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41. 发明申请

WO1998018342A1 METHOD OF PRODUCING FOOD FLAVORING AGENT 审中-公开
标题翻译：生产食品升华剂的方法
公开(公告)号：WO1998018342A1
公开(公告)日：1998-05-07
申请号：PCT/DK1997000443
申请日：1997-10-13
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S , KOFOED, Lene, Venke , FISCHER, Morten , NIELSEN, Per, Munk , POMMER, Klaus
IPC分类号： A23J03/34
CPC分类号： A23J3/346 , A23L27/24 , A23L27/50
摘要： The invention relates to the production of a food flavoring agent. More particularly the invention provides a process for producing a food flavoring agent, which method comprises the steps of preparing an aqueous slurry of plant protein and plant carbohydrate, treating the slurry with a protease, treating the slurry with a carbohydrase and maturation. By this method different flavor characteristics can be induced in the protein hydrolysate.
摘要翻译：本发明涉及食品调味剂的生产。更具体地，本发明提供了一种生产食品调味剂的方法，该方法包括以下步骤：制备植物蛋白质和植物碳水化合物的水性浆料，用蛋白酶处理浆料，用碳水化合物处理浆料并熟化。通过这种方法，可以在蛋白质水解产物中诱导不同的风味特征。

42. 发明申请

WO1998017770A1 COLOR CLARIFICATION METHODS 审中-公开
标题翻译：颜色澄清方法
公开(公告)号：WO1998017770A1
公开(公告)日：1998-04-30
申请号：PCT/US1997018536
申请日：1997-10-15
申请人： NOVO NORDISK BIOCHEM NORTH AMERICA, INC. , NOVO NORDISK A/S
发明人： NOVO NORDISK BIOCHEM NORTH AMERICA, INC. , NOVO NORDISK A/S , SALMON, Sonja, I. , MISHRA, Anita, R. , NIELSEN, Jack, B.
IPC分类号： C11D03/386
CPC分类号： C11D3/38645 , C11D3/226 , C11D3/3719 , C11D3/3788
摘要： The invention is directed to agents used in the retention of color values on fabrics formed from cellulose fibers (color clarification agents) and to a method for treatment of such fabrics. The method comprises treating a colored fabric with a cellulase and a polymer selected from the group consisting of a polyalkylene oxide graft polymer, a polyamino acid polymer, and a carboxylated polysaccharide polymer in an amount effective to preserve the color of the fabric after at least one wash cycle.
摘要翻译：本发明涉及用于保持由纤维素纤维（颜色澄清剂）形成的织物上的颜色值的试剂和用于处理这种织物的方法。该方法包括用纤维素酶和选自聚环氧烷接枝聚合物，聚氨基酸聚合物和羧化多糖聚合物的聚合物处理有色织物，其量有效地在至少一种洗涤循环。

43. 发明申请

WO1998016112A1 USE OF A CARBOHYDRATE BINDING DOMAIN IN BAKING 审中-公开
标题翻译：在烘烤中使用碳水化合物结合域
公开(公告)号：WO1998016112A1
公开(公告)日：1998-04-23
申请号：PCT/DK1997000427
申请日：1997-10-06
申请人： NOVO NORDISK A/S , FUGLSANG, Claus, Crone , JORGENSEN, Ole, Bill
发明人： NOVO NORDISK A/S
IPC分类号： A21D08/04
CPC分类号： A21D2/26 , A21D8/042
摘要： A bread improving composition comprising an effective amount of a cellulose binding domain in combination with an anti-staling enzyme, optionally in admixture with other enzymes, as well as the use of the composition in the preparation of dough and baked products.
摘要翻译：一种面包改良组合物，其包含有效量的纤维素结合结构域与抗老化酶组合，任选与其它酶混合，以及组合物在制备面团和烘焙产品中的用途。

44. 发明申请

WO1998015548A1 1,4-DISUBSTITUTED PIPERAZINES 审中-公开
标题翻译： 1,4-取代的哌嗪
公开(公告)号：WO1998015548A1
公开(公告)日：1998-04-16
申请号：PCT/DK1997000422
申请日：1997-10-02
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S , HOHLWEG, Rolf , MADSEN, Peter , JORGENSEN, Tine, Krogh , ANDERSEN, Knud, Erik , WATSON, Brett , POLIVKA, Zdenek , KONIGOVA, Otylie , KOVANDOVA, Martina , SILHANKOVA, Alexandra , VALENTA, Vladimir
IPC分类号： C07D405/12
CPC分类号： C07D213/74 , C07C2603/78 , C07D213/79 , C07D295/073 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to 1,4-disubstituted piperazines of general formula (I), wherein X, Y, Z, R , R and r are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for the treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.
摘要翻译：本发明涉及通式（I）的1,4-二取代哌嗪，其中X，Y，Z，R 1，R 2和r如在本说明书的详细部分中所定义或其盐，其制备方法，含有它们的组合物，以及其用于临床治疗疼痛，痛觉过敏和/或炎性病症的用途，其中C纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用，以及其用于治疗由胰岛素拮抗肽分泌和循环引起或与之相关的适应症，例如，非胰岛素依赖性糖尿病（NIDDM）和衰老相关性肥胖。

