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41. 发明专利

AU2017255086A1 Medicine for treating multiple sclerosis 未知
公开(公告)号：AU2017255086A1
公开(公告)日：2018-12-13
申请号：AU2017255086
申请日：2017-04-27
申请人： KYUSHU UNIVERSITY NATIONAL UNIVERSITY CORPORATION , NIPPON CHEMIPHAR CO LTD
发明人： IMAI TOSHIYASU , KAWASAKI TORU , OGAWA TORU , INOUE KAZUHIDE
IPC分类号： A61K45/00 , A61K31/551 , A61P25/00 , A61P25/04 , A61P43/00
摘要： A medicine for preventing and/or treating multiple sclerosis, particularly pain such as neuropathic pain associated with multiple sclerosis and the like, said medicine containing, as an active ingredient, a compound having an antagonistic activity on P2X4 receptors, e.g., a compound represented by general formula (IH), or a salt of the compound, or a hydrate or solvate of the compound or the salt.

42. 发明专利

PL2803662T3 ANTAGONISTA RECEPTORA P2X4 未知
公开(公告)号：PL2803662T3
公开(公告)日：2017-09-29
申请号：PL13736295
申请日：2013-01-10
申请人： NIPPON CHEMIPHAR CO
发明人： USHIODA MASATOSHI , KOBAYASHI KUNIO , SAITO DAISUKE , SAKUMA SHOGO , IMAI TOSHIYASU , INOUE KAZUHIDE
IPC分类号： C07D243/12 , A61K31/551 , A61K31/5513 , A61P25/04 , A61P43/00 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12

43. 发明专利

NZ627878A P2x4 receptor antagonist 未知
公开(公告)号：NZ627878A
公开(公告)日：2016-03-31
申请号：NZ62787813
申请日：2013-01-10
申请人： NIPPON CHEMIPHAR CO
发明人： USHIODA MASATOSHI , KOBAYASHI KUNIO , SAITO DAISUKE , SAKUMA SHOGO , IMAI TOSHIYASU , INOUE KAZUHIDE
IPC分类号： C07D243/12 , A61K31/551 , A61P25/04 , A61P43/00 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The disclosure relates to a diazepine derivative represented by general formula (I), wherein the variables R1 and R2 are a hydrogen atom, etc. or R1 and R2 together with a benzene ring to which they are attached are a naphthalene ring, etc.; R3 and R4 are a hydrogen atom, etc.; R5 is a hydrogen atom, etc.; R6 and R7 are a hydrogen atom, etc.; X is C, CH or N and Y is N, NH or C (=O), provided that when X is N, Y is not N or NH and when X is C or CH, Y is not C (=O); Z is an oxygen atom or a sulfur atom; A is a benzene ring, etc.; B is NHC (=O), etc.; D is an atomic bonding, etc.; E is an atomic bonding, etc.; G is benzene which may by substituted, etc.; and m is an integer of 0 to 5.) or a pharmaceutically acceptable salt thereof, and a P2X4 receptor antagonist.

