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41. 发明授权

US5141752A Delayed drug delivery device 失效
标题翻译：延迟给药装置
公开(公告)号：US5141752A
公开(公告)日：1992-08-25
申请号：US715256
申请日：1991-07-25
申请人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
发明人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
摘要翻译：一种剂型，其包含（1）立即可用的有效药物剂量，然后是药物的定时延迟剂量，或（2）定时延迟剂量的药物。

42. 发明授权

US5082668A Controlled-release system with constant pushing source 失效
标题翻译：具有恒定推压源的控制释放系统
公开(公告)号：US5082668A
公开(公告)日：1992-01-21
申请号：US595140
申请日：1990-10-09
申请人： Patrick S. L. Wong , Brian L. Barclay , Joseph C. Deters , Felix Theeuwes
发明人： Patrick S. L. Wong , Brian L. Barclay , Joseph C. Deters , Felix Theeuwes
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： A device is disclosed comprising a wall that surrounds a compartment. The compartment comprises a beneficial agent composition and a push composition. A passageway in the wall connects the compartment with the exterior of the device for delivering the beneficial agent at a rate governed, in combination, by the wall, the beneficial agent composition and the push composition through the passageway of the device over time.
摘要翻译：公开了一种包括围绕隔室的壁的装置。隔室包含有益剂组合物和推组合物。壁中的通道将隔室与装置的外部连接，用于通过墙壁，有益剂组合物和推动组合物通过装置的通道随时间而被组合地传递有益剂。

43. 发明授权

US5071656A Delayed onset transdermal delivery device 失效
标题翻译：延迟发作透皮递送装置
公开(公告)号：US5071656A
公开(公告)日：1991-12-10
申请号：US271207
申请日：1988-11-14
申请人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Alejandro Zaffaroni
发明人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Alejandro Zaffaroni
IPC分类号： A61K9/70 , A61K31/21
CPC分类号： A61K9/7069 , A61K31/21 , A61K9/7084 , A61K9/7092
摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in a predetermined temporal pattern at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continuous administration over extended time periods.
摘要翻译：描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。合适的方法包括设置在释放表面和试剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初对试剂不渗透，然后变为可渗透的。可以提供由一个或多个这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。延迟渗透性使得能够从连续和同时使用用于施用诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。

44. 发明授权

US5019397A Aqueous emulsion for pharmaceutical dosage form 失效
标题翻译：用于药物剂型的水性乳液
公开(公告)号：US5019397A
公开(公告)日：1991-05-28
申请号：US184478
申请日：1988-04-21
申请人： Patrick S. L. Wong , Felix Theeuwes
发明人： Patrick S. L. Wong , Felix Theeuwes
IPC分类号： A61M31/00 , A61K9/00 , A61K9/28 , A61K9/32 , A61K9/58 , A61K47/32
CPC分类号： A61K9/2866 , A61K9/0004 , A61K9/2846
摘要： A dosage form is disclosed comprising a cured emulsion that coat that surrounds a drug. The emulsion comprises a lower alkyl acrylate-lower alkyl methacrylate copolymer and ethyl cellulose. The emulsion optionally comprises a hydrophilic polymer.

45. 发明授权

US4976966A Delayed release osmotically driven fluid dispenser 失效
标题翻译：延迟释放渗透驱动的流体分配器
公开(公告)号：US4976966A
公开(公告)日：1990-12-11
申请号：US291725
申请日：1988-12-29
申请人： Felix Theeuwes , Patrick S. L. Wong
发明人： Felix Theeuwes , Patrick S. L. Wong
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： An osmotically driven pump is provided that is capable of being miniaturized to a size suited for swallowing or implanting in an animal. The pump may be used to administer a drug in fluid form after an initial activation period during which substantially no drug is administered. The basic components of the pump are a shaped semipermeable membrane that encapsulates an osmotically effective solute and preferably a drug or other beneficial agent and a discharge port through which the drug or other beneficial agent is dispensed. A semipermeable or microporous outer cover surrounds the semipermeable membrane and seals it from an external aqueous environment. A water-swellable composition is operatively positioned between the end of the semipermeable membrane and the outer cover. Preferably, a water wicking layer at least partially surrounds the semipermeable membrane and is also sealed within the outer cover. In operation, the pump is placed in an aqueous environment. Water from the environment passes through the semipermeable/microporous portion of the outer cover into the water-swellable composition. The water-swellable composition absorbs water, expands, and in piston-like fashion displaces the outer cover, thereby exposing the semipermeable membrane to the aqueous environment and activating the osmotic pump. The time required for the water-swellable composition to absorb water, expand and displace the outer cover provides an initial activation period during which substantially no drug is delivered by the pump.
摘要翻译：提供了一种渗透驱动的泵，其能够被小型化成适合于在动物中吞咽或植入的尺寸。在基本上不施用药物的初始活化期之后，泵可以用于以流体形式施用药物。泵的基本组分是封装渗透有效溶质，优选药物或其它有益剂的成形半透膜和药物或其它有益剂通过其分配的排出口。半透膜或微孔外壳围绕半透膜并将其与外部水性环境密封。可水膨胀组合物可操作地定位在半透膜的端部和外覆盖件之间。优选地，吸水层至少部分地包围半透膜并且也被密封在外盖内。在操作中，将泵放置在水性环境中。来自环境的水通过外盖的半透/微孔部分进入水溶胀性组合物。水溶胀性组合物吸收水，膨胀，并且以活塞样的方式取代外盖，从而将半透膜暴露于水性环境并激活渗透泵。水溶胀性组合物吸收水，膨胀和置换外盖所需的时间提供初始激活期，在此期间基本上没有药物由泵输送。

