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41. 发明申请

WO1997023617A1 ANTIMICROBIAL PROTEINS 审中-公开
标题翻译：抗微生物蛋白
公开(公告)号：WO1997023617A1
公开(公告)日：1997-07-03
申请号：PCT/EP1996005765
申请日：1996-12-20
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , NIELSEN, Klaus, Kristian , KROLL KRISTENSEN, Anne , BRUNSTEDT, Janne
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C12N15/29
CPC分类号： C07K14/415 , A01N65/08 , C12N15/8282
摘要： An antimicrobial protein comprising a peptide having the sequence -Gln/Cys-AA2-Pro/Ile-Asn/Thr/Leu-AA5-AA6-Cys-Cys-Ala/Asn-Gly/Lys-AA11-AA12-AA13-AA14-AA15-, with the proviso that AA2 and AA14 are not cysteine, and that AA4 is Leu when AA1 is Cys. An antimicrobial protein having the sequence depicted in any one of SEQ ID Nos 3, 5 or 6. Recombinant DNA encoding such proteins. A vector comprising such DNA which is expressible in plants and which is linked to a plant operable promoter and terminator. Plants transformed with such recombinant DNA; the progeny of such plants which contain the DNA stably incorporated and hereditable in a Mendelian manner, and/or the seeds of such plants or such progeny.
摘要翻译：包含具有序列-Gln / Cys-AA2-Pro / Ile-Asn / Thr / Leu-AA5-AA6-Cys-Cys-Ala / Asn-Gly / Lys-AA11-AA12-AA13-AA14- AA15-，条件是AA2和AA14不是半胱氨酸，当AA1是Cys时，AA4是Leu。具有SEQ ID No.3,5或6中任一项所示序列的抗微生物蛋白质。编码这种蛋白质的重组DNA。包含这样的DNA的载体，其在植物中可表达并与植物可操作的启动子和终止子连接。用这种重组DNA转化的植物; 这些植物的后代含有以孟德尔方式稳定掺入和遗传的DNA，和/或这种植物或其后代的种子。

