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41. 发明申请

US20070088241A1 Hand access laparoscopic device 有权
标题翻译：手动腹腔镜手术
公开(公告)号：US20070088241A1
公开(公告)日：2007-04-19
申请号：US11548955
申请日：2006-10-12
申请人： John Brustad , Jeremy Albrecht , Nabil Hilal , Gary Johnson , Charles Hart
发明人： John Brustad , Jeremy Albrecht , Nabil Hilal , Gary Johnson , Charles Hart
IPC分类号： A61F13/00
CPC分类号： A61B17/0293 , A61B17/02 , A61B17/0218 , A61B17/3423 , A61B17/3431 , A61B17/3439 , A61B17/3462 , A61B17/3496 , A61B17/3498 , A61B90/40 , A61B2017/00477 , A61B2017/00526 , A61B2017/0225 , A61B2017/0287 , A61B2017/3419 , A61B2017/347 , A61B2050/005 , A61B2050/0051
摘要： The invention relates to a hand access laparoscopy device having a gelcap, a retainer, a sleeve and a retention ring The gelcap includes gel that is bonded to a cap. The cap includes an inner cylindrical wall to which the gel in bonded, thereby providing a sealing area between the device and the wound in a body wall. By securing the gel to the inner cylindrical wall, the thickness of the gel and corresponding cap is minimized along with the overall footprint of the device. With the gel thickness reduced and able to be substantially flush, the “doming” phenomenon produced by insufflation of a patient's abdomen is reduced
摘要翻译：本发明涉及具有凝胶帽，保持器，套筒和保持环的手动腹腔镜装置。凝胶帽包括结合到帽的凝胶。该盖包括内部圆柱形壁，凝胶粘合到该内壁上，由此在该体壁中在该装置和该伤口之间提供密封区域。通过将凝胶固定到内圆柱形壁上，凝胶和相应的盖的厚度与装置的总体占地面积最小化。随着凝胶厚度降低并且能够基本上齐平，通过吹入患者腹部产生的“穹隆”现象减少

42. 发明申请

US20070088202A1 Circular surgical retractor 有权
标题翻译：圆形手术牵开器
公开(公告)号：US20070088202A1
公开(公告)日：2007-04-19
申请号：US11548767
申请日：2006-10-12
申请人： Jeremy Albrecht , Charles Hart , John Brustad
发明人： Jeremy Albrecht , Charles Hart , John Brustad
IPC分类号： A61B1/32
CPC分类号： A61B17/0293 , A61B17/02 , A61B17/0218 , A61B17/3423 , A61B17/3431 , A61B17/3439 , A61B17/3462 , A61B17/3496 , A61B17/3498 , A61B90/40 , A61B2017/00477 , A61B2017/00526 , A61B2017/0225 , A61B2017/0287 , A61B2017/3419 , A61B2017/347 , A61B2050/005 , A61B2050/0051
摘要： A wound retractor for retracting a surgical incision includes an inner ring, an outer ring and a distensible sleeve coupled to the inner and outer rings. The outer ring includes at least a pair of circular tubes coupled to each other. At least one of the circular tubes includes a lumen and a split that forms open ends. A noncompliant tubular hoop having a split therein is positioned in the lumen. The tubular hoop is oriented with its open ends positioned away from the split of the circular tubes. A core is positioned in the lumen of the tubular hoop. The core has a first end and a second end and is oriented with the ends positioned away from the split in the tubular hoop. The circular tubes may be parallel or may form a helical pattern similar to a Mobius strip
摘要翻译：用于缩回手术切口的缠绕牵开器包括联接到内环和外环的内环，外环和可扩张套管。外环包括彼此耦合的至少一对圆形管。圆形管中的至少一个包括形成开放端的管腔和裂口。其中分开的不合适的管状环位于内腔中。管状环被定向成其开口端定位成远离圆形管的分割。核心位于管状箍的内腔中。芯具有第一端和第二端，并且其端部定位成远离管状箍中的裂缝。圆形管可以是平行的或可以形成类似于Mobius条的螺旋形图案

