专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明申请

US20070161689A1 Indoles having anti-diabetic activity 有权
公开(公告)号：US20070161689A1
公开(公告)日：2007-07-12
申请号：US11714341
申请日：2007-03-06
申请人： John Acton , Sheryl Debenham , Kun Liu , Peter Meinke , Harold Wood , Regina Black
发明人： John Acton , Sheryl Debenham , Kun Liu , Peter Meinke , Harold Wood , Regina Black
IPC分类号： A61K31/425 , A61K31/42 , A61K31/416 , A61K31/405 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D209/10 , C07D209/12 , C07D209/14 , C07D209/30 , C07D209/36 , C07D401/04 , C07D401/06 , C07D403/12 , C07D405/06 , C07D413/04
摘要： Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

42. 发明申请

US20050227484A1 System for modifying small structures 有权
标题翻译：修改小结构的系统
公开(公告)号：US20050227484A1
公开(公告)日：2005-10-13
申请号：US11081934
申请日：2005-03-16
申请人： George Gu , Neil Bassom , Thomas Gannon , Kun Liu
发明人： George Gu , Neil Bassom , Thomas Gannon , Kun Liu
IPC分类号： H01L21/3205 , H01L21/768 , H01L23/52 , H01L21/00 , H01L21/44
CPC分类号： H01L21/76894 , C25D3/665 , C25D5/02 , C25F3/12 , C25F3/14 , H01L21/2885 , H01L21/32134 , H01L21/76892
摘要： A charge transfer mechanism is used to locally deposit or remove material for a small structure. A local electrochemical cell is created without having to immerse the entire work piece in a bath. The charge transfer mechanism can be used together with a charged particle beam or laser system to modify small structures, such as integrated circuits or micro-electromechanical system. The charge transfer process can be performed in air or, in some embodiments, in a vacuum chamber.
摘要翻译：电荷转移机构用于局部沉积或去除小结构的材料。产生局部电化学电池，而不必将整个工件浸入浴中。电荷转移机构可以与带电粒子束或激光系统一起使用以修改小结构，例如集成电路或微机电系统。电荷转移过程可以在空气中或在一些实施方案中在真空室中进行。

43. 发明授权

US09868738B2 Diazine-fused amidines as BACE inhibitors, compositions, and their use 有权
公开(公告)号：US09868738B2
公开(公告)日：2018-01-16
申请号：US15512081
申请日：2015-09-14
申请人： Merck Sharp & Dohme Corp. , Kun Liu , Shuwen He , Jared N. Cumming , Andrew W. Stamford
发明人： Kun Liu , Shuwen He , Jared N. Cumming , Andrew W. Stamford
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K45/06 , A61P25/00
摘要： In its many embodiments, the present invention provides certain C-6 spirocarbocyclic iminothiadiazine compounds, including compounds Formula (I) or a tautomer thereof, and pharmaceutically acceptable salts of said compounds and said tautomers, wherein R1A, R1B, R2, RA, ring A, RA, m, L1, RL, ring C, RC, and p are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.

44. 发明授权

US09718854B2 Selective glycosidase inhibitors and uses thereof 有权
公开(公告)号：US09718854B2
公开(公告)日：2017-08-01
申请号：US14008388
申请日：2012-03-20
申请人： Ramesh Kaul , Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Kun Liu , Harold G. Selnick , Zhongyong Wei , Changwei Mu , Yaode Wang , Xiaona Wang
发明人： Ramesh Kaul , Ernest J. McEachern , David J. Vocadlo , Yuanxi Zhou , Kun Liu , Harold G. Selnick , Zhongyong Wei , Changwei Mu , Yaode Wang , Xiaona Wang
IPC分类号： C07H19/24 , C07D513/04 , A61K31/429 , C12N9/99 , C12Q1/34 , C07H9/06 , C07H11/00 , C07H13/12 , C07H15/04 , C07H15/12 , C07H15/18 , C07H15/203 , C07H15/207 , C07H17/02 , C07H17/04 , A61K31/7056
CPC分类号： C07H19/24 , A61K31/7056 , C07D513/04 , C07H9/06 , C07H11/00 , C07H13/12 , C07H15/04 , C07H15/12 , C07H15/18 , C07H15/203 , C07H15/207 , C07H17/02 , C07H17/04 , C12N9/99 , C12Q1/34 , C12Y302/01169
摘要： The invention provides compounds of formula (I) with substituents as specified in claim 1 for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceuticals compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to over-expression of O-GlcNAcase or accumulation of O-GlcNac.

