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41. 发明授权

US07377901B2 Apparatus for collection of airway gases 有权
标题翻译：用于收集气道气体的装置
公开(公告)号：US07377901B2
公开(公告)日：2008-05-27
申请号：US10312242
申请日：2001-06-19
申请人： Per Djupesland , Wei Qian
发明人： Per Djupesland , Wei Qian
IPC分类号： A61B5/02 , G01N1/22 , G01N31/00 , G01N33/497 , B32B5/02 , B32B27/04 , B32B27/12
CPC分类号： A61B5/097
摘要： The invention relates to an apparatus for collection of airway gases from a subject comprising a first means for producing closure of the velum of the subject, and a second means for collection of the airway gases, wherein the first and second means need not be integral with each other.
摘要翻译：本发明涉及一种用于收集来自受试者的气道气体的装置，包括用于产生受试者的绒毛的闭合的第一装置和用于收集气道气体的第二装置，其中第一和第二装置不需要与彼此。

42. 发明申请

US20080067971A1 INDUCTION MOTOR CONTROLLER 有权
标题翻译：感应电动机控制器
公开(公告)号：US20080067971A1
公开(公告)日：2008-03-20
申请号：US11521018
申请日：2006-09-14
申请人： Wei Qian , Haihui Lu , Thomas A. Nondahl
发明人： Wei Qian , Haihui Lu , Thomas A. Nondahl
IPC分类号： H02P3/18
CPC分类号： H02P23/14 , H02P27/16 , Y10S388/917
摘要： An induction motor controller that may include three phase paths leading from a power input to a power output, a solid-state switching device interposed between the power input and the power output on each of the three phase paths, a voltage sensor coupled to two of the phase paths between the solid-state switching device and the power input, a current sensor on one of the phase paths, a processor communicatively coupled to the voltage sensor, the current sensor, and the solid state switching device; and a memory coupled to the processor. The processor may be configured to calculate a motor parameter based on a signal from the voltage sensor and a signal from the current sensor and store the calculated motor parameter in memory.
摘要翻译：一种感应电动机控制器，其可以包括从电力输入到功率输出的三相路径，插在电源输入端和三相路径中的每一个上的功率输出端之间的固态开关装置，固态开关器件和功率输入之间的相位路径，在一个相位路径上的电流传感器，通信地耦合到电压传感器，电流传感器和固态开关器件的处理器; 以及耦合到处理器的存储器。处理器可以被配置为基于来自电压传感器的信号和来自电流传感器的信号来计算电动机参数，并将计算的电动机参数存储在存储器中。

43. 发明授权

US06687199B1 Automated servo control system 有权
标题翻译：自动伺服控制系统
公开(公告)号：US06687199B1
公开(公告)日：2004-02-03
申请号：US09596861
申请日：2000-06-19
申请人： Paul Thanh Tran , Wei Qian
发明人： Paul Thanh Tran , Wei Qian
IPC分类号： G11B700
CPC分类号： G11B7/09
摘要： The present invention provides a method and system for servo control in an optical drive. The method includes initiating an execution of a multiplier and accumulator controller (MAC) by a processor; and automatically calculating a transfer function by the MAC based upon a sample servo data. The present invention provides a servo control system which utilizes a MAC which is directly linked to the sample servo data. When a processor commands the MAC to execute, the MAC receives the sample servo directly from an Analog-to-Digital Converter (ADC); retrieves the corresponding accumulated sample servo data from a memory; calculates the transfer function; and stores the results back into the memory. The processor then accesses the memory to retrieve the result. Because the MAC is able to calculate the transfer function with minimal intervention from the processor, significant processing resources and time are saved.
摘要翻译：本发明提供了一种用于光驱中伺服控制的方法和系统。该方法包括由处理器启动乘法器和累加器控制器（MAC）的执行; 并基于采样伺服数据自动计算MAC的传递函数。本发明提供了一种伺服控制系统，其利用与采样伺服数据直接连接的MAC。当处理器命令MAC执行时，MAC直接从模数转换器（ADC）接收采样伺服; 从存储器检索相应的累积采样伺服数据; 计算传递函数; 并将结果存储到内存中。然后，处理器访问存储器以检索结果。由于MAC能够以最少的处理干预来计算传递函数，因此节省了大量的处理资源和时间。

