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41. 发明申请

WO1994013685A1 PSICOFURANOSE AND PSICOPYRANOSE DERIVATIVES 审中-公开
标题翻译： PSICOFURANOSE和PSICOPYRANOSE衍生物
公开(公告)号：WO1994013685A1
公开(公告)日：1994-06-23
申请号：PCT/JP1993001796
申请日：1993-12-10
申请人： SAGAMI CHEMICAL RESEARCH CENTER , TERASHIMA, Shiro , KATOH, Tadashi , MATSUMOTO, Miyoko
发明人： SAGAMI CHEMICAL RESEARCH CENTER
IPC分类号： C07H07/027
CPC分类号： C07H19/04 , C07H7/027 , C07H19/01 , Y02P20/55
摘要： D-psicofuranose and D-psicopyranose derivatives represented by general formulae (I) and (II), useful as the key intermediates in a novel process for producing hydantocidin; wherein R through R may be the same or different from one another and each represents hydrogen or a hydroxyl-protecting group; and X represents optionally protected hydroxymethyl, carboxyl, carbamoyl or allophanoyl.
摘要翻译：由通式（I）和（II）表示的D-呋喃葡萄糖和D-灵芝吡喃糖衍生物，可用作生产水葫芦素的新方法中的关键中间体; 其中R 1至R 8可以彼此相同或不同，并且各自表示氢或羟基保护基; 并且X表示任选保护的羟甲基，羧基，氨基甲酰基或脲基。

42. 发明申请

WO1994006746A1 6-HEPTYNOIC AND HEPTENOIC ACID COMPOUNDS 审中-公开
标题翻译： 6-HEPTYNOIC和HEPTENOIC酸化合物
公开(公告)号：WO1994006746A1
公开(公告)日：1994-03-31
申请号：PCT/JP1993001349
申请日：1993-09-21
申请人： NISSAN CHEMICAL INDUSTRIES LTD. , SAGAMI CHEMICAL RESEARCH CENTER , HIYAMA, Tamejiro , MINAMI, Tatsuya , TAKAHASHI, Kyoko , MIYACHI, Nobuhide , OHARA, Yoshio
发明人： NISSAN CHEMICAL INDUSTRIES LTD. , SAGAMI CHEMICAL RESEARCH CENTER
IPC分类号： C07C59/42
CPC分类号： C07D405/06 , C07C57/18 , C07D215/14 , C07D309/30 , Y02P20/55
摘要： A novel process for producing a 7-substituted-3,5-dihydroxy carboxylic acid compound useful as an HMG-CoA reductase inhibitor, and novel 6-heptynoic and heptenoic acid compounds, respectively represented by general formulae (1) and (2), useful as the starting material for the above process, wherein Z represents (3) or (4); A represents -CO- or -CHOR1- (wherein R1 represents hydrogen or a hydroxyl-protecting group) and B represents -CO- or -CHOR2- (wherein R2 represents hydrogen or a hydroxyl-protecting group), provided that R1 and R2 may be combined together to form a ring; R3 represents hydrogen, C1-C8 alkyl, aralkyl, aryl, silyl, lithium, sodium, potassium, calcium or RpRqRrNH (wherein Rp, Rq and Rr represent each independently hydrogen, C1-C8 alkyl, aralkyl or aryl); R6 represents hydrogen or a protective group for triple bonds; and L represents borane, aluminum, zirconium, magnesium or silyl each substituted by C1-C9 alkyl, alkylene, aralkyl, aryl, alkoxy, substituted phenoyx or halogen. The use of the invention compounds and process enables an efficient production of a 7-substituted-3,5-dihydroxy carboxlylic acid compound useful as an HMG-CoA reductase inhibitor.
摘要翻译：分别由通式（1）和（2）表示的用于制备可用作HMG-CoA还原酶抑制剂的7-取代-3,5-二羟基羧酸化合物和新的6-庚炔和庚烯酸化合物的新方法，可用作上述方法的起始原料，其中Z表示（3）或（4）; A表示-CO-或-CHOR1-（其中R1表示氢或羟基保护基），B表示-CO-或-CHOR2-（其中R2表示氢或羟基保护基），条件是R1和R2可以结合在一起形成戒指; R3代表氢，C1-C8烷基，芳烷基，芳基，甲硅烷基，锂，钠，钾，钙或RpRqRrNH（其中Rp，Rq和Rr各自独立地为氢，C1-C8烷基，芳烷基或芳基）。 R6表示氢或三键保护基; L代表各自被C 1 -C 9烷基，亚烷基，芳烷基，芳基，烷氧基，取代的苯甲酸或卤素取代的硼烷，铝，锆，镁或甲硅烷基。使用本发明化合物和方法能够有效地生产用作HMG-CoA还原酶抑制剂的7-取代-3,5-二羟基羧酸化合物。