45. 发明授权

US09704203B2 Providing and managing privacy scores 有权
公开(公告)号：US09704203B2
公开(公告)日：2017-07-11
申请号：US12533694
申请日：2009-07-31
申请人： Tyrone W. A. Grandison , Sherry Guo , Kun Liu , Michael Maxmilien , Dwayne L. Richardson , Tony Sun
发明人： Tyrone W. A. Grandison , Sherry Guo , Kun Liu , Michael Maxmilien , Dwayne L. Richardson , Tony Sun
IPC分类号： G06F17/30 , G06F7/00 , G06Q50/00 , G06Q10/10
CPC分类号： G06Q50/01 , G06Q10/10
摘要： Methods for providing a privacy setting for a target user in a social network utilizing an electronic computing device are presented, the method including: causing the electronic computing device to retrieve a current privacy setting for a common profile item, where the common profile item corresponds with the target user and each of a number of users, and where the common profile item is one of a number of common profile items; causing the electronic computing device to calculate a common profile item sensitivity value for the common profile item based on the current privacy setting; causing the electronic computing device to calculate a common profile item visibility value for the common profile item based on the a current privacy setting and the sensitivity value for the common profile item; and causing the electronic computing device to calculate the privacy score of the target user.

46. 发明授权

US09424439B2 Secure data synchronization 有权
标题翻译：安全的数据同步
公开(公告)号：US09424439B2
公开(公告)日：2016-08-23
申请号：US13230121
申请日：2011-09-12
申请人： Matthew Z. Tamayo-Rios , Saurav Sinha , Ruslan Ovechkin , Gopinathan Kannan , Vijay G. Bharadwaj , Christopher R. Macaulay , Eric Fleischman , Nathan J. Ide , Kun Liu
发明人： Matthew Z. Tamayo-Rios , Saurav Sinha , Ruslan Ovechkin , Gopinathan Kannan , Vijay G. Bharadwaj , Christopher R. Macaulay , Eric Fleischman , Nathan J. Ide , Kun Liu
IPC分类号： H04L29/06 , G06F21/62 , G06F21/44 , H04L29/08
CPC分类号： G06F21/6218 , G06F21/44 , G06F21/6245 , G06F21/6272 , G06F2221/2107 , H04L63/0428 , H04L63/062 , H04L67/1095 , H04L67/1097
摘要： Techniques for secure data synchronization are described. In one or more implementations, techniques may be employed to conserve high cost data storage by storing larger portions of encrypted data in low cost storage, while storing relatively smaller encryption keys in higher cost storage. A device that is granted access to the encryption keys can retrieve the encrypted data from the low cost storage and use the encryption keys to decrypt the encrypted data.
摘要翻译：描述了用于安全数据同步的技术。在一个或多个实现中，可以采用技术来通过将较大部分的加密数据存储在低成本存储中，同时在较高成本存储中存储相对较小的加密密钥来节省高成本数据存储。授权访问加密密钥的设备可以从低成本存储中检索加密数据，并使用加密密钥对加密数据进行解密。

