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41. 发明授权

US08367828B2 PPAR active compounds 有权
公开(公告)号：US08367828B2
公开(公告)日：2013-02-05
申请号：US12768729
申请日：2010-04-28
申请人： James Arnold , Dean R. Artis , Clarence R. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
发明人： James Arnold , Dean R. Artis , Clarence R. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.

42. 发明申请

US20120015966A1 PPAR ACTIVE COMPOUNDS 审中-公开
标题翻译： PPAR活性化合物
公开(公告)号：US20120015966A1
公开(公告)日：2012-01-19
申请号：US13243703
申请日：2011-09-23
申请人： Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
发明人： Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
IPC分类号： A61K31/506 , C07D401/12 , C07D403/12 , A61K31/405 , A61K31/4439 , A61K31/4155 , A61P3/04 , A61P3/00 , A61P3/06 , A61P3/10 , A61P3/08 , A61P25/00 , A61P13/12 , A61P27/02 , A61P17/02 , A61P13/10 , A61P1/00 , A61P27/12 , A61P9/12 , A61P9/00 , A61P9/04 , A61P9/10 , A61P43/00 , A61P17/00 , A61P37/06 , A61P29/00 , A61P11/06 , A61P11/00 , A61P15/00 , A61P1/18 , A61P1/16 , A61P25/28 , A61P17/06 , A61P25/16 , A61P7/02 , A61P1/04 , A61P13/00 , A61P31/18 , A61P31/14 , A61P31/04 , A61P25/04 , A61P35/00 , C07D209/18
CPC分类号： C07D401/12 , C07D209/18 , C07D403/12
摘要： Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.
摘要翻译：描述了对PPARα，PPARδ和PPARγ中的至少一种具有活性的化合物，其可用于涉及调节PPARα，PPARδ和PPARγ中的至少一种的治疗和/或预防方法。

43. 发明授权

US08034821B2 Selective serine/threonine kinase inhibitors 有权
标题翻译：选择性丝氨酸/苏氨酸激酶抑制剂
公开(公告)号：US08034821B2
公开(公告)日：2011-10-11
申请号：US12698027
申请日：2010-02-01
申请人： John William Taunton, Jr. , Michael Cohen , Kevan Shokat , Chao Zhang
发明人： John William Taunton, Jr. , Michael Cohen , Kevan Shokat , Chao Zhang
IPC分类号： C07D487/04 , A61K31/52
CPC分类号： C07D487/04
摘要： Inhibition of protein kinases having one or more cysteine residues within the ATP binding site is effected by contacting the kinase, per se or in a cell or subject, with an inhibitory-effective amount of a compound having a heterocyclic core structure comprised of two or more fused rings containing at least one nitrogen ring atom, and an electrophilic substituent that is capable of reacting with a cysteine residue within the ATP binding site of a kinase.Preferred compounds include certain pyrrolopyrimidines and oxindoles having such an electrophilic substituent and optionally an aromatic or heteroaromatic substituent that is capable of interacting with a threonine or smaller residue located in the gatekeeper position of the kinase.Kinases lacking such cysteine residues may be engineered or modified so that they are capable of being inhibited by such compounds by replacing a valine or other amino acid residue within the ATP binding site by a cysteine residue.
摘要翻译：在ATP结合位点内具有一个或多个半胱氨酸残基的蛋白激酶的抑制通过使本身或细胞或受试者中的激酶与抑制有效量的具有由两个或更多个的杂环核心结构组成的化合物接触来实现含有至少一个氮环原子的稠环，以及能够与激酶的ATP结合位点内的半胱氨酸残基反应的亲电取代基。优选的化合物包括具有这样的亲电子取代基的某些吡咯并嘧啶和羟吲哚，以及任选的能够与位于激酶的关守位置的苏氨酸或更小残基相互作用的芳族或杂芳族取代基。缺乏这种半胱氨酸残基的激酶可以被改造或修饰，使得它们能够被这种化合物抑制，通过用半胱氨酸残基替换ATP结合位点内的缬氨酸或其它氨基酸残基。

