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41. 发明申请

US20110277305A1 STENTS WITH HIGH RADIAL STRENGTH AND METHODS OF MANUFACTURING SAME 审中-公开
标题翻译：具有高径向强度的制造方法及其制造方法
公开(公告)号：US20110277305A1
公开(公告)日：2011-11-17
申请号：US13189370
申请日：2011-07-22
申请人： Timothy A. Limon
发明人： Timothy A. Limon
IPC分类号： B23P11/00
CPC分类号： B29C67/0014 , A61F2/0077 , A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2210/0004 , A61F2250/0067 , B29C53/02 , B29C55/24 , B29C2793/0009 , B29L2031/7534 , Y10T29/49908
摘要： Polymeric stents having fracture toughness and resistance to recoil after deployment are disclosed along with methods of manufacturing such stents. Improvements to mechanical characteristics and other improvements may be achieved by having polymer chains within individual stent struts oriented in a direction that is closer to or in line with the axis of the individual stent struts. The desired orientation of polymer molecules may be achieved by one or any combination of extruding polymers into hollow tubes to induce axially oriented polymer chains, applying a tensile load to polymer tubes to induce axially oriented polymer chains, and radially expanding polymer tubes to induce circumferentially oriented polymer chains. Stent patterns include struts defining diamond shaped cells and/or W-shaped cells.
摘要翻译：公开了具有断裂韧性和部署后反冲性的聚合物支架以及制造这种支架的方法。机械特性和其它改进的改进可以通过使单独的支架支柱内的聚合物链沿与单个支架支柱的轴线更接近或一致的方向定向来实现。聚合物分子的期望取向可以通过挤出聚合物到中空管中的一种或任何组合来实现，以诱导轴向取向的聚合物链，向聚合物管施加拉伸载荷以诱导轴向取向的聚合物链，以及径向扩张的聚合物管以诱导圆周取向聚合物链。支架图案包括定义菱形细胞和/或W形细胞的支柱。

42. 发明授权

US08052701B1 Method and apparatus for rupturing a vulnerable plaque 有权
标题翻译：破坏易损斑块的方法和装置
公开(公告)号：US08052701B1
公开(公告)日：2011-11-08
申请号：US10453116
申请日：2003-06-02
申请人： Daniel L. Cox , Jeffrey Ellis , Timothy A. Limon
发明人： Daniel L. Cox , Jeffrey Ellis , Timothy A. Limon
IPC分类号： A61B17/32
CPC分类号： A61B17/320725 , A61B17/32075 , A61B2017/22051 , A61B2017/22081 , A61B2017/320008 , A61B2018/00005
摘要： Methods and apparatuses for treating a vulnerable plaque are described herein. In one aspect of the invention, the exemplary apparatus includes a medical device to treat a vulnerable plaque within a body lumen, where the medical device is adapted to position a rupturing device to rupture a fibrous cap of a vulnerable plaque. In one particular embodiment, the medical device includes a rupturing wire having a predetermined pattern to enable the rupturing device to rupture the fibrous cap of the vulnerable plaque. Other methods and apparatuses are also described.
摘要翻译：本文描述了用于治疗易损斑块的方法和装置。在本发明的一个方面，示例性装置包括用于治疗体腔内的易损斑块的医疗装置，其中医疗装置适于定位破裂装置以破坏易损斑块的纤维帽。在一个特定实施例中，医疗装置包括具有预定图案的破裂线，以使得破裂装置能够破坏易损斑块的纤维帽。还描述了其它方法和装置。

43. 发明申请

US20110112627A1 Stents with Enhanced Fracture Toughness 有权
标题翻译：具有增强的断裂韧性的支架
公开(公告)号：US20110112627A1
公开(公告)日：2011-05-12
申请号：US12772698
申请日：2010-05-03
申请人： David C. Gale , Bin Huang , Timothy A. Limon , Vincent J. Gueriguian
发明人： David C. Gale , Bin Huang , Timothy A. Limon , Vincent J. Gueriguian
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2/90 , A61F2/91 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91583 , A61F2002/9522 , A61F2210/0004 , A61F2220/0016 , A61L31/06 , A61L31/14 , A61L31/148 , B29C35/045 , B29C49/0005 , B29C49/14 , B29C49/4273 , B29C49/4823 , B29C55/22 , B29C55/24 , B29C69/001 , B29C2049/0089 , B29C2793/0009 , B29K2067/00 , B29K2067/046 , B29K2105/258 , B29K2995/006 , B29L2031/7534 , Y10T156/1026 , C08L67/04
摘要： Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed.
摘要翻译：公开了制造具有增强的断裂韧性的支架的支架和方法。

