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41. 发明授权

US07449027B2 Modifying fluid flow in a body vessel lumen to promote intraluminal flow-sensitive processes 有权
标题翻译：修改体内血管腔内的流体流动，以促进腔内流感敏感过程
公开(公告)号：US07449027B2
公开(公告)日：2008-11-11
申请号：US11093401
申请日：2005-03-29
申请人： James B. Hunt , Brian C. Case
发明人： James B. Hunt , Brian C. Case
IPC分类号： A61F2/06
CPC分类号： A61F2/2403 , A61B17/12022 , A61B17/12036 , A61B17/1204 , A61B17/12109 , A61B17/12131 , A61B50/30 , A61B2017/00783 , A61F2/2412 , A61F2/2475 , A61F2002/068 , A61F2250/006 , Y10S623/903
摘要： The present invention, in one embodiment, provides an implantable intraluminal fluid flow control system comprising an interface and a flow-modifying device positioned at a flow-modifying effective distance from the interface within the lumen of a body vessel. In one embodiment, the invention relates to maintaining, regulating or varying the fluid flow within a body vessel to preserve, promote, alter or enhance remodeling of tissue at the interface. Remodeling can include the resorption and replacement of implanted remodelable material with autologous tissue. The interface can comprise remodelable material such as small intestine submucosa. In one embodiment, one or more interfaces are positioned at flow-modifying effective distances from one or more flow-modifying devices. Related medical devices, kits and methods of treatment are also provided in some embodiments.
摘要翻译：本发明在一个实施例中提供了一种植入式管腔内流体流动控制系统，其包括界面和流动修改装置，所述界面和流动修改装置以与主体容器的内腔内的界面有效距离的流动修改方式定位。在一个实施方案中，本发明涉及维持，调节或改变体内容器内的流体流动以保持，促进，改变或增强组织在界面处的重塑。重塑可以包括用自体组织吸收和替换植入的可重塑材料。界面可以包括可重塑的材料，例如小肠粘膜下层。在一个实施例中，一个或多个接口被定位成与一个或多个流量修改设备的流动修改有效距离。在一些实施例中也提供了相关的医疗装置，套件和治疗方法。

42. 发明授权

US07442206B2 Methods and systems for modifying vascular valves 有权
标题翻译：改变血管瓣膜的方法和系统
公开(公告)号：US07442206B2
公开(公告)日：2008-10-28
申请号：US11260360
申请日：2005-10-27
申请人： Jacob A. Flagle , Brian C. Case
发明人： Jacob A. Flagle , Brian C. Case
IPC分类号： A61F2/24
CPC分类号： A61B17/00234 , A61B17/00491 , A61B17/064 , A61B17/122 , A61B18/1492 , A61B2017/00783 , A61F2/06 , A61F2/2475 , Y10S623/904
摘要： Described are methods and systems for modifying vascular valves in order to reduce retrograde blood flow through the valves. Preferred methods include connecting vascular valve leaflets with at least one remodelable material, such that the valve leaflets become fused by the ingrowth of the patient's native tissue. Preferred remodelable materials include collagenous extracellular matrix material, such as small intestine submucosa.
摘要翻译：描述了用于修改血管瓣膜以减少通过瓣膜的逆行血流量的方法和系统。优选的方法包括将血管瓣叶与至少一种可重塑材料连接，使得瓣膜小叶通过患者的天然组织的向内生长而变得熔化。优选的可重塑材料包括胶原细胞外基质材料，例如小肠粘膜下层。

43. 发明申请

US20080255580A1 MEDICAL DEVICE DELIVERY SYSTEM WITH SHEATH SEPARATION 有权
标题翻译：医疗器械输送系统与分离
公开(公告)号：US20080255580A1
公开(公告)日：2008-10-16
申请号：US12059241
申请日：2008-03-31
申请人： GRANT T. HOFFMAN , Brian C. Case
发明人： GRANT T. HOFFMAN , Brian C. Case
IPC分类号： A61B17/00
CPC分类号： A61F2/95 , A61F2/958 , A61F2/97
摘要： Medical device delivery systems and associated methods are provided. Delivery systems according to the invention include an elongated tubular member and a body member, such as a dilator, disposed therein. An intraluminal medical device is disposed on the dilator and within the tubular member prior to deployment. The delivery system includes a means for separating two or more portions of the distal end of the tubular member that aids in deploying the intraluminal medical device from the delivery system by separating two or more portions of the tubular member from each other to facilitate release of the intraluminal medical device from the body member. Various structures can be used for means for separating, including a cutting ring, activateable material on the tubular member, or other suitable structure. The provided devices and methods reduce friction occuring from relative movement between the sheath and dilator during deployment.
摘要翻译：提供医疗器械输送系统及相关方法。根据本发明的递送系统包括细长的管状构件和设置在其中的诸如扩张器的主体构件。在展开之前，将管腔内医疗装置设置在扩张器上并在管状构件内。递送系统包括用于分离管状构件的远端的两个或更多个部分的装置，其通过将管状构件的两个或更多个部分彼此分离来有助于将管腔内医疗装置从输送系统展开以便于释放管腔内医疗器械从身体成员。各种结构可以用于分离的装置，包括切割环，管状构件上的可激活材料或其他合适的结构。所提供的装置和方法减少在展开期间由护套和扩张器之间的相对运动发生的摩擦力。

