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41. 发明专利

AU2005262322B2 2-substituted heteroaryl compounds 未知
公开(公告)号：AU2005262322B2
公开(公告)日：2012-07-26
申请号：AU2005262322
申请日：2005-07-01
申请人： SYNTA PHARMACEUTICALS CORP
发明人： SUN LIJUN , DEMKO ZACHARY , WADA YUMIKO , ZHANG SHIJIE
IPC分类号： C07D413/02 , A61K31/5377
摘要： This invention relates to compounds of formula (I): or pharmaceutically acceptable salts, solvate, clathrates hydrates or polymorphs thereof, their compositions and methods of use and methods of making thereof. The compounds (and compositions) are useful in modulating IL-12 production and processes mediated by IL-12.

42. 发明专利

ES2377947T3 Compuestos de pirimidina como inhibidores de la interleucina 12 (IL-12) 未知
公开(公告)号：ES2377947T3
公开(公告)日：2012-04-03
申请号：ES02804468
申请日：2002-11-27
申请人： SYNTA PHARMACEUTICALS CORP
发明人： ONO MITSUNORI , SUN LIJUN , PRZEWLOKA TERESA , ZHANG SHIJIE , KOSTIK ELENA , YING WEIWEN , WADA YUMIKO , KOYA KEIZO , WU YAMING , ZHOU DAN , TATSUTA NORIAKI
IPC分类号： C07D239/32 , A61K31/295 , A61K31/506 , A61P29/00 , C07D239/38 , C07D239/47 , C07D239/48 , C07D239/50 , C07D239/52 , C07D239/56 , C07D279/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12
摘要： Compuesto de fórmula (I) R3 es Rc, alquenilo, alquinilo, ORc, OC (O) Rc, SO2Rc, S (O) Rc, S (O2) NRcRd, SRc, NRcRd, NRcCORd, NRcC (O) ORd, NRcC (O) NRcRd, NRcSO2Rd, CORc, C (O) ORc, o C (O) NRcRd; R5 es H o alquilo; n es 0, 1, 2, 3, 4, 5 o 6; X es O, S, S (O), S (O2) o NRc;Y es un enlace covalente, CH2, C (O), C=N-Rc, C=N-ORc, C=N-SRc, O, S, S (O), S (O2) o NRc; Z es N o CH; uno de entre U y V es N y el otro es CRc;y W es O, S, S (O), S (O2), NRc o NC (O) Rc; en el que cada Ra y Rb es, independientemente, H, alquilo, arilo, heteroarilo; y cada Rc y Rd es, independientemente, H, alquilo, arilo, heteroarilo, ciclilo, heterociclilo o alquilcarbonilo, en el que alquilo se refiere a un grupo alquilo que contiene hasta 6 átomos de carbono, alquenilo se refiere a un grupo alquenilo que contiene hasta 6 átomos de carbono y alquinilo se refiere a un grupo alquinilo que contiene hasta 6 átomos de carbono, y en el que los grupos alquilo, alquenilo, alquinilo, arilo, heteroarilo, ciclilo y heterociclilo están sustituidos opcionalmente.

43. 发明专利

AU781849B2 Inhibitors of IL-12 production 未知
公开(公告)号：AU781849B2
公开(公告)日：2005-06-16
申请号：AU5607400
申请日：2000-06-12
申请人： SYNTA PHARMACEUTICALS CORP
发明人： ONO MITSUNORI , WADA YUMIKO , BRUNKHORST BEATRICE , WARCHOL TADEUSZ , WRONA WOJCIECH , ZHOU DAN , VO NHA HUU , GILLIES STEPHEN
IPC分类号： A61K31/5377 , A61P1/04 , A61P17/06 , A61P25/28 , A61P29/00 , A61P31/04 , A61P43/00 , C07D251/52 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D413/14