43. 发明申请

WO1994003599A1 HUMAN cDNA AND PROTEIN WHICH SAID cDNA CODES FOR 审中-公开
标题翻译：人类cDNA和蛋白质，其中编码cDNA
公开(公告)号：WO1994003599A1
公开(公告)日：1994-02-17
申请号：PCT/JP1993001095
申请日：1993-08-04
申请人： SAGAMI CHEMICAL RESEARCH CENTER , KATO, Seishi , OH, Suwan , SEKINE, Shingo , KIM, Namsoon , KATO, Takae , IWAHORI, Akiyo
发明人： SAGAMI CHEMICAL RESEARCH CENTER
IPC分类号： C12N15/12
CPC分类号： C12N9/1007 , C07K14/47 , C12N9/14
摘要： The invention provides a human cDNA and a protein which said cDNA codes for, said protein serving as a material for novel drugs and diagnostic agents. More specifically, the invention provides a cDNA which originates in the mRNA expressed in human cells and wherein at least part of the base sequence thereof and part of the amino acid sequence of a protein which said cDNA codes for are elucidated, a protein which said cDNA codes for, and a vector which contains said cDNA, enables the preparation of a sense strand RNA and an antisense strand DNA against the DNA coding for said protein, and enables the expression of said protein by (in vitro) and/or (in vivo) translation.
摘要翻译：本发明提供了人cDNA和蛋白质，所述cDNA编码所述蛋白质作为新药物和诊断剂的材料。更具体地，本发明提供了起源于人细胞中表达的mRNA的cDNA，其中阐述了其cDNA编码的至少部分碱基序列和部分氨基酸序列的蛋白质，所述cDNA 编码和包含所述cDNA的载体能够针对编码所述蛋白质的DNA制备有义链RNA和反义链DNA，并且能够通过（体外）和/或（体内）表达所述蛋白质）翻译。

44. 发明申请

WO1992001671A1 HETEROCYCLE-SUBSTITUTED BENZENE DERIVATIVE, PRODUCTION THEREOF, AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT 审中-公开
标题翻译：取代苯并噻唑衍生物，其生产物和含有它们的除草剂作为活性成分
公开(公告)号：WO1992001671A1
公开(公告)日：1992-02-06
申请号：PCT/JP1991000950
申请日：1991-07-16
申请人： CHISSO CORPORATION , SAGAMI CHEMICAL RESEARCH CENTER , KAKEN PHARMACEUTICAL CO., LTD. , HIRAI, Kenji , YAMASHITA, Mitsuo , TATENO, Tomoko , EJIRI, Emiko , HARASAWA, Kikuko , ONJI, Yuichi , UGAI, Sadayuki , NAGATO, Shoin
发明人： CHISSO CORPORATION , SAGAMI CHEMICAL RESEARCH CENTER , KAKEN PHARMACEUTICAL CO., LTD.
IPC分类号： C07D209/48
CPC分类号： C07D209/48 , A01N37/32 , A01N43/56 , C07C69/96 , C07C205/43 , C07C217/88 , C07C219/34 , C07C271/28 , C07C2601/08 , C07C2601/14 , C07D231/56
摘要： A heterocycle-substituted benzene derivative represented by general formula (I) wherein R represents C3 to C8 cycloalkyl, X represents halogen, and Z represents (Ia) or (Ib) provided that the cycloalkyl may be substituted with C1 to C6 alkyl. This compound is excellent in that it has a remarkably high herbicidal effect against weeds growing in both upland and lowland fields in a low dose, while it has a remarkably low phytotoxicity against main crops.

