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41. 发明授权

US09510779B2 Analyte monitoring using one or more accelerometers 有权
标题翻译：使用一个或多个加速度计进行分析物监测
公开(公告)号：US09510779B2
公开(公告)日：2016-12-06
申请号：US12883770
申请日：2010-09-16
申请人： Jeroen Poeze , Johannes Bruinsma , Marcelo Lamego
发明人： Jeroen Poeze , Johannes Bruinsma , Marcelo Lamego
IPC分类号： A61B6/00 , A61B5/145 , A61B5/1455 , A61B5/00
CPC分类号： A61B5/14532 , A61B5/14551 , A61B5/6838 , A61B2562/0219 , A61B2562/0233
摘要： The present disclosure relates to methods, devices, and systems for measuring a blood analyte, such as glucose. The disclosure relates more specifically to the use in such methods, devices, and systems of one or more accelerometers to aid in the collection of data, operation of the device, filtering, and other uses. In some embodiments, the accelerometers are three-dimensional accelerometers. An accelerometer can be used in conjunction with analyte monitoring that may be performed with infrared, near infrared, or other wavelength spectroscopy. The accelerometer may allow a monitoring instrument to expect noisy measurement data, indicate positioning of a measurement site for improved expected results, indicate position of the instrument, or help the user properly place or control the instrument. It may also improve analyte monitoring by providing motion information that can be used to help determine and reduce or remove movement-related signal artifacts or noise that may be present within the monitoring signal.
摘要翻译：本公开涉及用于测量诸如葡萄糖的血液分析物的方法，装置和系统。本公开更具体地涉及在一个或多个加速度计的这种方法，设备和系统中的使用，以帮助数据的收集，设备的操作，过滤和其它用途。在一些实施例中，加速度计是三维加速度计。加速度计可以与可以用红外线，近红外或其他波长光谱法进行的分析物监测结合使用。加速度计可以允许监测仪器期望噪声测量数据，指示测量位置的定位以改善预期结果，指示仪器的位置，或帮助用户正确地放置或控制仪器。它还可以通过提供运动信息来改善分析物监测，运动信息可用于帮助确定和减少或消除可能存在于监测信号内的运动相关信号伪影或噪声。

42. 发明授权

US08740792B1 Patient monitor capable of accounting for environmental conditions 有权
标题翻译：患者监护仪能够考虑环境条件
公开(公告)号：US08740792B1
公开(公告)日：2014-06-03
申请号：US13179017
申请日：2011-07-08
申请人： Massi Joe E. Kiani , Marcelo Lamego , Michael O'Reilly
发明人： Massi Joe E. Kiani , Marcelo Lamego , Michael O'Reilly
IPC分类号： A61B5/00
CPC分类号： A61B5/7296 , A61B5/01 , A61B5/1112 , A61B5/14551 , A61B5/6815 , A61B5/6825 , A61B5/6826 , A61B5/6829
摘要： A patient monitoring system includes a sensor, a patient monitor and an environmental conditions module. The patient monitor receives signals indicative of measurements of physiological parameters from the sensor, as well as data indicative of one or more environmental conditions from the environmental conditions module. The patient monitor determines one or more measurements of one or more physiological parameters based on the signals received from the sensor and the data indicative of one or more environmental conditions.
摘要翻译：患者监测系统包括传感器，患者监护仪和环境条件模块。病人监护仪从传感器接收指示生理参数测量的信号，以及指示环境条件模块的一个或多个环境条件的数据。患者监视器基于从传感器接收的信号和指示一个或多个环境条件的数据来确定一个或多个生理参数的一个或多个测量值。

