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41. 发明授权

US07559952B2 Elastomeric polymer filament cosmetic implant 有权
标题翻译：弹性聚合物长丝化妆品植入物
公开(公告)号：US07559952B2
公开(公告)日：2009-07-14
申请号：US11015941
申请日：2004-12-17
申请人： Leonard Pinchuk
发明人： Leonard Pinchuk
IPC分类号： A61F2/02
CPC分类号： A61F2/0059 , A61B17/00491 , A61B17/06004 , A61B17/3468 , A61B2017/00495 , A61B2017/00792 , A61B2017/06038 , A61B2017/0618 , A61F2250/0068
摘要： A cosmetic implant comprises a filament made from a biocompatible elastomer. The elastomeric filament can be injected or pulled under one or more wrinkles. Once implanted under the wrinkle(s), the filament lifts and supports the tissue above it. Such lifting lessens (and possibly removes altogether) the appearance of the wrinkle(s). The biocompatible elastomeric filament is preferably made from a polyolefinic copolymer material having a triblock polymer backbone comprising polystyrene-polyisobutylene-polystyrene, which is herein referred to as “SIBS”; or alternatively can be made from silicon rubber, expanded polytetrafluorethelyene (ePTFE), polyurethane, polyolefin, copolymers of nylon, copolymers of polyester, or elastin.
摘要翻译：化妆品植入物包括由生物相容性弹性体制成的细丝。可以在一个或多个皱纹下注射或拉出弹性体细丝。一旦植入了皱纹（一个或多个），灯丝提升并支持其上方的组织。这种提升会减轻皱纹（甚至完全消除）皱纹的出现。生物相容的弹性体丝优选由具有包含聚苯乙烯 - 聚异丁烯 - 聚苯乙烯的三嵌段聚合物主链的聚烯烃共聚物材料制成，其在本文中称为“SIBS”; 或者可以由硅橡胶，膨胀聚四氟乙烯（ePTFE），聚氨酯，聚烯烃，尼龙共聚物，聚酯或弹性蛋白的共聚物制成。

42. 发明申请

US20080221668A1 EXPANDABLE SUPPORTIVE BRANCHED ENDOLUMINAL GRAFTS 审中-公开
标题翻译：可扩展的支持性分支性内支架
公开(公告)号：US20080221668A1
公开(公告)日：2008-09-11
申请号：US12107859
申请日：2008-04-23
申请人： Leonard Pinchuk , Yasushi Kato , Rysler Alcime
发明人： Leonard Pinchuk , Yasushi Kato , Rysler Alcime
IPC分类号： A61F2/06
CPC分类号： A61F2/90 , A61F2/07 , A61F2/885 , A61F2/89 , A61F2002/067 , A61F2002/072 , A61F2002/075 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/001 , A61F2230/0078 , A61F2250/0039
摘要： A method of manufacturing an endoluminal graft which is both expandable and supportive is provided in a form suitable for use in a branched body vessel location. The graft expands between a first diameter and a second, larger diameter. The support component is an expandable stent endoprosthesis. A liner is applied to the endoprosthesis in the form of a compliant wall material that is porous and biocompatible in order to allow normal cellular invasion upon implantation, without stenosis, when the expandable and supportive graft is at its second diameter. The supportive endoluminal graft is preferably provided as a plurality of components that are deployed separately at the branching body vessel location, one of which has a longitudinal seam defining leg portions within which the other components fit in a telescoping manner.
摘要翻译：提供可膨胀和支持的腔内移植物的方法，其形式适用于分支体血管位置。移植物在第一直径和第二直径较大的直径之间膨胀。支撑部件是可扩张的支架内置假体。将内衬施用于多孔且生物相容的柔性壁材料形式的内用假体，以便当可扩张和支持性移植物处于其第二直径时，在植入时允许正常的细胞侵入而没有狭窄。支持性腔内移植物优选地被设置为在分支体血管位置处分开设置的多个部件，其中一个部件具有限定腿部的纵向接缝，其中其它部件可以以伸缩方式配合。

43. 发明授权

US07314466B2 Minimally invasive vascular surgery 有权
标题翻译：微创血管手术
公开(公告)号：US07314466B2
公开(公告)日：2008-01-01
申请号：US10901409
申请日：2004-07-27
申请人： G. Banning Lary , Leonard Pinchuk
发明人： G. Banning Lary , Leonard Pinchuk
IPC分类号： A61M31/00
CPC分类号： A61K9/0019 , A61K47/02
摘要： A mixture for intravenous injection to treat damaged vascular structures contains a mixture of carbamide peroxide and a sclerosing agent. The injected mixture expresses blood from the affected vascular structure by formation of bubbles, in situ. The bubbles carry the sclerosing agent into contact with the lining of the vascular structure resulting in destruction. The size of the bubbles may be varied by adding hydrogen peroxide and varying the proportions of carbamide peroxide and hydrogen peroxide in the mixture.
摘要翻译：用于静脉注射以治疗受损血管结构的混合物含有过氧化脲和硬化剂的混合物。注射的混合物通过原位形成气泡从受影响的血管结构中表达血液。气泡携带硬化剂与血管结构的衬里接触导致破坏。可以通过加入过氧化氢和改变混合物中过氧化脲和过氧化氢的比例来改变气泡的大小。

