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41. 发明申请

US20090157430A1 SYNCHRONIZATION AND CONFIGURATION OF PATIENT MONITORING DEVICES 审中-公开
标题翻译：患者监测装置的同步和配置
公开(公告)号：US20090157430A1
公开(公告)日：2009-06-18
申请号：US12251339
申请日：2008-10-14
申请人： Peter Rule , Gil Rivas
发明人： Peter Rule , Gil Rivas
IPC分类号： G06Q50/00 , A61B5/00 , G06Q90/00
CPC分类号： A61B5/0002 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1459 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/4839 , G06F19/3418 , G06Q50/24 , G16H40/40
摘要： Some embodiments provide a system for synchronizing and configuring monitoring devices. In some embodiments, a patient monitoring device settings module is configured to automatically provide configuration settings to a plurality of patient monitoring devices. A monitoring device data module is configured to receive measurement data from at least one of the patient monitoring devices. An electronic medical records system interface is configured to provide patient data at least partially derived from the received measurement data to an electronic medical records system. A patient records interface is configured to provide patient data to at least one of the patient monitoring devices.
摘要翻译：一些实施例提供用于同步和配置监视设备的系统。在一些实施例中，患者监视设备设置模块被配置为自动地向多个患者监视设备提供配置设置。监视设备数据模块被配置为从至少一个患者监视设备接收测量数据。电子医疗记录系统接口被配置为将至少部分地从接收到的测量数据导出的患者数据提供给电子病历系统。患者记录界面被配置为向至少一个患者监视设备提供患者数据。

42. 发明申请

US20090156911A1 LOW DRAW VOLUME ANALYTE DETECTION SYSTEMS 审中-公开
标题翻译：低抽取分析检测系统
公开(公告)号：US20090156911A1
公开(公告)日：2009-06-18
申请号：US12247956
申请日：2008-10-08
申请人： Peter Rule , Richard Keenan
发明人： Peter Rule , Richard Keenan
IPC分类号： A61B5/155
CPC分类号： A61B5/14557 , A61B5/0059 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/412 , A61B2560/0443 , A61M5/1723 , A61M2230/201
摘要： Systems and methods for determining the concentration of an analyte in a sample such as bodily fluid are disclosed. Systems and methods disclosed herein comprise reducing the volume of sample withdrawn from the source of biological fluid. Low draw volume systems can be implemented using small inner diameter tube, valves and one or more sensors, for example. A method for calibrating a measurement of an analyte in a fluid sample for dilution of the fluid sample is also disclosed.
摘要翻译：公开了用于确定样品（例如体液）中的分析物的浓度的系统和方法。本文公开的系统和方法包括减少从生物流体源取出的样品的体积。例如，可以使用小的内径管，阀和一个或多个传感器来实现低抽油量系统。还公开了用于校准流体样品中用于稀释流体样品的分析物的测量的方法。

43. 发明申请

US20070161951A1 TREATMENT OF VASCULAR OCCLUSIONS USING ELEVATED TEMPERATURES 审中-公开
标题翻译：使用高温治疗血管闭塞症
公开(公告)号：US20070161951A1
公开(公告)日：2007-07-12
申请号：US11685643
申请日：2007-03-13
申请人： Douglas Hansmann , Peter Rule
发明人： Douglas Hansmann , Peter Rule
IPC分类号： A61F7/12
CPC分类号： A61B17/2202 , A61B2018/046
摘要： A method for providing a therapeutic effect to a treatment site within a patient's vasculature comprises positioning a catheter at the treatment site. The catheter includes a heating element and a fluid delivery lumen that is coupled to an exit port within a distal region of the catheter. The method further comprises passing the therapeutic compound through the delivery lumen and the exit port at a flow rate. The heated therapeutic compound is provided to the treatment site. The method further comprises exposing at least a portion of the treatment site and at least a portion of the delivered heated therapeutic compound to ultrasonic energy generated by the ultrasound radiating member.
摘要翻译：用于向患者的脉管系统内的治疗部位提供治疗效果的方法包括将导管定位在治疗部位。导管包括加热元件和流体输送腔，其与导管的远侧区域内的出口连接。该方法还包括以流速使治疗化合物通过输送腔和出口。将加热的治疗化合物提供给治疗部位。所述方法还包括将所述处理部位的至少一部分和所递送的加热治疗化合物的至少一部分暴露于由所述超声波辐射部件产生的超声波能量。

