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41. 发明授权

US08608795B2 Tapered loading system for implantable medical devices 有权
标题翻译：用于可植入医疗器械的锥形加载系统
公开(公告)号：US08608795B2
公开(公告)日：2013-12-17
申请号：US12328157
申请日：2008-12-04
申请人： Jeffry S. Melsheimer , Sean D. Chambers , Arman H. Valaie , Ram H. Paul
发明人： Jeffry S. Melsheimer , Sean D. Chambers , Arman H. Valaie , Ram H. Paul
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/0095 , A61F2/95 , A61F2002/9522 , Y10T29/53
摘要： Loading systems for compressing and loading an implantable medical device into a device chamber of a medical device delivery system are described. The loading systems include an elongate holding chamber within which the intraluminal medical device is disposed. A plunger has one or more attached pushers adapted to axially advance the intraluminal medical device through an intermediate portion of the holding chamber that has a tapered surface, which compresses the intraluminal medical device over a dilator of a medical device delivery system that has been introduced through the distal end of the elongate holding chamber. The elongate holding chamber can be placed within an outer storage container with an appropriate seal to for storage of the intraluminal medical device within the loading system. Methods of preparing an intraluminal medical device for implantation in a patient and kits useful in such methods are also described.
摘要翻译：描述了用于将可植入医疗装置压缩和装载到医疗装置输送系统的装置室中的装载系统。装载系统包括细长的保持室，其中设置管腔内医疗装置。柱塞具有一个或多个附接的推动器，其适于轴向前进管腔内医疗装置通过具有锥形表面的保持室的中间部分，该锥形表面压缩管腔内医疗装置通过已经被引入的医疗装置输送系统的扩张器细长保持室的远端。细长保持室可以放置在具有适当密封件的外部存储容器内，以便将管腔内医疗装置储存在装载系统内。还描述了制备用于植入患者的管腔内医疗装置的方法和用于这些方法的试剂盒。

42. 发明授权

US08518104B2 Methods for occluding bodily vessels 有权
标题翻译：闭塞体液的方法
公开(公告)号：US08518104B2
公开(公告)日：2013-08-27
申请号：US13206729
申请日：2011-08-10
申请人： Brian L. Bates , Ram H. Paul , Jacob A. Flagle
发明人： Brian L. Bates , Ram H. Paul , Jacob A. Flagle
IPC分类号： A61F2/06
CPC分类号： A61B17/12022 , A61B17/00008 , A61B17/12109 , A61B17/12181 , A61B17/12186 , A61B17/1219 , A61L27/3633 , A61L27/3645 , A61L27/50 , A61L27/54 , A61L31/005 , A61L31/04 , A61L31/14 , A61L31/16 , A61L2300/412 , A61L2430/36
摘要： Described are methods, devices, and systems for occluding or ablating vascular vessels. Noninvasive procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous valve insufficiency. Further described is the cooperative use of an angiogenic remodelable material with one or more sclerosing agents to cause closure of a targeted bodily vessel.
摘要翻译：描述了用于闭塞或消融血管的方法，装置和系统。非侵入性手术可用于闭塞和闭塞大隐静脉，例如在静脉瓣膜功能不全引起的静脉曲张治疗中。进一步描述的是具有一种或多种硬化剂的血管生成可重塑材料与靶器官血管闭合的协同使用。

43. 发明授权

US08475516B2 Low profile support frame and related intraluminal medical devices 有权
标题翻译：薄型支架和相关管腔内医疗器械
公开(公告)号：US08475516B2
公开(公告)日：2013-07-02
申请号：US13363871
申请日：2012-02-01
申请人： Ram H. Paul , Sean D. Chambers , Charles L. McIntosh , Charles W. Agnew
发明人： Ram H. Paul , Sean D. Chambers , Charles L. McIntosh , Charles W. Agnew
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/01 , A61F2/2412 , A61F2/2475 , A61F2/848 , A61F2/86 , A61F2/88 , A61F2002/016 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0066 , A61F2220/0075 , A61F2230/0013 , A61F2230/0021 , A61F2230/0026
摘要： A low profile support frame for use as an or in an expandable intraluminal medical device includes first and second wire members that define arcuate paths having opposing curves. Connectors join the wire members, and barbs can be disposed on the connectors. The support frame has radially compressed and radially expanded configurations. When the support frame is in the radially expanded configuration, substantially no portion of the support frame is disposed on a first transverse axis of the frame opposite one end of the frame and substantially no portion of the frame is disposed on a second transverse axis of the frame opposite the other end of the frame. The support frame can be used as an intraluminal medical device by itself or as a component in a medical device that includes other components, such as a stent, prosthetic valve, occluder, or filter.
摘要翻译：用作可扩展管腔内医疗装置中的或在可扩展的管腔内医疗装置中的低调支撑框架包括限定具有相对曲线的弓形路径的第一和第二线构件。连接器连接线构件，倒钩可以设置在连接器上。支撑框架具有径向压缩和径向扩张的构造。当支撑框架处于径向展开构型时，支撑框架的基本上没有部分设置在与框架的一端相对的框架的第一横向轴线上，并且基本上没有框架的任何部分设置在框架的第二横向轴线上框架与框架的另一端相对。支撑框架可以作为管腔内医疗装置本身或作为包括其它部件（例如支架，假体瓣膜，封堵器或过滤器）的医疗装置中的部件使用。

