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41. 发明专利

JPH0995454A ANTIULCERATIVE COMPOSITION 失效
公开(公告)号：JPH0995454A
公开(公告)日：1997-04-08
申请号：JP25535495
申请日：1995-10-02
申请人： MEIJI MILK PROD CO LTD
发明人： UCHIDA KATSUYUKI , IKEMATSU SHINYA , YOKOYAMA MINEHIKO , YAMASHITA AKIO , KUMAI HIDESHI , ODA MUNEHIRO , KATO NAOKI , SAKUMA SADATOSHI , MURAMATSU TAKASHI
IPC分类号： A61K38/00 , A61K38/18 , A61P1/04 , C07K14/47 , C07K14/52
摘要： PROBLEM TO BE SOLVED: To obtain an antiulcerative composition which has a new action mechanism similar to natural healing and is useful in therapy for gastric ulcer by formulating MK-protein, its derivative holding the biological activity of the protein or a part of them as an active ingredient. SOLUTION: MK protein, a growth and differentiation factor represented by either one of formulas I-III, its derivative which holds the biological activity of this protein, or at least one of their parts holding the biological activity of the protein is used as an active ingredient and mixed with a pharmaceutically permissible excipient, a binder, a disintegrator, a lubricant, a usually used carrier such as a solubilizer or the like, and diluent to prepare an oral medicine such as tablets, granules, capsules, syrup or troche or parenteral preparation such as injection solution, transrectal agent, eye drop or pereuteneous medicine. This medicine can be expected to have an antiulcerative effect by a new action mechanism similar to natural healing, for example, for ulcerative diseases in digestive organs such as gastric ulcer.

42. 发明专利

JPH08311073A NEW GOLD COMPLEX AND ANTIRHEUMATIC AGENT CONTAINING SAME AS ACTIVE INGREDIENT 失效
公开(公告)号：JPH08311073A
公开(公告)日：1996-11-26
申请号：JP35229495
申请日：1995-12-28
申请人： MEIJI MILK PROD CO LTD
发明人： ODA MUNEHIRO , ORIKI KAZUO , TAKAHASHI MASAHIRO , ITO HIROYUKI , SAKUMA SADATOSHI , NOMIYA KENJI
IPC分类号： A61K31/60 , A61K31/28 , A61K33/24 , A61P29/00 , C07F1/12
摘要： PURPOSE: To obtain the new gold complex capable of suppressing the generation of cell adhesion molecules at a low concentration, manifesting its efficacy in a small amount of accumulated gold in a body, and useful as an antirheumatic agent having less adverse effects. CONSTITUTION: This new gold complex is tri-sodium salt of aurous (I) bis-(thiosalicylate) of the formula. This complex is obtained by reacting (A) thiosalicylic acid, (B) NaOH and (C) sodium auric chloride in a solution prepared preferably so as to become 1:4:8 molar ratio of the component C : the component A : the component B. Further, the complex is used as an antirheumatic agent and its dose is preferably usually 0.001-100mg/kg/day as the gold complex.

43. 发明专利

JPH083007A ANTIBACTERIAL AND ANTIFUNGAL SPRAY 失效
公开(公告)号：JPH083007A
公开(公告)日：1996-01-09
申请号：JP13552394
申请日：1994-06-17
申请人： TOYO INK MFG CO , MEIJI MILK PROD CO LTD
发明人： KIKUCHI AKIRA , TAKAHATA YOSHIKO , ODA MUNEHIRO , SUZUKI YASUNORI , ITO HIROYUKI
IPC分类号： A01N25/02 , A01N25/06 , A01N55/02
摘要： PURPOSE:To obtain an antibacterial and antifungal spray exhibiting wide antibac terial and antifungal properties and a good action-persisting property, high in safety, and capable of simply giving the antibacterial and antifungal proper ties to floors, walls, underwear, socks, shoes, etc., by using a complex produced by coordinating silver ion with a thiol group-containing compound easy to spray. CONSTITUTION:The antibacterial and antifungal spray contains a complex in which a thiol group-containing compound (e.g. preferably thiosalicylic acid) is coordinated with silver ion). In the complex, the reaction molar ratio of the thiol group-containing compound to the silver ion is 0.1-4, and the counter- cation is preferably one selected from K , Na , Ca and Ba . The spray preferably further contains an aqueous binder (especially preferably polyvinyl alcohol). In the spray, toxicity, skin irritability, and mucosa irritability are extremely reduced, and safety is high.

