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41. 发明授权

US06984621B1 Wound contraction inhibitor 失效
标题翻译：伤口收缩抑制剂
公开(公告)号：US06984621B1
公开(公告)日：2006-01-10
申请号：US10111620
申请日：2000-10-25
申请人： Yukio Sumi , Kenichiro Hata , Minoru Ueda , Hisako Muramatsu , Takashi Muramatsu
发明人： Yukio Sumi , Kenichiro Hata , Minoru Ueda , Hisako Muramatsu , Takashi Muramatsu
IPC分类号： A01N37/18 , A61K38/00 , A61K31/70 , C07K16/00
CPC分类号： A61K38/57
摘要： The pharmaceutical formulation for inhibiting wound contraction of the present invention includes secretory leukocyte protease inhibitor as an active ingredient. The SLPI concentration in the pharmaceutical formulation is preferably 1–5000 ng/ml, and more preferably 1–100 ng/ml. The pharmaceutical formulation for inhibiting wound contraction of the present invention may be prepared as an external preparation including a base and the SLPI as an active ingredient. The pharmaceutical formulation for inhibiting wound contraction of the present invention may be prepared as an injection including the SLPI as an active ingredient. The external preparation may preferably include a preservative. The injection may preferably include a stabilizer (an antioxidant), a preservative and an analgesic agent.
摘要翻译：用于抑制本发明的伤口收缩的药物制剂包括分泌型白细胞蛋白酶抑制剂作为活性成分。药物制剂中的SLPI浓度优选为1-5000ng / ml，更优选为1-100ng / ml。用于抑制本发明的伤口收缩的药物制剂可以制备为包含底物和SLPI作为活性成分的外用制剂。用于抑制本发明的伤口收缩的药物制剂可以制备为包含SLPI作为活性成分的注射剂。外用制剂可优选包括防腐剂。注射剂可以优选包括稳定剂（抗氧化剂），防腐剂和止痛剂。

42. 发明申请

US20050208631A1 Polypeptide of N-acetylglucosamine-6-O-sulfotransferase and DNA encoding the same 有权
标题翻译： N-乙酰葡糖胺-6-O-磺基转移酶的多肽和编码它们的DNA
公开(公告)号：US20050208631A1
公开(公告)日：2005-09-22
申请号：US10966849
申请日：2004-10-15
申请人： Kenji Uchimura , Hideki Muramatsu , Kenji Kadomatsu , Reiji Kannagi , Osami Habuchi , Takashi Muramatsu
发明人： Kenji Uchimura , Hideki Muramatsu , Kenji Kadomatsu , Reiji Kannagi , Osami Habuchi , Takashi Muramatsu
IPC分类号： C12N15/09 , C07K16/28 , C07K16/44 , C12N9/10 , C12N15/54 , C12P19/04 , C12P19/26 , C12R1/91 , C12P19/28
CPC分类号： C07K16/2896 , C07K16/44 , C12N9/13 , C12P19/04
摘要： A polypeptide of N-acetylglucosamine-6-O-sulfotransferase and a DNA encoding the peptide are provided. The polypeptide is (a) or (b) below: (a) a polypeptide consisting of an amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide which comprises an amino acid sequence including substitution, deletion, insertion or transposition of one or few amino acids in the amino acid sequence of (a) and which has an enzymatic activity to transfer a sulfate group from a sulfate group donor to a hydroxyl group at 6 position of an N-acetylglucosamine residue located at a non-reducing end of an oligosaccharide represented by the formula I: GlcNAcβ1-3Gal β1-4GlcNAc (I) wherein GlcNAc represents an N-acetylglucosamine residue, Gal represents a galactose residue, β1-3 represents a β1-3 glycosidic linkage, and β1-4 represents a β1-4 glycosidic linkage.
摘要翻译：提供N-乙酰氨基葡萄糖-6-O-磺基转移酶的多肽和编码该肽的DNA。多肽为（a）或（b）：（a）由SEQ ID NO：2所示的氨基酸序列组成的多肽; 或（b）包含在（a）的氨基酸序列中包含一个或几个氨基酸的取代，缺失，插入或转座的氨基酸序列的多肽，其具有从硫酸基团转移硫酸基团的酶活性供体位于位于式I表示的寡糖的非还原性末端的N-乙酰葡糖胺残基6位的羟基：<？in-line-formula description =“In-line Formulas”end =“lead” 其中GlcNAc代表N-乙酰葡糖胺残基，Gal代表半乳糖残基，β1- 3代表β1-3糖苷键，β1-4代表β1-4糖苷键。