44. 发明授权

US07942191B2 Method and system for producing wide steel strip 有权
标题翻译：宽钢带生产方法及系统
公开(公告)号：US07942191B2
公开(公告)日：2011-05-17
申请号：US12780854
申请日：2010-05-14
申请人： Chao Zhang , Zhonghan Luo , Zemin Fang , Jionghui Mao , Shenglin Chen , Ruoping Wang , Xiangxin Wang
发明人： Chao Zhang , Zhonghan Luo , Zemin Fang , Jionghui Mao , Shenglin Chen , Ruoping Wang , Xiangxin Wang
IPC分类号： B22D11/124 , B22D11/126 , B22D27/04 , B21B1/46 , B21B13/22 , C21D8/02
CPC分类号： C21D8/0263 , B21B1/466 , B21B15/005 , B21B45/08 , C21D1/42 , C21D1/74 , C21D8/0215 , C21D8/0226 , Y02P10/253 , Y10T29/49991
摘要： A method for producing a wide steel strip using thin slab continuous casting and rolling by the following steps a) casting a molten steel into a thin slab having a thickness of between 50 and 90 mm; b) cutting; c) soaking; d) heating by electromagnetic induction; e) descaling; f) rolling; g) cooling with laminar flow; and h) coiling. The method can effectively control the solution and precipitation of carbon, nitrogen, and sulfide in steel with a low cost. The process is easy and flexible, and steel can be produced in a wide range of categories. Further provided is a system for producing a wide steel strip with thin slab continuous casting and rolling.
摘要翻译：一种通过以下步骤使用薄板坯连续铸造和轧制生产宽钢带的方法：a）将钢水铸造成厚度在50至90mm的薄板坯; b）切割; c）浸泡; d）电磁感应加热; e）除垢; f）滚动; g）层流冷却; 和h）卷取。该方法可以有效控制钢铁中碳，氮，硫化物的溶解和沉淀，成本低廉。该工艺简单灵活，可生产各种类型的钢。还提供了一种用于生产具有薄板坯连续铸造和轧制的宽钢带的系统。

45. 发明申请

US20110085558A1 Virtual and Logical Inter-Switch Links 有权
标题翻译：虚拟和逻辑交换机间链路
公开(公告)号：US20110085558A1
公开(公告)日：2011-04-14
申请号：US12575608
申请日：2009-10-08
申请人： Sathish Kumar Gnanasekaran , Chao Zhang , Daniel Ji Yong Park Chung , Subramanian Lakshmanan , Badrinath Kollu
发明人： Sathish Kumar Gnanasekaran , Chao Zhang , Daniel Ji Yong Park Chung , Subramanian Lakshmanan , Badrinath Kollu
IPC分类号： H04L12/56
CPC分类号： H04L45/586 , H04L12/4625 , H04L45/583 , H04L49/357 , H04L49/70
摘要： A Layer 2 network switch is partitionable into a plurality of switch fabrics. The single-chassis switch is partitionable into a plurality of logical switches, each associated with one of the virtual fabrics. The logical switches behave as complete and self-contained switches. A logical switch fabric can span multiple single-chassis switch chassis. Logical switches are connected by inter-switch links that can be either dedicated single-chassis links or logical links. An extended inter-switch link can be used to transport traffic for one or more logical inter-switch links. Physical ports of the chassis are assigned to logical switches and are managed by the logical switch. Legacy switches that are not partitionable into logical switches can serve as transit switches between two logical switches.
摘要翻译：二层网络交换机可分割成多个交换结构。单机箱交换机可分割成多个逻辑交换机，每个逻辑交换机与虚拟结构之一相关联。逻辑交换机表现为完整和自包含的交换机。逻辑交换矩阵可以跨多个单机箱交换机机箱。逻辑交换机通过可以是专用单机箱链路或逻辑链路的交换机间链路连接。可以使用扩展的交换机间链路来传输一个或多个逻辑交换机间链路的业务。机箱的物理端口分配给逻辑交换机，由逻辑交换机管理。不可分割到逻辑交换机的旧式交换机可以用作两个逻辑交换机之间的转接交换机。