44. 发明专利

ES2432265T3 Derivado de diazepindiona 未知
公开(公告)号：ES2432265T3
公开(公告)日：2013-12-02
申请号：ES10741334
申请日：2010-02-15
申请人： NIPPON CHEMIPHAR CO
发明人： SAKUMA SHOGO , TAKAHASHI TOSHIHIRO , USHIODA MASATOSHI , IMAI TOSHIYASU , INOUE KAZUHIDE
IPC分类号： C07D403/10 , A61K31/5513 , A61P25/04 , A61P43/00 , C07D413/10 , C07D417/10
摘要： Un derivado de diazepindiona que tiene la siguiente fórmula (I), o su sal farmacológicamente aceptable:en la que R1 representa un átomo de hidrógeno, un grupo alquilo que tiene de 1 a 8 átomos de carbono, un grupoalquenilo que tiene de 2 a 8 átomos de carbono, un grupo alquilo que tiene de 1 a 8 átomos de carbono sustituidocon 1 a 3 átomos de halógeno, o un grupo alquilo que tiene de 1 a 3 átomos de carbono sustituido con fenilo;cada uno de R2 y R3 representa independientemente un átomo de hidrógeno, un grupo alquilo que tiene de 1 a 8átomos de carbono, un grupo alcoxi que tiene de 1 a 8 átomos de carbono, un grupo alquilo que tiene de 1 a 8átomos de carbono sustituido con 1 a 3 átomos de halógeno, un grupo alcoxi que tiene de 1 a 8 átomos decarbono sustituido con 1 a 3 átomos de halógeno, un átomo de halógeno, hidroxilo, nitro, ciano, amino, un grupoalquilamino que tiene de 1 a 8 átomos de carbono, un grupo dialquilamino que tiene de 2 a 8 átomos de carbono,un grupo acilamino que tiene de 2 a 8 átomos de carbono, un grupo acilamino que tiene de 2 a 8 átomos decarbono sustituido con 1 a 3 átomos de halógeno, un grupo alquilsulfonilamino que tiene de 1 a 8 átomos decarbono, carboxilo, un grupo acilo que tiene de 2 a 8 átomos de carbono, un grupo alcoxicarbonilo que contiene unresto alcoxi que tiene de 1 a 8 átomos de carbono, carbamoílo, un grupo alquiltio que tiene de 1 a 8 átomos decarbono, un grupo alquilsulfinilo que tiene de 1 a 8 átomos de carbono, un grupo alquilsulfonilo que tiene de 1 a 8átomos de carbono, o sulfamoílo; cada uno de R4 y R5 representa independientemente un átomo de hidrógeno, un grupo alquilo que tiene de 1 a 8átomos de carbono, un grupo alquilo que tiene de 1 a 8 átomos de carbono sustituido con 1 a 3 átomos dehalógeno, o un grupo alquilo que tiene de 1 a 3 átomos de carbono sustituido con fenilo; y W representa un anillo heterocíclico de cinco o seis miembros que contiene de 1 a 4 átomos de nitrógeno comomiembros del anillo, y que opcionalmente tiene un sustituyente seleccionado del grupo que consiste en un grupoalquilo que tiene de 1 a 8 átomos de carbono, un grupo alquilo que tiene de 1 a 8 átomos de carbono sustituidocon 1 a 3 átomos de halógeno, un átomo de halógeno, ciano, oxo, y tioxo.

45. 发明专利

DK2397480T3 DIAZEPINDIONDERIVAT 未知
公开(公告)号：DK2397480T3
公开(公告)日：2013-09-02
申请号：DK10741334
申请日：2010-02-15
申请人： NIPPON CHEMIPHAR CO
发明人： SAKUMA SHOGO , TAKAHASHI TOSHIHIRO , USHIODA MASATOSHI , IMAI TOSHIYASU , INOUE KAZUHIDE
IPC分类号： C07D403/10 , A61K31/5513 , A61P25/04 , A61P43/00 , C07D413/10 , C07D417/10

46. 发明专利

CA2809113A1 P2X4 RECEPTOR ANTAGONIST 未知
公开(公告)号：CA2809113A1
公开(公告)日：2012-02-02
申请号：CA2809113
申请日：2011-07-27
申请人： NIPPON CHEMIPHAR CO
发明人： USHIODA MASATOSHI , SAKUMA SHOGO , TENDO ATSUSHI , IMAI TOSHIYASU , INOUE KAZUHIDE
IPC分类号： C07D241/44 , A61K31/498 , A61P25/04 , A61P43/00 , C07D401/04 , C07D401/12 , C07D403/10 , C07D409/12 , C07D413/10
摘要： A compound represented by general formula (II) (in the formula, R11 and R12 can be the same or different, and can represent hydrogen atoms, or C1-8 alkyl groups; R13 represents a hydrogen atom, or a C1-8 alkyl group; R14 represents a hydrogen atom, a C1-8 alkyl group, a C1-8 alkoxy group, a C1-8 alkyl group which has 1-3 halogen substituents, a C1-8 alkyl group which has a hydroxyl group substituent, a halogen atom, a hydroxyl group, a nitro group, a cyano group, an amino group, a C1-8 alkylamino group, an optionally substituted benzenesulfonyl amino group, or an optionally substituted heterocyclic group, etc., and chemical formula (7) represents a naphthalene ring, a tetrahydronaphthalene ring, or an indane ring) or a pharmacologically acceptable salt thereof, is used as a P2X4 receptor antagonist.

