC分类号： G03D5/04 , G03D3/02
CPC分类号： G03D5/04
摘要： In an apparatus for automatically processing a silver halide photographic light sensitive material by plural processes, provided with a conveyor for relatively conveying the material to the plural processes; and a processing solution supplying device for supplying a processing solution onto the material in at least one of the plural processes, the processing solution supplying device having plural jetting channels, each jetting channel comprising a jetting chamber in which the processing solution is accommodated, a jetting head provided with plural orifices each communicating with the jetting chamber, and a converting element to change the volume of the jetting chamber so that the processing solution is jetted through the plural orifices from the jetting chamber to an outside; each orifice has a length L and a diameter R and a ratio (L/R) is made within a range of 5 to 200.
摘要翻译：在用于通过多个工艺自动处理卤化银照相感光材料的设备中，设置有用于将材料相对地输送到多个工艺的输送机; 以及处理溶液供给装置，用于在多个处理中的至少一个中将处理溶液供给到所述材料上，所述处理液供给装置具有多个喷射通道，每个喷射通道包括其中容纳有所述处理溶液的喷射室，头部设置有与喷射室连通的多个孔，以及改变喷射室的体积的转换元件，使得处理溶液通过多个喷嘴从喷射室喷射到外部; 每个孔口具有长度L和直径R，并且比率（L / R）在5至200的范围内。

49. 发明授权

US5640710A Method for melt-decontaminating metal contaminated with radioactive substance 失效
标题翻译：用放射性物质污染的金属进行熔融净化的方法
公开(公告)号：US5640710A
公开(公告)日：1997-06-17
申请号：US561863
申请日：1995-11-22
申请人： Hiroaki Kobayashi , Hiroshi Igarashi , Michiru Fujita
发明人： Hiroaki Kobayashi , Hiroshi Igarashi , Michiru Fujita
IPC分类号： G21F9/30 , A62D3/00
CPC分类号： G21F9/308
摘要： A flux for effectively melt-decontaminating a zircaloy contaminated with a radioactive contaminant Pu.sub.2 O.sub.3 is provided. The flux comprises a mixture of a metal flux of a metal (e.g. Ca or Mg) having a higher chemical activity than plutonium at a temperature above the melting point of the zircaloy with a halide flux of metallic compound (e.g. SnF.sub.2, PbF.sub.2, CoF.sub.2, CsF.sub.2) of a halogen element having a higher atomic number than fluorine and has a smaller absolute value of the standard free energy of formation than a fluorination product of plutonium (i.e. PuOF). The addition of the flux to a molten zircaloy causes plutonium contained in the melt to be converted, through a two-step reaction, to PuOF which can be then separated as slag.
摘要翻译：提供了用于有效地熔化去污染被放射性污染物Pu2O3污染的锆石的助熔剂。焊剂包括在高于锆氧化物熔点的温度下具有比钚高的化学活性的金属（例如Ca或Mg）的金属助熔剂与金属化合物的卤化物焊剂（例如SnF 2，PbF 2，CoF 2， CsF2）具有比氟原子数更高的卤素元素，并且与钚的氟化产物（即PuOF）相比，具有比标准自由能的绝对值更小的绝对值。将熔剂添加到熔融锆氧化铝中导致熔体中所含的钚通过两步反应转化成PuOF，然后将其分离为渣。

50. 发明授权

US5529236A Wire bonding apparatus 失效
标题翻译：接线装置
公开(公告)号：US5529236A
公开(公告)日：1996-06-25
申请号：US322514
申请日：1994-10-14
申请人： Hiroaki Kobayashi
发明人： Hiroaki Kobayashi
IPC分类号： H01L21/60 , B23K20/00 , H01L21/00 , B23K31/12
CPC分类号： H01L24/85 , B23K20/007 , H01L24/78 , H01L2224/48091 , H01L2224/48247 , H01L2224/48465 , H01L2224/78301 , H01L2224/85 , H01L2924/00014 , H01L2924/01005 , H01L2924/01006 , H01L2924/01019 , H01L2924/01027 , H01L2924/01033 , H01L2924/01039 , H01L2924/01057 , H01L2924/01082 , H01L2924/04953
摘要： A wire bonding apparatus for semiconductor devices have a supporting block for holding a workpiece to which wires are bonded, a drive for driving the supporting block for holding the workpiece, the drive being capable of vertically moving and stopping the supporting block at a predetermined position, an optical means disposed above the supporting block and used for recognizing the pattern of the workpiece held on the supporting block, a storage means for prestoring each level of the workpiece so that the positions of not less than two places intended for recognition on the workpiece having difference in level conforms to the focal point of the optical means, and a control unit for controlling the drive for driving the supporting block, moving the workpiece to the position stored in the storage means and stopping the workpiece at that position. The supporting block is supported by a stroke bearing comprising a fixed part and a moving part which is moved and guided in the direction perpendicular to the fixed part. The drive for driving the supporting block comprises a cam shaft, a drive cam secured onto the cam shaft and generating a uniform velocity cam curve, a cam follower for coming contact with the drive cam, the cam follower being provided on the supporting block side, and a cam-driving pulse motor capable of rotating the cam shaft and electrically controlling the angle of rotation of the drive cam.
摘要翻译：一种用于半导体器件的引线接合装置具有用于保持接合线的工件的支撑块，用于驱动用于保持工件的支撑块的驱动器，该驱动能够将支撑块垂直移动和停止在预定位置，光学装置，其设置在所述支撑块上方，用于识别保持在所述支撑块上的所述工件的图案;存储装置，用于预先存储所述工件的每一级，使得不少于两个用于在所述工件上识别的位置的位置具有水平差符合光学装置的焦点，以及控制单元，用于控制用于驱动支撑块的驱动，将工件移动到存储在存储装置中的位置，并在该位置停止工件。支撑块由包括固定部分和沿垂直于固定部分的方向移动和引导的移动部件的行程轴承支撑。用于驱动支撑块的驱动装置包括凸轮轴，固定在凸轮轴上并产生均匀速度凸轮曲线的驱动凸轮，用于与驱动凸轮接触的凸轮从动件，凸轮从动件设置在支撑块侧上，以及能够旋转凸轮轴并电控制驱动凸轮的旋转角度的凸轮驱动脉冲电机。

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