47. 发明授权

US09322740B2 Distributed disturbance sensing device and the related demodulation method based on polarization sensitive optical frequency domain reflectometry 有权
标题翻译：分布式扰动感测装置及相关解调方法基于偏振敏感光频域反射测量
公开(公告)号：US09322740B2
公开(公告)日：2016-04-26
申请号：US13880732
申请日：2011-12-16
申请人： Tiegen Liu , Kun Liu , Zhenyang Ding , Junfeng Jiang , Dingjie Li
发明人： Tiegen Liu , Kun Liu , Zhenyang Ding , Junfeng Jiang , Dingjie Li
IPC分类号： G01M11/00 , G01D5/353 , G01H9/00
CPC分类号： G01M11/3172 , G01D5/35325 , G01D5/35329 , G01D5/35354 , G01H9/004 , G01M11/3181
摘要： This invention relates to a distributed disturbance sensing device based on polarization sensitive optical frequency domain reflectometry (OFDR) and the related demodulation thereof. The device, adopting OFDR, polarization controlling and analysis techniques, consists of a ultra-narrow linewidth tunable laser source module, polarization generating and polarization splitting balanced detecting module, laser source optical frequency and phase monitoring module, high-speed optical switch and so on to establish a large-scale and long-distance optical sensing network. The demodulation method consists of analysis the polarization information from sensing optical fiber, the method of suppressing and compensating of the non-linear optical frequency and the laser phase noise, super-resolution analyzing, advanced denoising method and the polarization information analysis method based on Jones and Mueller's matrices using distributed wave plate model of optical fiber.
摘要翻译：本发明涉及基于偏振敏感光频域反射测量（OFDR）的分布式扰动感测装置及其相关解调。该器件采用OFDR，偏振控制和分析技术，由超窄线可调谐激光源模块，偏振产生和偏振分光平衡检测模块，激光源光频相位监控模块，高速光开关等组成建立大型和长距离光传感网络。解调方法包括分析来自感测光纤的偏振信息，抑制和补偿非线性光频率和激光相位噪声的方法，超分辨率分析，高级去噪方法和基于琼斯的极化信息分析方法和使用光纤分布波板模型的Mueller矩阵。

48. 发明授权

US09193717B2 Mineralocorticoid receptor antagonists 有权
标题翻译：盐皮质激素受体拮抗剂
公开(公告)号：US09193717B2
公开(公告)日：2015-11-24
申请号：US14350888
申请日：2012-10-08
申请人： Hong Shen , Christine Yang , Jason M. Cox , Kun Liu
发明人： Hong Shen , Christine Yang , Jason M. Cox , Kun Liu
IPC分类号： C07D413/04 , C07D413/14 , C07D403/04 , A61K31/422 , A61K31/4439 , A61K31/506 , A61K31/5377
CPC分类号： C07D413/04 , A61K31/422 , A61K31/4439 , A61K31/506 , A61K31/5377 , C07D403/04 , C07D413/14
摘要： The present invention is directed to compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, that are aldosterone receptor antagonists which might be useful for treating aldosterone-mediated diseases. The invention furthermore relates to processes for preparing compounds of the Formula (I), to their possible use for the treatment of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of the Formula (I).
摘要翻译：本发明涉及可用于治疗醛固酮介导的疾病的醛固酮受体拮抗剂的式（I）化合物及其药学上可接受的盐。本发明还涉及制备式（I）化合物，其可能用于治疗上述疾病和为此目的制备药物的方法，以及包含式（I）化合物的药物组合物。

49. 发明授权

US09074957B2 High stable fiber fabry-perot pressure sensor with glue-free packing and its fabrication method 有权
标题翻译：高稳定纤维法布里 - 珀罗压力传感器，无胶包装及其制造方法
公开(公告)号：US09074957B2
公开(公告)日：2015-07-07
申请号：US13880733
申请日：2012-05-28
申请人： Junfeng Jiang , Tiegen Liu , Jinde Yin , Kun Liu , Yu Liu
发明人： Junfeng Jiang , Tiegen Liu , Jinde Yin , Kun Liu , Yu Liu
IPC分类号： G02B27/00 , G02B1/00 , G01L11/02 , G02B26/00 , G02B5/28 , G02B6/293
CPC分类号： G01L11/025 , G01L11/02 , G02B5/28 , G02B5/284 , G02B6/29358 , G02B26/001
摘要： The present invention relates to a high stable fiber fabry-perot pressure sensor with glue-free packing and its fabrication method. The sensor includes a sensor head, a sensor body with a through-hole in the axial direction and a optical fiber. The sensor head is a 4-layer structure, which includes the first silicon wafer, the first Pyrex glass wafer, the second silicon wafer and the second Pyrex glass wafer. The rear surface of the first silicon wafer forms the first reflecting surface of the fabry-perot (F-P) cavity, and the second silicon wafer provides the second reflecting surface for the F-P cavity. The second Pyrex glass wafer is welded together with the sensor body. The optical fiber is fixed in the sensor body by a CO2 laser welding to achieve the glue-free packing. When the external pressure is applied to deform the first layer silicon wafer, the F-P cavity length will change. When a broad band source is used, the variation of the cavity length can be obtained by collecting the reflection spectrum or low-coherence interference fringe of the sensor, thus the pressure information can be obtained. The structure of the invention can effectively eliminate the affect of environmental factors, such as temperature and humidity, and greatly promoting the measuring accuracy.
摘要翻译：本发明涉及具有无胶包装的高稳定性纤维法布里 - 珀罗压力传感器及其制造方法。传感器包括传感器头，在轴向具有通孔的传感器本体和光纤。传感器头是4层结构，其包括第一硅晶片，第一Pyrex玻璃晶片，第二硅晶片和第二Pyrex玻璃晶片。第一硅晶片的后表面形成fabry-perot（F-P）腔的第一反射表面，而第二硅晶片为F-P腔提供第二反射表面。第二个Pyrex玻璃晶片与传感器主体焊接在一起。光纤通过CO2激光焊接固定在传感器主体中，实现无胶包装。当施加外部压力以使第一层硅晶片变形时，F-P腔体长度将改变。当使用宽带源时，可以通过收集传感器的反射光谱或低相干干涉条纹来获得腔长度的变化，从而可以获得压力信息。本发明的结构能有效消除温湿度等环境因素的影响，大大提高了测量精度。

