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41. 发明授权

US06780510B2 Biocompatible adhesives 有权
标题翻译：生物相容性粘合剂
公开(公告)号：US06780510B2
公开(公告)日：2004-08-24
申请号：US10278054
申请日：2002-10-22
申请人： Matthew F. Ogle , Andrea L. McConico
发明人： Matthew F. Ogle , Andrea L. McConico
IPC分类号： B32B2738
CPC分类号： C09J163/00 , A61L24/046 , Y10T428/31511 , Y10T428/31515 , C08L63/00
摘要： Novel adhesive compositions are described that include an epoxyamine and, preferably, a curing agent. The adhesive composition can be used in surgical settings such as implanting bioprostheses and/or in manufacturing of bioprostheses. Biocompatible substrates can be adhered together by an adhesive bond formed by curing of the epoxyamine adhesive composition.
摘要翻译：描述了包括环氧胺和优选固化剂的新型粘合剂组合物。粘合剂组合物可用于手术设置，例如植入生物预处理和/或生产生物假体的制造。可通过由环氧胺粘合剂组合物的固化形成的粘合剂粘结生物相容的基材。

42. 发明申请

US20130273580A1 ELISA ASSAY KIT, ELISA FOR DETERMINING DESMOSINE LEVELS FROM URINE SAMPLES AND DIAGNOSTIC URINE ASSAYS FOR ANEURYSMS 审中-公开
标题翻译： ELISA测定试剂盒，用于测定尿液样品中的降血糖水平的ELISA和用于神经元的诊断尿液测定
公开(公告)号：US20130273580A1
公开(公告)日：2013-10-17
申请号：US13448734
申请日：2012-04-17
申请人： Barry C. Starcher , Marina A. Durward , Laurie Lynch , Matthew F. Ogle
发明人： Barry C. Starcher , Marina A. Durward , Laurie Lynch , Matthew F. Ogle
IPC分类号： G01N33/53 , G01N21/76
CPC分类号： G01N33/54306 , G01N2333/78
摘要： Improved ELISA assay formats are described that provide for effective measurement of desmosine, an elastin degradation product, in urine samples. The urine samples can be effectively introduced into the assay with little or no sample preparation. The competitive ELISA assay based on high titer polyclonal antibodies is suitable for commercial application. Desirable antibodies can be generated using desmosine bound to a protein or the like using a protein crosslinking agent. The desmosine assay are found to be useful for the diagnosis of aortic aneurysms in which desmosine levels of patients with aortic aneurysms have been found to be significantly elevated relative to a control group.
摘要翻译：描述了改进的ELISA测定形式，其提供尿液样品中去肌氨酸（一种弹性蛋白降解产物）的有效测量。可以很少或没有样品制备而将尿液样品有效地引入到测定中。基于高滴度多克隆抗体的竞争性ELISA测定适用于商业应用。使用蛋白质交联剂与蛋白质等结合的去肌苷可以产生理想的抗体。发现脊索动物测定可用于主动脉瘤的诊断，其中发现主动脉瘤患者的去氨酸水平相对于对照组显着升高。

43. 发明授权

US08206412B2 Embolic protection during percutaneous heart valve replacement and similar procedures 有权
标题翻译：经皮心脏瓣膜置换时的栓塞保护及类似手术
公开(公告)号：US08206412B2
公开(公告)日：2012-06-26
申请号：US12489108
申请日：2009-06-22
申请人： Jason A. Galdonik , Matthew F. Ogle , Edward Anderson , Mark W. I. Webster
发明人： Jason A. Galdonik , Matthew F. Ogle , Edward Anderson , Mark W. I. Webster
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61F2/01 , A61F2/24 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/008 , A61F2230/0093
摘要： Various devices are described to provide filtering of flow from the aorta to the left carotid artery and the right carotid artery. The filters can be brought into a desired position through one or more peripheral arteries. A single filter device can provide the desired filtering or a plurality of devices can be used. In particular a single filter device can span between the brachiocephalic artery and the left carotid artery. These filter devices can be used effectively to capture emboli generated during procedures on the heart so that emboli do not travel to the patient's brain where the emboli can cause a stroke or other adverse event. In particular, these filters can be used during percutaneous procedures on the heart, such as endovascular heart valve replacement.
摘要翻译：描述了各种装置以提供从主动脉到左颈动脉和右颈动脉的流动的过滤。过滤器可以通过一个或多个外周动脉进入期望的位置。单个过滤器装置可以提供期望的过滤，或者可以使用多个装置。特别地，单个过滤器装置可以跨越头臂动脉和左颈动脉之间。这些过滤装置可以有效地用于捕获在心脏手术过程中产生的栓子，以便栓塞不会到达患者的脑部，导致栓塞引起中风或其他不良事件。特别地，这些过滤器可以在心脏经皮手术期间使用，例如血管内心脏瓣膜置换。

