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41. 发明申请

WO2020131649A1 NOVEL CRYSTALLINE FORMS OF AN NRTTI COMPOUND 审中-公开
公开(公告)号：WO2020131649A1
公开(公告)日：2020-06-25
申请号：PCT/US2019/066436
申请日：2019-12-16
申请人： MERCK SHARP & DOHME CORP. , SKOMSKI, Daniel , SU, Yongchao , XU, Wei , CUBROVIC, Marko
发明人： SKOMSKI, Daniel , SU, Yongchao , XU, Wei , CUBROVIC, Marko
IPC分类号： A61K31/70 , C07H19/16 , C07H19/173
摘要： The present disclosure provides novel anhydrate crystalline Forms 1 and 4 of 4'- Ethynyl-2-fluoro-2'-deoxyadenosine and pharmaceutical compositions thereof, each of which may be useful for the inhibition of HIV reverse transcriptase, the treatment or prophylaxis of HIV infection and/or the treatment, prophylaxis and/or delay in the onset or progression of AIDS or ARC.

42. 发明申请

WO2014100362A1 APPARATUS AND METHOD FOR GENERATING DESCRIPTORS TO TRANSFER DATA TO AND FROM NON-VOLATILE SEMICONDUCTOR MEMORY OF A STORAGE DRIVE 审中-公开
标题翻译：用于生成描述符以传输数据到存储驱动器的非易失性半导体存储器的装置和方法
公开(公告)号：WO2014100362A1
公开(公告)日：2014-06-26
申请号：PCT/US2013/076437
申请日：2013-12-19
申请人： MARVELL WORLD TRADE LTD. , LEE, Chi Kong , AU, Siu-Hung Frederick , PARK, Jungil , SHIN, Hyunsuk , XU, Wei , HE, Jinjin , SUN, Fei
发明人： LEE, Chi Kong , AU, Siu-Hung Frederick , PARK, Jungil , SHIN, Hyunsuk , XU, Wei , HE, Jinjin , SUN, Fei
IPC分类号： G06F3/06 , G06F13/16
CPC分类号： G06F12/0246 , G06F3/061 , G06F3/064 , G06F3/0659 , G06F3/0679 , G06F3/0688 , G06F13/1668 , G11C16/32
摘要： A storage drive including first, second, third, fourth and fifth modules. The first module is configured to control transfer of blocks of data between a host device and the storage drive. The second module is configured to transfer the blocks of data to and from a non-volatile semiconductor memory in the storage drive. The third module is configured to generate a first descriptor, which describes a transfer of blocks of data between the second module and the non-volatile semiconductor memory. The fourth module is configured to, according to the first descriptor, generate second descriptors. Each of the second descriptors corresponds to a respective one of the blocks of data. The fifth module is configured to generate instruction signals based on the second descriptors. The second module is configured to, based on the instruction signals, transfer the blocks of data between the first module and the non-volatile semiconductor memory.
摘要翻译：包括第一，第二，第三，第四和第五模块的存储驱动器。第一个模块被配置为控制主机设备和存储驱动器之间的数据块传输。第二模块被配置为将数据块传送到存储驱动器中的非易失性半导体存储器和/或从其移出。第三模块被配置为生成第一描述符，其描述在第二模块和非易失性半导体存储器之间传输数据块。第四模块被配置为根据第一描述符生成第二描述符。每个第二描述符对应于数据块中的相应一个。第五模块被配置为基于第二描述符生成指令信号。第二模块被配置为基于指令信号在第一模块和非易失性半导体存储器之间传送数据块。