45. 发明申请

WO1987004720A1 HYBRID PLASMINOGEN ACTIVATOR-LIKE POLYPEPTIDE 审中-公开
标题翻译：混合型PLASMINOGEN激活剂类似多肽
公开(公告)号：WO1987004720A1
公开(公告)日：1987-08-13
申请号：PCT/JP1987000065
申请日：1987-01-30
申请人： SAGAMI CHEMICAL RESEARCH CENTER , CENTRAL GLASS COMPANY, LIMITED , HODOGAYA CHEMICAL COMPANY, LIMITED , NIPPON SODA COMPANY, LIMITED , NISSAN CHEMICAL INDUSTRIES, LIMITED , TOYO SODA MANUFACTURING CO., LTD.
发明人： SAGAMI CHEMICAL RESEARCH CENTER , CENTRAL GLASS COMPANY, LIMITED , HODOGAYA CHEMICAL COMPANY, LIMITED , NIPPON SODA COMPANY, LIMITED , NISSAN CHEMICAL INDUSTRIES, LIMITED , TOYO SODA MANUFACTURING CO., LTD. , TAGAWA, Michito , WADA, Masakatsu , YAMANDA, Masayuki , YOKOYAMA, Midori , NUMAO, Naganori
IPC分类号： C12N15/00
CPC分类号： C12N9/6456 , A61K38/00 , C07K2319/00 , C12N15/70
摘要： A hybrid plasminogen activator-like polypeptide comprising a polypeptide region responsible for an affinity to fibrin derived from a tissue plasminogen activator polypeptide and a polypeptide region responsible for an enzyme activity derived from a prourokinase polypeptide; a DNA segment coding for the hybrid polypeptide; plasmid containing the DNA segment; a microorganism transformed with the DNA; and a process for production of the hybrid polypeptide comprising culturing the microorganism and recovering the hybrid polypeptide from the cultured cells.
摘要翻译：一种杂合纤维蛋白溶酶原激活剂样多肽，其包含负责来自组织纤溶酶原激活剂多肽的纤维蛋白亲和力的多肽区域和负责源自原尿激酶多肽的酶活性的多肽区域; 编码杂合多肽的DNA区段; 含有DNA片段的质粒; 用DNA转化的微生物; 以及杂交多肽的制备方法，包括培养微生物并从培养的细胞中回收杂交多肽。

46. 发明申请

WO1987002046A1 POLY(DI-SUBSTITUTED ACETYLENE)/POLYORGANOSILOXANE GRAFT COPOLYMER AND GAS SEPARATION MEMBRANE 审中-公开
标题翻译：聚（二取代的乙烯）/聚硅氧烷硅酸盐共聚物和气体分离膜
公开(公告)号：WO1987002046A1
公开(公告)日：1987-04-09
申请号：PCT/JP1986000507
申请日：1986-10-03
申请人： SAGAMI CHEMICAL RESEARCH CENTER , TOYO SODA MANUFACTURING CO., LTD. , MATSUI, Kiyohide , NAGASE, Yu , UCHIKURA, Masaki
发明人： SAGAMI CHEMICAL RESEARCH CENTER , TOYO SODA MANUFACTURING CO., LTD.
IPC分类号： C08G77/42
CPC分类号： C08G77/442 , B01D71/44 , B01D71/78
摘要： A selective gas separation membrane, which can concentrate an oxygen gas in a gas mixture, particularly air, which can permeate oxygen in a large amount, and which has excellent permselectivity and membrane strength. This membrane is formed of a novel poly(di-substituted acetylene)polyorganosiloxane graft copolymer composed of a main chain of poly(di-substituted acetylene) and a side chain of polyorganosiloxane.

47. 发明申请

WO1986005182A1 BETA-LACTAM COMPOUND 审中-公开
标题翻译： BETA-LACTAM化合物
公开(公告)号：WO1986005182A1
公开(公告)日：1986-09-12
申请号：PCT/JP1986000121
申请日：1986-03-07
申请人： SAGAMI CHEMICAL RESEARCH CENTER , TUNEMOTO, Daiei , NISHIDE, Kiyoharu , KOHORI, Takeo , KONDO, Kiyoshi
发明人： SAGAMI CHEMICAL RESEARCH CENTER
IPC分类号： C07D499/48
CPC分类号： C07D499/00 , Y02P20/55
摘要： beta -Lactam compounds, which are represented by formula (I) wherein R represents a hydrogen atom or a protective group for an amino group, and W represents (II) ou (III) wherein R represents a hydrogen atom, a salt-forming cation, a protective group for a carboxyl group, or an anion, R represents a hydrogen atom or CH2R , wherein R is a hydrogen atom of a residue of a nucleophilic compound. The compounds show a remarkably strong antibacterial effect against Gram-negative bacteria and resistant Gram-negative bacteria as well as Gram-positive bacteria.
摘要翻译：由式（I）表示的β-内酰胺化合物，其中R 1表示氢原子或氨基的保护基，W表示（II）ou（III），其中R 2表示氢原子，成盐阳离子，羧基保护基或阴离子，R 3表示氢原子或CH 2 R 4，其中R 4是亲核化合物的残基的氢原子。这些化合物对革兰氏阴性细菌和抗革兰氏阴性菌以及革兰氏阳性菌具有非常强的抗菌作用。

