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41. 发明申请

US20130144300A1 APPLICATOR KIT 审中-公开
标题翻译：应用工具包
公开(公告)号：US20130144300A1
公开(公告)日：2013-06-06
申请号：US13553305
申请日：2012-07-19
申请人： Sebastian Vogt , Daniela Villone , Frank Finis , Rüdiger Creuzburg
发明人： Sebastian Vogt , Daniela Villone , Frank Finis , Rüdiger Creuzburg
IPC分类号： A61F2/28
CPC分类号： A61F2/4601 , A61B17/7095 , A61B17/8811 , A61B17/8819 , A61B17/8825
摘要： An applicator and applicator kit for particulate bone replacement materials, autologous or heterologous cancellous bone, demineralised bone matrix. The applicator (1) contains a hollow tube (12) including on one end a bladed shutter. The applicator comprises first fastener (15) for engaging a second component. The second component contains a rod (2) with a handle (21) on one end and a plunger (22) on the opposite end. The rod is arranged in a guide sleeve which is moved along the rod (2) and comprises second fastening means (23) that can be connected to the fastener (15) of the applicator (1) in reversible manner. The applicator kit contains a mixing cup connected to the tube (12) instead of the rod such that the material to be applied is filled into the tube (12) easily prior to application.
摘要翻译：用于颗粒状骨置换材料的自动或异种松质骨，脱钙骨基质的涂抹器和涂抹器套件。施加器（1）包含中空管（12），该中空管（12）的一端包括叶片快门。涂抹器包括用于接合第二部件的第一紧固件（15）。第二部件包括在一端具有手柄（21）的杆（2）和在另一端上的柱塞（22）。杆被布置在沿着杆（2）移动的引导套筒中，并且包括能够以可逆方式连接到施用器（1）的紧固件（15）的第二紧固装置（23）。施用器套件包含连接到管（12）而不是杆的混合杯，使得待施用的材料在施用之前容易地填充到管（12）中。

42. 发明申请

US20120132104A1 DENTAL MATERIALS CONTAINING ANTIMICROBIAL AGENTS, PARTICULARLY FOR THE PREVENTION OF PLAQUE DEPOSITS 审中-公开
标题翻译：含有抗菌剂的牙科材料，特别是防止沉淀物
公开(公告)号：US20120132104A1
公开(公告)日：2012-05-31
申请号：US13382699
申请日：2010-07-24
申请人： Klaus Ruppert , Mario Beyer , Sebastian Vogt
发明人： Klaus Ruppert , Mario Beyer , Sebastian Vogt
IPC分类号： A61K6/00 , C07D401/06 , C08F220/14 , A61K6/083 , C08F236/20
CPC分类号： A61K6/0088 , A61K6/0017 , A61K6/0023 , A61K6/0067 , A61K6/0091 , A61K6/024 , A61K6/083 , A61K6/10 , C08L33/10
摘要： Dental material is provided with at least one antimicrobial active substance that is applied onto inorganic particles or organic polymer beads and is bound non-covalently to the particles or polymer beads.This results in a dental material on which plaque colonisation is prevented.
摘要翻译：牙科材料设置有至少一种抗微生物活性物质，其被施加到无机颗粒或有机聚合物珠粒上并与颗粒或聚合物珠粒非共价结合。这导致防止斑块定植的牙科材料。

