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41. 发明授权

US08961787B2 Systems and methods for processing complex biological materials 有权
标题翻译：用于处理复杂生物材料的系统和方法
公开(公告)号：US08961787B2
公开(公告)日：2015-02-24
申请号：US12325672
申请日：2008-12-01
申请人： Nichole Lea Wood , Reginald Donovan Smith , Hongyi Zhou , Liming Yu , Brian Polizzotti , Peter Miller
发明人： Nichole Lea Wood , Reginald Donovan Smith , Hongyi Zhou , Liming Yu , Brian Polizzotti , Peter Miller
IPC分类号： C02F9/00 , B01D63/02 , A61M1/02 , B01D61/28 , B01D61/30
CPC分类号： G01N33/491 , A61M1/029 , B01D61/28 , B01D61/30 , B01D63/02 , B01D2313/18 , B01D2313/50 , C12N5/0647 , C12N5/0665 , G01N1/4077 , G01N2001/4083 , G01N2001/4088
摘要： Method and systems, for processing biological material, that contain a biological material in a vessel; add an aggregating agent to the material in the vessel and allow the material to separate into two or more distinct submaterials; extract one or more of the submaterials from the vessel; automatically transport one or more of the submaterials remaining in the vessel to a filtration device; and collect a resulting target retentate into a target retentate receptacle.
摘要翻译：用于处理在容器中含有生物材料的生物材料的方法和系统; 向容器中的材料添加聚集剂，并使材料分离成两个或更多不同的子材料; 从容器中提取一种或多种副材料; 将剩余在容器中的一种或多种副材料自动输送到过滤装置; 并将得到的目标滞留物收集到目标滞留容器中。

42. 发明授权

US08778278B2 Non bio-adhesive polymer coating composition, articles and devices thereof 失效
标题翻译：非生物粘合剂聚合物涂料组合物，其制品及其装置
公开(公告)号：US08778278B2
公开(公告)日：2014-07-15
申请号：US12503581
申请日：2009-07-15
申请人： Mingna Xiong , Bing Zhang , Liping Zheng , Hui Lei , Su Lu , Liming Yu , Lin Chen , Wenqing Peng , Yanrong Zhu
发明人： Mingna Xiong , Bing Zhang , Liping Zheng , Hui Lei , Su Lu , Liming Yu , Lin Chen , Wenqing Peng , Yanrong Zhu
IPC分类号： B01L3/00
CPC分类号： G01N33/54393 , B01L3/50 , C08G77/26 , C08G77/28 , C08G77/60 , C08L83/04 , C08L83/08 , C09D5/1675 , Y10T428/31612 , Y10T428/31663
摘要： The invention is a device comprising a substrate and a material provided on at least a portion of the substrate and having an exposed surface. The exposed surface of the material is non bio-adhesive. The invention further includes a non bio-adhesive material composition and a method of making a device having the same non bio-adhesive surface. The invention further provides a device having a coating of a hydrophobic material. In particular, the hydrophobic material coated portion of the device is resistant to bio-adhesion.
摘要翻译：本发明是一种器件，其包括衬底和设置在衬底的至少一部分上并具有暴露表面的材料。材料的暴露表面是非生物粘合剂。本发明还包括非生物粘合剂材料组合物和制造具有相同非生物粘合剂表面的装置的方法。本发明还提供了具有疏水性材料的涂层的装置。特别地，该装置的疏水材料涂覆部分具有抗生物粘附性。

43. 发明授权

US08691939B2 Compositions, methods, and kits for assaying complement activation 失效
标题翻译：用于测定补体激活的组合物，方法和试剂盒
公开(公告)号：US08691939B2
公开(公告)日：2014-04-08
申请号：US11811425
申请日：2007-06-08
申请人： Liming Yu , Anup Sood , Mark Felipe Baptista
发明人： Liming Yu , Anup Sood , Mark Felipe Baptista
IPC分类号： A61K38/00
CPC分类号： C07K14/472 , C12Q1/37 , G01N2333/96441
摘要： The present invention provides a fluorogenic composition for assaying complement activation that comprises a substrate for C3 convertase that is linked to a first fluorophore and a second fluorophore, wherein the fluorescence of the first and second fluorophores are mutually substantially quenched when the two fluorophores are present at a distance less than the characteristic distance for the two fluorophores. In one embodiment, the fluorescence of the first fluorophore is substantially quenched by the second fluorophore, and the second fluorophore emits heat upon quenching. The present invention also provides a method for assaying complement activation, wherein the method includes the steps of incubating a biological sample with a polymer to provide a polymeric biological sample, followed by incubating the polymeric biological sample with the fluorogenic composition, and measuring the fluorescence. The method may optionally include the step of measuring the optical properties of the biological sample prior to the incubation steps. The present invention further provides a kit for assaying complement activation that comprises the fluorogenic composition disclosed herein.
摘要翻译：本发明提供了用于测定补体活化的荧光组合物，其包含与第一荧光团和第二荧光团连接的C3转化酶底物，其中当两个荧光团存在于第一荧光团和第二荧光团时，第一和第二荧光团的荧光相互基本上骤冷距离小于两个荧光团的特征距离。在一个实施方案中，第一荧光团的荧光基本上被第二荧光团猝灭，第二荧光团在淬火时发出热。本发明还提供了用于测定补体活化的方法，其中该方法包括以下步骤：用聚合物孵育生物样品以提供聚合生物样品，随后将聚合物生物样品与荧光组合物一起温育，并测量荧光。该方法可以可选地包括在孵育步骤之前测量生物样品的光学性质的步骤。本发明还提供了用于测定补体活化的试剂盒，其包含本文公开的荧光组合物。

