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41. 发明授权

US08580790B2 (Heterocycle/condensed piperidine)-(piperazinyl)-1-alkanone or (heterocycle/condensed pyrrolidine)-(piperazinyl)-1-alkanone derivatives and use thereof as p75 inhibitors 有权
公开(公告)号：US08580790B2
公开(公告)日：2013-11-12
申请号：US13490904
申请日：2012-06-07
申请人： Marco Baroni , Francoise Bono , Sandrine Delbary-Gossart , Valentina Vercesi
发明人： Marco Baroni , Francoise Bono , Sandrine Delbary-Gossart , Valentina Vercesi
IPC分类号： A61K31/50 , A61K31/501
CPC分类号： C07D487/08 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The disclosure relates to (heterocycle-fused piperidine)-(piperazinyl)-1-alkanone derivatives and (heterocycle-fused pyrrolidine)-(piperazinyl)-1-alkanone derivatives of formula (I): wherein A, W, R2 and n are as defined in the disclosure, to the method of preparation thereof and the therapeutic use thereof.

42. 发明授权

US08519143B2 Derivatives of (bridged piperazinyl)-1-alkanone and use thereof as p75 inhibitors 有权
标题翻译：（桥连哌嗪基）-1-烷酮的衍生物及其作为p75抑制剂的用途
公开(公告)号：US08519143B2
公开(公告)日：2013-08-27
申请号：US13473885
申请日：2012-05-17
申请人： Marco Baroni , Francoise Bono , Sandrine Delbary-Gossart
发明人： Marco Baroni , Francoise Bono , Sandrine Delbary-Gossart
IPC分类号： C07D211/70
CPC分类号： C07D471/08
摘要： The present invention relates to derivatives of ((phenyl)-3,6-dihydropyridin-1-yl)(bridged piperazinyl)-1-alkanone derivatives and ((phenyl)-2,5-dihydropyrrol-1-yl) (bridged piperazinyl)-1-alkanone corresponding to Formula (I): in which the variables are as defined herein, to the preparation thereof and to the therapeutic use thereof.
摘要翻译：本发明涉及（（苯基）-3,6-二氢吡啶-1-基）（桥连哌嗪基）-1-烷酮衍生物和（（苯基）-2,5-二氢吡咯-1-基）（桥接哌嗪基）-1-烷基酮对应于式（I）：其中变量如本文所定义，其制备及其治疗用途。

43. 发明授权

US08256473B2 Supporting and weighing device for containers 有权
标题翻译：集装箱支架和称重装置
公开(公告)号：US08256473B2
公开(公告)日：2012-09-04
申请号：US12223191
申请日：2007-02-13
申请人： Gianpietro Zanini , Marco Baroni
发明人： Gianpietro Zanini , Marco Baroni
IPC分类号： B65B1/30
CPC分类号： B65B3/28 , B65B1/32 , B67C3/007 , B67C3/202 , G01G17/04
摘要： A container supplied to a carousel type filling unit is directed onto a supporting and weighing device (1) that presents a hollow body (12) attached to the carousel and housing a load cell. The hollow body (12) is equipped with a pedestal (19) presenting a platform (20) on which to stand the container, and a connecting element (21) of which a first end (21a) is coupled with the load cell internally of the hollow body (12) and a second end (21b), opposite to the first end (21a), is secured to the platform (20). To advantage, the first end (21a) of the connecting element (21) is seated in a through opening (13) afforded by the underside of the hollow body (12).
摘要翻译：提供给转盘式填充单元的容器被引导到支撑和称重装置（1）上，该装置（1）呈现附接到转盘上的中空体（12）并容纳测力传感器。中空体（12）配备有一个具有平台（20）的基座（19），在该平台上搁置容器，连接元件（21）的第一端（21a）与负载单元中空体（12）和与第一端（21a）相对的第二端（21b）固定在平台（20）上。有利的是，连接元件（21）的第一端（21a）位于由中空体（12）的下侧提供的通孔（13）中。

44. 发明授权

US08247404B2 Derivatives of 2-oxoalkyl-1-piperazin-2-one, preparation method thereof and therapeutic use of same 有权
标题翻译： 2-氧代烷基-1-哌嗪-2-酮的衍生物及其制备方法及其治疗用途
公开(公告)号：US08247404B2
公开(公告)日：2012-08-21
申请号：US12966408
申请日：2010-12-13
申请人： Marco Baroni , Francoise Bono , Sandrine Delbary-Gossart
发明人： Marco Baroni , Francoise Bono , Sandrine Delbary-Gossart
IPC分类号： A61K31/497 , A61K31/55 , A01N43/00 , C07D401/00 , C07D213/44 , C07D295/00
CPC分类号： C07D401/14
摘要： The present invention relates to derivatives of 4-{2-[phenyl-3,6-dihydropyridin-1-yl]-2-oxoalkyl}-1-piperazin-2-one and 4-{2-[phenyl-2,5-dihydropyrrol-1-yl]-2-oxoalkyl}-1-piperazin-2-one having general formula (I): in which A, B, m, R3 and n are as defined herein. The invention also relates to the preparation thereof and to the therapeutic use thereof.
摘要翻译：本发明涉及4- {2- [苯基-3,6-二氢吡啶-1-基] -2-氧代烷基} -1-哌嗪-2-酮和4- {2- [苯基-2,5 - 二氢吡咯-1-基] -2-氧代烷基} -1-哌嗪-2-酮，其中A，B，m，R 3和n如本文所定义。本发明还涉及其制备及其治疗用途。