44. 发明申请

US20130138202A1 BLOOD PERFUSION DEVICE 审中-公开
标题翻译：血液灌注装置
公开(公告)号：US20130138202A1
公开(公告)日：2013-05-30
申请号：US13761391
申请日：2013-02-07
申请人： Ram H. Paul , Richard A. Swift , Oliver Bach , Ralf Steiner , Angela R. Barnett , Keith R. Milner
发明人： Ram H. Paul , Richard A. Swift , Oliver Bach , Ralf Steiner , Angela R. Barnett , Keith R. Milner
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2/07 , A61F2/848 , A61F2/915 , A61F2002/075 , A61F2002/8483 , A61F2002/91558 , A61F2002/91575 , A61F2210/0076 , A61F2220/0016 , A61F2220/0075 , A61F2250/0023 , A61F2250/0036 , A61F2250/0037
摘要： A perfusion device and a delivery system for repair of a damaged portion of a body vessel. Perfusion device can include a tubular body that is self-expandable, having a proximal portion, a distal portion, and an intermediate portion. One or more series of barbs can be disposed circumferentially along the intermediate portion. Barbs are capable of penetrating into the tunica intima and tunica media of said vessel wall upon insertion of said device into said body vessel, and not into said tunica adventitia. A graft can be associated with the tubular body. Graft has a proximal end and a distal end, and preferably extends entirely along a luminal wall of the tubular body. Graft may also extend along an exterior surface of the tubular body at the proximal and distal portions. A remodelable covering can be applied along the intermediate portion. Delivery devices for the perfusion implant and methods of delivering the perfusion implant are also provided.
摘要翻译：灌注装置和用于修复身体血管损伤部分的输送系统。灌注装置可以包括可自膨胀的管状体，其具有近端部分，远端部分和中间部分。一个或多个串联的倒钩可以沿着中间部分周向设置。倒钩在将所述装置插入所述身体容器中时能够渗入所述血管壁的中膜和中膜，并且不会进入所述外膜。移植物可以与管状体相关联。移植物具有近端和远端，优选地沿管状体的腔壁完全延伸。移植物也可以在近端部分和远端部分沿管状体的外表面延伸。可以沿着中间部分施加可重塑的覆盖物。还提供用于灌注植入物的递送装置和递送灌注植入物的方法。

45. 发明申请

US20090143857A1 TAPERED LOADING SYSTEM FOR IMPLANTABLE MEDICAL DEVICES 有权
标题翻译：用于可植入医疗器械的切割加载系统
公开(公告)号：US20090143857A1
公开(公告)日：2009-06-04
申请号：US12328157
申请日：2008-12-04
申请人： Jeffry S. Melsheimer , Sean D. Chambers , Arman H. Valaie , Ram H. Paul
发明人： Jeffry S. Melsheimer , Sean D. Chambers , Arman H. Valaie , Ram H. Paul
IPC分类号： A61F2/24
CPC分类号： A61F2/0095 , A61F2/95 , A61F2002/9522 , Y10T29/53
摘要： Loading systems for compressing and loading an implantable medical device into a device chamber of a medical device delivery system are described. The loading systems include an elongate holding chamber within which the intraluminal medical device is disposed. A plunger has one or more attached pushers adapted to axially advance the intraluminal medical device through an intermediate portion of the holding chamber that has a tapered surface, which compresses the intraluminal medical device over a dilator of a medical device delivery system that has been introduced through the distal end of the elongate holding chamber. The elongate holding chamber can be placed within an outer storage container with an appropriate seal to for storage of the intraluminal medical device within the loading system. Methods of preparing an intraluminal medical device for implantation in a patient and kits useful in such methods are also described.
摘要翻译：描述了用于将可植入医疗装置压缩和装载到医疗装置输送系统的装置室中的装载系统。装载系统包括细长的保持室，其中设置管腔内医疗装置。柱塞具有一个或多个附接的推动器，其适于轴向前进管腔内医疗装置通过具有锥形表面的保持室的中间部分，该锥形表面压缩管腔内医疗装置通过已经被引入的医疗装置输送系统的扩张器细长保持室的远端。细长保持室可以放置在具有适当密封件的外部存储容器内，以便将管腔内医疗装置储存在装载系统内。还描述了制备用于植入患者的管腔内医疗装置的方法和用于这些方法的试剂盒。