45. 发明申请

WO1998015546A1 N-SUBSTITUTED AZAHETEROCYCLIC COMPOUNDS 审中-公开
标题翻译： N-取代的杂环化合物
公开(公告)号：WO1998015546A1
公开(公告)日：1998-04-16
申请号：PCT/DK1997000421
申请日：1997-10-02
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S , JORGENSEN, Tine, Krogh , HOHLWEG, Rolf , MADSEN, Peter , ANDERSEN, Knud, Erik , TREPPENDAHL, Svend , OLSEN, Uffe, Bang , POLIVKA, Zdenek , SILHANKOVA, Alexandra , SINDELAR, Karel , VALENTA, Vladimir , KALISZ, Tomas
IPC分类号： C07D401/06
CPC分类号： C07D401/06 , A61K31/445 , A61K31/55 , C07D211/60 , C07D401/10 , C07D401/12 , C07D403/06
摘要： The present invention relates to novel N-substituted azaheterocyclic compounds of general formula (I), wherein X, Y, Z, A, R , R , r and s are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to secretion and circulation of insulin antagonising peptides.
摘要翻译：本发明涉及通式（I）的新型N-取代氮杂环化合物，其中X，Y，Z，A，R 1，R 2，r和s如本发明的详细部分所定义描述或其盐，其制备方法，含有它们的组合物，以及其用于临床治疗疼痛，痛觉过敏和/或炎性病症的用途，其中C纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用作为其用于治疗由胰岛素拮抗肽分泌和循环引起或与其相关的适应症的用途。

46. 发明申请

WO1998015257A1 DIAMINOBENZOIC ACID DERIVATIVES AS DYE PRECURSORS 审中-公开
标题翻译：二氨基苯甲酸衍生物作为染色体前体
公开(公告)号：WO1998015257A1
公开(公告)日：1998-04-16
申请号：PCT/DK1997000435
申请日：1997-10-08
申请人： NOVO NORDISK A/S , SORENSEN, Niels, Henrik , KIRK, Ole , LOLCK, Rikke , DESLER, Torben
发明人： NOVO NORDISK A/S
IPC分类号： A61K07/13
CPC分类号： A61Q5/10 , A61K8/445 , C09B17/02 , D06P1/32 , G01N33/535
摘要： The invention relates to substrates which develops colour on oxidation of general formula (I). The invention also relates to the use of said substrates for dyeing, e.g. keratinous fibers, in particular hair, dyeing textiles, a dyeing composition and a method for dyeing keratinous fibers.
摘要翻译：本发明涉及在通式（I）的氧化上显色的基材。本发明还涉及所述基材用于染色的用途。角质纤维，特别是毛发，染色纺织品，染色组合物和染色角质纤维的方法。

47. 发明申请

WO1998013479A1 AN ENZYME WITH CYCLOMALTODEXTRIN GLUCANOTRANSFERASE (CGTASE) ACTIVITY 审中-公开
标题翻译：环孢菌素葡萄糖转运酶（CGTASE）活性的酶
公开(公告)号：WO1998013479A1
公开(公告)日：1998-04-02
申请号：PCT/DK1997000411
申请日：1997-09-26
申请人： NOVO NORDISK A/S , SJOHOLM, Carsten , PROWE, Steffen , ANTRANIKIAN, Garabed
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/10
CPC分类号： C12N9/1074 , A21D8/042
摘要： The present invention relates to a novel alkali stable CGTase which mainly produces alpha-cyclodextrin, an enzyme composition comprising said CGTase, and the use of said enzyme and enzyme composition for a number of industrial applications, e.g., in a dough-improving composition.
摘要翻译：本发明涉及主要生产α-环糊精的新型碱稳定CGT酶，包含所述CGT酶的酶组合物，以及所述酶和酶组合物在许多工业应用中的用途，例如在面团改良组合物中的用途。