44. 发明申请

US20080058955A1 PROSTHETIC TESTICLE 审中-公开
标题翻译：假药
公开(公告)号：US20080058955A1
公开(公告)日：2008-03-06
申请号：US11844198
申请日：2007-08-23
申请人： Gary Bradford Shirley , Ram H. Paul , Brian C. Case
发明人： Gary Bradford Shirley , Ram H. Paul , Brian C. Case
IPC分类号： A61F2/02 , A46B11/00
CPC分类号： A61L27/56 , A61F2/0059 , A61F2/022 , A61F2230/0076 , A61F2250/0068 , A61L27/34 , A61L27/3641 , C08L75/04
摘要： A prosthetic testicle is provided that is able to mimic the movement and feel of a natural testicle while at the same time being able to remodel itself into native tissue. Additionally, the prosthetic testicle is able to provide long-term delivery of drugs into the patient.
摘要翻译：提供了一种能够模仿天然睾丸运动和手感的假体睾丸，同时能够将自身改造成天然组织。此外，假体睾丸能够向患者提供药物的长期输送。

45. 发明授权

US10413652B2 Systems and methods for use and control of an automated separator with adsorption columns 有权
公开(公告)号：US10413652B2
公开(公告)日：2019-09-17
申请号：US14110587
申请日：2011-04-13
申请人： John T. Foley , Jonathan Prendergast , Lan T. Nguyen , Brian C. Case
发明人： John T. Foley , Jonathan Prendergast , Lan T. Nguyen , Brian C. Case
IPC分类号： A61M1/36
摘要： Blood treatment systems and methods are provided for combining a blood separation system and an adsorption device. The blood separation system is configured to separate a blood component from blood, while the adsorption device is configured to receive at least a portion of the separated blood component and process it. The blood separation system includes a fluid flow element and a controller. The fluid flow element is configured for flowing the separated blood component into the adsorption device. The controller controls the fluid flow element based at least in part on one or more processing parameters. The processing parameters include a maximum flow rate of the separated blood component flowed into the adsorption device, a maximum pressure of the separated blood component flowed into the adsorption device, and/or the volume of fluid in a location of the system.

46. 发明授权

US09533089B2 Centrifugation system with red blood cell barrier 有权
标题翻译：具有红细胞屏障的离心系统
公开(公告)号：US09533089B2
公开(公告)日：2017-01-03
申请号：US14008651
申请日：2012-03-28
申请人： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
发明人： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
IPC分类号： A61M1/36 , B04B5/04
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/128 , A61M2205/3331 , A61M2205/3337 , B04B5/0442 , B04B2005/045 , C12N5/0634 , C12N5/0641 , C12N5/0644
摘要： Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.
摘要翻译：提供离心系统和方法用于将血液分离成其组成部分。离心机的内壁和外壁各自包括朝向另一壁延伸的突起。分离室被容纳在离心机之间的壁之间，其中腔室包括用于使血液进入腔室的入口端口，用于使等离子体流出腔室的等离子体出口和用于使红细胞流出的红细胞出口的房间。随着室中的离心机容纳在壁之间，第一突出部延伸到分离的血液成分流向等离子体出口端口的路径中，并防止细胞血液成分流入等离子体出口。第二突出部延伸到朝向红细胞出口流动的分离的血液成分的路径中，并防止血浆流入红细胞出口。

47. 发明授权

US08834351B2 Methods for modifying vascular vessel walls 有权
公开(公告)号：US08834351B2
公开(公告)日：2014-09-16
申请号：US13048492
申请日：2011-03-15
申请人： Brian C. Case , Michael C. Hiles , Jacob A. Flagle , F. Joseph Obermiller , Umesh H. Patel
发明人： Brian C. Case , Michael C. Hiles , Jacob A. Flagle , F. Joseph Obermiller , Umesh H. Patel
IPC分类号： A61F2/00 , A61F2/24 , A61L27/36 , A61L27/38
CPC分类号： A61L27/3633 , A61F2/2475 , A61L27/3604 , A61L27/3641 , A61L27/3645 , A61L27/3839
摘要： This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.