44. 发明授权

US08123775B2 Embolism protection devices 有权
标题翻译：栓塞保护装置
公开(公告)号：US08123775B2
公开(公告)日：2012-02-28
申请号：US10806311
申请日：2004-03-22
申请人： Matthew F. Ogle
发明人： Matthew F. Ogle
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12027 , A61B17/12036 , A61B17/12109 , A61B17/12168 , A61B17/12172 , A61B17/1219 , A61F2/01 , A61F2002/016 , A61F2002/018 , A61F2230/008 , A61F2230/0091 , A61F2250/0067 , A61L31/04 , A61L31/14 , A61L2430/36
摘要： Embolism protection devices can be formed with a biocompatible expandable polymer that can expand upon release within a patient's vessel. Upon release, the structure can be configured to filter flow through the vessel. The material of the embolism protection devices can release one or more biologically active agents, such as a thrombolitic agent, including, for example, tPA. Alternatively or additionally, the embolism protection device can be connected to a tether that elutes one or more biologically active agents.
摘要翻译：栓塞保护装置可以用生物相容性可膨胀聚合物形成，其可以在患者血管内释放时膨胀。释放后，该结构可被配置成过滤通过容器的流动。栓塞保护装置的材料可以释放一种或多种生物活性剂，例如血栓栓塞剂，包括例如tPA。或者或另外，栓塞保护装置可以连接到洗脱一种或多种生物活性剂的系链。

45. 发明申请

US20110313445A1 EMBOLIC PROTECTION DURING PERCUTANEOUS HEART VALVE REPLACEMENT AND SIMILAR PROCEDURES 有权
标题翻译：超声心动图更换和类似程序期间的手术保护
公开(公告)号：US20110313445A1
公开(公告)日：2011-12-22
申请号：US13218183
申请日：2011-08-25
申请人： Jason A. Galdonik , Matthew F. Ogle , Edward Anderson , Mark W. I. Webster
发明人： Jason A. Galdonik , Matthew F. Ogle , Edward Anderson , Mark W. I. Webster
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61F2/01 , A61F2/24 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/008 , A61F2230/0093
摘要： Various devices are described to provide filtering of flow from the aorta to the left carotid artery and the right carotid artery. The filters can be brought into a desired position through one or more peripheral arteries. A single filter device can provide the desired filtering or a plurality of devices can be used. In particular a single filter device can span between the brachiocephalic artery and the left carotid artery. These filter devices can be used effectively to capture emboli generated during procedures on the heart so that emboli do not travel to the patient's brain where the emboli can cause a stroke or other adverse event. In particular, these filters can be used during percutaneous procedures on the heart, such as endovascular heart valve replacement.
摘要翻译：描述了各种装置以提供从主动脉到左颈动脉和右颈动脉的流动的过滤。过滤器可以通过一个或多个外周动脉进入期望的位置。单个过滤器装置可以提供期望的过滤，或者可以使用多个装置。特别地，单个过滤器装置可以跨越头臂动脉和左颈动脉之间。这些过滤装置可以有效地用于捕获在心脏手术过程中产生的栓子，以便栓塞不会到达患者的脑部，导致栓塞引起中风或其他不良事件。特别地，这些过滤器可以在心脏经皮手术期间使用，例如血管内心脏瓣膜置换。

