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41. 发明授权

US07470709B2 Benzimidazole quinolinones and uses thereof 失效
标题翻译：苯并咪唑喹啉酮及其用途
公开(公告)号：US07470709B2
公开(公告)日：2008-12-30
申请号：US10644055
申请日：2003-08-19
申请人： Paul A. Barsanti , Dirksen Bussiere , Stephen D. Harrison , Carla C. Heise , Johanna M. Jansen , Elisa Jazan , Timothy D. Machajewski , Christopher McBride , William R. McCrea, Jr. , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Joel B. Silver , Allan S. Wagman , Marion Wiesmann , Kelly Wayman
发明人： Paul A. Barsanti , Dirksen Bussiere , Stephen D. Harrison , Carla C. Heise , Johanna M. Jansen , Elisa Jazan , Timothy D. Machajewski , Christopher McBride , William R. McCrea, Jr. , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith B. Pfister , Savithri Ramurthy , Paul A. Renhowe , Cynthia M. Shafer , Joel B. Silver , Allan S. Wagman , Marion Wiesmann , Kelly Wayman
IPC分类号： A61K31/47
CPC分类号： C07D401/04 , A61K31/4375 , A61K31/4709 , A61K31/496 , A61K31/52 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D453/02 , C07D453/06 , C07D471/04
摘要： Methods of inhibiting various enzymes and treating various conditions are provided that include administering to a subject a compound of Structure I or IB, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I and IB have the following structures and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting various enzymes and for use in treating conditions mediated by such enzymes.
摘要翻译：提供了抑制各种酶和治疗各种病症的方法，其包括向受试者施用结构I或IB的化合物，其药学上可接受的盐，其互变异构体或互变异构体的药学上可接受的盐。具有结构I和IB的化合物具有以下结构并具有本文所述的变量。这些化合物可用于制备用于抑制各种酶的药物，并用于治疗由这些酶介导的病症。

42. 发明申请

US20070299039A1 Substituted benz-azoles and methods of their use as inhibitors of Raf kinase 失效
标题翻译：取代的苯并唑及其用作Raf激酶抑制剂的方法
公开(公告)号：US20070299039A1
公开(公告)日：2007-12-27
申请号：US11282939
申请日：2005-11-18
申请人： Payman Amiri , Wendy Fantl , Teresa Hansen , Barry Levine , Christopher McBride , Daniel Poon , Savithri Ramurthy , Paul Renhowe , Cynthia Shafer , Sharadha Subramanian , Leonard Sung
发明人： Payman Amiri , Wendy Fantl , Teresa Hansen , Barry Levine , Christopher McBride , Daniel Poon , Savithri Ramurthy , Paul Renhowe , Cynthia Shafer , Sharadha Subramanian , Leonard Sung
IPC分类号： A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/5377 , A61K31/55 , A61K31/665 , A61P35/00 , C07D401/10 , C07D401/14 , C07D413/10 , C07D413/14 , C07D417/10
CPC分类号： C07D401/14 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要翻译：提供了新的取代的苯并唑化合物，抑制人或动物受试者中Raf激酶活性的组合物和方法。新化合物组合物可以单独使用或与至少一种另外的药物组合使用，用于治疗Raf激酶介导的病症，例如癌症。

43. 发明申请

US20050209456A1 Quinolinone derivatives 有权
标题翻译：喹啉酮衍生物
公开(公告)号：US20050209456A1
公开(公告)日：2005-09-22
申请号：US11092137
申请日：2005-03-29
申请人： Paul Renhowe , Cynthia Shafer , Timothy Machajewski , Sabina Pecchi , Christopher McBride
发明人： Paul Renhowe , Cynthia Shafer , Timothy Machajewski , Sabina Pecchi , Christopher McBride
IPC分类号： C07D243/08 , A61K31/19 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/513 , A61K31/5377 , A61K31/541 , A61K31/551 , A61P35/00 , A61P43/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D453/02 , C07D471/04 , C07D487/08 , C07D519/00 , C07D43/02
CPC分类号： C07D409/04 , A61K31/19 , A61K31/4709 , A61K31/4745 , A61K31/513 , C07D401/04 , C07D401/14 , C07D405/04 , C07D413/04 , C07D417/04 , C07D453/02 , C07D471/04 , A61K2300/00
摘要： A method for synthesizing a 4-amino substituted quinolinone includes reacting a substituted or unsubstituted 2-benzimidazolyl-2-acetate with a substituted or unsubstituted 2-aminobenzonitrile in the presence of a base or an acid. A 4-amino substituted quinolinone compound is formed by the reaction, and the 4-amino substituted quinolinone compound comprises a benzimidazole group.
摘要翻译：合成4-氨基取代的喹啉酮的方法包括在碱或酸的存在下使取代或未取代的2-苯并咪唑-2-乙酸酯与取代或未取代的2-氨基苄腈反应。通过反应形成4-氨基取代的喹啉酮化合物，4-氨基取代的喹啉酮化合物包括苯并咪唑基。