43. 发明申请

US20120009327A1 Method and Device for Coating of a Medical Implant 有权
标题翻译：医疗植入物的涂覆方法和装置
公开(公告)号：US20120009327A1
公开(公告)日：2012-01-12
申请号：US13171903
申请日：2011-06-29
申请人： Sebastian Vogt , Hubert Büchner
发明人： Sebastian Vogt , Hubert Büchner
IPC分类号： A61F2/28 , B05D7/00 , A61L27/30 , B05C11/00
CPC分类号： A61L27/12 , A61L27/306 , A61L27/32 , A61L2420/02 , B05D1/28 , C23C26/00
摘要： The invention relates to a method for coating of a medical implant that can be used to apply a calcium salt to the surface of a medical implant easily and without expensive coating equipment and little expenditure of time.Accordingly, a method is provided that includes(i) providing a medical implant that includes at least one surface to be coated; (ii) providing a body that includes at least one calcium salt with a Mohs hardness of no more than 5.5 on at least one of its surfaces; and (iii) rubbing said body having the calcium salt-containing surface onto the at least one medical implant surface to be coated in order to coat said surface of the medical implant with the at least one calcium salt.
摘要翻译：本发明涉及一种医用植入物的涂覆方法，该方法可用于将钙盐轻易应用于医用植入物的表面，并且不需要昂贵的涂层设备和少量的时间消耗。因此，提供了一种方法，其包括（i）提供包括至少一个待涂覆表面的医用植入物; （ii）在其表面的至少一个上提供包含莫希硬度不超过5.5的至少一种钙盐的主体; 和（iii）将具有含钙盐表面的所述身体摩擦至待涂覆的至少一个医用植入物表面上，以便用所述至少一种钙盐涂覆医用植入物的所述表面。

44. 发明授权

US07923019B2 Antibiotic/s containing bone substitute material with sustained active substance release 有权
标题翻译：含有持久活性物质释放的骨替代材料的抗生素
公开(公告)号：US07923019B2
公开(公告)日：2011-04-12
申请号：US11294001
申请日：2005-12-05
申请人： Klaus-Dieter Kühn , Sebastian Vogt
发明人： Klaus-Dieter Kühn , Sebastian Vogt
IPC分类号： A61K33/42 , A61F2/00
CPC分类号： A61L27/025 , A61L27/54 , A61L2300/404 , A61L2300/406 , A61L2430/02
摘要： Antibiotic/s containing bone substitute material is described which is characterized in that it is composed of a compacted mixture of granules of calcium sulfate dihydrate, calcium carbonate and at least one representative of the aminoglycoside antibiotics, lincosamide antibiotics, glycopeptide antibiotics, macrolide antibiotics, ketolide antibiotics, the nitroimidazoles, the fluorochinolone antibiotics and the oxazolidinone antibiotics, the steroid antibiotics, the antiseptic agents and the fungicidal/fungistatic antibiotics which are partly or entirely sheathed with a layer of glycerol tripalmitate and/or glycerol tristearate and/or glycerol trilaurate and/or 1-hexadecyl alcohol which connects the granules with each other.
摘要翻译：描述了含有抗生素的骨替代材料，其特征在于其由硫酸钙二水合物，碳酸钙和至少一种氨基糖苷类抗生素代谢物的压实混合物，氯胺素抗生素，糖肽抗生素，大环内酯类抗生素，酮内酯抗生素，硝基咪唑，氟喹诺酮抗生素和恶唑烷酮抗生素，类固醇抗生素，防腐剂和杀真菌/抑菌抗生素，其部分或全部用三层棕榈酸甘油酯和/或甘油三硬脂酸酯和/或甘油三月桂酸酯和/ 或将该颗粒彼此连接的1-十六烷基醇。

45. 发明授权

US07920144B2 Method and system for visualization of dynamic three-dimensional virtual objects 有权
标题翻译：动态三维虚拟物体可视化的方法与系统
公开(公告)号：US07920144B2
公开(公告)日：2011-04-05
申请号：US11328562
申请日：2006-01-10
申请人： Sebastian Vogt , Frank Sauer , Ali Khamene
发明人： Sebastian Vogt , Frank Sauer , Ali Khamene
IPC分类号： G06T15/70
CPC分类号： G06T13/20 , G06T15/005
摘要： A method for visualization of dynamic three-dimensional (3D) virtual objects comprises storing a plurality of static 3D key-models respectively describing a dynamic 3D object in at least one of a number of poses and shapes; and rendering the dynamic 3D object by interpolation of the 3D key-models by performing the interpolation in a vertex shader program of a programmable graphics processing unit (GPU).
摘要翻译：一种用于可视化动态三维（3D）虚拟对象的方法包括以多个姿态和形状中的至少一个存储分别描述动态3D对象的多个静态3D关键字模型; 以及通过在可编程图形处理单元（GPU）的顶点着色器程序中执行插值来对3D键模型进行插值来呈现动态3D对象。