44. 发明申请

US20100289191A1 METHODS OF FABRICATING STENTS WITH ENHANCED FRACTURE TOUGHNESS 有权
标题翻译：具有增强断裂韧性的手术方法
公开(公告)号：US20100289191A1
公开(公告)日：2010-11-18
申请号：US12845536
申请日：2010-07-28
申请人： DAVID C. GALE , Bin Huang , Timothy A. Limon , Vincent J. Gueriguian
发明人： DAVID C. GALE , Bin Huang , Timothy A. Limon , Vincent J. Gueriguian
IPC分类号： B29C49/08
CPC分类号： A61F2/915 , A61F2/90 , A61F2/91 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91583 , A61F2002/9522 , A61F2210/0004 , A61F2220/0016 , A61L31/06 , A61L31/14 , A61L31/148 , B29C35/045 , B29C49/0005 , B29C49/14 , B29C49/4273 , B29C49/4823 , B29C55/22 , B29C55/24 , B29C69/001 , B29C2049/0089 , B29C2793/0009 , B29K2067/00 , B29K2067/046 , B29K2105/258 , B29K2995/006 , B29L2031/7534 , Y10T156/1026 , C08L67/04
摘要： Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed.
摘要翻译：公开了制造具有增强的断裂韧性的支架的支架和方法。

45. 发明申请

US20090234432A1 Polymer Stent With Break-Away Links For Enhanced Stent Retention 有权
标题翻译：具有突破性链接的聚合物支架用于增强支架保留
公开(公告)号：US20090234432A1
公开(公告)日：2009-09-17
申请号：US12047040
申请日：2008-03-12
申请人： Stephen D. Pacetti , Timothy A. Limon , Yunbing Wang
发明人： Stephen D. Pacetti , Timothy A. Limon , Yunbing Wang
IPC分类号： A61F2/82 , B29C53/30 , B29C63/34 , B29C65/76 , B29C65/08 , B29C65/02
CPC分类号： A61F2/82 , A61F2/91 , A61F2/915 , A61F2002/9522 , A61F2250/0071 , B29C65/08 , B29C65/1606 , B29C65/1612 , B29C65/1645 , B29C65/1664 , B29C65/1667 , B29C65/48 , B29C65/4895 , B29C65/76 , B29C66/1122 , B29C66/53241 , B29C66/612 , B29C66/69 , B29C66/71 , B29C66/73117 , B29C66/73791 , B29C66/8122 , B29C66/83221 , B29C67/0014 , B29C2035/0822 , B29C2035/0827 , B29K2001/00 , B29K2001/12 , B29K2001/14 , B29K2001/18 , B29K2023/00 , B29K2023/083 , B29K2023/086 , B29K2025/00 , B29K2027/06 , B29K2027/08 , B29K2029/00 , B29K2033/20 , B29K2055/02 , B29K2059/00 , B29K2067/043 , B29K2067/046 , B29K2069/00 , B29K2071/00 , B29K2075/00 , B29K2077/00 , B29K2079/08 , B29K2083/00 , B29K2995/006 , B29L2023/007 , B29L2028/00 , B29L2031/605 , B29L2031/7534 , B29L2031/7542 , B29K2905/00 , B29K2067/00 , B29K2033/12 , B29K2033/08 , B29K2031/04 , B29K2027/16 , B29K2025/08 , B29K2025/06 , B29K2023/22 , B29K2023/18 , B29K2023/08 , B29K2009/06 , B29K2003/00
摘要： Polymer stents with break-away links and methods of forming the links for improved stent retention on an expandable member during delivery are disclosed.
摘要翻译：公开了具有脱离链节的聚合物支架和形成用于在递送期间在可扩张构件上改善支架保持的连接件的方法。

46. 发明申请

US20080275537A1 Stents with High Radial Strength and Methods of Manufacturing Same 有权
标题翻译：具有高径向强度的支架及其制造方法相同
公开(公告)号：US20080275537A1
公开(公告)日：2008-11-06
申请号：US12114608
申请日：2008-05-02
申请人： Timothy A. Limon
发明人： Timothy A. Limon
IPC分类号： A61F2/82 , B29C53/00
CPC分类号： B29C67/0014 , A61F2/0077 , A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2210/0004 , A61F2250/0067 , B29C53/02 , B29C55/24 , B29C2793/0009 , B29L2031/7534 , Y10T29/49908
摘要： Polymeric stents having fracture toughness and resistance to recoil after deployment are disclosed along with methods of manufacturing such stents. Improvements to mechanical characteristics and other improvements may be achieved by having polymer chains within individual stent struts oriented in a direction that is closer to or in line with the axis of the individual stent struts. The desired orientation of polymer molecules may be achieved by one or any combination of extruding polymers into hollow tubes to induce axially oriented polymer chains, applying a tensile load to polymer tubes to induce axially oriented polymer chains, and radially expanding polymer tubes to induce circumferentially oriented polymer chains. Stent patterns include struts defining diamond shaped cells and/or W-shaped cells.
摘要翻译：公开了具有断裂韧性和部署后反冲性的聚合物支架以及制造这种支架的方法。机械特性和其它改进的改进可以通过使单独的支架支柱内的聚合物链沿与单个支架支柱的轴线更接近或一致的方向定向来实现。聚合物分子的期望取向可以通过挤出聚合物到中空管中的一种或任何组合来实现，以诱导轴向取向的聚合物链，向聚合物管施加拉伸载荷以诱导轴向取向的聚合物链，以及径向扩张的聚合物管以诱导圆周取向聚合物链。支架图案包括定义菱形细胞和/或W形细胞的支柱。