44. 发明授权

US5576548A Nuclear imaging enhancer 失效
标题翻译：核成像增强剂
公开(公告)号：US5576548A
公开(公告)日：1996-11-19
申请号：US464393
申请日：1995-06-05
申请人： Laurence P. Clarke , Wei Qian , Maria Kallergi
发明人： Laurence P. Clarke , Wei Qian , Maria Kallergi
IPC分类号： G06T1/40 , G06T5/00 , G01T1/20
CPC分类号： G06T5/002 , A61B6/4258 , A61B6/5205 , A61B6/5258 , G06T2207/20064 , G06T2207/20084
摘要： A wavelet based neural network (WNN) is proposed for image restoration using a nuclear gamma camera. The WNN first segments the image noise from the detected signal using a wavelet or multi-resolution method and then restores the detector resolution using the neural network. An example of methods is described for detecting beta particles (bremsstrahlung radiation) but the proposed WNN can be applied to either the detection of positrons or gamma rays using the gamma camera.
摘要翻译：提出了一种基于小波的神经网络（WNN），用于使用核伽马相机进行图像恢复。 WNN首先使用小波或多分辨率方法从检测到的信号中分割图像噪声，然后使用神经网络恢复检测器分辨率。描述了用于检测β粒子（bre致辐射）的方法的一个实例，但是所提出的WNN可以应用于使用γ照相机检测正电子或γ射线。

45. 发明申请

US20140206664A1 Heterocycle Amido Alkyloxy Substituted Quinazoline Derivative and Use Thereof 审中-公开
标题翻译：杂环酰氨基烷氧基取代的喹唑啉衍生物及其用途
公开(公告)号：US20140206664A1
公开(公告)日：2014-07-24
申请号：US14002415
申请日：2012-12-13
申请人： Wei Qian
发明人： Wei Qian
IPC分类号： C07D491/107 , C07D487/10 , C07D487/04 , C07D491/06 , C07D495/10 , C07D471/04 , C07D498/08 , C07D471/10
CPC分类号： C07D491/107 , C07D239/94 , C07D401/12 , C07D403/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/06 , C07D495/10 , C07D498/08
摘要： Heterocycle amino alkyloxy substituted quinazoline derivatives as represented by the structural Formula (I) and pharmaceutically acceptable salts thereof, capable of inhibiting the activity of receptor tyrosine kinase EGFR, and being used to treat cancers related to the expression of the receptor tyrosine kinase of the ErbB family are provided.
摘要翻译：由结构式（I）表示的杂环氨基烷氧基取代的喹唑啉衍生物及其药学上可接受的盐，其能够抑制受体酪氨酸激酶EGFR的活性，并用于治疗与ErbB受体酪氨酸激酶的表达有关的癌症家庭被提供。

46. 发明授权

US08759097B2 Inhibition of dynamin related protein 1 to promote cell death 有权
标题翻译：抑制dynamin相关蛋白1促进细胞死亡
公开(公告)号：US08759097B2
公开(公告)日：2014-06-24
申请号：US13450345
申请日：2012-04-18
申请人： Wei Qian , Bennett Van Houten
发明人： Wei Qian , Bennett Van Houten
IPC分类号： A61K31/517 , A61P35/00 , A61K38/38 , C12N5/09
CPC分类号： A61K45/06 , A61K31/517 , A61K33/24 , A61K2300/00
摘要： The present invention relates to compositions and methods for reducing cell proliferation and/or promoting cell death by inhibiting Drp1. It is based, at least in part, on the discoveries that (i) Drp1 disruption-induced mitochondrial hyperfusion is functionally linked to the cell cycle regulation apparatus, so that Drp1 inhibition results in a disruption of the cell cycle and DNA aberrancies; (ii) inhibition of both Drp1 and ATR are synthetic lethal causing increased DNA damage and apoptotic cell death; and (iii) even in resistant cell lines, Drp1 inhibitor (e.g., mdivi-1) together with a second antiproliferative agent (e.g., cisplatin or carboplatin) act synergistically to promote apoptosis. Accordingly, the present invention provides for novel anticancer strategies.
摘要翻译：本发明涉及通过抑制Drp1来减少细胞增殖和/或促进细胞死亡的组合物和方法。至少部分基于以下发现：（i）Drp1破坏诱导的线粒体增生与细胞周期调节装置功能相关，使得Drp1抑制导致细胞周期和DNA异常的破坏; （ii）Drp1和ATR两者的抑制是合成致死的，导致DNA损伤增加和凋亡细胞死亡; 和（iii）即使在抗性细胞系中，Drp1抑制剂（例如，mdivi-1）与第二抗增殖剂（例如顺铂或卡铂）一起起协同作用以促进细胞凋亡。因此，本发明提供了新颖的抗癌策略。

