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41. 发明申请

US20130143332A1 SPFS SENSOR EQUIPPED WITH MECHANISM PURIFYING NON-SPECIFICALLY ADSORPTIVE CONTAMINANTS 有权
标题翻译： SPFS传感器配有机械净化非特异性吸附污染物
公开(公告)号：US20130143332A1
公开(公告)日：2013-06-06
申请号：US13817356
申请日：2011-07-27
申请人： Masanori Tsukagoshi , Takatoshi Kaya , Noriaki Yamamoto
发明人： Masanori Tsukagoshi , Takatoshi Kaya , Noriaki Yamamoto
IPC分类号： G01N21/64
CPC分类号： G01N21/6402 , G01N21/05 , G01N21/648 , G01N33/54373 , G01N33/54393
摘要： [Object] It is an object of the invention to provide a sensor area which can suppress a decrease in assay signal and an increase in assay blank in an SPFS measurement.[Solution] An SPFS sensor chip of the invention includes a purification area and a sensor area arranged upstream and downstream, respectively, relative to each other along a flow direction in a channel for surface plasmon-field enhanced fluorescence spectroscopy [SPFS].
摘要翻译：发明内容本发明的目的是提供一种传感器区域，其可以抑制测定信号的降低和SPFS测量中测定空白的增加。 [解决方案]本发明的SPFS传感器芯片包括分别在表面等离激元增强荧光光谱通道（SPFS）中沿着流动方向相对于彼此布置的上游和下游的净化区域和传感器区域。

42. 发明授权

US08178290B2 Solid support 有权
标题翻译：坚实的支持
公开(公告)号：US08178290B2
公开(公告)日：2012-05-15
申请号：US13110473
申请日：2011-05-18
申请人： Noriaki Yamamoto , Keigo Tamaki , Koji Miyazaki , Akihisa Nakajima
发明人： Noriaki Yamamoto , Keigo Tamaki , Koji Miyazaki , Akihisa Nakajima
IPC分类号： C12Q1/24 , C12Q1/68
CPC分类号： G01N33/54326 , G01N33/5308 , G01N33/5695 , G01N2333/916
摘要： The present invention provides a solid support for performing steps of isolation of cell or extraction and purification of nucleic acid, safely, easily, efficiently, and with high yield in the genetic test for investigating the presence of pathogenic bacterial infection. A solid support for binding with cell as an embodiment of the above-described solid support, comprises a polypeptide having capability of binding with my colic acid-containing glycolipid which is immobilized on the surface of a carrier. In addition, a solid support for binding with nucleic acid as another embodiment of the above-described solid support, comprises a polypeptide having capability of binding with nucleic acid which is immobilized on the surface of a carrier.
摘要翻译：本发明提供了用于在用于调查病原性细菌感染的存在的遗传测试中进行细胞分离或核酸提取和纯化的步骤的安全，容易，有效和高产率的固体支持。作为上述固体支持物的实施方案，与细胞结合的固体支持物包含能够与我的含有酸性链烷酸的糖脂结合的多肽，其被固定在载体的表面上。此外，作为上述固体支持物的另一个实施方案与核酸结合的固体支持物包含具有与固定在载体表面上的核酸结合的能力的多肽。

43. 发明申请

US20110177511A1 METHOD FOR DETERMINING BREAST CANCER METASTASIS AND METHOD FOR EVALUATING SERUM 审中-公开
标题翻译：用于确定乳腺癌的方法和用于评估血清的方法
公开(公告)号：US20110177511A1
公开(公告)日：2011-07-21
申请号：US13119643
申请日：2009-09-17
申请人： Noriaki Yamamoto , Masahiro Kajita , Ayako Sakai
发明人： Noriaki Yamamoto , Masahiro Kajita , Ayako Sakai
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154 , C12Q2600/156
摘要： It is determined that the breast cancer has metastasized when methylation is detected in the CpG island of at least one selected from the group consisting of GSTP1, RASSF1A and RARb by detecting methylation in CpG island of each of GSTP1, RASSF1A and RARb contained in serum obtained from a patient who has undergone surgery to remove breast cancer.
摘要翻译：通过检测获得的血清中含有的GSTP1，RASSF1A和RARb中的每一个的CpG岛的甲基化，确定了在选自GSTP1，RASSF1A和RARb中的至少一种的CpG岛中的甲基化检测到乳腺癌转移来自经历手术以清除乳腺癌的患者。