44. 发明申请

US20070083091A1 Analyte detection system with reduced sample volume 有权
标题翻译：分析物检测系统，样品量减少
公开(公告)号：US20070083091A1
公开(公告)日：2007-04-12
申请号：US11504139
申请日：2006-08-15
申请人： Bernhard Sterling , Jennifer Gable , James Braig , Mark Weschler , Peng Zheng , Peter Rule , Richard Keenan
发明人： Bernhard Sterling , Jennifer Gable , James Braig , Mark Weschler , Peng Zheng , Peter Rule , Richard Keenan
IPC分类号： A61B5/00
CPC分类号： A61B5/14546 , A61B5/145 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M2230/20 , G01N35/1095
摘要： In certain embodiments, a method samples a body fluid of a patient. The method includes providing a fluid handling system having one or more fluid passageways. The method further includes infusing an infusion fluid by way of a fluid handling system into a patient through one or more fluid passageways. The method further includes obtaining a sample of body fluid by way of a fluid handling system from a patient through one or more fluid passageways. The obtained sample is no more than 5 milliliters in volume. The method further includes analyzing at least an analyzed portion of the obtained sample by way of an analyte detection system operatively associated with the fluid handling system to determine a concentration of at least one analyte.
摘要翻译：在某些实施方案中，方法对患者的体液进行取样。该方法包括提供具有一个或多个流体通道的流体处理系统。该方法还包括通过流体处理系统通过一个或多个流体通道将输注液输入患者体内。该方法还包括通过来自患者的流体处理系统通过一个或多个流体通道获得体液样品。所得样品的体积不超过5毫升。该方法还包括通过可操作地与流体处理系统相关联的分析物检测系统分析所获得的样品的至少一部分分析物，以确定至少一种分析物的浓度。

45. 发明申请

US20070060872A1 Apparatus and methods for analyzing body fluid samples 审中-公开
公开(公告)号：US20070060872A1
公开(公告)日：2007-03-15
申请号：US11352956
申请日：2006-02-13
申请人： W. Hall , David Callicoat , Jennifer Gable , James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard Keenan
发明人： W. Hall , David Callicoat , Jennifer Gable , James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard Keenan
IPC分类号： A61M31/00 , A61B5/00 , A61D5/00
CPC分类号： A61B5/14546 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M2230/20
摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength λ. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.

46. 发明申请

US20060189926A1 Apparatus and methods for analyzing body fluid samples 审中-公开
公开(公告)号：US20060189926A1
公开(公告)日：2006-08-24
申请号：US11316407
申请日：2005-12-21
申请人： W. Hall , David Callicoat , Jennifer Gable , James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard Keenan
发明人： W. Hall , David Callicoat , Jennifer Gable , James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard Keenan
IPC分类号： A61M31/00 , A61B5/00
CPC分类号： A61B5/14546 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M2230/20
摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength B. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.

47. 发明授权

US07061593B2 Device and method for in vitro determination of analyte concentrations within body fluids 失效
公开(公告)号：US07061593B2
公开(公告)日：2006-06-13
申请号：US10219627
申请日：2002-08-14
申请人： James R. Braig , Peter Rule , Philip C. Hartstein
发明人： James R. Braig , Peter Rule , Philip C. Hartstein
IPC分类号： G01N33/48
CPC分类号： A61B5/01 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150503 , A61B5/150618 , A61B5/150717 , A61B5/15087 , A61B5/15107 , A61B5/15136 , A61B5/1514 , A61B5/15194 , A61B5/157 , A61B5/6826 , A61B5/6838 , A61B2562/0295 , A61B2562/12 , G01N21/35
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

48. 发明授权

US06958809B2 Reagent-less whole-blood glucose meter 有权
标题翻译：无试剂全血糖仪
公开(公告)号：US06958809B2
公开(公告)日：2005-10-25
申请号：US10055875
申请日：2002-01-21
申请人： Bernhard B. Sterling , Philip C. Hartstein , Ken I. Li , Mark D. Agostino , David C. Klonoff , Robert D. Gaffney , Jennifer H. Gable , Ken G. Witte , Mike A. Munrow , Daniel S. Goldberger , Julian M. Cortella , James R. Braig , Peter Rule
发明人： Bernhard B. Sterling , Philip C. Hartstein , Ken I. Li , Mark D. Agostino , David C. Klonoff , Robert D. Gaffney , Jennifer H. Gable , Ken G. Witte , Mike A. Munrow , Daniel S. Goldberger , Julian M. Cortella , James R. Braig , Peter Rule
IPC分类号： A61B5/00 , G01N21/35 , G01N33/48
CPC分类号： A61B5/01 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150503 , A61B5/15087 , A61B5/15107 , A61B5/15136 , A61B5/1514 , A61B5/15186 , A61B5/157 , A61B5/6826 , A61B5/6838 , A61B2562/0295 , A61B2562/12 , G01N21/35
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.
摘要翻译：能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。全血系统还具有光束的光路中的检测器。全血系统还具有容纳源和检测器的壳体。全血系统还具有位于束的光路中的样品元件。样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