43. 发明授权

US08630691B2 Multi-stream sensor front ends for noninvasive measurement of blood constituents 有权
标题翻译：多流传感器前端用于无创测量血液成分
公开(公告)号：US08630691B2
公开(公告)日：2014-01-14
申请号：US12534812
申请日：2009-08-03
申请人： Marcelo Lamego , Sean Merritt , Cristiano Dalvi , Hung Vo , Johannes Bruinsma , Jeroen Poeze , Ferdyan Lesmana , Massi Joe E. Kiani
发明人： Marcelo Lamego , Sean Merritt , Cristiano Dalvi , Hung Vo , Johannes Bruinsma , Jeroen Poeze , Ferdyan Lesmana , Massi Joe E. Kiani
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/14552 , A61B5/6816 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61B5/6843 , A61B2562/0233 , A61B2562/04 , A61B2562/046 , A61B2562/146
摘要： The present disclosure relates to an interface for a noninvasive glucose sensor that comprises a front-end adapted to receive an input signals from optical detectors and provide corresponding digital signals. In one embodiment, the front-end comprises switched capacitor circuits that are capable of handling multiple streams signals from the optical detectors. In another embodiment, the front-end comprises transimpedance amplifiers that are capable of handling multiple streams of input signals. In this embodiment, the transimpedance amplifier may be configured based on its own characteristics, such as its impedance, the impedance of the photodiodes to which it is coupled, and the number of photodiodes to which it is coupled.
摘要翻译：本公开涉及一种用于非侵入式葡萄糖传感器的接口，其包括适于接收来自光学检测器的输入信号并提供相应数字信号的前端。在一个实施例中，前端包括能够处理来自光学检测器的多个流信号的开关电容器电路。在另一个实施例中，前端包括能够处理多个输入信号流的跨阻放大器。在该实施例中，跨阻抗放大器可以基于其自身的特性，例如其阻抗，与其耦合的光电二极管的阻抗以及与其耦合的光电二极管的数量来配置。

44. 发明申请

US20110218816A1 SPOT CHECK MONITOR CREDIT SYSTEM 有权
标题翻译： SPOT检查监视器信用系统
公开(公告)号：US20110218816A1
公开(公告)日：2011-09-08
申请号：US13110833
申请日：2011-05-18
申请人： Gregory A. Olsen , Marcelo Lamego , Cristiano Dalvi , Johannes Bruinsma , Jeroen Poeze , Massi Joe E. Kiani
发明人： Gregory A. Olsen , Marcelo Lamego , Cristiano Dalvi , Johannes Bruinsma , Jeroen Poeze , Massi Joe E. Kiani
IPC分类号： G06Q50/00 , G06Q10/00 , H04B10/04
CPC分类号： A61B5/14551 , A61B5/6826 , A61B5/6838 , G06Q40/00 , G06Q50/22
摘要： A spot check credit system advantageously includes various embodiments for obtaining authorization or payment for each measurement, groups of measurements, times of measurement or the like. In an embodiment, the system utilizes a server that communicates web pages over a computer network. In an embodiment, the system utilizes a digital communication device such as a photocommunicative key.
摘要翻译：现金支票信用系统有利地包括用于获得每次测量的授权或支付，测量组，测量次数等的各种实施例。在一个实施例中，系统利用通过计算机网络传送网页的服务器。在一个实施例中，该系统利用数字通信设备，例如光通信密钥。

45. 发明申请

US20110004082A1 MULTI-STREAM DATA COLLECTION SYSTEM FOR NONINVASIVE MEASUREMENT OF BLOOD CONSTITUENTS 有权
标题翻译：多流量数据采集系统用于非血液测量血液成分
公开(公告)号：US20110004082A1
公开(公告)日：2011-01-06
申请号：US12829352
申请日：2010-07-01
申请人： Jeroen Poeze , Marcelo Lamego , Sean Merritt , Cristiano Dalvi , Hung Vo , Johannes Bruinsma , Ferdyan Lesmana , Massi Joe E. Kiani
发明人： Jeroen Poeze , Marcelo Lamego , Sean Merritt , Cristiano Dalvi , Hung Vo , Johannes Bruinsma , Ferdyan Lesmana , Massi Joe E. Kiani
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/14552 , A61B5/6816 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61B5/6843 , A61B2562/0233 , A61B2562/04 , A61B2562/046 , A61B2562/146
摘要： The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.
摘要翻译：本公开涉及用于测量各种血液成分或分析物（例如葡萄糖）的非侵入性方法，装置和系统。在一个实施例中，光源包括LED和超发光LED。光源发射至少约1610nm，约1640nm和约1665nm的波长的光。在一个实施例中，检测器包括以特殊几何形状布置的多个光电检测器，其包括基本上线性的基本相等的间隔几何形状，基本上线性的基本上不等间隔的几何形状以及基本上网格的几何形状。

46. 发明授权

US08688183B2 Emitter driver for noninvasive patient monitor 有权
标题翻译：用于无创患者监护仪的发射器驱动器
公开(公告)号：US08688183B2
公开(公告)日：2014-04-01
申请号：US12875062
申请日：2010-09-02
申请人： Johannes Bruinsma , Cristiano Dalvi , Marcelo Lamego
发明人： Johannes Bruinsma , Cristiano Dalvi , Marcelo Lamego
IPC分类号： A61B5/00
CPC分类号： A61B5/14552 , A61B5/0059 , A61B5/6826 , A61B2560/045 , A61B2562/0233 , A61B2562/046 , A61B2562/222
摘要： Embodiments of the present disclosure include an emitter driver configured to be capable of addressing substantially 2N nodes with N cable conductors configured to carry activation instructions from a processor. In an embodiment, an address controller outputs an activation instruction to a latch decoder configured to supply switch controls to activate particular LEDs of a light source.
摘要翻译：本公开的实施例包括发射器驱动器，其被配置为能够寻址基本2N个节点，其中N个电缆导体被配置为携带来自处理器的激活指令。在一个实施例中，地址控制器向配置成提供开关控制以激活光源的特定LED的锁存解码器输出激活指令。