44. 发明申请

US20090112665A1 EXECUTION DECISION SUPPORT PROGRAM AND DEVICE OF REGULATION MEASURES 有权
标题翻译：执行决策支持计划和监管措施
公开(公告)号：US20090112665A1
公开(公告)日：2009-04-30
申请号：US12246823
申请日：2008-10-07
申请人： Masataka Tanaka , Noriyasu Ninagawa , Yuzo Hiroshige , Noriaki Yamamoto
发明人： Masataka Tanaka , Noriyasu Ninagawa , Yuzo Hiroshige , Noriaki Yamamoto
IPC分类号： G06Q10/00 , G06Q50/00
CPC分类号： G06Q10/00 , G06Q10/063 , G06Q10/0631 , G06Q10/06311 , G06Q10/06313 , G06Q10/06315 , G06Q10/06316 , G06Q10/0639 , G06Q10/083 , G06Q10/087
摘要： The present invention calculates a predicted accumulative import amount for each chemical substance for each month by using information on a predicted monthly shipping amount and the amount of a chemical substance contained in the product and specifies the chemical substance whose predicted accumulative import amount exceeds a regulation threshold and the time when the import amount exceeds the regulation threshold. The present invention specifies the product containing the chemical substance, calculates the predicted shipping amount of the product from the threshold excess time of the chemical substance to the end of the year, and calculates the loss amount caused by the loss of sales opportunities from the profit per unit sales amount for each product when any regulation measures are not executed on the chemical substance. The present invention finally calculates the ratio of the expense necessary for the measures and the summed value, and displays the ratio.
摘要翻译：本发明通过使用关于预测的月运送量和产品中含有的化学物质的量的信息来计算每个化学物质的每个化学物质的预测累计进口量，并且指定预测的累积进口量超过调节阈值的化学物质进口金额超过监管门槛的时间。本发明规定了含有化学物质的产品，从化学物质的阈值超过时间到年底计算产品的预计运输量，并计算由利润损失引起的销售机会造成的损失当对化学物质不执行任何管制措施时，每个产品的单位销售额。本发明最终计算措施所需的费用与总和值的比率，并显示该比率。

45. 发明申请

US20080096213A1 Method for confirming conversion treatment and nucleic acid molecule used therefor 审中-公开
标题翻译：用于确认转化处理的方法和用于其的核酸分子
公开(公告)号：US20080096213A1
公开(公告)日：2008-04-24
申请号：US11902254
申请日：2007-09-20
申请人： Masahiro Kajita , Noriaki Yamamoto , Ayako Sakai , Hideki Ishihara
发明人： Masahiro Kajita , Noriaki Yamamoto , Ayako Sakai , Hideki Ishihara
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12Q1/6827 , C12Q2565/1015 , C12Q2545/114 , C12Q2545/101
摘要： There is provided a method for confirming conversion treatment of non-methylated cytosine, including a step of mixing a DNA taken from a living body, with a nucleic acid for accuracy control having a sequence A which is not contained in a genome of the living body and contains cytosine, a step of converting non-methylated cytosine in the mixture into a base other than cytosine, a step of detecting the sequence A and/or a sequence A′ which has a sequence obtained by converting cytosine in the sequence A into the base other than cytosine, and a step of determining whether the conversion step has been properly performed or not based on the result of the detection step.
摘要翻译：提供了一种确认非甲基化胞嘧啶的转化处理的方法，包括将从活体取得的DNA混合的步骤与用于精确控制的核酸的步骤，所述序列A不包含在生物体的基因组中并含有胞嘧啶，将混合物中的非甲基化胞嘧啶转化为除胞嘧啶以外的碱基的步骤，检测序列A和/或A序列的步骤，其具有通过将序列A中的胞嘧啶转化为碱基以外的碱基，以及基于检测步骤的结果确定转化步骤是否已经被适当地进行的步骤。