46. 发明授权

US07872018B2 Compounds and methods for kinase modulation, and indications therefor 失效
标题翻译：用于激酶调节的化合物和方法及其适应症
公开(公告)号：US07872018B2
公开(公告)日：2011-01-18
申请号：US11962044
申请日：2007-12-20
申请人： Prabha N. Ibrahim , Ryan Bremer , Chao Zhang , Jiazhong Zhang , Klaus-Peter Hirth , Guoxian Wu , Hongyao Zhu
发明人： Prabha N. Ibrahim , Ryan Bremer , Chao Zhang , Jiazhong Zhang , Klaus-Peter Hirth , Guoxian Wu , Hongyao Zhu
IPC分类号： A61K31/454 , A61P35/00 , C07D471/04
CPC分类号： C07D471/04
摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
摘要翻译：描述了对蛋白激酶有活性的化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。

47. 发明申请

US20100324065A1 Compounds and methods for development of Ret Modulators 有权
标题翻译： Ret调制剂开发的化合物和方法
公开(公告)号：US20100324065A1
公开(公告)日：2010-12-23
申请号：US12082665
申请日：2008-04-11
申请人： Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
发明人： Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
IPC分类号： A61K31/497 , A61K31/437
CPC分类号： C07D471/04
摘要： Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
摘要翻译：描述了在Ret上活性的化合物，以及使用这些化合物的方法。还描述了使用X射线晶体学测定的Ret替代物的晶体结构。使用这种Ret替代晶体和结构信息可以例如用于鉴定分子支架和开发结合并调节Ret的配体，并用于基于已知配体鉴定改良的配体。

48. 发明申请

US20100256365A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 有权
公开(公告)号：US20100256365A1
公开(公告)日：2010-10-07
申请号：US12616079
申请日：2009-11-10
申请人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
发明人： Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Gaston Habets , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Brian West , Yoshisa Suzuki , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Wayne Spevak , Hanna Cho , Samuel J. Gillette , Guoxian Wu , Hongyao Zhu , Shenghua Shi
IPC分类号： C07D413/14 , C07D401/14 , C07F7/02 , C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

49. 发明授权

US07531568B2 PPAR active compounds 失效
标题翻译： PPAR活性化合物
公开(公告)号：US07531568B2
公开(公告)日：2009-05-12
申请号：US11289656
申请日：2005-11-29
申请人： Jack Lin , Dean R. Artis , Prabha N. Ibrahim , Chao Zhang , Rebecca Zuckerman , Ryan Bremer , Shenghua Shi , Byunghun Lee
发明人： Jack Lin , Dean R. Artis , Prabha N. Ibrahim , Chao Zhang , Rebecca Zuckerman , Ryan Bremer , Shenghua Shi , Byunghun Lee
IPC分类号： A61K31/405 , C07D403/02
CPC分类号： C07D209/36 , C07D209/30 , C07D209/40
摘要： Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.
摘要翻译：描述了对PPARα，PPARδ和PPARγ中的至少一种具有活性的化合物，其可用于涉及调节PPARα，PPARδ和PPARγ的至少一种的治疗和/或预防方法。

50. 发明申请

US20090105297A1 Compounds Modulating C-Kit Activity 失效
标题翻译：调节C-Kit活性的化合物
公开(公告)号：US20090105297A1
公开(公告)日：2009-04-23
申请号：US12244730
申请日：2008-10-02
申请人： Prabha N. Ibrahim , Clarence R. Hurt , Chao Zhang , Jiazhong Zhang
发明人： Prabha N. Ibrahim , Clarence R. Hurt , Chao Zhang , Jiazhong Zhang
IPC分类号： A61K31/4745
CPC分类号： A61K31/4745
摘要： Compounds with 7-azaindole core structure with activity toward the receptor protein tyrosine kinase c-kit, compositions useful for treatment c-kit-mediate diseases or conditions, and methods of use thereof, are provided. Further provided are methods of c-kit ligand identification and design.
摘要翻译：提供了具有对受体蛋白酪氨酸激酶c-kit活性的7-氮杂吲哚核心结构的化合物，可用于治疗c-kit介导疾病或病症的组合物及其使用方法。还提供了c-kit配体鉴定和设计的方法。

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