45. 发明授权

US07186720B2 Tetrahydropyridyl-alkyl-heterocycles, method for preparing the same and pharmaceutical compositions containing the same 失效
标题翻译：四氢吡啶基 - 烷基 - 杂环，其制备方法和含有它们的药物组合物
公开(公告)号：US07186720B2
公开(公告)日：2007-03-06
申请号：US10475460
申请日：2002-04-19
申请人： Marco Baroni , Bernard Bourrie , Pierre Casellas
发明人： Marco Baroni , Bernard Bourrie , Pierre Casellas
IPC分类号： A61K31/498 , A61K31/502 , A61K31/4709 , A61K31/4439 , C07D401/06 , C07D401/14
CPC分类号： C07D401/06 , C07D401/14
摘要： The present invention relates to compounds of formula (I): in which X represents N or CH; R1 represents a hydrogen or halogen atom or a CF3 group; R2 and R3 independently represent a hydrogen atom or a methyl group; n is 0 or 1; A represents an optionally substituted nitrogenous heterocycle; and to their N-oxides and to their salts or solvates, to the pharmaceutical compositions and the medicaments comprising them, and to a process for their preparation.
摘要翻译：本发明涉及式（I）化合物：其中X表示N或CH; R 1表示氢或卤素原子或CF 3 N 3基团; R 2和R 3独立地表示氢原子或甲基; n为0或1; A表示任选取代的含氮杂环; 以及它们的N-氧化物及其盐或溶剂化物，涉及药物组合物和包含它们的药物及其制备方法。

46. 发明申请

US20050209216A1 Phenyl-and pyridyl-diazaheterocycles having a tnf-modulating activity 审中-公开
标题翻译：具有tnf调节活性的苯基和吡啶基 - 二氮杂环
公开(公告)号：US20050209216A1
公开(公告)日：2005-09-22
申请号：US10518652
申请日：2003-06-16
申请人： Marco Baroni , Bernard Bourrie , Pierre Casellas
发明人： Marco Baroni , Bernard Bourrie , Pierre Casellas
IPC分类号： A61K31/497 , A61K31/55 , A61K31/551 , A61P1/04 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P19/02 , A61P19/06 , A61P19/08 , A61P19/10 , A61P25/04 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/06 , A61P31/10 , A61P31/12 , A61P33/06 , A61P35/00 , A61P37/00 , A61P37/04 , A61P43/00 , C07D215/04 , C07D217/02 , C07D241/08 , C07D401/06 , C07D401/12 , C07D401/14 , C07D487/04 , A61K31/495 , A61K31/496 , C07D43/02
CPC分类号： C07D215/04 , C07D217/02 , C07D241/08 , C07D401/06 , C07D401/14
摘要： The present invention relates to compounds of formula (I): in which X represents N or CH; R1 represents a hydrogen or halogen atom or a CF3 group; W represents a diazoheterocycle; R2 and R3 independently represent a hydrogen atom or a methyl group; n is 0 or 1; A represents a quinoline or an isoquinoline which are optionally substituted.
摘要翻译：本发明涉及式（I）化合物：其中X表示N或CH; R 1表示氢或卤素原子或CF 3 N 3基团; W代表重氮杂环; R 2和R 3独立地表示氢原子或甲基; n为0或1; A代表任选取代的喹啉或异喹啉。

47. 发明授权

US5488151A {(7S)-7-[(2R )-2-(3-chlorophenyl)-2-hydroxyethylamino)-2-hydroxyethylamino]5,} acetic acid and its pharmaceutically acceptable salts 失效
标题翻译： {（7S）-7 - [（2R）-2-（3-氯苯基）-2-羟乙基氨基）-2-羟乙基氨基] 5,6,7,8-四氢萘-2-基氧基}乙酸及其药学上可接受的盐
公开(公告)号：US5488151A
公开(公告)日：1996-01-30
申请号：US250830
申请日：1994-05-31
申请人： Marco Baroni , Roberto Cecchi , Tiziano Croci
发明人： Marco Baroni , Roberto Cecchi , Tiziano Croci
IPC分类号： A61K31/19 , A61P1/04 , A61P3/04 , A61P25/24 , A61P25/26 , A61P27/02 , C07C217/54 , C07C217/62 , C07C217/74 , C07C229/40
CPC分类号： C07C217/54 , C07C217/62 , C07C2102/10
摘要： The present invention relates to the novel compound {(7S)-7-[(2R)-2-(3-chlorophenyl)-2-hydroxyethylamino]-5,6,7,8-tetrahydronaphthalen-2-yloxy}acetic acid of formula (I): ##STR1## and its pharmaceutically acceptable salts, which act as .beta..sub.3 -adrenergic agonists, and to the pharmaceutical compositions and laboratory reagents in which it is present.
摘要翻译：本发明涉及新的化合物{（7S）-7 - [（2R）-2-（3-氯苯基）-2-羟乙基氨基] -5,6,7,8-四氢萘-2-基氧基}乙酸式（I）：其作为β3-肾上腺素能激动剂的药学上可接受的盐及其存在于其中的药物组合物和实验室试剂。