46. 发明申请

US20070088266A1 Liquid transfer apparatus and control method therefor 审中-公开
标题翻译：液体输送装置及其控制方法
公开(公告)号：US20070088266A1
公开(公告)日：2007-04-19
申请号：US11496638
申请日：2006-08-01
申请人： Kazuo Yamauchi , Takayoshi Sawano , Noriaki Yamamoto
发明人： Kazuo Yamauchi , Takayoshi Sawano , Noriaki Yamamoto
IPC分类号： A61M37/00
CPC分类号： A61M5/14216 , A61M5/16854
摘要： A residual liquid quantity in a syringe is reduced to the minimum. There are detected with high precision malfunctions due to chokes in pipes and incomplete switchings of an electromagnetic valve and a broken valve without a contamination problem produced. When a syringe pump is powered on, a motor is driven at low speed so that liquid in a syringe is discharged completely. When a desynchronization of the motor is detected by comparing motor driving pulses obtained by a rotary encoder with motor driving pulses supplied to the motor, a stop signal is supplied to a motor driver and the position of a rod is memorized as the origin of the syringe pump in an origin sensor. While the syringe pump is in a normal operating state, the position of the rod is detected to be at the origin to supply a stop signal to the motor driver.
摘要翻译：注射器中的残留液量减少到最小。检测到由于管道中的扼流圈和电磁阀的不完全切换以及不产生污染问题的断开阀而导致的高精度故障。当注射器泵通电时，电机以低速驱动，使注射器中的液体完全排出。当通过将由旋转编码器获得的电动机驱动脉冲与提供给电动机的电动机驱动脉冲进行比较来检测电动机的同步时，将停止信号提供给电动机驱动器，并且将杆的位置存储为注射器的原点泵入原点传感器。当注射器泵处于正常运行状态时，检测到杆的位置在原点，以向马达驱动器提供停止信号。

47. 发明申请

US20050071029A1 Defect influence degree evaluation method and design support system 失效
公开(公告)号：US20050071029A1
公开(公告)日：2005-03-31
申请号：US10923044
申请日：2004-08-23
申请人： Noriaki Yamamoto , Tatsuya Suzuki , Takayuki Nishi , Toru Wakuta
发明人： Noriaki Yamamoto , Tatsuya Suzuki , Takayuki Nishi , Toru Wakuta
IPC分类号： G05B19/418 , G06F19/00 , G06Q50/00 , G06Q50/04
CPC分类号： G06Q10/06 , Y02P90/86
摘要： At a stage before manufacture (product design stage or manufacturing process design stage), influence of defect occurrence in a component or process on other components and processes is estimated, and defect importance is evaluated to support the manufacturing process design. Failure rates of components are previously stored in a database. At a product design stage, an assembly fraction defective is calculated for an assembly process of each component of the product. Component arrangement relations are extracted from product design information. A component fraction defective is calculated based on the assembly fraction defective and the component failure rate. A numerical value indicating an influence degree of each assembly process is calculated by multiplying component fraction defectives by coefficients based on of the component arrangement relations and the component fraction defective, for relating components in each assembly process. Thereby, influence degrees of each component and process are evaluated.

48. 发明授权

US5713660A Illumination optical apparatus 失效
标题翻译：照明光学仪器
公开(公告)号：US5713660A
公开(公告)日：1998-02-03
申请号：US334665
申请日：1994-11-04
申请人： Takashi Mori , Hideki Komatsuda , Noriaki Yamamoto
发明人： Takashi Mori , Hideki Komatsuda , Noriaki Yamamoto
IPC分类号： G02B19/00 , G02B27/00 , G03F7/20 , F21V5/04
CPC分类号： G03F7/70091 , G02B19/0028 , G02B19/0047
摘要： An illumination optical apparatus according to the present invention comprises a light source, a collector mirror having an ellipsoidal surface of revolution for reflecting and collecting light from the light source, a collimator lens for converting the light collected by the collector mirror into nearly parallel beams, an optical integrator for producing a plurality of light source images from the beams outgoing from the collimator lens, and a condenser lens for condensing light from the plurality of light source images to illuminate a body to be illuminated in a superimposed manner. Wherein the collimator lens is arranged to satisfy the following condition, R.sub.max
摘要翻译：根据本发明的照明光学装置包括光源，具有用于反射和收集来自光源的光的旋转椭圆面的集光镜，用于将由集光镜收集的光转换成几乎平行的光束的准直透镜，用于从来自准直透镜的光束产生多个光源图像的光学积分器，以及用于聚集来自多个光源图像的光的聚光镜，以照亮重叠的被照明体。其中准直透镜被设置为满足以下条件，Rmax