42. 发明申请

WO1997009316A1 4-[2-(PYRIMIDIN-4-OXY- OR 4-YLAMINO)-ETHYL]-PHENYL-OXIMES 审中-公开
标题翻译： 4- [2-（吡啶基-4-氧代 - 或4-氯苯基） - 乙基] - 苯基氧化
公开(公告)号：WO1997009316A1
公开(公告)日：1997-03-13
申请号：PCT/EP1996003864
申请日：1996-09-03
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SCHAUB, Fritz , LAMBERTH, Clemens
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C07D239/42
CPC分类号： C07D495/04 , A01N43/54 , C07C69/78 , C07C251/48 , C07C251/54 , C07D239/34 , C07D239/88 , C07D239/94
摘要： The invention discloses 4-[2-(pyrimidin-4-yloxy- or -4-ylamino)-ethyl]-phenyl-oximes of formula (I), wherein Z is NH or oxygen, R1 is hydrogen, C1-4alkyl, C1-4haloalkyl or C3-6cycloalkyl, R2 is hydrogen, C1-10alkyl, C3-8alkenyl, C3-8alkynyl, C3-8haloalkenyl, C1-8alkoxy-C1-4alkyl, C3-8alkenyloxy-C1-4alkyl, C3-8haloalkenyloxy-C1-4alkyl, C3-8alkynyloxy-C1-4alkyl, C1-8haloalkoxy-C1-4alkyl, C1-8alkylthio-C1-4alkyl, aryl, aryloxy-C1-4alkyl, aryl-C1-4alkoxy-C1-4alkyl, heteroaryloxy-C1-4alkyl, C1-4alkoxy-C1-4alkoxy-C1-4alkyl, or aryl-C1-8alkyl, R3 and R4 independently are halogen, C1-4alkyl, C1-4alkoxy, C1-4alkoxy-C1-4alkyl, C1-4alkoxycarbonyl-C1-4alkyl, C1-4alkoxycarbonyl, cyano-C1-4alkyl, cyano, or -COOH, or R3 and R4 together form a bridge member selected from 1,4-butylene, 1,4-butadienylene, or -S-CH=CH- each optionally substituted by one or two radicals selected from halogen or C1-4alkyl; the use of such compounds for the control of undesired acarinae, fungi, and insects, compositions for facilitating such use, and the preparation of the compounds of formula (I).
摘要翻译：本发明公开了式（I）的4- [2-（嘧啶-4-基氧基 - 或-4-基氨基） - 乙基] - 苯基 - 肟，其中Z是NH或氧，R 1是氢，C 1-4烷基，C 1 4-卤代烷基或C 3-6环烷基，R 2是氢，C 1-10烷基，C 3-8烯基，C 3-8炔基，C 3-8卤代烯基，C 1-8烷氧基-C 1-4烷基，C 3-8烯烃氧基-C 1-4烷基，C 3-8卤代烯氧基-C 1-4烷基，C 3-8炔基氧基-C 1-4烷基，C 1-8卤代烷氧基-C 1-4烷基，C 1-8烷硫基-C 1-4烷基，芳基，芳氧基-C 1-4烷基，芳基-C 1-4烷氧基-C 1-4烷基，杂芳氧基-C 1-4烷基，C 1 1-4烷氧基-C 1-4烷氧基-C 1-4烷基或芳基-C 1-8烷基，R 3和R 4独立地是卤素，C 1-4烷基，C 1-4烷氧基，C 1-4烷氧基-C 1-4烷基，C 1-4烷氧基羰基-C 1-4烷基，C 1 -C 4烷氧基 4-烷氧基羰基，氰基-C 1-4烷基，氰基或-COOH，或R 3和R 4一起形成选自1,4-亚丁基，1,4-丁二烯基或-S-CH = CH-的桥连体，各自任选被选自卤素或C 1-4烷基的一个或两个基团; 使用这种化合物来控制不希望的螨虫，真菌和昆虫，促进这种用途的组合物和式（I）化合物的制备。

43. 发明申请

WO1997003654A2 PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：药物组合物
公开(公告)号：WO1997003654A2
公开(公告)日：1997-02-06
申请号：PCT/EP1996003066
申请日：1996-07-12
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , GUITARD, Patrice , HAEBERLIN, Barbara , LINK, Rainer , RICHTER, Friedrich
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： A61K09/14
CPC分类号： A61K31/4745 , A61K9/145 , A61K9/146 , A61K31/436 , A61K31/445 , Y10S514/885 , Y10S514/922 , Y10S514/95 , Y10S514/964 , Y10S514/97
摘要： A pharmaceutical composition in the form of a solid dispersion comprising a macrolide, e.g. a rapamycin or an ascomycin, and a carrier medium.
摘要翻译：固体分散体形式的药物组合物，其包含大环内酯，例如雷帕霉素或子囊霉素，以及载体介质。