44. 发明专利

AU2004289303A1 Fused heterocyclic compounds 未知
公开(公告)号：AU2004289303A1
公开(公告)日：2005-05-26
申请号：AU2004289303
申请日：2004-11-10
申请人： SYNTA PHARMACEUTICALS CORP
发明人： WADA YUMIKO , LI HAO , DEMKO ZACHARY , SUN LIJUN , PRZEWLOKA TERESA , ONO MITSUNORI , CHIMMANAMADA DINESH
IPC分类号： A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/541 , C07D239/84 , C07D239/88 , C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/04 , C07D413/14 , C07D471/04 , C07D475/06 , C07D491/04
摘要： This invention provides fused heterocyclic compounds, pharmaceutical compositions of the compounds, and methods of using the compounds for the treatment of, inter alia, IL-12 related disease and disorders.

45. 发明专利

CA2538188A1 DIHYDROPYRIDINE COMPOUNDS FOR TREATING OR PREVENTING METABOLIC DISORDERS 未知
公开(公告)号：CA2538188A1
公开(公告)日：2005-03-24
申请号：CA2538188
申请日：2004-09-10
申请人： SYNTA PHARMACEUTICALS CORP
发明人： FOLEY KEVIN , ONO MITSUNORI , BORELLA CHRISTOPHER , KOYA KEIZO , PRZEWLOKA TERESA , ZHANG SHIJIE , XIA ZHI-QIANG , SUN LIJUN , CHEN SHOUJUN , LI HAO , ZHOU DAN , WADA YUMIKO
IPC分类号： A61K31/4709 , A61K31/47 , A61K31/4741 , A61K31/4743 , A61K31/4745 , C07D215/20 , C07D215/54 , C07D221/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D471/02 , C07D491/02 , C07D491/04 , C07D498/02
摘要： This invention relates to dihydropyridine compounds of formula: (I) or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein A2, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, and m are defined herein, and compositions comprising such compounds. The invention al so relates to methods of preventing or treating metabolic disorders, such as diabetes mellitus, and conditions and complications associated with diabetes mellitus, comprising administering to a subject in need thereof a compound o f formula (I) or a composition comprising such a compound. The invention furth er relates to kits comprising a compound of formula (I).

46. 发明专利

NO20042742L 未知
公开(公告)号：NO20042742L
公开(公告)日：2004-08-24
申请号：NO20042742
申请日：2004-06-29
申请人： SYNTA PHARMACEUTICALS CORP
发明人： ONO MITSUNORI , WADA YUMIKO , SUN LIJUN , TATSUTA NORIAKI , WU YAMING , YING WEIWEN , PRZEWLOKA TERESA , ZHANG SHIJIE , KOSTIK ELENA , KOYA KEIZO , ZHOU DAN
IPC分类号： C07D239/42 , A61K20060101 , A61K31/5377 , A61K31/541 , A61P1/04 , A61P3/10 , A61P17/06 , A61P25/00 , A61P29/00 , A61P31/04 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/14 , C07D239/32 , A61K31/506
摘要： This invention features pyrimidine compounds of formula (I): R1 is each of R2 and R4 is H; R3 is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is NRc; Y is covalent bond, CH2, C(O), C-N-Rc, C-N-ORc, C-N-SRc, O, S, S(O), S(O2), or NRc; Z is N or CH; one of U and V is N, and the other is CRc; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which each of Ra and Rb, independently, is H, alkyl, aryl, heteroaryl; and Rc is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl.

47. 发明专利

IS7287A Pýrimídín efnasambönd 未知
公开(公告)号：IS7287A
公开(公告)日：2004-05-26
申请号：IS7287
申请日：2004-05-26
申请人： SYNTA PHARMACEUTICALS CORP
发明人： ONO MITSUNORI , SUN LIJUN , PRZEWLOKA TERESA , ZHANG SHIJIE , KOSTIK ELENA , YING WEIWEN , WADA YUMIKO , KOYA KEIZO , WU YAMING , ZHOU DAN , TATSUTA NORIAKI
IPC分类号： C07D239/42 , A61K20060101 , A61K31/5377 , A61K31/541 , A61P1/04 , A61P3/10 , A61P17/06 , A61P25/00 , A61P29/00 , A61P31/04 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/14 , A61K