48. 发明申请

WO1998002460A1 SELECTIVE ACYLATION METHOD 审中-公开
标题翻译：选择性方法
公开(公告)号：WO1998002460A1
公开(公告)日：1998-01-22
申请号：PCT/DK1997000296
申请日：1997-07-04
申请人： NOVO NORDISK A/S , HANSEN, Louis, Brammer
发明人： NOVO NORDISK A/S
IPC分类号： C07K14/62
CPC分类号： C07K14/62 , A61K38/00
摘要： A method of selectively acylating an insulin, an insulin analogue or a precursor thereof having a free epsilon -amino group of a Lys residue contained therein and at least one free alpha -amino group which method comprises reacting the epsilon -amino group with an activated amide in a polar solvent in the presence of a base.
摘要翻译：选择性酰化其中含有Lys残基的游离ε-氨基的胰岛素，胰岛素类似物或其前体和至少一种游离α-氨基的方法，该方法包括使ε-氨基与活化酰胺在极性溶剂中，在碱的存在下。

49. 发明申请

WO1998001473A1 METHOD FOR THE PRODUCTION OF PRECURSORS OF INSULIN, PRECURSORS OF INSULIN ANALOGUES, AND INSULIN LIKE PEPTIDES 审中-公开
标题翻译：胰高血糖素前列腺素，胰岛素类似物前体和胰岛素样肽的制备方法
公开(公告)号：WO1998001473A1
公开(公告)日：1998-01-15
申请号：PCT/DK1997000297
申请日：1997-07-04
申请人： NOVO NORDISK A/S , EGEL-MITANI, Michi , BRANDT, Jakob , VAD, Knud
发明人： NOVO NORDISK A/S
IPC分类号： C07K14/62
CPC分类号： C12R1/865 , C07K14/62 , C12N9/60 , C12N15/81
摘要： The present invention relates to a novel method for the production of precursors of insulin, precursors of insulin analogues, and insulin like peptides in genetically modified yeast cells having reduced activity of YAP3 protease. The invention further comprises said genetically modified yeast cells, and a method for the preparation of said yeast cells.
摘要翻译：本发明涉及在具有降低的YAP3蛋白酶活性的遗传修饰的酵母细胞中生产胰岛素前体，胰岛素类似物前体和胰岛素样肽的新方法。本发明还包括所述遗传修饰的酵母细胞，以及制备所述酵母细胞的方法。

50. 发明申请

WO1998001168A2 DOSE SETTING DEVICE 审中-公开
标题翻译：剂量设定装置
公开(公告)号：WO1998001168A2
公开(公告)日：1998-01-15
申请号：PCT/DK1997000253
申请日：1997-06-09
申请人： NOVO NORDISK A/S , POULSEN, Jens, Ulrik , LJUNGGREEN, Henrik , CHRISTENSEN, Lars, Hofmann
发明人： NOVO NORDISK A/S
IPC分类号： A61M00/00
CPC分类号： A61M5/20 , A61M5/14546 , A61M5/14566 , A61M5/31525 , A61M5/31546 , A61M2005/31588 , A61M2205/581 , G06F19/00 , Y10S128/01
摘要： In a drug delivery device a dose to be apportioned from a cartridge is set by changing the relative position of co-operating dose setting elements (3, 5) and is injected by pressing a button (5) until this button abuts a stop (6). By operation of count up (7) or count down (8) buttons the dose is set and read into an electronic circuit (9) comprising a microprocessor and the dose setting movement of the dose setting elements relative to each other is performed by a motor (11) controlled by the circuit in accordance with the read in dose. The set dose is shown on a display (10). The motor (11) is further controlled to perform certain movements of the piston rod (3) so as retraction of this rod when a cartridge (1) is going to be changed an advancing of the piston rod to abutment with the piston (2) after the cartridge has been changed and further to advance this piston to expel air from the cartridge.
摘要翻译：在药物输送装置中，通过改变配合剂量设定元件（3,5）的相对位置来设定从药筒分配的剂量，并且通过按压按钮（5）来注射直到该按钮抵靠止动件（6））。通过计数（7）或倒计时（8）按钮的操作，剂量被设置并读入包括微处理器的电子电路（9），并且剂量设定元件相对于彼此的剂量设定运动由电动机（11）由电路按照读取剂量控制。设定的剂量显示在显示器（10）上。电动机（11）被进一步控制以执行活塞杆（3）的某些运动，以便当筒（1）将改变活塞杆的前进以与活塞（2）邻接时，该杆的缩回，在盒被改变之后，并且进一步推进该活塞以从盒中排出空气。

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