49. 发明授权

US5636003A Illumination optical apparatus and scanning exposure apparatus 失效
标题翻译：照明光学装置和扫描曝光装置
公开(公告)号：US5636003A
公开(公告)日：1997-06-03
申请号：US365532
申请日：1994-12-28
申请人： Osamu Tanitsu , Takashi Mori , Noriaki Yamamoto
发明人： Osamu Tanitsu , Takashi Mori , Noriaki Yamamoto
IPC分类号： G03F7/20 , H01L21/027
CPC分类号： G03F7/70058 , G03F7/70358
摘要： An illumination optical apparatus for illuminating an object to be illuminated in an arcuate or rectangular shape. A first optical integrator forms a plurality of light source images in a substantially linear arrangement, based on a beam of parallel rays. Then a second optical integrator forms a plurality of light source images in a substantially square arrangement, based on the beam from the first optical integrator. A relay optical system is disposed between the first and second optical integrator, and makes a position of the light source images formed by the first optical cintegrator conjugate with a position of the light source images formed by the second optical integrator.
摘要翻译：一种照明光学装置，用于以弓形或矩形的形状照亮被照明的物体。第一光学积分器基于平行光束形成基本线性排列的多个光源图像。然后，基于来自第一光学积分器的光束，第二光学积分器以基本上正方形的布置形成多个光源图像。中继光学系统设置在第一和第二光学积分器之间，并且使由第一光学整形器形成的光源图像的位置与由第二光学积分器形成的光源图像的位置共轭。

50. 发明授权

US4565601A Method and apparatus for controlling sample temperature 失效
标题翻译：用于控制样品温度的方法和装置
公开(公告)号：US4565601A
公开(公告)日：1986-01-21
申请号：US675863
申请日：1984-11-28
申请人： Yutaka Kakehi , Norio Nakazato , Yoshimasa Fukushima , Kousai Hiratsuka , Fumio Shibata , Noriaki Yamamoto , Tsunehiko Tsubone
发明人： Yutaka Kakehi , Norio Nakazato , Yoshimasa Fukushima , Kousai Hiratsuka , Fumio Shibata , Noriaki Yamamoto , Tsunehiko Tsubone
IPC分类号： B61D19/02 , C23C14/54 , G05D23/19 , H01J37/20 , B44C1/22 , C03C15/00 , C03C25/06 , C23F1/02
CPC分类号： G05D23/1919 , C23C14/541 , H01J37/20
摘要： This invention relates to a method and apparatus for controlling temperature of a sample and is intended to prevent a sample from being deformed by the pressure of a heat transmission gas by mounting and fixing the sample being mounted and processed in a vacuum on and to the sample stand and supplying the heat transmission gas to the gap between the under surface of the sample thus fixed and the sample stand; effectively control the temperature of the sample being processed in a vacuum by limiting the size of the gap between the under surface of the sample and the sample stand; and make the heat transmission gas least affect the process by limiting the flow of the heat transmission gas in the vacuum process chamber.
摘要翻译：本发明涉及一种用于控制样品温度的方法和装置，旨在通过将真空中安装和处理的样品安装并固定到样品上来防止样品被传热气体的压力变形将传热气体放置并供给到如此固定的样品的下表面与样品台之间的间隙; 通过限制样品的下表面和样品台之间的间隙的大小，有效地控制在真空中正在处理的样品的温度; 并且通过限制真空处理室中的传热气体的流动使得传热气体对该过程最不重要。

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