48. 发明授权

US08458992B2 Capping machine 有权
标题翻译：封盖机
公开(公告)号：US08458992B2
公开(公告)日：2013-06-11
申请号：US12671156
申请日：2008-07-30
申请人： Gianpietro Zanini , Marco Baroni
发明人： Gianpietro Zanini , Marco Baroni
IPC分类号： B67B3/20
CPC分类号： B67B3/22 , B67B3/2033
摘要： Containers are closed with screw caps by a carousel machine of which a central drum (31) is rotatable about a vertical axis (A) and carries a set of capping units (36) equipped with respective capping heads (37), each presenting a gripper (38) by which the cap (3) is held, and a mechanism (66) by which the hinged jaws (39) of the gripper (38) are opened and closed; each capping head (37) is capable of axial motion induced by components incorporated into the relative unit (36), which are guided axially in their movements and supported by auxiliary components (40; 49, 50) associated rigidly with the central drum (31).
摘要翻译：容器用圆盘传送带封闭，中心鼓（31）围绕垂直轴线（A）旋转，并传送一套装有各自的封盖头（37）的封盖单元（36）（38），其中保持盖（3），以及机构（66），夹持器（38）的铰接爪（39）通过该机构打开和关闭; 每个封盖头（37）能够由结合到所述相关单元（36）中的部件引起的轴向运动，所述部件在其运动中被轴向引导并由与中心鼓（31）刚性关联的辅助部件（40; 49,50）支撑）。

49. 发明授权

US08375682B2 Gripping apparatus for capping assemblies in container packaging machines 失效
标题翻译：用于容器包装机中封盖组件的夹持装置
公开(公告)号：US08375682B2
公开(公告)日：2013-02-19
申请号：US12671136
申请日：2008-07-30
申请人： Gianpietro Zanini , Marco Baroni
发明人： Gianpietro Zanini , Marco Baroni
IPC分类号： B67B3/20
CPC分类号： B65B7/2835 , B65B59/04 , B67B3/2066 , B67B2201/10
摘要： Capping assemblies (2) of the type fitted to capping units (1a) in a machine for packaging containers filled with fluid or powdered products are equipped with a gripping apparatus (1) comprising a gripper (4) with three arms (5), each carrying an adapter (20) furnished with a pad (20b) offered in direct contact to the cap, through which the gripping action is applied. Each adapter (20) is secured to a fitting (17, 18) insertable into a socket (16) afforded by the bottom of a structural member (6) that forms the main part of each arm (5) and is hinged to the movable head of a relative capping assembly (2); when inserted into the structural member (6), the fitting (17, 18) is retained automatically by a snap lock mechanism (12) incorporated into the arm (5), which can be released subsequently by introducing the tip of a screwdriver into a slot (18a) created in the side of the fitting (17, 18) and levering the components apart.
摘要翻译：在装有流体或粉末产品的容器的包装容器的机器中安装有封盖装置（1a）的类型的封盖组件（2）装备有夹持装置（1），其包括具有三个臂（5）的夹持器（5）携带适配器（20），所述适配器（20）配备有直接接触盖的提供的垫（20b），通过该适配器施加夹紧动作。每个适配器（20）被固定到可插入由形成每个臂（5）的主要部分的结构构件（6）的底部提供的插座（16）中的配件（17,18），并且铰接到可移动的相对封盖组件（2）的头部; 当插入到结构构件（6）中时，配件（17,18）由结合到臂（5）中的卡扣锁定机构（12）自动保持，随后可以通过将螺丝刀的尖端引入到臂在所述配件（17,18）的侧面中形成并且将所述部件分开的槽（18a）。

50. 发明授权

US08202871B2 Indol-2-one derivatives disubstituted in the 3-position, preparation thereof and therapeutic use thereof 有权
标题翻译： 3-位上二取代的吲哚-2-酮衍生物及其治疗用途
公开(公告)号：US08202871B2
公开(公告)日：2012-06-19
申请号：US13012321
申请日：2011-01-24
申请人： Marco Baroni , Letizia Puleo
发明人： Marco Baroni , Letizia Puleo
IPC分类号： A61K31/496 , A61K31/454 , A61K31/4439 , C07D209/40 , C07D401/12 , C07D401/14 , C07D405/04 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/141
CPC分类号： C07D209/40 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The present application discloses compounds of the formula: and pharmaceutical compositions containing same and their use for treating and preventing various pathologies, including obesity, appetite disorders, excess weight and diabetes.
摘要翻译：本申请公开了下式的化合物：和含有它们的药物组合物及其用于治疗和预防各种病症的用途，包括肥胖症，食欲障碍，超重和糖尿病。

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