46. 发明授权

US07976516B2 Medical device having mechanically interlocked segments 有权
标题翻译：具有机械互锁段的医疗装置
公开(公告)号：US07976516B2
公开(公告)日：2011-07-12
申请号：US11157476
申请日：2005-06-21
申请人： Jason A. Galdonik , James Pokorney , Matthew F. Ogle
发明人： Jason A. Galdonik , James Pokorney , Matthew F. Ogle
IPC分类号： A61M5/00
CPC分类号： A61M25/0905 , A61B2017/00477
摘要： A biocompatible medical device having a segmented element including a first segment having a first shaped interface and a second segment having a second shaped interface configured to operably couple the first shaped interface. When the first shaped interface is engaging the second shaped interface to form a joined segmented element, the first segment and the second segment cannot be decoupled by movement along an axis through the element. The medical device further includes a locking element configured to engage the joined segmented element with a sliding motion to prevent decoupling of the first segment with respect to the second segment by preventing significant relative movement of the segments with a component of the movement perpendicular to the axis.
摘要翻译：一种具有分段元件的生物相容性医疗装置，其包括具有第一形状界面的第一区段和具有构造成可操作地连接第一成形界面的第二形状界面的第二区段。当第一形状界面接合第二形状界面以形成连接的分段元件时，第一段和第二段不能通过沿着穿过该元件的轴的移动来解耦。该医疗装置还包括锁定元件，该锁定元件构造成以滑动运动与接合的分段元件接合，以防止第一段相对于第二段解耦，这是通过阻止具有垂直于该轴线的运动分量的段的显着相对运动。

47. 发明申请

US20110081423A1 Tissue Stabilization for Heart Failure 有权
标题翻译：组织稳定心力衰竭
公开(公告)号：US20110081423A1
公开(公告)日：2011-04-07
申请号：US12845414
申请日：2010-07-28
申请人： Norman R. Weldon , Matthew F. Ogle
发明人： Norman R. Weldon , Matthew F. Ogle
IPC分类号： A61K31/353 , A61K31/7034 , A61K36/63 , A61K36/00 , A61K36/82 , A61K36/484 , A61K36/886 , A61K35/56 , A61K31/11 , A61K31/13 , A61K31/336 , A61K31/655 , A61P9/04 , A61P9/00 , A61M25/00 , B82Y5/00
CPC分类号： A61M25/00 , A61L27/227 , A61L27/24 , A61L27/54 , A61L2300/252 , A61L2430/20
摘要： Methods and devices for the stabilization of heart tissue to treat congestive heart failure using a therapeutic composition are discussed. The therapeutic composition can comprise an elastin stabilization agent, a collagen stabilization agent, or a combination thereof and be applied to the pericardium, to the outer surface of the myocardium, or a combination thereof using a catheter type of device with an attached reservoir. Controlled placement and release of the therapeutic composition can be achieved using a delivery vehicle to formulate the composition.
摘要翻译：讨论了使用治疗组合物稳定心脏组织以治疗充血性心力衰竭的方法和装置。治疗组合物可以包括弹性蛋白稳定剂，胶原稳定剂或其组合，并且使用具有连接的储存器的导管型装置将其施加到心包的外表面或其组合。治疗组合物的控制放置和释放可以使用递送载体来制备组合物来实现。

48. 发明授权

US07879067B2 Fiber based embolism protection device 有权
公开(公告)号：US07879067B2
公开(公告)日：2011-02-01
申请号：US11865891
申请日：2007-10-02
申请人： Jason A. Galdonik , Matthew F. Ogle , Jim Pokorney , Thomas F. Hinnenkamp
发明人： Jason A. Galdonik , Matthew F. Ogle , Jim Pokorney , Thomas F. Hinnenkamp
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2/013 , A61F2230/0006 , A61F2230/005 , A61M25/09 , A61M2025/09175 , B33Y80/00
摘要： Improved embolism protection devices comprises fibers that can have one configuration for delivery of the device and a second configuration in which the device is deployed for filtering of flow within a vessel. In some embodiments, the fibers can be connected to a fiber support, which is connected to an actuating element. The actuating element controls the transition from the delivery configuration to the deployed configuration. The embolism protection device can comprise a guidewire. The fibers can be attached at one end to a fiber support structure and at another end to the guidewire. A hypotube can be attached to the proximal end of the fibers while the guidewire is attached at the distal end of the fibers with the guidewire extending within a central channel of the hypotube. The hypotube can be used to guide the delivery of treatment structures, such as a balloon and/or a stent.