48. 发明申请

WO1986004351A1 STABILIZED HUMAN PROUROKINASE 审中-公开
标题翻译：稳定人体免疫球蛋白
公开(公告)号：WO1986004351A1
公开(公告)日：1986-07-31
申请号：PCT/JP1986000031
申请日：1986-01-24
申请人： SAGAMI CHEMICAL RESEARCH CENTER , CENTRAL GLASS COMPANY, LIMITED , HODOGAYA CHEMICAL COMPANY, LIMITED , NIPPON SODA COMPANY, LIMITED , NISSAN CHEMICAL INDUSTRIES, LIMITED , TOYO SODA MANUFACTURING COMPANY, LIMITED , MIYAKE, Toshio , HIBINO, Yasuo , KOBAYASHI, Yoichi , WATABE, Ken , OMORI, Muneki , MIKI, Tetsuzo , YOKOYAMA, Midori , MATSUMOTO, Reiko , WATANABE, Kazuo , NUMAO, Naganori
发明人： SAGAMI CHEMICAL RESEARCH CENTER , CENTRAL GLASS COMPANY, LIMITED , HODOGAYA CHEMICAL COMPANY, LIMITED , NIPPON SODA COMPANY, LIMITED , NISSAN CHEMICAL INDUSTRIES, LIMITED , TOYO SODA MANUFACTURING COMPANY, LIMITED
IPC分类号： C12N09/72
CPC分类号： C12N9/6462 , C12N15/73 , C12Y304/21073
摘要： Stabilized human prourokinase-like polypeptides wherein the 135th lysine from the N-terminal of human prourokinase is substituted by an amino acid other than basic amino acids, the 157th phenylalanine is substituted by an acidic amino acid, or both of the amino acids are substituted as described above; DNA segment which codes said polypeptides; plasmid which contains said DNA segment; E. coli transformed by said plasmid; and a process for preparing said polypeptide by using said E. coli. The polypeptides are stable against proteases such as plasmin, thrombin, trypsin, etc., thus being easily purified and collected in a pure form. When applied to a living body, the polypeptides are expected to provide a persistent fibrinolytic activity.

49. 发明申请

WO1984000755A1 AMINO POLYOL DERIVATIVES 审中-公开
标题翻译：氨基多元醇衍生物
公开(公告)号：WO1984000755A1
公开(公告)日：1984-03-01
申请号：PCT/JP1983000263
申请日：1983-08-12
申请人： SAGAMI CHEMICAL RESEARCH CENTER , HIYAMA, Tamejiro , KOBAYASHI, Kazuhiro
发明人： SAGAMI CHEMICAL RESEARCH CENTER
IPC分类号： C07D317/30
CPC分类号： C07H15/04 , C07D213/72 , C07D317/30 , C07D317/72
摘要： Novel amino polyol derivtives represented by (I), wherein R and R' each represent hydrogen, alkyl or aryl or, when taken together, R and R' represent alkylene, R1 represents lower alkyl, R2 represents hydrogen or acyl, and R3 represents lower alkyl, and a process for preparing them using (II) and (III), as starting materials. The amino polyol derivatives (I) are useful as intermediates for synthesizing amino sugars such as daunosamine, 3-epi-daunosamine, acosamine, ristosamine, etc. which constitutes the sugar moiety of daunomycin useful as oncostatic agent.

50. 发明申请

WO1998021328A3 HUMAN PROTEINS HAVING TRANSMEMBRANE DOMAINS AND DNAS ENCODING THESE PROTEINS 审中-公开
公开(公告)号：WO1998021328A3
公开(公告)日：1998-05-22
申请号：PCT/JP1997004056
申请日：1997-11-07
申请人： SAGAMI CHEMICAL RESEARCH CENTER , PROTEGENE INC. , KATO, Seishi , SEKINE, Shingo , YAMAGUCHI, Tomoko , KOBAYASHI, Midori
发明人： SAGAMI CHEMICAL RESEARCH CENTER , PROTEGENE INC.
IPC分类号： C12N15/12

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