46. 发明申请

US20080200977A1 Artificial Valve Prostheses with a Free Leaflet Portion 有权
标题翻译：人造阀门假肢与自由传单部分
公开(公告)号：US20080200977A1
公开(公告)日：2008-08-21
申请号：US12030945
申请日：2008-02-14
申请人： Ram H. Paul , Gary B. Shirley
发明人： Ram H. Paul , Gary B. Shirley
IPC分类号： A61F2/06
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2475 , A61F2220/005 , A61F2220/0058 , A61F2250/0036
摘要： One embodiment of the present invention provides an implantable valve prosthesis. The valve prosthesis includes a frame defining a lumen extending between a proximal frame end and a distal frame end along a longitudinal axis, and a first valve leaflet positioned within the lumen and having a distal edge attached to the frame and a proximal edge free of the frame. The first valve leaflet comprises a first and a second slit extend distally from the proximal edge and defining a free portion of the first valve leaflet between the first and second slits. The first valve leaflet is movable between a first position that allows fluid flow in a first, antegrade, direction and a second position that restricts flow in a second, retrograde direction.
摘要翻译：本发明的一个实施例提供一种可植入瓣膜假体。瓣膜假体包括框架，该框架限定沿着纵向轴线在近端框架端和远端框架端之间延伸的内腔，以及定位在内腔内并且具有附接到框架的远侧边缘的第一瓣膜小叶和没有帧。第一阀瓣包括从近侧边缘向远侧延伸的第一和第二狭缝，并且在第一和第二狭缝之间限定第一瓣膜叶片的自由部分。第一阀瓣可在第一位置和第二位置之间移动，该第一位置允许流体沿第一，顺流方向和第二位置流动，从而限制第二逆向方向的流动。

47. 发明授权

US06663599B2 Hemostasis cannula 有权
标题翻译：止血套管
公开(公告)号：US06663599B2
公开(公告)日：2003-12-16
申请号：US09845951
申请日：2001-04-30
申请人： Thomas A. Osbourne , Ram H. Paul
发明人： Thomas A. Osbourne , Ram H. Paul
IPC分类号： A61M5178
CPC分类号： A61M39/0606 , A61M2039/062 , A61M2039/0633 , A61M2039/064 , A61M2039/0653
摘要： A hemostasis cannula includes a housing having a passage therethrough sized to receive a catheter and a valve body mounted in the passage. The valve body includes an opening therethrough which forms a seal around a catheter enclosed within the cannula. In one embodiment, a ring of raised material surrounds the opening. In another embodiment, a ring of raised material surrounds the hole, and an internal ring of material lines at least a portion of the interior of the opening. The valve body is compressed within the cannula housing. When the catheter is removed, the valve body closes thus blocking air flow into the patient's blood vessel and also blocking blood flow out of the patient's blood vessel. The cannula housing also includes a side port for introducing fluids into the patient's blood vessel.
摘要翻译：止血插管包括具有穿过其尺寸设置成接纳导管的通道的壳体和安装在通道中的阀体。阀体包括穿过其中的开口，围绕套管内的导管形成密封。在一个实施例中，凸起的材料环围绕开口。在另一个实施例中，凸起的材料环围绕孔，并且内部的材料环线在开口内部的至少一部分上。阀体在套管外壳内被压缩。当导管被移除时，阀体关闭，从而阻挡进入患者血管的气流并且还阻止血液流出患者的血管。插管壳体还包括用于将流体引入患者血管的侧端口。

48. 发明授权

US5267966A Hemostasis cannula and method of making a valve for same 失效
标题翻译：止血套管及其制作方法
公开(公告)号：US5267966A
公开(公告)日：1993-12-07
申请号：US952354
申请日：1992-09-28
申请人： Ram H. Paul
发明人： Ram H. Paul
IPC分类号： A61M39/06 , A61M5/178
CPC分类号： A61M39/0606 , A61M2039/062 , A61M2039/0633 , A61M2039/064 , Y10T137/7881 , Y10T137/7885
摘要： A hemostasis cannula comprising a housing having a passage therethrough sized to receive a catheter and a valve body mounted in the passage. The valve body includes an opening in one side thereof which forms a seal around a catheter enclosed within the cannula. The opening includes a cylindrical recess and four tapered slits extending from the base of the recess to a point shaped opening at the other side of said valve body. The method of making the slits includes cutting them with a four sided pyramid shaped tool.
摘要翻译：止血插管，其包括具有穿过其尺寸设置成接纳导管的通道的壳体和安装在通道中的阀体。阀体包括在其一侧的开口，围绕套管内的导管形成密封。开口包括圆柱形凹部和从凹部的基部延伸到位于所述阀体的另一侧的点状开口的四个锥形狭缝。制造狭缝的方法包括用四面棱锥形工具切割它们。

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