44. 发明授权

US07959808B2 Polysulfone membranes methods and apparatuses 有权
标题翻译：聚砜膜方法和装置
公开(公告)号：US07959808B2
公开(公告)日：2011-06-14
申请号：US12262643
申请日：2008-10-31
申请人： Gary William Yeager , Liming Yu , Daniel Steiger , Yanshi Zhang
发明人： Gary William Yeager , Liming Yu , Daniel Steiger , Yanshi Zhang
IPC分类号： B01D61/00 , B01D39/00 , B01D53/22
CPC分类号： B01D71/68 , B01D2323/02 , B01D2325/36 , C08L39/08 , C08L81/06 , C08L2666/04
摘要： The present invention relates to methods and apparatuses for water filtration comprising contacting a water stream with a membrane comprising a polysulfone having structural units of Formula I wherein X is OH, NR1R2, or OR3; R1 and R2 are independently at each occurrence hydrogen, a C1-C5000 aliphatic radical, a C3-C12 cycloaliphatic radical, a C3-C12 aromatic radical, a polypeptide, a combination thereof, or R1 and R2 taken together form a 5- or 6-membered aliphatic ring or a 5-membered aromatic ring; R3 is a C1-C20 aliphatic radical, C3-C12 cycloaliphatic radical, C3-C12 aromatic radical, or a combination thereof; B′ and C′ are independently at each occurrence a nitro group, C1-C20 aliphatic radical, C3-C12 cycloaliphatic radical, C3-C12 aromatic radical, or a combination thereof; and q and r are independently at each occurrence 0 to 4. The present invention also relates to a method and apparatus for gas separation, the method comprising contacting a gas stream with a membrane comprising a polysulfone having structural units of Formula I.
摘要翻译：本发明涉及水过滤的方法和装置，包括使水流与包含具有式I结构单元的聚砜的膜接触，其中X是OH，NR1R2或OR3; R1和R2各自独立地为氢，C1-C5000脂族基团，C3-C12脂环族基团，C3-C12芳族基团，多肽，其组合，或者R 1和R 2一起形成5-或6 脂族环或5元芳环; R3是C1-C20脂族基团，C3-C12脂环族基团，C3-C12芳族基团或其组合; B'和C'在每次出现时独立地为硝基，C 1 -C 20脂族基，C 3 -C 12脂环族基，C 3 -C 12芳族基或其组合; 并且q和r在每次出现时独立地为0至4.本发明还涉及一种用于气体分离的方法和装置，所述方法包括使气流与包含具有式I结构单元的聚砜的膜接触。

45. 发明授权

US07790410B2 Method and apparatus for determining hemocompatibility 有权
标题翻译：测定血液相容性的方法和装置
公开(公告)号：US07790410B2
公开(公告)日：2010-09-07
申请号：US12110104
申请日：2008-04-25
申请人： Liming Yu , Aaron Dulgar-Tulloch
发明人： Liming Yu , Aaron Dulgar-Tulloch
IPC分类号： C12Q1/56
CPC分类号： G01N33/86
摘要： Provided herein are techniques for screening materials for hemocompatibility. Hemocompatible materials may be advantageous when incorporated into devices that may come into direct contact with blood or other bodily fluids. Such techniques take advantage of conformational changes in fibrinogen when adsorbed onto certain materials. As a result of conformational changes, the fibrinogen has altered responsiveness to cleavage by thrombin. Accordingly, the products of thrombin cleavage of fibrinogen may be assessed to determine the hemocompatibility of a material.
摘要翻译：本文提供了用于筛选血液相容性的材料的技术。当结合到可能与血液或其他体液直接接触的装置中时，血液相容性材料可能是有利的。当吸附到某些材料上时，这种技术利用纤维蛋白原的构象变化。作为构象变化的结果，纤维蛋白原已经改变了对凝血酶切割的反应性。因此，可以评估纤维蛋白原凝血酶切割的产物以确定材料的血液相容性。