46. 发明申请

US20110062637A1 LOCAL SYSTEM FOR THE RELEASE OF ACTIVE PRINCIPLE AND PROCESS FOR ITS MANUFACTURE 失效
标题翻译：用于释放活动原理的本地系统及其制造方法
公开(公告)号：US20110062637A1
公开(公告)日：2011-03-17
申请号：US12949260
申请日：2010-11-18
申请人： Klaus-Dieter Kuhn , Sebastian Vogt
发明人： Klaus-Dieter Kuhn , Sebastian Vogt
IPC分类号： B29C45/72
CPC分类号： A61K9/0024 , A61J2200/20 , A61K9/1611 , A61K9/1635 , A61L27/16 , A61L27/54 , A61L2300/406 , C08L33/12
摘要： A local system for the release of active principle is described which consists of approximately spherical or rotation symmetrical bodies which are composed essentially of polymethyl methacrylate or polymethyl methacrylate co-methyl acrylate, zirconium dioxide or barium sulphate and one or more pharmaceutical active principles, in particular antibiotics, and which are produced by radical polymerisation, radical polymerisation activators effective in the temperature range of 10-80° C. or residues of these polymerisation activators from the groups of aromatic amines, heavy metal salts and barbiturates not being contained therein.A process for the production of the local system for the release of active principle in the case of which a) a paste is produced by mixing methyl methacrylate, polymethyl methacrylate or polymethyl methacrylate co-methyl acrylate, zirconium dioxide and/or barium sulphate, one or more pharmaceutical active principles and a thermally decomposing radical initiator, the paste having a viscosity such that it cannot be deformed at room temperature by the effect of gravity; b) the paste is injection moulded by an injection moulding device without heating at room temperature into approximately spherical or rotation-symmetrical bodies or the approximately spherical or rotation symmetrical bodies are injection-moulded onto a wire; c) the bodies are heated to a temperature at which the polymerisation initiator decomposes.
摘要翻译：描述了用于释放有效原理的局部系统，其由大致球形或旋转对称的主体组成，其主要由聚甲基丙烯酸甲酯或聚甲基丙烯酸甲酯共聚甲基丙烯酸酯，二氧化锆或硫酸钡组成，以及一种或多种药物活性成分，特别是抗生素，其通过自由基聚合制备，在10-80℃的温度范围内有效的自由基聚合活化剂或不含有芳族胺，重金属盐和巴比妥酸盐基团的这些聚合活化剂的残基。制备用于释放活性成分的局部体系的方法，其中a）通过混合甲基丙烯酸甲酯，聚甲基丙烯酸甲酯或聚甲基丙烯酸甲酯共聚甲基丙烯酸酯，二氧化锆和/或硫酸钡，或更多的药物活性成分和热分解性自由基引发剂，所述糊具有使其在室温下不受重力的影响而不能变形的粘度; b）浆料通过注射成型装置注射成型，而不在室温下加热成近似球形或旋转对称的体，或将近似球形或旋转的对称体注射到线上; c）将物体加热到聚合引发剂分解的温度。