47. 发明授权

US08515509B2 Multi-stream emitter for noninvasive measurement of blood constituents 有权
标题翻译：用于非侵入性测量血液成分的多流发射器
公开(公告)号：US08515509B2
公开(公告)日：2013-08-20
申请号：US12534825
申请日：2009-08-03
申请人： Johannes Bruinsma , Marcelo Lamego , Sean Merritt , Cristiano Dalvi , Hung Vo , Jeroen Poeze , Ferdyan Lesmana , Massi Joe E. Kiani
发明人： Johannes Bruinsma , Marcelo Lamego , Sean Merritt , Cristiano Dalvi , Hung Vo , Jeroen Poeze , Ferdyan Lesmana , Massi Joe E. Kiani
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/14552 , A61B5/6816 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61B5/6843 , A61B2562/0233 , A61B2562/04 , A61B2562/046 , A61B2562/146
摘要： The present disclosure relates to an emitter that is suitable for a noninvasive blood constituent sensor. The emitter is configured as a point optical source that comprises a plurality of LEDs that emit a sequence of pulses of optical radiation across a spectrum of wavelengths. In some embodiments, the plurality of sets of optical sources may each comprise at least one top-emitting LED and at least one super luminescent LED. In some embodiments, the emitter comprises optical sources that transmit optical radiation in the infrared or near-infrared wavelengths suitable for detecting glucose. In order to achieve the desired SNR for detecting analytes like glucose, the emitter may be driven using a progression from low power to higher power. In addition, the emitter may have its duty cycle modified to achieve a desired SNR.
摘要翻译：本发明涉及适用于无创血液成分传感器的发射器。发射器被配置为点光源，其包括发射穿过波长频谱的光辐射的脉冲序列的多个LED。在一些实施例中，多组光源可以各自包括至少一个顶部发射LED和至少一个超级发光LED。在一些实施例中，发射器包括透射适合于检测葡萄糖的红外或近红外波长的光辐射的光源。为了实现用于检测诸如葡萄糖的分析物的期望的SNR，可以使用从低功率到较高功率的进程来驱动发射器。此外，发射器可以修改其占空比以实现期望的SNR。

48. 发明授权

US08471713B2 Interference detector for patient monitor 有权
标题翻译：用于病人监护仪的干扰检测器
公开(公告)号：US08471713B2
公开(公告)日：2013-06-25
申请号：US12841965
申请日：2010-07-22
申请人： Jeroen Poeze , Jesse Chen , Mathew Paul , Marcelo Lamego , Massi Joe E. Kiani
发明人： Jeroen Poeze , Jesse Chen , Mathew Paul , Marcelo Lamego , Massi Joe E. Kiani
IPC分类号： G08B23/00
CPC分类号： G01R13/0281 , A61B5/0015 , A61B5/0261 , A61B5/14532 , A61B5/14551 , A61B5/7203 , A61B5/7228 , A61B2560/0242 , A61B2560/0276 , G01R29/0814
摘要： A system is disclosed for detecting and calculating the level of ambient and/or environmental noise, such as electromagnetic interference generated by electric power lines, ambient lights, light dimmers, television or computer displays, power supplies or transformers, and medical equipment. In some embodiments, the system performs frequency analysis on the interference signal detected by light photodetectors and determines the power of the interference signal concentrated in the analyzed frequency bands. The worst-case interference level can be determined by selecting the maximum from the computed power values. In some embodiments, the determined interference signal power can be compared with the noise tolerance of a patient monitoring system configured to reliably and non-invasively detect physiological parameters of a user. The results of the comparison can be presented to the user audio-visually. In some embodiments, the system can be used to perform spot check measurements of electromagnetic interference.
摘要翻译：公开了一种用于检测和计算环境和/或环境噪声的水平的系统，例如由电力线，环境光，光调光器，电视或计算机显示器，电源或变压器和医疗设备产生的电磁干扰。在一些实施例中，系统对由光检测器检测到的干扰信号进行频率分析，并确定集中在分析频带中的干扰信号的功率。最坏情况的干扰电平可以通过从计算的功率值中选择最大值来确定。在一些实施例中，所确定的干扰信号功率可以与被配置为可靠且非侵入地检测用户的生理参数的患者监视系统的噪声容限进行比较。比较的结果可以直观地呈现给用户。在一些实施例中，该系统可用于执行电磁干扰的抽查检查测量。