46. 发明授权

US07612883B2 Dynamic plasmonics-enabled signal enhancement, a device comprising the same, and a method using the same 失效
标题翻译：动态等离子体激元信号增强，包括其的装置及其使用方法
公开(公告)号：US07612883B2
公开(公告)日：2009-11-03
申请号：US11749950
申请日：2007-05-17
申请人： Long Que , Jeffrey Bernard Fortin , Christopher Fred Keimel , Liming Yu , Zhiyong Wang
发明人： Long Que , Jeffrey Bernard Fortin , Christopher Fred Keimel , Liming Yu , Zhiyong Wang
IPC分类号： G01N21/25
CPC分类号： G01N21/648 , B01L3/5025 , B01L3/502761 , B01L2300/0636 , B01L2300/0654 , B01L2300/0819
摘要： Disclosed herein is a plasmonics platform comprising a substrate; a plurality of periodically spaced nanoholes and/or nanoparticles disposed upon the substrate; wherein the average first order of periodicity between the nanoholes and/or the nanoparticles is about 5 to about 1,000 nm; and a microelectromechanical and/or a nanoelectromechanical system in operative communication with the substrate so as to vary the average first order of periodicity between the nanoholes and/or the nanoparticles.
摘要翻译：本文公开了一种等离子体激元平台，其包括基底; 多个周期性间隔开的纳米孔和/或纳米颗粒设置在基底上; 其中所述纳米孔和/或纳米颗粒之间的平均一级周期为约5至约1000nm; 以及与所述基板操作性连通的微机电和/或纳米机电系统，以便改变所述纳孔与/或纳米颗粒之间的周期的平均一级。

47. 发明授权

US07193507B2 Siren housing 失效
标题翻译：警报器房屋
公开(公告)号：US07193507B2
公开(公告)日：2007-03-20
申请号：US11105741
申请日：2005-04-14
申请人： Liming Yu
发明人： Liming Yu
IPC分类号： G08B3/00
CPC分类号： G08B3/10
摘要： A siren housing has a dish-shaped base having a back wall adapted to be secured to as support structure. The base is configured and dimensioned to contain siren components. A post projects forwardly from the back wall. The post has a cylindrical sidewall terminating at a front rim. At least one channel circumscribes a segment of the sidewall at a location spaced rearwardly from the front rim. Entry and exit slots communicate with the channel at spaced locations along the length thereof. The entry slot leads to the front rim and the exit slot leading towards the back wall. A dish-shaped cover has a front wall. A cylindrical sleeve projects rearwardly from the front wall, the sleeve having at least one pin projecting radially inwardly therefrom. The sleeve is dimensioned for axial insertion onto the post. The pin is arranged: to enter the channel via the entry slot; and to coact with the channel in supporting the cover above the base for movement between open and closed positions; and to exit the channel via the exit slot to accommodate seating of the closed cover on the base.
摘要翻译：警报器壳体具有盘形基座，其具有适于被固定为支撑结构的后壁。基座的配置和尺寸设置为包含警报组件。一个职位从后墙向前推进。该柱具有终止于前缘的圆柱形侧壁。至少一个通道在与前边缘向后间隔的位置处限定侧壁的一段。入口和出口槽沿其长度在间隔的位置与通道连通。入口槽通向前缘，而出口槽通向后壁。碟形盖有一个前壁。圆柱形套筒从前壁向后突出，套筒具有从其径向向内突出的至少一个销。套筒的尺寸设计用于轴向插入柱上。引脚布置为：通过入口插槽进入通道; 并且与通道协作以支撑基座上方的盖以在打开和关闭位置之间移动; 并通过出口槽离开通道，以容纳封闭盖在基座上的安置。