47. 发明申请

US20070293938A1 Methods of fabricating stents with enhanced fracture toughness 有权
$Methods of fabricating stents with enhanced fracture toughness$
标题翻译：制造具有增强的断裂韧性的支架的方法
公开(公告)号：US20070293938A1
公开(公告)日：2007-12-20
申请号：US11454968
申请日：2006-06-15
申请人： David C. Gale , Bin Huang , Timothy A. Limon , Vincent J. Gueriguian
发明人： David C. Gale , Bin Huang , Timothy A. Limon , Vincent J. Gueriguian
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/90 , A61F2/91 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91583 , A61F2002/9522 , A61F2210/0004 , A61F2220/0016 , A61L31/06 , A61L31/14 , A61L31/148 , B29C35/045 , B29C49/0005 , B29C49/14 , B29C49/4273 , B29C49/4823 , B29C55/22 , B29C55/24 , B29C69/001 , B29C2049/0089 , B29C2793/0009 , B29K2067/00 , B29K2067/046 , B29K2105/258 , B29K2995/006 , B29L2031/7534 , Y10T156/1026 , C08L67/04
摘要： Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed.
摘要翻译：公开了制造具有增强的断裂韧性的支架的支架和方法。

48. 发明申请

US20070281073A1 Enhanced adhesion of drug delivery coatings on stents 审中-公开
标题翻译：增强药物递送涂层在支架上的附着力
公开(公告)号：US20070281073A1
公开(公告)日：2007-12-06
申请号：US11446489
申请日：2006-06-01
申请人： David C. Gale , Daniel Castro , Timothy A. Limon , Bin Huang
发明人： David C. Gale , Daniel Castro , Timothy A. Limon , Bin Huang
IPC分类号： A61L33/00
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/606 , A61L2420/02
摘要： Methods of enhancing adhesion of drug delivery coatings on stents are disclosed.
摘要翻译：公开了增加药物递送涂层在支架上的粘附性的方法。

49. 发明授权

US07273495B2 Intravascular stent and method of use 有权
标题翻译：血管内支架及其使用方法
公开(公告)号：US07273495B2
公开(公告)日：2007-09-25
申请号：US10841697
申请日：2004-05-06
申请人： Timothy A. Limon
发明人： Timothy A. Limon
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/828 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2230/0054
摘要： An expandable stent is implanted in a body lumen, such as a coronary artery, peripheral artery, or other body lumen for treating an area of vulnerable plaque. The invention provides for a an intravascular stent having a plurality of cylindrical rings connected by undulating links. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen. A central section is positioned between distal and proximal sections and is aligned with the area of vulnerable plaque to enhance growth of endothelial cells over the fibrous cap of the vulnerable plaque to reinforce the area and reduce the likelihood of rupture.
摘要翻译：将可扩张的支架植入体腔，例如冠状动脉，外周动脉或其他体腔，用于治疗易损斑块的区域。本发明提供一种血管内支架，其具有通过波浪形连杆连接的多个圆柱形环。支架在纵向具有高度的柔性，但具有足够的容器壁覆盖和径向强度足以保持打开动脉或其他体腔。中心部分定位在远端和近端部分之间，并与脆性斑块的区域对准，以增强内皮细胞在易损斑块的纤维帽上的生长，以加强该区域并降低破裂的可能性。

50. 发明授权

US06846323B2 Intravascular stent 有权
标题翻译：血管内支架
公开(公告)号：US06846323B2
公开(公告)日：2005-01-25
申请号：US10438632
申请日：2003-05-15
申请人： Philip S. Yip , P. H. Wilson Tsang , Henjen Ho , Timothy A. Limon , Svava Maria Atladottir
发明人： Philip S. Yip , P. H. Wilson Tsang , Henjen Ho , Timothy A. Limon , Svava Maria Atladottir
IPC分类号： A61F2/00 , A61F2/06 , A61F2/90
CPC分类号： A61F2/915 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2230/0013 , A61F2230/0054 , A61F2250/0036
摘要： An intravascular stent assembly for implantation in a body vessel, such as a coronary artery, includes undulating circumferential rings having peaks on the proximal end and valleys on the distal end. Adjacent rings are coupled together by links. The rings and links are arranged so that the stent has good conformability as it traverses through, or is deployed in, a tortuous body lumen. The stent is also configured such that the likelihood of peaks and valleys on adjacent rings which point directly at each other to overlap in tortuous body vessels is reduced.
摘要翻译：用于植入诸如冠状动脉的体容器中的血管内支架组件包括在近端具有峰和在远端的谷的起伏的周向环。相邻环通过链接耦合在一起。环和链节被布置成使得支架在穿过或部署在曲折的体腔中时具有良好的适形性。支架还被构造成使得相邻环上的峰和谷的直接相对于在曲折的体血管中重叠的可能性降低。

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