43. 发明申请

US20070073314A1 MANUALLY ACTUATED SURGICAL CLIP APPLIER 有权
标题翻译：手动启动手术夹具
公开(公告)号：US20070073314A1
公开(公告)日：2007-03-29
申请号：US11536467
申请日：2006-09-28
申请人： Donald Gadberry , Frans Vandenbroek , Gary Johnson , Charles Hart , David Hearn
发明人： Donald Gadberry , Frans Vandenbroek , Gary Johnson , Charles Hart , David Hearn
IPC分类号： A61B17/10
CPC分类号： A61B17/128 , A61B17/1285 , A61B2017/0046 , A61B2017/0488
摘要： A surgical clip applier is provided having a cartridge carrying multiple surgical clips with a manual graspable actuator configured to sequentially deliver clips to the jaws of the clip applier. Both the cartridge and the jaws are connectable to a scissors-like actuator arranged to translate motion from finger loops to the jaws to open and close the jaws and thus close or crimp a delivered clip between the jaws.
摘要翻译：提供了一种手术夹具，其具有带有多个外科夹具的药筒，手动夹持致动器构造成将夹子顺序地递送到施夹器的钳口。盒和夹爪都可连接到剪刀式致动器，其被布置成将手指环的运动转移到钳口，以打开和关闭钳口，并且因此封闭或压紧夹爪之间的传送夹子。

44. 发明申请

US20070060507A1 GROWTH FACTOR HOMOLOG ZVEGF3 有权
标题翻译：生长因子HOMOLOG ZVEGF3
公开(公告)号：US20070060507A1
公开(公告)日：2007-03-15
申请号：US11552378
申请日：2006-10-24
申请人： Zeren Gao , Charles Hart , Christopher Piddington , Paul Sheppard , Kimberly Shoemaker
发明人： Zeren Gao , Charles Hart , Christopher Piddington , Paul Sheppard , Kimberly Shoemaker
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译：公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。还公开了多肽的多聚体。多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。

45. 发明申请

US20070009863A1 Off-highway vehicle trail map directory 审中-公开
标题翻译：非公路车辆轨迹图目录
公开(公告)号：US20070009863A1
公开(公告)日：2007-01-11
申请号：US10964955
申请日：2004-10-14
申请人： Alan Hart , Charles Hart
发明人： Alan Hart , Charles Hart
IPC分类号： G09B29/00
CPC分类号： G09B29/02 , G09B29/10
摘要： A trail map directory for off-highway vehicles is disclosed. The directory includes a binder having a plurality of individual map pages laminated for dry ease writing and for ease of cleaning. A mechanism is provided for releasably attaching each map page to the binder. A key map is positioned towards the front of the binder, and the key map is subdivided into individual regional map display portions corresponding to the individual map pages. Each map page is preferably a substantially flat, relatively stiff laminated panel. The panel has first and second faces located on opposite surfaces thereof, and first and second side edges which define the width dimension of the panel. Each panel first face includes an enlarged map display portion indexed relative to the key map and is in the form of an enhanced topographical map overlaid with off-road trails present within the map boundary. The trails are color-coded to indicate relative difficulty of use. The first face further includes trail symbols relative to the indicated off-road trails. Each second face includes an index to trail symbols appearing on the first face. The second face may also include GPS coordinates pertinent to the geographical points on the topographical map as well as driving directions to the off-road trails. Finally, an apparatus is disposed along each panel first side edge for releasably attaching the panel to the binder for removal for individual use.
摘要翻译：公开了一种用于非公路车辆的轨迹图目录。该目录包括具有多个单独的地图页面的粘合剂，用于干燥书写和易于清洁。提供了一种用于将每个地图页面可释放地附接到装订器的机构。关键地图朝向装订器的前部定位，并且将关键图细分成与各个地图页对应的各个区域地图显示部分。每个地图页面优选地是基本平坦的，相对较硬的层压板。面板具有位于其相对表面上的第一和第二面，以及限定面板的宽度尺寸的第一和第二侧边缘。每个面板第一面包括相对于键映射索引的放大地图显示部分，并且是以与地图边界内存在的越野轨迹重叠的增强的地形图的形式。路线是颜色编码的，表示使用相对困难。第一面还包括相对于指示的越野路线的轨迹符号。每个第二面包括一个索引，用于跟踪出现在第一面上的符号。第二面还可以包括与地形图上的地理点相关的GPS坐标以及到越野小径的驾驶方向。最后，沿着每个面板第一侧边缘设置一个装置，用于可释放地将面板连接到粘合剂上用于单独使用。