48. 发明申请

US20140045671A1 CENTRIFUGATION SYSTEM WITH RED BLOOD CELL BARRIER 有权
标题翻译：红血球细胞分离系统
公开(公告)号：US20140045671A1
公开(公告)日：2014-02-13
申请号：US14008651
申请日：2012-03-28
申请人： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
发明人： Kyungyoon Min , Richard I. Brown , John T. Foley , Brian C. Case
IPC分类号： A61M1/36
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/128 , A61M2205/3331 , A61M2205/3337 , B04B5/0442 , B04B2005/045 , C12N5/0634 , C12N5/0641 , C12N5/0644
摘要： Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.
摘要翻译：提供离心系统和方法用于将血液分离成其组成部分。离心机的内壁和外壁各自包括朝向另一壁延伸的突起。分离室被容纳在离心机之间的壁之间，其中腔室包括用于使血液进入腔室的入口端口，用于使等离子体流出腔室的等离子体出口和用于使红细胞流出的红细胞出口的房间。随着室中的离心机容纳在壁之间，第一突出部延伸到分离的血液成分流向等离子体出口端口的路径中，并防止细胞血液成分流入等离子体出口。第二突出部延伸到朝向红细胞出口流动的分离的血液成分的路径中，并防止血浆流入红细胞出口。

49. 发明授权

US08641776B2 Methods for modifying vascular vessel walls 有权
标题翻译：改变血管壁的方法
公开(公告)号：US08641776B2
公开(公告)日：2014-02-04
申请号：US13048458
申请日：2011-03-15
申请人： Brian C. Case , Michael C. Hiles , Jacob A. Flagle , F. Joseph Obermiller , Umesh H. Patel
发明人： Brian C. Case , Michael C. Hiles , Jacob A. Flagle , F. Joseph Obermiller , Umesh H. Patel
IPC分类号： A61F2/02
CPC分类号： A61B17/12 , A61F2/07 , A61F2/2475 , A61F2002/075 , A61F2002/077
摘要： This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.
摘要翻译：本发明在一个方面涉及用生物材料治疗血管血管。生物材料可以是加强和/或支持血管壁的可重塑材料。另外，生物材料可以包括多种天然存在或添加的生物活性剂和/或活细胞群体。

50. 发明授权

US08444666B2 Retrievable filter 有权
标题翻译：可检索过滤器
公开(公告)号：US08444666B2
公开(公告)日：2013-05-21
申请号：US10662216
申请日：2003-09-12
申请人： Dusan Pavcnik , Brian C. Case , John A. Kaufman , Michael L. Garrison , Jacob A. Flagle
发明人： Dusan Pavcnik , Brian C. Case , John A. Kaufman , Michael L. Garrison , Jacob A. Flagle
IPC分类号： A61B17/00 , A61F2/06 , A61F2/82
CPC分类号： A61F2/01 , A61F2002/016 , A61F2230/005 , A61F2230/0067
摘要： A filter may have an apical hub and a plurality of divergent legs. A first attachment member may be separate from, but attached to the second end of at least one of the plurality of divergent legs. A second attachment member may be separate from, but attached to a stent. The first and second attachment members may be separate from, but attachable to one another to releasably attach the filter to the stent. One of the first attachment member and the second attachment member may include an attachment wire that is positioned in a lumen of a tubular member or one of the first attachment member and the second attachment member may comprise a cannula. In some implementations, an upward motion applied to the retrieval connection member may disengage at least one attachment wire of the first attachment member from the second attachment member.
摘要翻译：过滤器可以具有顶端毂和多个发散腿。第一附接构件可以与多个发散腿中的至少一个分开，但是附接到多个发散腿中的至少一个的第二端。第二附接构件可以与支架分离但附接到支架。第一和第二附接构件可以彼此分离，但可彼此附接以将过滤器可释放地附接到支架。第一附接构件和第二附接构件中的一个可以包括定位在管状构件的内腔中的附接线，或者第一附接构件和第二附接构件中的一个可以包括套管。在一些实施方式中，施加到取回连接构件的向上运动可以使第一附接构件的至少一个附接线与第二附接构件脱离接触。

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