47. 发明授权

US07858109B2 Implant material 有权
标题翻译：植入材料
公开(公告)号：US07858109B2
公开(公告)日：2010-12-28
申请号：US11675127
申请日：2007-02-15
申请人： Klaus-Dieter Kühn , Sebastian Vogt
发明人： Klaus-Dieter Kühn , Sebastian Vogt
IPC分类号： A61F2/00 , A61K31/70 , A61K38/16 , A61K31/496
CPC分类号： A61K9/0024 , A61K9/2072 , A61K9/70 , A61K31/7036 , A61L27/54 , A61L2300/406
摘要： Form bodies, which can be rotationally-symmetrical or irregularly-shaped, consist of at least one member of the group of the antibiotic salts, gentamicin myristate, gentamicin palmitate, gentamicin stearate, tobramycin myristate, tobramycin palmitate, tobramycin stearate, amikacin myristate, amikacin palmitate, amikacin stearate, vancomycin palmitate, vancomycin stearate, ramoplanin palmitate, ramoplanin stearate, levofloxacin palmitate, levofloxacin stearate, ofloxacin palmitate, ofloxacin stearate, moxifloxacin palmitate, moxifloxacin stearate, clindamycin palmitate, and clindamycin stearate. A medical device for implantation, in which the form bodies are arranged on a biodegradable filament at a distance of 1 mm to 25 mm as well as a method for the manufacture of the medical device and the use of the form bodies or the medical device to treat chronic osteomyelitis are described.
摘要翻译：可以旋转对称或不规则形状的成形体由至少一种抗生素盐，庆大霉素，肉豆蔻酸庆大霉素，庆大霉素棕榈酸酯，肉豆蔻酸庆大霉素，妥布霉素棕榈酸酯，妥布霉素棕榈酸酯，肉豆蔻酸阿米卡星，阿米卡星棕榈酸盐，阿米卡星硬脂酸盐，万古霉素棕榈酸酯，拉莫洛维林棕榈酸酯，拉莫洛宁硬脂酸酯，左氧氟沙星棕榈酸酯，左氧氟沙星硬脂酸酯，氧氟沙星棕榈酸酯，氧氟沙星硬脂酸酯，莫西沙星棕榈酸酯，莫西沙星硬脂酸酯，克林霉素棕榈酸酯和克林霉素硬脂酸酯。一种用于植入的医疗装置，其中，所述成形体以1mm至25mm的距离布置在生物可降解的长丝上，以及用于制造所述医疗装置的方法以及所述成形体或所述医疗装置的使用描述治疗慢性骨髓炎。

48. 发明授权

US07655706B2 Polymethylmethacrylate bone cement 有权
标题翻译：聚甲基丙烯酸甲酯骨水泥
公开(公告)号：US07655706B2
公开(公告)日：2010-02-02
申请号：US11447807
申请日：2006-06-06
申请人： Klaus-Dieter Kühn , Sebastian Vogt
发明人： Klaus-Dieter Kühn , Sebastian Vogt
IPC分类号： A61F2/28
CPC分类号： A61L27/50 , A61L24/001 , A61L24/06 , A61L27/16 , A61L2430/02 , C08L33/12
摘要： A polymethylmethacrylate bone cement with a liquid monomer component and a solid component contains in the monomer liquid, for example, 0.001-1.00 mass percent of a dye or dye mixture that is insoluble or poorly soluble in methacrylic acid methylester and, for example, 0.001-2.00 mass percent of a synthetically produced, protein-free, hydrophobic, low molecular or oligomeric solubilizer for the dye or dye mixture. The solubilizer preferably is liquid or pasty at room temperature. The monomer liquid is translucent at room temperature. Preferably, 0.001-1.00 mass percent of a dye or dye mixture that is insoluble or poorly soluble in methacrylic acid methylester and, preferably, 0.001-2.00 mass percent of a synthetically produced, protein-free, hydrophobic, low molecular or oligomeric solubilizer that is liquid or pasty at room temperature are homogeneously dissolved in the polymethacrylate or polymethylacrylate of the powder component.
摘要翻译：具有液体单体组分和固体组分的聚甲基丙烯酸甲酯骨粘固剂在单体液体中含有例如0.001-1.00质量％的不溶于或难溶于甲基丙烯酸甲酯的染料或染料混合物，例如，用于染料或染料混合物的合成产生的无蛋白质，疏水性，低分子或低聚增溶剂的2.00质量％。增溶剂在室温下优选为液体或糊状。单体液体在室温下是半透明的。优选0.001〜1.00质量％的不溶于或难溶于甲基丙烯酸甲酯的染料或染料混合物，优选0.001-2.00质量％的合成产生的无蛋白质，疏水性，低分子或低聚物的增溶剂，其为液体或糊状物均匀地溶解在粉末组分的聚甲基丙烯酸酯或聚甲基丙烯酸甲酯中。