46. 发明申请

US20060224164A1 SURGICAL ACCESS DEVICE WITH PENDENT VALVE 有权
公开(公告)号：US20060224164A1
公开(公告)日：2006-10-05
申请号：US11423819
申请日：2006-06-13
申请人： Charles Hart , John Brustad , Nabil Hilal , Henry Kahle
发明人： Charles Hart , John Brustad , Nabil Hilal , Henry Kahle
IPC分类号： A61F11/00
CPC分类号： A61B17/3498 , A61B17/3423 , A61B17/3462 , A61B2017/3464
摘要： A surgical access device, such as a trocar, includes a pendent valve having an elongate structure extending from a proximal end to a septum valve disposed at a distal end. In operation, the elongate structure follows the angle of the instrument to pre-position the septum valve into the path of the instrument where it is not significantly challenged during instrument insertion or manipulation. The pendant valve can be made to float at both the proximal end and the distal end of the elongate structure, to further reduce the vulnerability of the septum valve. Since the valve is less vulnerable to instrument insertion, it can be formed to minimize friction and maximize the functional range of the access device.

47. 发明申请

US20050165444A1 Tissue fusion/welder apparatus corporation 有权
标题翻译：组织熔接设备公司
公开(公告)号：US20050165444A1
公开(公告)日：2005-07-28
申请号：US10504279
申请日：2003-01-16
申请人： Charles Hart , Gary Johnson , Said Hilal , John Brustad
发明人： Charles Hart , Gary Johnson , Said Hilal , John Brustad
IPC分类号： A61B17/12 , A61B20060101 , A61B17/00 , A61B17/08 , A61B17/32 , A61B18/04 , A61B18/12 , A61B18/14
CPC分类号： A61B17/12013 , A61B18/1442 , A61B18/1445 , A61B18/1477 , A61B2017/320052 , A61B2018/00404 , A61B2018/00601 , A61B2018/0063 , A61B2018/1412 , A61B2018/1425 , A61B2018/143 , A61B2018/1455
摘要： A tissue welding apparatus is adapted to fuse a first piece of tissue to a second piece of tissue which are disposed in a surface proximate relationship. An elongate shaft carries a first jaw, and a second opposing jaw moveable relative to the first jaw. At least one penetrating member is carried by the first jaw and moveable relative to the second jaw to create a channel through the first piece of material and the second piece of material. A source of heat is coupled to the penetrating member for denaturing the tissue defining the channel. This denatured tissue forms a column binding the first piece of tissue to the second piece of tissue. A chemical agent can be carried to the tissue with the penetrating member.
摘要翻译：组织焊接装置适于将第一片组织熔合到第二片组织中，所述第二片组织布置在表面邻近关系中。细长轴承载第一钳口和相对于第一钳口可移动的第二相对钳口。至少一个穿透构件由第一钳口承载并且可相对于第二钳口移动以形成穿过第一块材料和第二块材料的通道。热源耦合到穿透构件，用于使限定通道的组织变性。这种变性组织形成将第一片组织结合到第二片组织的柱。化学试剂可以用穿透构件携带到组织。