44. 发明申请

WO1996039811A1 IMMUNOCOMPROMISED ANIMALS COMPRISING HUMAN SYNOVIAL TISSUE 审中-公开
标题翻译：包含人体征服组织的免疫组织化学动物
公开(公告)号：WO1996039811A1
公开(公告)日：1996-12-19
申请号：PCT/EP1996002457
申请日：1996-06-06
申请人： SANDOZ LTD. , SYSTEMIX, INC. , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH
发明人： SANDOZ LTD. , SYSTEMIX, INC. , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , KNUDSEN, David, E., B.
IPC分类号： A01K67/027
CPC分类号： A01K67/0271
摘要： Immunocompromised hosts are provided, comprising a functional human synovial sac and articular cartilage. An intact human fetal patella is introduced into the xenogeneic host at a site that permits survival of the tissue, and permits experimental manipulation.Engrafted patella show early differentiation into a columnar matrix and stratification consistent with joint cartilage. The patellar articular surface is closely overlaid with a single layer of large cuboidal to attenuated cells with a central, oval to brick shaped nuclei and clear to pale eosinophilic cytoplasm consistent with synoviocytes. This layer reflects on itself at the margins of the patellar graft and closes, forming a complete envelope over the patellar articular surface. The human articular tissue is useful for investigating the effects of agents such as bacteria and bacterial peptides, cytokines and proteases on synovial function and dysfunction, growing neoplastic synovial sarcoma tissue in a natural environment, studying the hematopoietic interactions that are involved in various inflammatory arthritic diseases, and determining the role of HLA haplotypes in development of joint diseases.
摘要翻译：提供了免疫受损宿主，包括功能性人滑膜和关节软骨。将完整的人胎儿髌骨引入到允许组织存活的位点的异种宿主中，并允许实验操作。移植的髌骨显示早期分化成柱状基质并且与关节软骨一致。髌骨关节表面紧密地覆盖着一层大的长方体细胞，具有中心的，椭圆形到砖状的细胞核，并且与滑膜细胞一致的清澈至浅的嗜酸性细胞质。该层在髌骨移植物的边缘自身反射并闭合，在髌骨关节面上形成完整的包膜。人关节组织可用于研究细菌和细菌肽，细胞因子和蛋白酶等药物对滑膜功能和功能障碍的作用，在自然环境中生长的肿瘤滑膜肉瘤组织，研究各种炎症性关节炎疾病涉及的造血相互作用，并确定HLA单倍体在关节疾病发展中的作用。

45. 发明申请

WO1996037490A1 BENZOPYRANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：苯并噻唑和含有它们的药物组合物
公开(公告)号：WO1996037490A1
公开(公告)日：1996-11-28
申请号：PCT/EP1996002257
申请日：1996-05-24
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , MANLEY, Paul, W.
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C07D405/04
CPC分类号： C07D405/04 , C07D311/70 , C07D405/12 , C07D405/14 , C07D493/04
摘要： The invention provides novel 2,2-di(C1-5alkyl)- or trans-2,2-di(C1-5alkyl)-3,4-dihydro-3-hydroxy- -4-carboxamido-6-(N-arylsulfonamido)-2H-1-benzopyrans; and N-oxides, esters and salts thereof; processes for their production; and their uses as pharmaceuticals, e.g. as K -channel openers, bronchodilators and agents for the suppression of airways hyperreactivity, e.g., for use in the treatment of asthma.
摘要翻译：本发明提供新的2,2-二（C 1-5烷基） - 或反式-2,2-二（C 1-5烷基）-3,4-二氢-3-羟基-4-甲酰胺基-6-（N-芳基亚磺酰氨基基）-2H-1-苯并吡喃; 和N-氧化物，酯和盐; 生产过程; 及其作为药物的用途。作为K +通道开放剂，支气管扩张剂和用于抑制气道高反应性的药剂，例如用于治疗哮喘。

46. 发明申请

WO1996009755A1 PLANTS WITH DELAYED OR INHIBITED RIPENING OR SENESCENCE 审中-公开
标题翻译：延迟或禁止的植物鞣制或敏感
公开(公告)号：WO1996009755A1
公开(公告)日：1996-04-04
申请号：PCT/EP1995003811
申请日：1995-09-25
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , DE NIJS, Johannes, Jacobus, Maria , BROER, Jacobus , VAN DOORN, Johannes, Elizabert
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： A01H01/04
CPC分类号： A01H5/10 , A01H1/04
摘要： The present invention provides, inter alia, a method of obtaining plants which exhibit delayed or inhibited fruit ripening and/or vegetable tissue senescence comprising: (i) growing seedlings thereof in the presence of an auxin polar transport inhibitor and selecting those seedlings the hypocotyledon of which grows at an acute angle of less than about 70 DEG to the horizontal; and/or (ii) contacting the seeds of plants which have a low or reduced polar auxin transport with a conjugation inhibitory amount of an inhibitor of cytokinin-N glycosyl conjugation and selecting from the thus contacted seeds those which germinate.
摘要翻译：本发明尤其提供一种获得显示延迟或抑制果实成熟和/或植物组织衰老的植物的方法，其包括：（i）在生长素极性转运抑制剂存在下生长其幼苗，并选择这些幼苗的下胚轴其以与水平面小于约70度的锐角生长; 和/或（ii）使具有低或降低的极性生长素转运的植物的种子与缀合抑制量的细胞分裂素-N <7,9>糖基缀合抑制剂接触，并从所接触的种子中选择那些发芽的那些。