44. 发明专利

JPH07126432A ANTIMICROBIAL AND ANTIFUNGAL RESIN COMPOSITION AND MASTERBATCH 失效
公开(公告)号：JPH07126432A
公开(公告)日：1995-05-16
申请号：JP27647193
申请日：1993-11-05
申请人： TOYO INK MFG CO , MEIJI MILK PROD CO LTD
发明人： KINOSHITA YUKIYOSHI , ODA MUNEHIRO , SUZUKI YASUNORI
IPC分类号： A01N25/10 , A01N25/22 , A01N25/34 , A01N55/02 , C08K5/36 , C08L101/00
摘要： PURPOSE:To obtain an antimicrobial and antifungal resin composition, having low toxicity, reduced in skin and mucosal irritancies, excellent in persistence of activities and safety and useful as fiber, films, etc., by dispersing a complex in which a thiol group-containing compound is coordinated with silver ions in a resin. CONSTITUTION:This antimicrobial and antifungal resin composition is obtained by dispersing a complex in which a thiol group-containing compound such as thiosalicylic acid is coordinated with silver ions in a resin such as PE. Furthermore, this masterbatch is prepared by dispersing preferably 10-80wt.% complex in the resin.

45. 发明专利

JPH0532025B2 失效
公开(公告)号：JPH0532025B2
公开(公告)日：1993-05-14
申请号：JP7930085
申请日：1985-04-16
申请人： MEIJI MILK PROD CO LTD
发明人： IMADA MASARU , YOSHAMA HIROSHI , ODA MUNEHIRO
IPC分类号： C12N5/00 , C12N5/07 , C12N5/071 , C12N9/64 , C12R1/91

46. 发明专利

JPS601878B2 失效
公开(公告)号：JPS601878B2
公开(公告)日：1985-01-17
申请号：JP304081
申请日：1981-01-14
申请人： MEIJI MILK PROD CO LTD
发明人： TSUCHA FUMYASU , MYAZAWA KYUSHICHI , KANBE MICHIO , ODA MUNEHIRO , EBISAWA NAOYUKI
IPC分类号： C08B37/00 , A61K31/715 , A61P35/00 , C12P19/04 , C12R1/225 , C12R1/46

47. 发明专利

JPS5959187A Method and apparatus for cell culture 失效
标题翻译：细胞培养的方法和装置
公开(公告)号：JPS5959187A
公开(公告)日：1984-04-04
申请号：JP16973482
申请日：1982-09-30
申请人： Meiji Milk Prod Co Ltd
发明人： MURAKAMI HIRONORI , TSUCHIYA FUMIYASU , KANBE MICHIO , YOSHIYAMA YOSHIHIRO , ODA MUNEHIRO , HAYAZAKI JIYUNICHI
IPC分类号： C12M3/00 , C12N5/00 , C12N5/07 , C12N5/071
摘要： PURPOSE: To culture adherent cells in high efficiency, by proliferating the cells on the substrate without immersing the substrate in culture liquid while contacting the substrate with the culture liquid.
CONSTITUTION: The substrate container 3 is fully packed with the substrates 1, the culture liquid is sprayed from the sprayer 4 placed at the top of the culture tank 2 to effect the thorough contact of the liquid with the substrates 1, and the culture liquid dripped to the bottom of the container 3 is collected in the tank 20 and circulated to the sprayer 4 with a pump. The substrate container 3 is aerated with a gas having necessary composition simultaneously to the initiation of the culture. The gas is introduced into the culture tank 2 from the gas diffuser 17 attached at the top or bottom of the culture tank and made to contact countercurrently or concurrently with the culture liquid. The adherent cells can be proliferated on the substrate which is not immersed in but contacted with the culture liquid, in high efficiency.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：以高效率培养贴壁细胞，通过增加底物上的细胞，而不将基质浸入培养液中，同时使基质与培养液接触。构成：将基材容器3充满基材1，从放置在培养槽2顶部的喷雾器4喷出培养液，使液体与基材1充分接触，滴加培养液将容器3的底部收集在罐20中并用泵循环到喷雾器4中。基底容器3在培养开始时同时具有必要组成的气体充气。将气体从附着在培养罐顶部或底部的气体扩散器17引入培养槽2中，并与培养液逆流或同时接触。粘附细胞可以在没有浸入培养液中但与培养液接触的基质上增殖，而且效率高。