43. 发明申请

WO2013113166A1 USER EQUIPMENT, RADIO BASE STATION AND RESPECTIVE METHODS THEREIN FOR JOINT TRANSMITTING AND RECEIVING PROCEDURE 审中-公开
标题翻译：用户设备，无线电基站和联合发送和接收程序的相关方法
公开(公告)号：WO2013113166A1
公开(公告)日：2013-08-08
申请号：PCT/CN2012/070864
申请日：2012-02-03
申请人： TELEFONAKTIEBOLAGET L M ERICSSON (PUBL) , ZHANG, Haochuan , SHEN, Hong , HU, Yang , XU, Wei
发明人： ZHANG, Haochuan , SHEN, Hong , HU, Yang , XU, Wei
IPC分类号： H04L25/02
CPC分类号： H04W72/0446 , H04B7/024 , H04B7/043 , H04B7/0452 , H04B7/0456 , H04B7/046 , H04B7/0617 , H04B7/0619 , H04B7/0626 , H04B7/0632 , H04B7/0634 , H04B7/0842 , H04B7/0854 , H04L5/0035 , H04L25/0204 , H04L25/03949
摘要： A user equipment, UE, (300), a radio base station, RBS, (400) and a respective method (100) and (200) therein for joint transmit and receive procedure are provided. The method (100) in the UE comprises receiving (110) at a time slot n, a first transmission from the RBS, the transmission comprising a first pre-coded symbol; and estimating (120) a real channel referring to a transfer function of the channel and an effective channel referring to the real channel adjusted by transmission weights for the received first transmission. The method further comprises determining (130) a combining vector based on the effective channel, and determining (140) a feedback vector based on the combining vector and the real channel. The method comprises transmitting (150) the feedback vector to the RBS, to be used by the RBS for determining an SLNR pre-coding vector for a second transmission to the UE in a subsequent time slot.
摘要翻译：提供了用于联合发送和接收过程的用户设备，UE，（300），无线电基站，RBS，（400）和相应的方法（100）和（200）。 UE中的方法（100）包括：在时隙n处接收（110）来自RBS的第一传输，所述传输包括第一预编码符号; 以及参考所述信道的传递函数估计（120）实际信道，以及参考由所接收的第一传输的发送权重调整的所述实际信道的有效信道。该方法还包括基于有效信道确定（130）组合向量，以及基于组合向量和实数信道确定（140）反馈向量。该方法包括向RBS发送（150）反馈向量，由RBS使用，用于在随后的时隙中确定用于向UE的第二传输的SLNR预编码向量。

44. 发明申请

WO2012068051A1 DUAL PHASE CATALYSTS SYSTEM FOR MIXED OLEFIN HYDRATIONS 审中-公开
标题翻译：双相催化剂体系的混合烯烃水合物
公开(公告)号：WO2012068051A1
公开(公告)日：2012-05-24
申请号：PCT/US2011/060703
申请日：2011-11-15
申请人： SAUDI ARABIAN OIL COMPANY , ARAMCO SERVICES COMPANY , XU, Wei
发明人： XU, Wei
IPC分类号： C07C29/04 , C07C31/12 , B01J27/16 , B01J27/188 , B01J31/08 , B01J31/10 , B01J31/26 , B01J35/00 , C10L1/18
CPC分类号： B01J31/34 , B01J27/16 , B01J27/18 , B01J29/70 , B01J31/08 , C07C29/04 , C07C31/12 , C10L1/02 , C10L1/023 , C10L1/026 , C10L1/1824
摘要： Processes for producing mixed alcohols from mixed olefins and the catalyst systems for making such alcohols are provided. Additionally, processes for producing fuel compositions having mixed alcohols prepared from mixed olefins are also provided as embodiments of the present invention. The catalyst systems include a dual phase catalyst system that includes a water soluble acid catalyst and a solid acid catalyst.
摘要翻译：提供了由混合烯烃制备混合醇的方法和用于制备这种醇的催化剂体系。另外，作为本发明的实施方式，还提供了生产具有由混合烯烃制备的混合醇的燃料组合物的方法。催化剂体系包括含有水溶性酸催化剂和固体酸催化剂的双相催化剂体系。

45. 发明申请

WO2012022047A1 ROD SYSTEM FOR GRADUAL DYNAMIC SPINAL FIXATION 审中-公开
标题翻译：脊柱动力学脊柱固定系统
公开(公告)号：WO2012022047A1
公开(公告)日：2012-02-23
申请号：PCT/CN2010/076195
申请日：2010-08-20
申请人： TONGJI UNIVERSITY , CHENG, Liming , YU, Yan , ZENG, Zhili , XU, Wei , JIA, Yongwei , QIAN, Lie , ZHU, Rui , WANG, Jianjie , WU, Zhourui
发明人： CHENG, Liming , YU, Yan , ZENG, Zhili , XU, Wei , JIA, Yongwei , QIAN, Lie , ZHU, Rui , WANG, Jianjie , WU, Zhourui
IPC分类号： A61B17/70 , A61F2/44
CPC分类号： A61B17/7026 , A61B17/7004 , A61B17/7023 , A61B17/7025 , A61B17/7031 , A61B2017/00004
摘要： A rod system includes two rods each with a head and a shaft, two elastic members each fitted around one shaft against one head, and a case defining a first inner portion, a second inner portion, and a third inner portion in communication with the first and the second inner portions. A first rod with a first elastic member is seated in the first inner portion so the first elastic member abuts the bottom of first inner portion and the first head protrudes into the third inner portion. A second rod and a second elastic member is seated in the second portion so the second elastic member abuts the bottom of the second inner portion and the second head protrudes into the third inner portion and abuts the first head.
摘要翻译：棒系统包括两个杆，每个杆具有头部和轴，两个弹性构件，每个弹性构件围绕一个轴围绕一个头部安装;以及壳体，其限定第一内部部分，第二内部部分和与第一内部部分连通的第三内部部分和第二内部部分。具有第一弹性构件的第一杆位于第一内部部分中，使得第一弹性构件抵靠第一内部部分的底部，并且第一头部突出到第三内部部分中。第二杆和第二弹性构件位于第二部分中，使得第二弹性构件邻接第二内部部分的底部，并且第二头部突出到第三内部部分中并邻接第一头部。