48. 发明专利

AU2002357033A1 PYRIMIDINE COMPOUNDS 未知
公开(公告)号：AU2002357033A1
公开(公告)日：2003-06-17
申请号：AU2002357033
申请日：2002-11-27
申请人： SYNTA PHARMACEUTICALS CORP
发明人： KOYA KEIZO , WU YAMING , ZHOU DAN , TATSUTA NORIAKI , ONO MITSUNORI , SUN LIJUN , PRZEWLOKA TERESA , ZHANG SHIJIE , KOSTIK ELENA , YING WEIWEN , WADA YUMIKO
IPC分类号： C07D239/42 , A61K20060101 , A61K31/5377 , A61K31/541 , A61P1/04 , A61P3/10 , A61P17/06 , A61P25/00 , A61P29/00 , A61P31/04 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/14
摘要： This invention features pyrimidine compounds of formula (I): R1 is each of R2 and R4 is H; R3 is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is NRc; Y is covalent bond, CH2, C(O), C-N-Rc, C-N-ORc, C-N-SRc, O, S, S(O), S(O2), or NRc; Z is N or CH; one of U and V is N, and the other is CRc; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which each of Ra and Rb, independently, is H, alkyl, aryl, heteroaryl; and Rc is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl.

49. 发明专利

CA2854186A1 ADMINISTRATION OF A BIS(THIOHYDRAZIDE AMIDE) COMPOUND FOR TREATING CANCERS 未知
公开(公告)号：CA2854186A1
公开(公告)日：2013-05-16
申请号：CA2854186
申请日：2012-11-09
申请人： SYNTA PHARMACEUTICALS CORP
发明人： SANG JIM , WADA YUMIKO
IPC分类号： A61K31/165 , A61K31/337 , A61K45/06 , A61P35/00 , A61P35/02
摘要： Administration of a bis(thiohydrazide amide) compound is found to be surprisingly effective at treating subjects with cancer. Methods of treating a subject with cancer comprising continuously administering a bis(thiohydrazide amide) compound, or administering a bis(thiohydrazide amide) compound such that a constant concentration of the compound is achieved in the subject, are disclosed.

50. 发明专利

CA2587590A1 PYRIMIDINE COMPOUNDS AND USES THEREOF 未知
公开(公告)号：CA2587590A1
公开(公告)日：2006-06-08
申请号：CA2587590
申请日：2005-11-18
申请人： SYNTA PHARMACEUTICALS CORP
发明人： LU RONGZHEN , WADA YUMIKO , HSIA ALBERT Y
IPC分类号： A61K31/5377
摘要： This invention features pyrimidine compounds of formula (I): Rt is aryl, or heteroaryl; each of R2 and R4, independently, is halogen, nitro, cyano, isothionitro, SRc, or ORc; or R2 and R4, taken together, is carbonyl; R3 is Rc, alkenyl, alkynyl, ORc, OC(O)Rc, SO2Rc, S(O)Rc, S(O2)NRcRd, NRcRd, NRcCORd, NRcC(O)ORd, NRcC(O)NRcRd, NRcSO2Rd, CORc, C(O)ORc, or C(O)NRcRd; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is O, S, S(O), S(O2), or NRc; Y is a covalent bond, CH2, C(O), C═N—Rc, C═N—ORc, C═N—SRc, O, S, S(O), S(O2), or NRc; Z is N or CH; one of U and V is N, and the other is CRc; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which each of Ra and Rb, independently, is H, alkyl, aryl, heteroaryl; and each of Rc and Rd, independently, is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl. The featured compounds inhibit the production of IL-12, IL-23 and IL-27 and are useful for treating disorders associated with IL-12, IL-23 and IL-27 overproduction or misregulation, such as inflammatory and immune disorders,

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