47. 发明申请

US20140170070A1 STABLE COLLOIDAL GOLD NANOPARTICLES WITH CONTROLLABLE SURFACE MODIFICATION AND FUNCTIONALIZATION 审中-公开
标题翻译：具有可控表面改性和功能化的稳定的胶体金纳米颗粒
公开(公告)号：US20140170070A1
公开(公告)日：2014-06-19
申请号：US14187416
申请日：2014-02-24
申请人： Wei Qian , Makoto Murakami , Yuki Ichikawa , Yong Che
发明人： Wei Qian , Makoto Murakami , Yuki Ichikawa , Yong Che
IPC分类号： A61K49/00 , A61K47/10 , A61K41/00 , G01N21/65
CPC分类号： A61K49/0002 , A61K9/0019 , A61K9/1688 , A61K41/0057 , A61K47/10 , B01J13/0034 , B01J13/0043 , B82Y5/00 , B82Y30/00 , B82Y40/00 , G01N21/64 , G01N21/658 , G01N33/531 , G01N33/54346 , G01N2021/3595
摘要： In the present invention, a method of producing stable bare colloidal gold nanoparticles is disclosed. The nanoparticles can subsequently be subjected to partial or full surface modification. The method comprises preparation of colloidal gold nanoparticles in a liquid by employing a top-down nanofabrication method using bulk gold as a source material. The surface modification of these nanoparticles is carried out by adding one or multiple types of ligands each containing functional groups which exhibit affinity for gold nanoparticle surfaces to produce the conjugates. Because of the high efficiency and excellent stability of the nanoparticles produced by this method, the fabricated gold nanoparticle conjugates can have surface coverage with functional ligands which can be tuned to be any percent value between 0 and 100%.
摘要翻译：在本发明中，公开了一种制备稳定的裸胶体金纳米颗粒的方法。随后可以对纳米颗粒进行部分或全面修饰。该方法包括使用以大块金为原料的自顶向下纳米制造方法在液体中制备胶体金纳米颗粒。这些纳米颗粒的表面改性是通过添加一种或多种类型的配体，每个配体包含对金纳米颗粒表面具有亲和性以产生共轭物的官能团。由于通过该方法制备的纳米颗粒的高效率和优异的稳定性，所制备的金纳米颗粒共轭物可以具有表面覆盖的功能性配体，其可被调整为0至100％之间的任何百分比值。

48. 发明申请

US20130301979A1 Isolation of components on optical device 有权
公开(公告)号：US20130301979A1
公开(公告)日：2013-11-14
申请号：US13506705
申请日：2012-05-09
申请人： Wei Qian , Dazeng Feng , Mehdi Asghari , Joan Fong
发明人： Wei Qian , Dazeng Feng , Mehdi Asghari , Joan Fong
IPC分类号： G02B6/122 , G02B6/136 , H01L31/18
CPC分类号： H01L31/105 , G02F1/0147 , G02F1/025 , G02F1/0305 , G02F1/225 , G02F2201/063 , G02F2201/501
摘要： The optical device includes an active component on a base. The active component is a light sensor and/or a light modulator. The active component including an active medium that includes a ridge and slab regions. The ridge extends upwards from the base and is positioned between the slab regions. The ridge defines a portion of a waveguide on the base. One or more isolation trenches each extends into the slab regions of the active medium and is at least partially spaced apart from the ridge of the active medium.