46. 发明申请

WO2010147768A1 PHARMACEUTICAL COMPOSITIONS OF COMBINATIONS OF DIPEPTIDYL PEPTIDASE-4 INHIBITORS WITH PIOGLITAZONE 审中-公开
标题翻译： DIPEPTIDYL PEPTIDASE-4抑制剂与PIOGLITAZONE组合的药物组合物
公开(公告)号：WO2010147768A1
公开(公告)日：2010-12-23
申请号：PCT/US2010/037356
申请日：2010-06-04
申请人： MERCK SHARP & DOHME CORP. , BIRRINGER, Nicholas , JOHN, Christopher, T. , PROCOPIO, Adam , REGE, Bhagwant , ROSEN, Lawrence, A. , SOTTHIVIRAT, Sutthilug , XU, Wei
发明人： BIRRINGER, Nicholas , JOHN, Christopher, T. , PROCOPIO, Adam , REGE, Bhagwant , ROSEN, Lawrence, A. , SOTTHIVIRAT, Sutthilug , XU, Wei
IPC分类号： A61K31/44
CPC分类号： A61K45/06 , A61K31/44 , A61K31/4439 , A61K2300/00
摘要： This invention relates to pharmaceutical compositions comprising fixed-dose combinations of a dipeptidyl peptidase-4 inhibitor and pioglitazone, methods of preparing such pharmaceutical compositions, and methods of treating Type 2 diabetes with such pharmaceutical compositions.
摘要翻译：本发明涉及包含二肽基肽酶-4抑制剂和吡格列酮的固定剂量组合的药物组合物，制备这种药物组合物的方法，以及用这种药物组合物治疗2型糖尿病的方法。

47. 发明申请

WO2009067164A1 LASER SCORING OF GLASS SHEETS AT HIGH SPEEDS AND WITH LOW RESIDUAL STRESS 审中-公开
标题翻译：玻璃片的激光切割在高速和低残留应力下
公开(公告)号：WO2009067164A1
公开(公告)日：2009-05-28
申请号：PCT/US2008/012770
申请日：2008-11-14
申请人： CORNING INCORPORATED , ABRAMOV, Anatoli A , SUN, Yawei , XU, Wei , ZHOU, Naiyue
发明人： ABRAMOV, Anatoli A , SUN, Yawei , XU, Wei , ZHOU, Naiyue
IPC分类号： C03B33/09 , B23K26/073
CPC分类号： C03B33/091 , Y02P40/57
摘要： Experimental data is presented which shows that laser scoring of glass sheets (112) with existing techniques produces unacceptable levels of residual stress in the separated sheets as the scoring speed is increased. Methods for solving this problem are disclosed which employ elongated and, preferably, asymmetrically-truncated laser beams (13). The methods allow glass sheets (112) to be scored at speeds of 1000mm/s and above with low levels of residual stress, e.g., levels of residual stress which are less than or equal to 500 psi. Such low levels of residual stress translate into low levels of distortion during the manufacture of display panels (e.g., LCD panels) as well as in improved properties of the separated edges. The methods can be used with glasses of various types including glasses having low coefficients of thermal expansion.
摘要翻译：实验数据显示，现有技术的玻璃板（112）的激光刻痕在分选片材中随着刻痕速度的提高而产生不可接受的残余应力水平。公开了解决这个问题的方法，其采用细长的，优选的是非对称截断的激光束（13）。这些方法允许玻璃板（112）以1000mm / s以上的速度刻痕，残留应力低，例如小于或等于500psi的残余应力水平。这种低水平的残余应力在显示面板（例如LCD面板）的制造过程中转化为低水平的变形以及分离边缘的改进的性质。该方法可用于各种类型的眼镜，包括具有低热膨胀系数的眼镜。