46. 发明授权

US4971790A Dosage form for lessening irritation of mocusa 失效
标题翻译：减轻蛀牙刺激的剂型
公开(公告)号：US4971790A
公开(公告)日：1990-11-20
申请号：US370313
申请日：1989-06-22
申请人： Paul R. Magruder , Patrick S. L. Wong , Felix Theeuwes , George V. Guittard
发明人： Paul R. Magruder , Patrick S. L. Wong , Felix Theeuwes , George V. Guittard
IPC分类号： A61K9/00 , A61M31/00 , A61K31/74
CPC分类号： A61M31/002 , A61K9/0004
摘要： A composition of matter comprising a drug, a neutral hydrogel and an ionic hydrogel. The composition can be administered from a delivery system to a biological receptor over time.
摘要翻译：包含药物，中性水凝胶和离子水凝胶的物质组合物。组合物可以随时间从递送系统施用于生物受体。

47. 发明授权

US4966769A Method for delivering dosage form for diltiazem 失效
标题翻译：递送地尔硫卓剂量的方法
公开(公告)号：US4966769A
公开(公告)日：1990-10-30
申请号：US350440
申请日：1989-05-11
申请人： George V. Guittard , Patrick S. L. Wong , Felix Theeuwes , Richard Cortese
发明人： George V. Guittard , Patrick S. L. Wong , Felix Theeuwes , Richard Cortese
IPC分类号： A61K9/00 , A61K31/55
CPC分类号： A61K9/0004 , A61K31/55
摘要： A device is disclosed for delivering diltiazem at a controlled and substantially zero order rate over a prolonged period of time.
摘要翻译：公开了一种用于在长时间段内以受控且基本为零级速率输送硫氮的装置。

48. 发明授权

US4948592A Pulsed drug delivery 失效
标题翻译：脉冲给药
公开(公告)号：US4948592A
公开(公告)日：1990-08-14
申请号：US313211
申请日：1989-02-21
申请人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
发明人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
摘要翻译：一种剂型，其包含（1）立即可用的有效药物剂量，然后是药物的定时延迟剂量，或（2）定时延迟剂量的药物。

49. 发明授权

US4904474A Delivery of drug to colon by oral disage form 失效
标题翻译：通过口服分离形式将药物递送至结肠
公开(公告)号：US4904474A
公开(公告)日：1990-02-27
申请号：US147840
申请日：1988-01-25
申请人： Felix Theeuwes , George V. Guittard , Patrick S. L. Wong
发明人： Felix Theeuwes , George V. Guittard , Patrick S. L. Wong
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： A drug delivery device is disclosed for delivering a drug to the colon. The device comprises means for delaying the delivery of drug in the stomach, means for delaying delivery of drug in the small intestine, and means for delivering drug in the colon.
摘要翻译：公开了用于将药物递送至结肠的药物递送装置。该装置包括用于延迟药物在胃中的递送的装置，用于延迟药物在小肠中的递送的装置，以及用于在结肠中递送药物的装置。

50. 发明授权

US4777049A Constant release system with pulsed release 失效
标题翻译：脉冲释放恒定释放系统
公开(公告)号：US4777049A
公开(公告)日：1988-10-11
申请号：US1599
申请日：1987-01-08
申请人： Paul R. Magruder , Brian Barclay , Patrick S. L. Wong , Felix Theeuwes
发明人： Paul R. Magruder , Brian Barclay , Patrick S. L. Wong , Felix Theeuwes
IPC分类号： A61K9/00 , A61M31/00 , A61K9/48 , A61K9/52
CPC分类号： A61K9/0004 , A61M31/002
摘要： An osmotic delivery system is disclosed for delivering a useful agent at a controlled and constant rate modulated by a pulsed delivery of the useful agent to an environment of use.
摘要翻译：公开了一种渗透递送系统，用于以受控和恒定的速率递送有用的试剂，该有用试剂通过有用试剂的脉冲输送调节到使用环境。

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