49. 发明申请

US20100119605A1 COMPOSITIONS FOR TISSUE STABILIZATION 审中-公开
标题翻译：用于组织稳定的组合物
公开(公告)号：US20100119605A1
公开(公告)日：2010-05-13
申请号：US12617322
申请日：2009-11-12
申请人： Jason C. Isenburg , Matthew F. Ogle
发明人： Jason C. Isenburg , Matthew F. Ogle
IPC分类号： A61K31/11 , A61K9/00 , A61P9/00 , A61K31/13
CPC分类号： A61K31/11 , A61K31/13 , A61K36/185 , A61K36/484 , A61K36/63 , A61K36/82 , A61K36/886 , A61L27/507 , A61L27/54 , A61L31/16 , A61L2300/624 , A61K2300/00
摘要： Collagen crosslinking/stabilization composition optionally in combination with elastin crosslinking composition as treatment of vascular aneurysms, methods of using the compositions, especially with respect to in vivo procedures are described. The treatment is achieved through the delivery of an effective amount of crosslinking/stabilization composition to the site of the aneurysm. The crosslinking/stabilization agent may be embedded in a delivery composition and delivered to the site of aneurysm using a delivery device. The site of the aneurysm may be isolated for treatment using the delivery device. The elastin stabilization agent may be simultaneously or sequentially delivered with the collagen crosslinking/stabilization agent for the treatment of vascular aneurysms in the isolated section of blood vessel.
摘要翻译：描述了任选地与作为血管动脉瘤治疗的弹性蛋白交联组合物组合的胶原交联/稳定化组合物，特别是关于体内程序的方法。通过将有效量的交联/稳定化组合物递送到动脉瘤部位来实现治疗。交联/稳定剂可以嵌入到递送组合物中并使用递送装置递送到动脉瘤部位。可以使用输送装置隔离动脉瘤部位进行治疗。弹性蛋白稳定剂可以与胶原交联/稳定剂同时或依次递送，用于在血管的隔离部分治疗血管动脉瘤。

50. 发明申请

US20090326575A1 Embolic protection during percutaneous heart valve replacement and similar procedures 有权
标题翻译：经皮心脏瓣膜置换时的栓塞保护及类似手术
公开(公告)号：US20090326575A1
公开(公告)日：2009-12-31
申请号：US12489108
申请日：2009-06-22
申请人： Jason A. Galdonik , Matthew F. Ogle , Edward Anderson , Mark W.I. Webster
发明人： Jason A. Galdonik , Matthew F. Ogle , Edward Anderson , Mark W.I. Webster
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61F2/01 , A61F2/24 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/008 , A61F2230/0093
摘要： Various devices are described to provide filtering of flow from the aorta to the left carotid artery and the right carotid artery. The filters can be brought into a desired position through one or more peripheral arteries. A single filter device can provide the desired filtering or a plurality of devices can be used. In particular a single filter device can span between the brachiocephalic artery and the left carotid artery. These filter devices can be used effectively to capture emboli generated during procedures on the heart so that emboli do not travel to the patient's brain where the emboli can cause a stroke or other adverse event. In particular, these filters can be used during percutaneous procedures on the heart, such as endovascular heart valve replacement.
摘要翻译：描述了各种装置以提供从主动脉到左颈动脉和右颈动脉的流动的过滤。过滤器可以通过一个或多个外周动脉进入期望的位置。单个过滤器装置可以提供期望的过滤，或者可以使用多个装置。特别地，单个过滤器装置可以跨越头臂动脉和左颈动脉之间。这些过滤装置可以有效地用于捕获在心脏手术过程中产生的栓子，以便栓塞不会到达患者的脑部，导致栓塞引起中风或其他不良事件。特别地，这些过滤器可以在心脏经皮手术期间使用，例如血管内心脏瓣膜置换。

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