44. 发明申请

US20050203101A1 Benzimidazole quinolinones and uses thereof 审中-公开
标题翻译：苯并咪唑喹啉酮及其用途
公开(公告)号：US20050203101A1
公开(公告)日：2005-09-15
申请号：US10839793
申请日：2004-05-05
申请人： Paul Barsanti , Dirksen Bussiere , Stephen Harrison , Carla Heise , Johanna Jansen , Elisa Jazan , Timothy Machajewski , Christopher McBride , William McCrea , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith Pfister , Savithri Ramurthy , Paul Renhowe , Cynthia Shafer , Joel Silver , Allan Wagman , Marion Wiesmann , Kelly Wayman
发明人： Paul Barsanti , Dirksen Bussiere , Stephen Harrison , Carla Heise , Johanna Jansen , Elisa Jazan , Timothy Machajewski , Christopher McBride , William McCrea , Simon Ng , Zhi-Jie Ni , Sabina Pecchi , Keith Pfister , Savithri Ramurthy , Paul Renhowe , Cynthia Shafer , Joel Silver , Allan Wagman , Marion Wiesmann , Kelly Wayman
IPC分类号： A61K31/4375 , A61K31/4709 , A61K31/496 , A61K31/52 , A61P35/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D453/02 , C07D453/06 , C07D471/04 , C07D43/14
CPC分类号： C07D401/04 , A61K31/4375 , A61K31/4709 , A61K31/496 , A61K31/52 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D453/02 , C07D453/06 , C07D471/04
摘要： Methods of treating cancer include contacting a cancer cell with 4-amino-5-fluoro-3-(5-piperazin-1-yl-1H-benzimidazol-2-yl)quinolin-2(1H)-one, 4-amino-5-fluoro-3-[5-(4-methyl-4-oxidopiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one, tautomers thereof, pharmaceutically acceptable salts thereof, pharmaceutically acceptable salts of the tautomers thereof, or a mixture thereof.
摘要翻译：治疗癌症的方法包括使癌细胞与4-氨基-5-氟-3-（5-哌嗪-1-基-1H-苯并咪唑-2-基）喹啉-2（1H） - 酮，4-氨基-5- 5-氟-3- [5-（4-甲基-4-氧代哌嗪-1-基）-1H-苯并咪唑-2-基]喹啉-2（1H） - 酮，其互变异构体，其药学上可接受的盐，药学上可接受的其互变异构体的盐或其混合物。

45. 发明申请

US20050182988A1 Adaptive clock skew in a variably loaded memory bus 失效
标题翻译：可变加载的内存总线中的自适应时钟偏移
公开(公告)号：US20050182988A1
公开(公告)日：2005-08-18
申请号：US11107044
申请日：2005-04-15
申请人： Christopher McBride , Paul Brownell , Timothy McJunkin
发明人： Christopher McBride , Paul Brownell , Timothy McJunkin
IPC分类号： G06F1/10 , G06F12/00 , G06F1/12
CPC分类号： G06F1/10
摘要： The preferred embodiments of the present invention are directed to the selective phase lag and time delay of clock signals within a computer system to compensate for additional parasitic capacitance that may be added to that system because of its open architecture. More particularly, the preferred embodiments are directed to clock signal path circuits where each circuit has multiple signal paths of varying lengths. By allowing the clock signals to propagate along a particular path, phase lag or time delay is added to those clock signals. Selection of a particular path for the clock signal is made by activating electrically controlled switches which themselves are activated or deactivated by software programs that run during power-up of the computer system that determine required phase lag or time delay of those clock signals as a function of parasitic capacitance in the computer system.
摘要翻译：本发明的优选实施例涉及计算机系统内的时钟信号的选择性相位滞后和时间延迟，以补偿由于其开放架构而可能添加到该系统的附加寄生电容。更具体地，优选实施例涉及时钟信号路径电路，其中每个电路具有不同长度的多个信号路径。通过允许时钟信号沿特定路径传播，相位滞后或时间延迟被添加到那些时钟信号。用于时钟信号的特定路径的选择是通过激活电控开关来实现的，该开关本身由计算机系统的上电期间运行的软件程序激活或去激活，所述软件程序确定那些时钟信号作为一个功能的所需相位滞后或时间延迟的计算机系统中的寄生电容。

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