48. 发明申请

WO2008143759A1 PYRIMIDINONES AS CASEIN KINASE II (CK2) MODULATORS 审中-公开
标题翻译：吡啶二酮作为CASEIN KINASE II（CK2）调节剂
公开(公告)号：WO2008143759A1
公开(公告)日：2008-11-27
申请号：PCT/US2008/005419
申请日：2008-04-24
申请人： EXELIXIS, INC. , KOLTUN, Elena S. , KEARNEY, Patrick , AAY, Naing , ARCALAS, Arlyn , CHAN, Wai Ki Vicky , CURTIS, Jeffry Kimo , DU, Hongwang , HUANG, Ping , KANE, Brian , KIM, Moon Hwan , PACK, Michael , TSUHAKO, Amy L. , XU, Wei , ZAHARIA, Cristiana A. , ZHOU, Peiwen
发明人： KOLTUN, Elena S. , KEARNEY, Patrick , AAY, Naing , ARCALAS, Arlyn , CHAN, Wai Ki Vicky , CURTIS, Jeffry Kimo , DU, Hongwang , HUANG, Ping , KANE, Brian , KIM, Moon Hwan , PACK, Michael , TSUHAKO, Amy L. , XU, Wei , ZAHARIA, Cristiana A. , ZHOU, Peiwen
IPC分类号： C07D403/04 , C07D405/04 , C07D413/04 , C07D417/04 , A61K31/513 , A61P35/00
CPC分类号： C07D405/04 , C07D403/04 , C07D413/04 , C07D417/04
摘要： A compound having Formula I :or a pharmaceutically acceptable salt thereof, wherein X, R, R and R are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof. The compounds of Fomula I are inhibitors of Casein kinase II (CK2) pathways.
摘要翻译：具有式I的化合物或其药学上可接受的盐，其中X，R，R和R如说明书中所定义; 其药物组合物; 及其使用方法。 Fomula I的化合物是酪蛋白激酶II（CK2）途径的抑制剂。

49. 发明申请

WO2008073825A1 LXR AND FXR MODULATORS 审中-公开
标题翻译： LXR和FXR调制器
公开(公告)号：WO2008073825A1
公开(公告)日：2008-06-19
申请号：PCT/US2007/086787
申请日：2007-12-07
申请人： EXELIXIS, INC. , BOREN, Brant, Clayton , BUSCH, Brett, B. , GU, Xiao-hui , JAMMALAMADAKA, Vasu , LU, Shao-po , MARTIN, Richard , MOHAN, Raju , SCHWEIGER, Edwin , STEVENS, William, C., Jr. , WANG, Tie-lin , XIE, Yinong , XU, Wei
发明人： BOREN, Brant, Clayton , BUSCH, Brett, B. , GU, Xiao-hui , JAMMALAMADAKA, Vasu , LU, Shao-po , MARTIN, Richard , MOHAN, Raju , SCHWEIGER, Edwin , STEVENS, William, C., Jr. , WANG, Tie-lin , XIE, Yinong , XU, Wei
IPC分类号： C07D233/90 , C07D231/10 , A61K31/415 , A61K31/4164 , A61P3/10
CPC分类号： C07D233/90 , C07D231/10
摘要： Compounds of the invention are disclosed, such as compounds of formulae LX - LXIV, and pharmaceutically acceptable salts, isomers, or prodrugs thereof, which are useful as modulators of the activity of liver X receptors (LXR) and Farnesoid X receptors (FXR), where R 00 , R 200 , R 400 , R 500 , J 11 , J 21 , G 1 , G 21 , and Q are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
摘要翻译：公开了本发明的化合物，例如式LX-LXIV的化合物及其药学上可接受的盐，异构体或前药，其可用作肝脏X受体（LXR）和法呢甾X受体（FXR）的活性的调节剂，其中R 00，R 200，R 400，R 500，J 11， J 21，G 1，G 21和Q如本文所定义。还公开了含有化合物的药物组合物和使用该化合物的方法。

50. 发明申请

WO2008063315A2 C-TERMINAL DOMAIN TRUNCATION OF MGLUR1α BY CALPAIN AND USES THEREOF 审中-公开
标题翻译： CALPAIN对MGLUR1α的C-末端结构域切断及其应用
公开(公告)号：WO2008063315A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/021806
申请日：2007-10-12
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , BAUDRY, Michel , XU, Wei
发明人： BAUDRY, Michel , XU, Wei
IPC分类号： A61K38/10
CPC分类号： A61K38/10 , C12Q1/37 , G01N33/6896 , G01N33/9406 , G01N2500/02 , G01N2800/28
摘要： A composition comprising a peptide or a peptidomimetic thereof that inhibits the C-terminal domain truncation of mGluRlα by calpain, wherein the peptide is 10-30 amino acids in length and contains a sequence that is at least 70% homologous to VIKPLTKSYQGSGK. Also disclosed are methods of detecting the C-terminal domain truncation of mGluRlα by calpain, methods of inhibiting the C-terminal domain truncation of mGluRlα in a neuron, and methods of identifying a compound that inhibits the C-terminal domain truncation of mGluRlα.
摘要翻译：包含通过钙蛋白酶抑制mGluR1α的C-末端结构域截短的肽或其肽模拟物的组合物，其中所述肽长度为10-30个氨基酸并且含有至少70个％与VIKPLTKSYQGSGK同源。还公开了通过钙蛋白酶检测mGluR1α的C-末端结构域截短的方法，抑制神经元中mGluR1α的C-末端结构域截短的方法，以及鉴定抑制mGluR1α的C-末端结构域截短的化合物的方法。 / p>

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