47. 发明申请

WO1995027490A1 USE OF SEROTONIN ANTAGONISTS (5HT3) FOR TREATING FIBROMYALGIA 审中-公开
标题翻译：使用丝氨酸拮抗剂（5HT3）治疗纤维母细胞瘤
公开(公告)号：WO1995027490A1
公开(公告)日：1995-10-19
申请号：PCT/EP1995001264
申请日：1995-04-06
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , MÜLLER, Wolfgang , STRATZ, Thomas
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： A61K31/445
CPC分类号： A61K31/538 , A61K31/40 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/4184 , A61K31/437 , A61K31/439 , A61K31/46
摘要： 5-HT3 antagonists (e.g. tropisetron, ondansetron) are useful in the treatment of fibromyalgia.
摘要翻译： 5-HT3拮抗剂（例如托烷司琼，昂丹司琼）可用于治疗纤维肌痛。

48. 发明申请

WO1994027438A1 HERBICIDAL COMPOSITIONS 审中-公开
标题翻译：除草剂组合物
公开(公告)号：WO1994027438A1
公开(公告)日：1994-12-08
申请号：PCT/EP1994001669
申请日：1994-05-24
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD.
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD. , BOYLES, Mark, Caroll , BRINKMAN, Bart, Aloysaus , FENDERSON, John, Melvin
IPC分类号： A01N37/40
CPC分类号： A01N37/40 , A01N39/04 , A01N61/00 , A01N47/36 , A01N43/50 , A01N43/70 , A01N25/32 , A01N2300/00
摘要： Co-application of dicamba and amino acid synthesis (ALS) inhibitor herbicides reduce the incidence of phytotoxic effects, particularly in grassy crops.
摘要翻译：麦草酸和氨基酸合成（ALS）抑制剂除草剂的共同应用降低了植物毒性作用的发生，特别是在草地作物中。