49. 发明申请

US20130046204A1 MODULATED PHYSIOLOGICAL SENSOR 有权
标题翻译：调制生理传感器
公开(公告)号：US20130046204A1
公开(公告)日：2013-02-21
申请号：US13584447
申请日：2012-08-13
申请人： Marcelo Lamego , Cristiano Dalvi , Hung Vo
发明人： Marcelo Lamego , Cristiano Dalvi , Hung Vo
IPC分类号： A61B5/11 , A61B7/00
CPC分类号： A61B5/0051 , A61B5/4884 , A61B5/6843 , A61B2562/0219
摘要： A modulated physiological sensor is a noninvasive device responsive to a physiological reaction of a living being to an internal or external perturbation that propagates to a skin surface area. The modulated physiological sensor has a detector configured to generate a signal responsive to the physiological reaction. A modulator varies the coupling of the detector to the skin so as to at least intermittently maximize the detector signal. A monitor controls the modulator and receives an effectively amplified detector signal, which is processed to calculate a physiological parameter indicative of the physiological reaction.
摘要翻译：调制的生理传感器是响应于生物体向传播到皮肤表面区域的内部或外部扰动的生理反应的非侵入性装置。经调制的生理传感器具有检测器，其被配置为产生响应生理反应的信号。调制器改变检测器与皮肤的耦合，以便至少间歇地使检测器信号最大化。监视器控制调制器并接收有效放大的检测器信号，其被处理以计算指示生理反应的生理参数。

50. 发明申请

US20110082711A1 PERSONAL DIGITAL ASSISTANT OR ORGANIZER FOR MONITORING GLUCOSE LEVELS 审中-公开
标题翻译：个人数字助理或组织监测葡萄糖水平
公开(公告)号：US20110082711A1
公开(公告)日：2011-04-07
申请号：US12898663
申请日：2010-10-05
申请人： Jeroen Poeze , Gregory A. Olsen , Marcelo Lamego , Massi Joe E. Kiani
发明人： Jeroen Poeze , Gregory A. Olsen , Marcelo Lamego , Massi Joe E. Kiani
IPC分类号： G06Q50/00 , A61B5/00
CPC分类号： A61B5/0022 , A61B5/02241 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/14552 , A61B5/6824 , A61B5/6825 , A61B5/7275 , A61B5/7285 , A61B5/742 , A61B5/7435 , A61B5/746 , A61B5/7475 , A61B2562/0233 , G06F19/3418 , G06F19/3456 , G06F19/3475 , G06Q10/10 , G06Q10/109 , G06Q50/22 , G06Q50/24 , G16H10/60 , G16H10/65 , G16H40/63 , G16H50/20
摘要： The present disclosure provides a personal health organizer that enables patients and healthcare personnel to manage health data. The personal health organizer can be a portable device adapted to receive physiological reading data from a health data collection device or derive reading data from signals acquired by a sensor, or a software module/platform for performing same that is configured to be executed on a general purpose computing device such as a mobile phone/computer. The personal health organizer integrates reading data with applications that assist and promote health management, including reminders, alerts and health data tracking. The reading data obtained can be forwarded to healthcare providers so they can provide feedback such as alerts and diagnoses to the user. The personal health organizer can also support electronic medical record integration via networked computing so that locally stored medical data are automatically synchronized with remotely stored medical data records.
摘要翻译：本公开提供了一种个人健康组织者，其使患者和医护人员能够管理健康数据。个人健康组织者可以是适于从健康数据收集装置接收生理学阅读数据的便携式装置，或从由传感器获得的信号或用于执行相同功能的软件模块/平台获取读取数据，该软件模块/平台被配置为在一般诸如移动电话/计算机的目的计算设备。个人健康组织者将阅读数据与帮助和促进健康管理的应用程序集成，包括提醒，警报和健康数据跟踪。获得的阅读数据可以转发给医疗保健提供者，以便他们可以向用户提供诸如警报和诊断的反馈。个人健康组织者还可以通过网络计算支持电子医疗记录整合，使得本地存储的医疗数据与远程存储的医疗数据记录自动同步。

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