47. 发明专利

CA2789641A1 DIAZEPINEDIONE DERIVATIVE 未知
公开(公告)号：CA2789641A1
公开(公告)日：2010-08-19
申请号：CA2789641
申请日：2010-02-15
申请人： NIPPON CHEMIPHAR CO
发明人： SAKUMA SHOGO , TAKAHASHI TOSHIHIRO , USHIODA MASATOSHI , IMAI TOSHIYASU , INOUE KAZUHIDE
IPC分类号： C07D403/10 , A61K31/5513 , A61P25/04 , A61P43/00 , C07D413/10 , C07D417/10
摘要： A diazepinedione derivative represented by general formula (I) or a pharmacologically acceptable salt thereof is used as a P2X4 receptor antagonist. (In the formula, R1 represents a hydrogen atom, a C1-8 alkyl, etc.; R2 and R3 each represents a hydrogen atom, a C1-8 alkyl, a halogen atom, etc.; R4 and R5 each represents a hydrogen atom, a C1-8 alkyl, etc.; and W represents a tetrazole residue, etc.)

48. 发明公开

EP1795526A4 N-SUBSTITUTED N-(4-PIPERIDINYL)AMIDE DERIVATIVE 审中-公开
标题翻译： N-取代的N-（4-哌啶基）酰胺衍生物
公开(公告)号：EP1795526A4
公开(公告)日：2010-10-13
申请号：EP05785892
申请日：2005-09-13
申请人： NIPPON CHEMIPHAR CO
发明人： TAKAHASHI TOSHIHIRO , ENDO TSUYOSHI , USHIODA MASATOSHI , KOBAYASHI KUNIO , YAMAKAWA TOMIO , SHIKA KIICHI , KAWASAKI TORU , IMAI TOSHIYASU
IPC分类号： C07D211/58 , A61K31/4468 , A61K31/4525 , A61K31/4535 , A61P25/02 , A61P25/04 , C07D405/12 , C07D409/12
CPC分类号： C07D211/58 , C07D405/12 , C07D409/12

49. 发明公开

EP2631229A4 P2X4 RECEPTOR ANTAGONIST 失效
标题翻译： P2X4-REZEPTORANTAGONIST
公开(公告)号：EP2631229A4
公开(公告)日：2013-12-18
申请号：EP11812499
申请日：2011-07-27
申请人： NIPPON CHEMIPHAR CO
发明人： USHIODA MASATOSHI , SAKUMA SHOGO , TENDO ATSUSHI , IMAI TOSHIYASU , INOUE KAZUHIDE
IPC分类号： C07D241/44 , A61K31/498 , A61P25/04 , A61P43/00 , C07D241/38 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D409/12 , C07D413/10
CPC分类号： C07D413/10 , C07D241/38 , C07D241/44 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D409/12
摘要： A compound having the following formula (II) or a pharmacologically acceptable salt thereof is used as a P2X 4 receptor antagonist: wherein each of R 11 and R 12 is hydrogen, C 1-8 alkyl or the like; R 13 is hydrogen, C 1-8 alkyl or the like; R 14 is hydrogen, C 1-8 alkyl, C 1-8 alkoxy, C 1-8 alkyl having 1-3 halogens, C 1-8 hydroxyalkyl, halogen, hydroxyl, nitro, cyano, amino, C 1-8 alkylamino, benzenesulfonylamino optionally having a substituent, a heterocyclic group optionally having a substituent or the like; and the condensed ring consisting of W 1 and the neighboring benzene ring is naphthalene, tetrahydronaphthalene, or indan ring.
摘要翻译：具有下式（II）的化合物或其药理学上可接受的盐用作P2X 4受体拮抗剂：其中R 11和R 12中的每一个是氢，C 1-8烷基等; R 13是氢，C 1-8烷基等; R 14是氢，C 1-8烷基，C 1-8烷氧基，具有1-3个卤素的C 1-8烷基，C 1-8羟基烷基，卤素，羟基，硝基，氰基，氨基，C 1-8烷基氨基，任选具有取代基的苯磺酰基氨基，任选具有取代基的杂环基等; 由W 1和邻近苯环组成的稠环为萘，四氢萘或茚满环。

50. 发明公开

EP2058304A4 P2X4 RECEPTOR ANTAGONIST 审中-公开
标题翻译： P2X4受体拮抗剂
公开(公告)号：EP2058304A4
公开(公告)日：2012-10-10
申请号：EP07806431
申请日：2007-08-24
申请人： NIPPON CHEMIPHAR CO
发明人： SAKUMA SHOGO , ENDO TSUYOSHI , IMAI TOSHIYASU , KANAKUBO NORIKO , ARAI MASAHIKO , TAKAHASHI TOSHIHIRO , YAMAKAWA TOMIO , TSUDA MAKOTO , INOUE KAZUHIDE
IPC分类号： C07D243/24 , A61K31/5513 , A61P25/04 , A61P43/00
CPC分类号： C07D243/20 , C07D243/22 , C07D243/24

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