49. 发明申请

WO1994020627A1 MANNOSE OR XYLOSE BASED POSITIVE SELECTION 审中-公开
标题翻译： MANNOSE或基于XYLOSE的积极选择
公开(公告)号：WO1994020627A1
公开(公告)日：1994-09-15
申请号：PCT/EP1994000575
申请日：1994-02-28
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD. , BOJSEN, Kirsten , DONALDSON, Iain , HALDRUP, Anna , JOERSBOE, Morten , KREIBERG, Jette, Dina , NIELSEN, John , OKKELS, Finn, Thyge , PETERSEN, Steen, Guldager
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： C12N15/82
CPC分类号： C07H15/203 , C07H15/26 , C07H17/02 , C07H19/16 , C07H19/20 , C12N5/0025 , C12N9/90 , C12N9/92 , C12N15/65 , C12N15/8209 , C12N15/8245 , C12Y503/01008
摘要： The present invention provides a method for identifying or selecting from a population of eukaryotic cells cultivated on or in a medium containing at least one compound, cells which have a metabolic advantage as a result of having being transformed, wherein: (i) the cells are transformed with a nucleotide sequence or a co-introduced nucleotide sequence one of which comprises a region which: (a) encodes a protein which is involved in the metabolism of the compound, and/or (b) regulates the activity of the protein; and (ii) the compound is mannose or xylose or a derivative or a precursor of these, or a substrate of the protein, or is capable of being metabolized by the transformed cells into such a substrate, with the proviso that the compound is not mannos when the proteine is mannose 6 phosphate isomerase. The invention also includes a method according to the preceding paragraph wherein the compounds are are not so limited with the proviso that an agent which reduces the toxicity to the cells of the compound is added to the medium. It is preferred that where a toxicity-reducing agent has been added to the culture medium, the compound is mannose and the nucleotide or co-introduced nucleotide sequence encodes mannose-6-phosphate isomerase.
摘要翻译：本发明提供了鉴定或选择培养在含有至少一种化合物的培养基中的真核细胞群体的方法，所述培养基具有作为转化结果具有代谢优势的细胞，其中：（i）细胞是用核苷酸序列或共同引入的核苷酸序列转化，其中之一包含以下区域：（a）编码参与化合物代谢的蛋白质和/或（b）调节蛋白质的活性; 和（ii）化合物是甘露糖或木糖或其衍生物或前体，或蛋白质的底物，或能够被转化的细胞代谢成这样的底物，条件是该化合物不是甘露糖当蛋白为甘露糖6磷酸异构酶时。本发明还包括根据前述段落的方法，其中化合物不限于此，条件是向培养基中加入降低化合物细胞毒性的试剂。优选的是，当向培养基中加入毒性降低剂时，化合物是甘露糖，核苷酸或共同引入的核苷酸序列编码甘露糖-6-磷酸异构酶。

50. 发明申请

WO1994010125A1 GLYCERIN DERIVATIVES AND USES THEREOF 审中-公开
标题翻译：甘氨酸衍生物及其用途
公开(公告)号：WO1994010125A1
公开(公告)日：1994-05-11
申请号：PCT/EP1993002917
申请日：1993-10-21
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD. , NAGAHAMA, Shizuo , OCHIAI, Keiko , OHBA, Setsuya , TOMITA, Takako , WAKABAYASHI, Toshio
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： C07C69/587
CPC分类号： C07C69/587
摘要： A compound of formula (I) wherein R1 and R2 are acyl groups derived from different unsaturated fatty acids, both R1 groups being identical, one acyl group of R1 and R2 is an acyl group derived from eicosapentaenoic acid or docosahexaenoic acid, and theother acyl group is an acyl group derived from linoleic acid, gamma -linolenic acid, eicosapentaenoic acid or docosahexaenoic acid, and which is preferably in pure form comprising at least 90 % of the compound, has platelet aggregation inhibition activity and can be effectively used not only as a medicine for the therapy or prevention of thrombotic inflammation and platelet aggregation-induced arterial sclerosis, but also as a well-balanced nutrient clysis. Also certain compounds of formula (I), in particular the compound in which R1 is an eicosapentaenoyl residue and R2 is a gamma -linolenoyl residue, have anti-hypertriglyceridemic activity and are useful for the therapeutic treatment or prevention of diseases caused by hypertriglyceridemic such as cardiac infarction or arteriosclerosis.
摘要翻译：式（I）的化合物，其中R 1和R 2是衍生自不同不饱和脂肪酸的酰基，两个R 1基团相同，R 1和R 2的一个酰基是衍生自二十碳五烯酸或二十二碳六烯酸的酰基，以及其它酰基是衍生自亚油酸，γ-亚麻酸，二十碳五烯酸或二十二碳六烯酸的酰基，其优选为包含至少90％的化合物的纯形式，具有血小板聚集抑制活性，并且可以有效地用作用于治疗或预防血栓形成炎症和血小板聚集诱导的动脉硬化的药物，还可以作为平衡的营养物质溶解。还有某些式（I）化合物，特别是其中R 1为二十碳五烯酰基残基且R 2为γ-亚苄基酰基残基的化合物具有抗高甘油三酯血症活性，并且可用于治疗或预防由高甘油三酯血症引起的疾病，例如心肌梗塞或动脉硬化。

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