48. 发明专利

JPS57117504A Antitumor agent 失效
标题翻译：抗菌剂
公开(公告)号：JPS57117504A
公开(公告)日：1982-07-22
申请号：JP304081
申请日：1981-01-14
申请人： Meiji Milk Prod Co Ltd
发明人： TSUCHIYA FUMIYASU , MIYAZAWA KIYUUSHICHI , KANBE MICHIO , ODA MUNEHIRO , EBISAWA NAOYUKI
IPC分类号： C08B37/00 , A61K31/715 , A61P35/00 , C12P19/04 , C12R1/225 , C12R1/46
摘要： NEW MATERIAL:An antitumor agent containing a high polymeric polysaccharide substance MPS-80 having the following physico-chemical properties as an active constituent: (1) Elementary analysis (%): C, 42.2; H, 6.9; O, 50.4. (2) Melting point (decomposition point): Discolors at about 262°C, and blackens at 263W264°C. (3) Specific rotatory power[α]D
18 =+33.2 (C=0.5%). (4) Solubility: Soluble in water, and insoluble in methanol, acetone, ether, etc. (5) Color reactions: Positive to the Molisch and anthrone reactions, and negative to the aniline-hydrochloric acid and biuret reactions, etc. (6) The freeze-dried substance is white fibrous.
USE: An antitumor agent.
PROCESS: A strain of the genus Lactobacillus or Streptococuus, e.g. Lactobacillus jugurti No. 851 (FERM-P No. 5851) or Streptococcus thermophilus No. 127 (FERM-P No. 5850), is cultivated, and the aimed substance is obtained from the culture by the separation and the purification.
COPYRIGHT: (C)1982,JPO&Japio
摘要翻译：新材料：含有具有以下物理化学性质的高分子多糖物质MPS-80作为活性成分的抗肿瘤剂：（1）元素分析（％）：C，42.2; H，6.9; O，50.4。（2）熔点（分解点）：脱色在约262℃，黑色在263-264℃。（3）比旋光度αD 18 = + 33.2（C = 0.5％）。（4）溶解性：易溶于水，不溶于甲醇，丙酮，乙醚等。（5）显色反应：对Molisch和蒽酮反应呈阳性，对苯胺 - 盐酸和缩二脲反应均为阴性（6））冻干物质为白色纤维。用途：抗肿瘤剂。方法：乳杆菌属或链球菌属的菌株，例如培养19号乳杆菌（FERM-P No.5851）或嗜热链球菌127号（FERM-P No.5850），通过分离和纯化从培养物中获得目标物质。

49. 发明专利

JPS5572120A IMPROVEMENT IN PRODUCTIVITY OF INTERFERON 失效
公开(公告)号：JPS5572120A
公开(公告)日：1980-05-30
申请号：JP14535378
申请日：1978-11-27
申请人： MEIJI MILK PROD CO LTD
发明人： TSUCHIYA FUMIYASU , MIYAZAWA KIYUUSHICHI , KANBE MICHIO , ODA MUNEHIRO , EBISAWA NAOYUKI
IPC分类号： C12P21/00 , A61K38/21 , A61P43/00
摘要： PURPOSE:To improve the productivity of interferon, by culturing cells in the presence of specific bacterial cells as interferon-inducing substance. CONSTITUTION:In the production of interferon by culturing cells, the productivity of interferon is improved by adding cells of bacteria belonging to Lactobacillus genus, e.g. Lactobacillus bulgaricus, Lactobacillus jugurti, Lactobacillus helveticus, etc. to the medium, as interferon-inducing substance. High interferon-inducing activity, and low toxicity.

50. 发明专利

JPS54104655A BIOLOGICAL WASTE WATER DISPOSAL METHOD 失效
公开(公告)号：JPS54104655A
公开(公告)日：1979-08-17
申请号：JP988078
申请日：1978-02-02
申请人： MEIJI MILK PROD CO LTD
发明人： ODA MUNEHIRO , MATSUDA KOUJIROU , KANBE MICHIO , TSUCHIYA FUMIYASU , HIBINO KOUICHI
IPC分类号： C02F3/12

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