43. 发明申请

US20050035985A1 Inkjet recording apparatus 有权
标题翻译：喷墨记录装置
公开(公告)号：US20050035985A1
公开(公告)日：2005-02-17
申请号：US10916957
申请日：2004-08-11
申请人： Akihiro Taguchi , Nobuya Yamamoto , Tetsushi Aoki , Takashi Muramatsu , Minoru Maekawara , Shingo Tsubotani
发明人： Akihiro Taguchi , Nobuya Yamamoto , Tetsushi Aoki , Takashi Muramatsu , Minoru Maekawara , Shingo Tsubotani
IPC分类号： B41J2/175 , B41J2/195
CPC分类号： B41J2/17566 , B41J2/17523 , B41J2/195
摘要： An inkjet recording apparatus includes: exchangeable first and second ink cartridges; a recording head which jets ink to a recording medium; an intermediate tank which receives the ink from the ink cartridge and supplies the ink to the recording head; a detecting sensor which detects whether ink residual quantity of an ink cartridge is not more than predetermined quantity based on ink quantity in the intermediate tank; a switching section which, if the ink residual quantity is not more than the predetermined quantity, switches the ink cartridge for supplying the ink to the intermediate tank; a first detector which detects the reset of the first ink cartridge; a second detector which detects the reset of the second ink cartridge; and a controller which, if the first ink cartridge is reset, controls the switching section to switch the second ink cartridge to the first ink cartridge, for supplying the ink.
摘要翻译：喷墨记录装置包括：可更换的第一和第二墨盒; 将墨水喷射到记录介质上的记录头; 中间罐，其从墨盒接收墨水并将墨水供应到记录头; 检测传感器，其基于中间容器中的墨水量来检测墨盒的墨水剩余量是否不大于预定量; 切换部，如果墨剩余量不大于预定量，则将用于供应墨的墨盒切换到中间罐; 第一检测器，其检测第一墨盒的复位; 检测第二墨盒的复位的第二检测器; 以及控制器，如果第一墨盒被复位，则控制切换部分将第二墨盒切换到第一墨盒以供应墨水。

44. 发明授权

US5629284A Method for treating retinal diseases 失效
标题翻译：治疗视网膜疾病的方法
公开(公告)号：US5629284A
公开(公告)日：1997-05-13
申请号：US505907
申请日：1995-07-24
申请人： Kazuhiko Unoki , Hitoshi Arimura , Akiko Okubo , Norio Ohba , Takashi Muramatsu , Hisako Muramatsu
发明人： Kazuhiko Unoki , Hitoshi Arimura , Akiko Okubo , Norio Ohba , Takashi Muramatsu , Hisako Muramatsu
IPC分类号： A61K38/18 , A61K38/00 , A61K31/725
CPC分类号： A61K38/18 , A61K31/727 , A61K38/1825
摘要： A method for treating retinal diseases includes administering an effective amount of midkine to patients suffering from retinal diseases. The method of the invention is effective in ameliorating optical disorders of retinas and is quite safe.
摘要翻译：治疗视网膜疾病的方法包括给患有视网膜疾病的患者施用有效量的中期因子。本发明的方法有效地改善视网膜的光学障碍，并且是相当安全的。

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