48. 发明申请

US20050159647A1 Surgical access apparatus and method 有权
公开(公告)号：US20050159647A1
公开(公告)日：2005-07-21
申请号：US11062022
申请日：2005-02-18
申请人： Charles Hart , John Brustad
发明人： Charles Hart , John Brustad
IPC分类号： A61B1/313 , A61B17/32 , A61B17/34 , A61B19/00 , A61B1/00 , A61M37/00
CPC分类号： A61B17/3417 , A61B1/3132 , A61B17/3474 , A61B90/30 , A61B2017/320044 , A61B2017/349 , A61B2090/08021 , A61B2090/373
摘要： A laparoscopic insufflation device is provided in the configuration of a coil with a blunt tip. The device is capable of passing through the abdominal wall without cutting tissue, and exiting the abdominal wall substantially parallel to the inner surface. While rotation of the coiled device results in forward movement through the abdominal wall, a counter force can be applied to the device to create a safety space between the wall and the interior organs. With the blunt distal tip, parallel exit angle, and safety space, there is substantially no threat to the interior organs during placement of the device. Further space can be generated with the use of pressured gas to produce an abdominal cavity for the subsequent placement of trocars. By rotatably attaching the coiled insufflation device to a trocar, the advantage of a counter force can be used not only to establish the safety space but also to pull the trocar into the abdominal wall with a counterforce which resists tenting.

49. 发明申请

US20050159358A1 Growth factor homolog zvegf3 有权
标题翻译：生长因子同源物zvegf3
公开(公告)号：US20050159358A1
公开(公告)日：2005-07-21
申请号：US11021088
申请日：2004-12-22
申请人： Zeren Gao , Charles Hart , Christopher Piddington , Paul Sheppard , Kimberly Shoemaker , Debra Gilbertson , James West
发明人： Zeren Gao , Charles Hart , Christopher Piddington , Paul Sheppard , Kimberly Shoemaker , Debra Gilbertson , James West
IPC分类号： A61K38/00 , A61K38/18 , C07K14/475 , C07K14/52 , C07H21/04
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译：公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。所述多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。还公开了多肽的多聚体。多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。

50. 发明申请

US20050149096A1 Catheter with conduit traversing tip 审中-公开
标题翻译：导管穿过导管
公开(公告)号：US20050149096A1
公开(公告)日：2005-07-07
申请号：US10745262
申请日：2003-12-23
申请人： Said Hilal , Matthew Petrime , Charles Hart
发明人： Said Hilal , Matthew Petrime , Charles Hart
IPC分类号： A61B17/00 , A61B17/02 , A61B17/34 , A61M25/00 , A61M25/01 , A61M29/00
CPC分类号： A61M25/0069 , A61B17/0218 , A61B17/3207 , A61B17/3478 , A61B2017/00473 , A61B2017/22094 , A61B2017/3454 , A61B2017/346 , A61M25/0068 , A61M25/01
摘要： A catheter facilitating traversal of restrictions in body conduits includes a shaft having a distal tip with a shape that is non-conical, radially twisted, and rectangular in radial cross section. An outer surface of the tip includes at least one side section extending from a blunt point radially outwardly with progressive positions proximally along an axis of the tip. The side section includes a proximal portion in proximity to the shaft, and a distal portion twisted radially with respect to the proximal portion. The catheter can be adapted for placement over a guidewire and can be made transparent thereby facilitating visualization through an endoscope in the catheter.
摘要翻译：促进身体管道中的限制的穿透的导管包括具有远侧末端的轴，其具有非圆锥形，径向扭曲并且具有径向横截面矩形的形状。尖端的外表面包括至少一个侧面部分，其从钝点径向向外延伸，并且沿着尖端的轴线向近侧延伸。侧部包括靠近轴的近侧部分和相对于近端部分径向扭转的远端部分。导管可以适于放置在导丝上并且可以制成透明的，从而便于通过导管中的内窥镜进行可视化。

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