49. 发明授权

US07653226B2 Flexible generation of digitally reconstructed radiographs 有权
标题翻译：灵活地生成数字重建的X光片
公开(公告)号：US07653226B2
公开(公告)日：2010-01-26
申请号：US10953342
申请日：2004-09-29
申请人： Jens Gühring , Sebastian Vogt , Ali Khamene
发明人： Jens Gühring , Sebastian Vogt , Ali Khamene
IPC分类号： G06K9/00 , G06K9/40 , A61B5/00 , A61B6/00
CPC分类号： G06T15/08
摘要： A system and corresponding method for flexible generation of digitally reconstructed radiograph (DRR) images on a graphics processing unit (GPU) are provided, the system including a processor, an imaging adapter in signal communication with the processor for receiving volumetric data, an integration unit in signal communication with the processor for integrating the volumetric data into incremental line integrals, and a modeling unit in signal communication with the processor for modeling composite line integrals from the incremental line integrals; and the corresponding method including receiving three-dimensional (3D) volumetric data into a graphics pipeline, integrating the 3D volumetric data into incremental line integrals along a plurality of viewing rays, modeling composite line integrals from the incremental line integrals, and adding the incremental line integrals for each composite line integral to form pixels of the DRR image.
摘要翻译：提供了一种用于在图形处理单元（GPU）上灵活生成数字重建X射线照片（DRR）图像的系统和相应方法，该系统包括处理器，与处理器进行信号通信的成像适配器，用于接收体积数据，整合单元与处理器的信号通信，用于将体积数据集成到增量线积分中，以及与处理器进行信号通信的建模单元，用于从增量线积分建模复合线积分; 以及相应的方法，包括将三维（3D）体积数据接收到图形管线中，将3D体积数据集成到沿着多个观察射线的增量线积分中，从增量线积分建模复合线积分，以及将增量线每个复合线的积分积分以形成DRR图像的像素。

50. 发明申请

US20070254011A1 Bone Formation Agent and Method of Production 有权
标题翻译：骨形成剂及其生产方法
公开(公告)号：US20070254011A1
公开(公告)日：2007-11-01
申请号：US10580549
申请日：2004-11-25
申请人： Matthias Schnabelrauch , Sebastian Vogt , Dieter Reif , Ute (Erbe) Reif
发明人： Matthias Schnabelrauch , Sebastian Vogt , Dieter Reif , Ute (Erbe) Reif
IPC分类号： A61L24/00 , A61L27/42 , A61L27/46
CPC分类号： A61L24/0084 , A61L24/0036 , A61L24/0042 , A61L27/46 , A61L27/56 , A61L27/58 , A61L2430/02
摘要： A method of producing a self-hardening, bioabsorbable composite material, the material produced and its areas of application are described. The method is based on the principal method steps (I) immobilisation of a polymerisation initiator in a microporous pore system of a first partial amount of a bioabsorbable calcium phosphate used in producing the self-hardening, bioabsorbable composite material, (II) immobilisation of a polymerisation activator in the microporous pore system of a second partial amount of the bioabsorbable calcium phosphate used in producing the self-hardening, bioabsorbable composite material and (III) homogeneous mixing of the components according to (I) and (II) with a liquid or paste-form, multi-functional monomer capable of forming a biocompatible, bioabsorbable polymer network or a corresponding monomer mixture and, optionally, with further constituents which modify the properties of the monomer or monomer mixture. The described self-hardening, bioabsorbable composite materials can be used as bone adhesives for the fixing of bone fractures, as shaped pieces of standardised dimensions and as implants that are individual to a patient in the context of regenerative bone healing in humans and animals.
摘要翻译：描述了生产自硬化生物可吸收复合材料的方法，所生产的材料及其应用领域。该方法基于主要方法步骤（I）将聚合引发剂固定在用于生产自硬化生物可吸收复合材料的第一部分量的生物可吸收磷酸钙的微孔孔系统中，（II）固定化用于生产自硬化生物可吸收复合材料的第二部分量的生物可吸收磷酸钙的微孔孔体系中的聚合活化剂和（III）根据（I）和（II）的组分与液体或糊状的多功能单体，其能够形成生物相容的生物可吸收的聚合物网络或相应的单体混合物，并且任选地具有改变单体或单体混合物的性质的其它组分。所描述的自硬化生物可吸收复合材料可用作固定骨折的骨粘合剂，作为标准尺寸的成形件，以及在人和动物的再生骨愈合背景下对患者个体的植入物。

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