50. 发明申请

US20140208858A1 High stable fiber fabry-perot pressure sensor with glue-free packing and its fabrication method 有权
标题翻译：高稳定纤维法布里 - 珀罗压力传感器，无胶包装及其制造方法
公开(公告)号：US20140208858A1
公开(公告)日：2014-07-31
申请号：US13880733
申请日：2012-05-28
申请人： Junfeng Jiang , Tiegen Liu , Jinde Yin , Kun Liu , Yu Liu
发明人： Junfeng Jiang , Tiegen Liu , Jinde Yin , Kun Liu , Yu Liu
IPC分类号： G01L11/02
CPC分类号： G01L11/025 , G01L11/02 , G02B5/28 , G02B5/284 , G02B6/29358 , G02B26/001
摘要： The present invention relates to a high stable fiber fabry-perot pressure sensor with glue-free packing and its fabrication method. The sensor includes a sensor head, a sensor body with a through-hole in the axial direction and a optical fiber. The sensor head is a 4-layer structure, which includes the first silicon wafer, the first Pyrex glass wafer, the second silicon wafer and the second Pyrex glass wafer. The rear surface of the first silicon wafer forms the first reflecting surface of the fabry-perot (F-P) cavity, and the second silicon wafer provides the second reflecting surface for the F-P cavity. The second Pyrex glass wafer is welded together with the sensor body. The optical fiber is fixed in the sensor body by a CO2 laser welding to achieve the glue-free packing When the external pressure is applied to deform the first layer silicon wafer, the F-P cavity length will change. When a broad band source is used, the variation of the cavity length can be obtained by collecting the reflection spectrum or low-coherence interference fringe of the sensor, thus the pressure information can be obtained. The structure of the invention can effectively eliminate the affect of environmental factors, such as temperature and humidity, and greatly promoting the measuring accuracy.
摘要翻译：本发明涉及具有无胶包装的高稳定性纤维法布里 - 珀罗压力传感器及其制造方法。传感器包括传感器头，在轴向具有通孔的传感器本体和光纤。传感器头是4层结构，其包括第一硅晶片，第一Pyrex玻璃晶片，第二硅晶片和第二Pyrex玻璃晶片。第一硅晶片的后表面形成fabry-perot（F-P）腔的第一反射表面，而第二硅晶片为F-P腔提供第二反射表面。第二个Pyrex玻璃晶片与传感器主体焊接在一起。光纤通过CO2激光焊接固定在传感器主体中，实现无胶包装当施加外部压力使第一层硅晶片变形时，F-P腔体长度将发生变化。当使用宽带源时，可以通过收集传感器的反射光谱或低相干干涉条纹来获得腔长度的变化，从而可以获得压力信息。本发明的结构能有效消除温湿度等环境因素的影响，大大提高了测量精度。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式