49. 发明申请

US20050197619A1 Ultrasound enhanced central venous catheter 有权
标题翻译：超声增强中心静脉导管
公开(公告)号：US20050197619A1
公开(公告)日：2005-09-08
申请号：US11046052
申请日：2005-01-28
申请人： Peter Rule , Douglas Hansmann , Dominic Vogt , Curtis Genstler , Thomas McNamara
发明人： Peter Rule , Douglas Hansmann , Dominic Vogt , Curtis Genstler , Thomas McNamara
IPC分类号： A61B20060101 , A61B17/20
CPC分类号： B08B9/00 , A61B17/2202 , A61B90/70 , A61B2090/701 , A61M2025/0019 , B08B9/043 , B08B2209/005
摘要： A central venous catheter comprises an ultrasound assembly. In one arrangement, the radiating member is used to remove a blockage from the central venous catheter. In another arrangement, inserting an ultrasound assembly into a central venous catheter. The ultrasound assembly comprises an ultrasound radiating member mounted on an elongate support structure. The method further comprises positioning the ultrasound assembly within the central venous catheter such that the ultrasound radiating member is adjacent to a deposited material formed on a portion of the central venous catheter. The method further comprises supplying an electrical current to the ultrasound radiating member to expose the deposited material to ultrasonic energy. The method further comprises passing a therapeutic compound through the central venous catheter to expose the deposited material to the therapeutic compound simultaneously with ultrasonic energy.
摘要翻译：中心静脉导管包括超声组件。在一种布置中，辐射构件用于从中心静脉导管移除堵塞物。在另一种布置中，将超声组件插入中心静脉导管中。超声组件包括安装在细长支撑结构上的超声辐射构件。该方法还包括将超声组件定位在中心静脉导管内，使得超声辐射构件与形成在中心静脉导管的一部分上的沉积材料相邻。该方法还包括向超声辐射构件提供电流以将沉积的材料暴露于超声波能量。该方法还包括使治疗化合物通过中心静脉导管，以同时用超声能量将沉积的材料暴露于治疗化合物。

50. 发明申请

US20050137520A1 Catheter with ultrasound-controllable porous membrane 审中-公开
标题翻译：导管与超声可控多孔膜
公开(公告)号：US20050137520A1
公开(公告)日：2005-06-23
申请号：US10977502
申请日：2004-10-29
申请人： Peter Rule , Douglas Hansmann , Robert Wilcox
发明人： Peter Rule , Douglas Hansmann , Robert Wilcox
IPC分类号： A61B17/22 , A61M37/00 , A61B17/20
CPC分类号： A61B17/2202 , A61M37/0092
摘要： A catheter system for delivering ultrasonic energy and a therapeutic compound to a treatment site within a patient's vasculature comprises a tubular body having an energy delivery section. The catheter system further comprises a fluid delivery lumen extending at least partially through the tubular body. The catheter system further comprises a semi-permeable membrane positioned along a portion of the fluid delivery lumen. The membrane has an increased porosity when exposed to ultrasonic energy. The catheter system further comprises an inner core configured for insertion into the tubular body. The inner core comprises an elongate electrical conductor having a plurality of flattened regions. Each flattened region has a first flat side and a second flat side opposite the first flat side. The inner core further comprises a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor. A first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor. The inner core further comprises wiring such that a voltage can be applied from the elongate electrical conductor across the first and second ultrasound radiating members allowing the first and second ultrasound radiating members to be driven simultaneously.
摘要翻译：用于将超声能量和治疗性化合物输送到患者脉管系统内的治疗部位的导管系统包括具有能量输送部分的管状体。导管系统还包括至少部分地延伸通过管状体的流体输送腔。导管系统还包括沿流体输送腔的一部分定位的半透膜。当暴露于超声能量时，膜具有增加的孔隙率。该导管系统还包括被配置成插入到管状体内的内芯。内芯包括具有多个扁平区域的细长电导体。每个扁平区域具有与第一平坦侧相对的第一平坦侧和第二平坦侧。内芯还包括与细长电导体的扁平区域成对安装的多个超声波辐射构件。第一超声波辐射构件安装到细长电导体的第一平坦侧，并且第二超声波辐射构件安装到细长电导体的第二平坦侧。内芯还包括布线，使得可以从细长的导体穿过第一和第二超声波辐射构件施加电压，允许同时驱动第一和第二超声波辐射构件。

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