49. 发明申请

US20120294956A1 INHIBITION OF DYNAMIN RELATED PROTEIN 1 TO PROMOTE CELL DEATH 有权
标题翻译：抑制DYNAMIN相关蛋白1促进细胞死亡
公开(公告)号：US20120294956A1
公开(公告)日：2012-11-22
申请号：US13450345
申请日：2012-04-18
申请人： Wei Qian , Bennett Van Houten
发明人： Wei Qian , Bennett Van Houten
IPC分类号： A61K31/517 , A61P35/00 , A61K38/38 , C12N5/09 , A61K33/24
CPC分类号： A61K45/06 , A61K31/517 , A61K33/24 , A61K2300/00
摘要： The present invention relates to compositions and methods for reducing cell proliferation and/or promoting cell death by inhibiting Drp1. It is based, at least in part, on the discoveries that (i) Drp1 disruption-induced mitochondrial hyperfusion is functionally linked to the cell cycle regulation apparatus, so that Drp1 inhibition results in a disruption of the cell cycle and DNA aberrancies; (ii) inhibition of both Drp1 and ATR are synthetic lethal causing increased DNA damage and apoptotic cell death; and (iii) even in resistant cell lines, Drp1 inhibitor (e.g., mdivi-1) together with a second antiproliferative agent (e.g., cisplatin or carboplatin) act synergistically to promote apoptosis. Accordingly, the present invention provides for novel anticancer strategies.
摘要翻译：本发明涉及通过抑制Drp1来减少细胞增殖和/或促进细胞死亡的组合物和方法。至少部分基于以下发现：（i）Drp1破坏诱导的线粒体增生与细胞周期调节装置功能相关，使得Drp1抑制导致细胞周期和DNA异常的破坏; （ii）Drp1和ATR两者的抑制是合成致死的，导致DNA损伤增加和凋亡细胞死亡; 和（iii）即使在抗性细胞系中，Drp1抑制剂（例如，mdivi-1）与第二抗增殖剂（例如顺铂或卡铂）一起起协同作用以促进细胞凋亡。因此，本发明提供了新颖的抗癌策略。

50. 发明授权

US08300999B2 Reducing optical loss in reflective optical gratings 有权
标题翻译：减少反射光栅光损耗
公开(公告)号：US08300999B2
公开(公告)日：2012-10-30
申请号：US12927412
申请日：2010-11-12
申请人： Wei Qian , Dazeng Feng , Cheng-Chih Kung , Joan Fong , Mehdi Asghari
发明人： Wei Qian , Dazeng Feng , Cheng-Chih Kung , Joan Fong , Mehdi Asghari
IPC分类号： G02B6/34 , G02B6/26 , G02B6/28 , G02B6/10
CPC分类号： G02B6/124 , G02B6/29326 , G02B6/29328
摘要： An optical device includes a light-transmitting medium on a base. The light-transmitting medium at least partially defines a free propagation region through which light signals travel. A reflective grating is positioned such that light signals can travel through the free propagation region and be received by the optical grating. The optical grating is configured to reflect the received light signal back into the free propagation region. The optical grating reflects the light signals such that light signals associated with different wavelengths separate as the light signals travel through the free propagation region. The portion of the light-transmitting medium that defines the free propagation region has a facet through with the light signals are transmitted. The grating includes a buffer layer between the facet and a reflecting layer that is configured to reflect the light signals received by the grating.
摘要翻译：光学装置包括在基座上的透光介质。透光介质至少部分地限定光信号行进的自由传播区域。反射光栅被定位成使得光信号可以穿过自由传播区域并被光栅接收。光栅被配置为将接收的光信号反射回自由传播区域。光栅反射光信号，使得与不同波长相关联的光信号随着光信号穿过自由传播区域而分离。限定自由传播区域的光传输介质的一部分具有透过光信号的小平面。光栅包括在小面和反射层之间的缓冲层，其被配置为反射由光栅接收的光信号。

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