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    • 44. 发明授权
    • Preparation of novel particles for inhalation
    • 用于吸入的新型颗粒的制备
    • US06652837B1
    • 2003-11-25
    • US09394233
    • 1999-09-13
    • David A. EdwardsRobert S. LangerRita VanbeverJeffrey MintzesJue WangDonghao Chen
    • David A. EdwardsRobert S. LangerRita VanbeverJeffrey MintzesJue WangDonghao Chen
    • A61K912
    • A61K9/0075A61K9/1617A61K9/1623A61K9/1641A61K9/1647A61K9/1658A61K31/135A61K31/137A61K38/28A61K38/38A61K47/6927Y10S514/958
    • Particles incorporating a surfactant and/or a hydrophilic or hydrophobic complex of a positively or negatively charged therapeutic agent and a charged molecule of opposite charge for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the particles are made of a biodegradable material and have a tap density less than 0.4 g/cm3 and a mass mean diameter between 5 &mgr;m and 30 &mgr;m, which together yield an aerodynamic diameter of the particles of between approximately one and three microns. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of poly(lactic acid) or poly(glycolic acid) or copolymers thereof. Alternatively, the particles may be formed solely of a therapeutic or diagnostic agent and a surfactant. Surfactants can be incorporated on the particle surface for example by coating the particle after particle formation, or by incorporating the surfactant in the material forming the particle prior to formation of the particle. Exemplary surfactants include phosphoglycerides such as dipalmitoyl phosphatidylcholine (DPPC). The particles can be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide a variety of therapeutic agents. Formation of complexes of positively or negatively charged therapeutic agents with molecules of opposite charge can allow control of the release rate of the agents into the blood stream following administration.
    • 提供了将具有正或负电荷的治疗剂的表面活性剂和/或亲水或疏水配合物和用于药物递送至肺系统的带电分子的相反电荷的颗粒,以及用于其合成和给药的方法。 在一个优选的实施方案中,颗粒由可生物降解的材料制成,并且具有小于0.4g / cm 3的振实密度和5μm和30μm之间的质量平均直径,这两个颗粒之间的颗粒的空气动力学直径在 大约一到三微米。 颗粒可以由可生物降解的材料如可生物降解的聚合物形成。 例如,颗粒可以由聚(乳酸)或聚(乙醇酸)或其共聚物形成。 或者,颗粒可以仅由治疗剂或诊断剂和表面活性剂形成。 表面活性剂可以结合在颗粒表面上,例如通过在颗粒形成之后涂覆颗粒,或者通过在形成颗粒之前将表面活性剂并入形成颗粒的材料中。 示例性表面活性剂包括磷酸甘油酯,例如二棕榈酰磷脂酰胆碱(DPPC)。 这些颗粒可以有效地雾化,用于给呼吸道施用以允许全身或局部递送各种各样的治疗剂。 正电荷或带负电荷的治疗剂与相反电荷分子的复合物的形成可以允许在给药后将药剂释放到血流中的释放速率。
    • 47. 发明授权
    • Methods and apparatus for robust video stabilization
    • 稳健视频稳定的方法和装置
    • US08929610B2
    • 2015-01-06
    • US13368279
    • 2012-02-07
    • Hailin JinAseem O. AgarwalaJue Wang
    • Hailin JinAseem O. AgarwalaJue Wang
    • G06K9/00G06K9/36H04N7/18H04N5/225G06T7/00G06T7/20
    • G06T7/33G06T7/246G06T2207/10016G06T2207/20028G06T2207/30241
    • Methods and apparatus for robust video stabilization. A video stabilization technique applies a feature tracking technique to an input video sequence to generate feature trajectories. The technique applies a video partitioning technique to segment the input video sequence into factorization windows and transition windows. The technique smoothes the trajectories in each of the windows, in sequence. For factorization windows, a subspace-based optimization technique may be used. For transition windows, a direct track optimization technique that uses a similarity motion model may be used. The technique then determines and applies warping models to the frames in the video sequence. In at least some embodiments, the warping models may include a content-preserving warping model, a homography model, a similarity transform model, and a whole-frame translation model. The warped frames may then be cropped according to a cropping technique.
    • 稳健视频稳定的方法和装置。 视频稳定技术将特征跟踪技术应用于输入视频序列以产生特征轨迹。 该技术应用视频分割技术将输入视频序列分解为分解窗口和转换窗口。 该技术顺序地平滑每个窗口中的轨迹。 对于分解窗口,可以使用基于子空间的优化技术。 对于转换窗口,可以使用使用相似度运动模型的直接跟踪优化技术。 该技术然后确定并应用翘曲模型到视频序列中的帧。 在至少一些实施例中,翘曲模型可以包括内容保留翘曲模型,单应性模型,相似度变换模型和全帧翻译模型。 然后可以根据裁剪技术裁剪翘曲的框架。