48. 发明申请

US20060232434A1 Siren housing 失效
标题翻译：警报器房屋
公开(公告)号：US20060232434A1
公开(公告)日：2006-10-19
申请号：US11105741
申请日：2005-04-14
申请人： Liming Yu
发明人： Liming Yu
IPC分类号： G08B23/00
CPC分类号： G08B3/10
摘要： A siren housing has a dish-shaped base having a back wall adapted to be secured to as support structure. The base is configured and dimensioned to contain siren components. A post projects forwardly from the back wall. The post has a cylindrical side wall terminating at a front rim. At least one channel circumscribes a segment of said side wall at a location spaced rearwardly from said front rim. Entry and exit slots communicate with said channel at spaced locations along the length thereof. The entry slot leads to said front rim and the exit slot leading towards said back wall. A dish-shaped cover has a front wall. A cylindrical sleeve projects rearwardly from said front wall, said sleeve having at least one pin projecting radially inwardly therefrom. The sleeve is dimensioned for axial insertion onto said post. The pin is arranged: 1) to enter said channel via said entry slot; 2) to coact with said channel in supporting said cover above said base for movement between open and closed positions; and 3) to exit said channel via said exit slot to accommodate seating of said closed cover on said base.
摘要翻译：警报器壳体具有盘形基座，其具有适于被固定为支撑结构的后壁。基座的配置和尺寸设置为包含警报组件。一个职位从后墙向前推进。该柱具有终止于前缘的圆柱形侧壁。至少一个通道在与所述前边缘向后间隔开的位置处限定所述侧壁的一段。入口和出口槽沿着其长度在间隔的位置处与所述通道连通。入口槽通向所述前边缘和导向所述后壁的出口槽。碟形盖有一个前壁。圆柱形套筒从所述前壁向后突出，所述套筒具有从其径向向内突出的至少一个销。套筒的尺寸用于轴向插入到所述柱上。引脚布置为：1）通过所述入口槽进入所述通道; 2）与所述通道共同支撑在所述基座上方的所述盖以在打开和关闭位置之间运动; 以及3）通过所述出口槽离开所述通道以容纳所述封闭盖在所述基座上的安置。

49. 发明申请

US20050122116A1 Method and apparatus for use of the real component of a magnetic field of multicomponent resistivity measurements 有权
标题翻译：使用多组分电阻率测量的磁场的实际分量的方法和装置
公开(公告)号：US20050122116A1
公开(公告)日：2005-06-09
申请号：US10994830
申请日：2004-11-22
申请人： Liming Yu , Berthold Kriegshauser
发明人： Liming Yu , Berthold Kriegshauser
IPC分类号： G01V3/28 , G01V3/10
CPC分类号： G01V3/28
摘要： Multi-component induction measurements are made using a resistivity logging tool in an anistropic earth formation. A subset of the multi-component measurements are inverted to first determine horizontal resistivities. Using the determined horizontal resistivities and another subset of the multi-component measurements, the vertical resistivities are obtained. Results of using the in-phase signals are comparable to those obtained using multifrequency focusing of quadrature signals.
摘要翻译：多分量感应测量使用电磁测井工具在无水土层中进行。多组分测量的子集被反转以首先确定水平电阻率。使用确定的水平电阻率和多分量测量的另一子集，获得垂直电阻率。使用同相信号的结果与使用正交信号的多频聚焦获得的结果相当。

50. 发明授权

US06900640B2 Method and apparatus for a multi-component induction instrument measuring system for geosteering and formation resistivity data interpretation in horizontal, vertical and deviated wells 失效
标题翻译：用于水平，垂直和偏斜井的地质导向和地层电阻率数据解释的多分量感应仪测量系统的方法和装置
公开(公告)号：US06900640B2
公开(公告)日：2005-05-31
申请号：US10214436
申请日：2002-08-07
申请人： Otto N. Fanini , Stanislav W. Forgang , Berthold Kriegshauser , Liming Yu
发明人： Otto N. Fanini , Stanislav W. Forgang , Berthold Kriegshauser , Liming Yu
IPC分类号： G01V3/28 , G01V3/18
CPC分类号： G01V3/28
摘要： An improved induction tool for formation resistivity evaluations. The tool provides electromagnetic transmitters and sensors suitable for transmitting and receiving magnetic fields in radial directions that are orthogonal to the tool's longitudinal axis with minimal susceptibility to errors associated with parasitic eddy currents induced in the metal components surrounding the transmitter and receiver coils. Various transmitter receiver combinations are provided to select sensitivity to a desired reservoir formation properties, for example, different orientations xy, xz, yz, 20-40, 20-90, and combinations, such as, Symmetric—symmetric; Asymmetric—symmetric; and Asymmetric—asymmetric. Measurements made with a multi-component logging instrument when used in a substantially horizontal, vertical or deviated borehole in earth formations are diagnostic of the direction of resistive beds relative to the position of the borehole.
摘要翻译：改进的地层电阻率评估感应工具。该工具提供电磁发射器和传感器，适用于在与工具的纵向轴线正交的径向方向上发射和接收磁场，对与发射器和接收器线圈周围的金属部件中感应的寄生涡流有关的误差的影响最小。提供各种发射器接收器组合以选择对期望的储层形成性质的灵敏度，例如不同取向xy，xz，yz，20-40,20-90以及诸如对称对称的组合; 不对称; 和非对称不对称。使用多组分测井仪器在地层中基本上水平，垂直或偏斜的钻孔中进行的测量是电阻床相对于钻孔位置的方向的诊断。

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