44. 发明申请

US20070282436A1 Stent-valve and deployment catheter for use therewith 审中-公开
标题翻译：支架阀和展开导管与其一起使用
公开(公告)号：US20070282436A1
公开(公告)日：2007-12-06
申请号：US11336683
申请日：2006-01-20
申请人： Leonard Pinchuk
发明人： Leonard Pinchuk
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/91 , A61F2220/0016 , A61F2220/005 , A61F2230/0054
摘要： A stent-valve device includes a non-collapsible valve component and a stent component having a first ring connected to a second ring. The first ring has a characteristic first diameter and a valve support for supporting the valve component. The second ring is contractible and expandable between a second diameter less than a third diameter. The second diameter is less than the first diameter and the third diameter is greater than the first diameter. The first ring preferably includes a plurality of elements that extend downward to feet that project radially inward. The valve component rests on the feet for support. A seal is preferably disposed about the first ring. The valve component may be mechanical valve prosthesis, a bio-prosthesis (such as a non-collapsible porcine valve) or a polymer-based prosthesis. In another aspect of the invention, a deployment catheter is provided for effectively deploying the stent-valve device(s) described herein.
摘要翻译：支架阀装置包括不可折叠的阀部件和具有连接到第二环的第一环的支架部件。第一环具有特征的第一直径和用于支撑阀部件的阀支撑件。第二环是可收缩的并且在小于第三直径的第二直径之间可膨胀。第二直径小于第一直径，第三直径大于第一直径。第一环优选地包括从径向向内突出地向下延伸到脚的多个元件。阀组件支撑在支脚上。优选地围绕第一环设置密封件。阀部件可以是机械瓣膜假体，生物假体（例如不可折叠的猪阀）或基于聚合物的假体。在本发明的另一方面，提供了用于有效地展开本文所述的支架 - 阀装置的展开导管。

45. 发明申请

US20070245904A1 Hand-Holdable Egg-Based Food Product and Method of Producing Same 审中-公开
标题翻译：手持蛋类食品及其生产方法
公开(公告)号：US20070245904A1
公开(公告)日：2007-10-25
申请号：US11379608
申请日：2006-04-21
申请人： Leonard Pinchuk
发明人： Leonard Pinchuk
IPC分类号： A47J37/06
CPC分类号： A47J43/20
摘要： A hand-holdable egg-based food product (and method of producing same) preferably includes a hand-holdable member having first and second portions. An edible part, which preferably surrounds and is supported by the hand-holdable member first portion, includes a processed egg-based composition that is substantially cooked and has a solid form that substantially retains its shape when warmed. The second portion of the hand-holdable member provides gripping surfaces that can be manually picked up and held by a human hand for handling and eating as desired. The edible part can include at least one additive (e.g., vegetable(s), meat(s), cheese(s), spice(s)) that is mixed with the processed egg-based composition. The processed egg-based composition is preferably realized by mixing a liquid form egg-based composition. Advantageously, the hand-holdable egg-based food product need not be consumed with carbohydrates, can be handled with ease, does not come apart, and is therefore suitable for eating on the run.
摘要翻译：手持式蛋类食品（及其制造方法）优选包括具有第一部分和第二部分的手持部件。优选地围绕并由手持构件第一部分支撑的可食用部分包括经加工的蛋基组合物，其基本上被烹饪并具有当加热时基本上保持其形状的固体形式。可手持构件的第二部分提供可手动拾取并由人手抓住的抓握表面，以便根据需要进行处理和进食。可食用部分可以包括与经加工的蛋类组合物混合的至少一种添加剂（例如，蔬菜，肉，奶酪，香料）。经处理的蛋类组合物优选通过混合液体形式的基于蛋的组合物来实现。有利地，可手持的蛋类食品不需要与碳水化合物一起消耗，可以容易地处理，不会分开，因此适合在运行中进食。

46. 发明申请

US20070142698A1 Flattened tubular mesh sling and related methods 有权
标题翻译：扁平管状网吊带及相关方法
公开(公告)号：US20070142698A1
公开(公告)日：2007-06-21
申请号：US11314284
申请日：2005-12-20
申请人： George Bourne , Leonard Pinchuk
发明人： George Bourne , Leonard Pinchuk
IPC分类号： A61F2/02
CPC分类号： A61F2/0045 , A61F2002/0068 , A61F2250/0028 , Y10T156/10
摘要： The invention generally relates to surgically implantable supportive slings. More specifically, in various embodiments, the invention is directed to multilayer mesh slings formed from a tubular mesh material.
摘要翻译：本发明一般涉及可手术植入的支撑吊索。更具体地，在各种实施例中，本发明涉及由管状网状材料形成的多层网状吊索。

47. 发明申请

US20060129095A1 Drug delivery apparatus 审中-公开
标题翻译：药物输送装置
公开(公告)号：US20060129095A1
公开(公告)日：2006-06-15
申请号：US11007599
申请日：2004-12-08
申请人： Leonard Pinchuk
发明人： Leonard Pinchuk
IPC分类号： A61M29/00
CPC分类号： A61M25/007 , A61M2025/0036 , A61M2025/004
摘要： A drug delivery apparatus is provided which enables a medical professional to conveniently and controllably distribute drugs over an expanded target area within a patent. The apparatus comprises a catheter tube attached to a fluid delivery component. The catheter tube includes a distal end, a proximal end, a plurality of holes distributed along the length of the catheter tube, a first lumen which is not connected to any of said plurality of holes and extends from the proximal end toward the distal end of the tube, and a plurality of other lumens, each of which extends from the proximal end of the catheter tube to a respective hole or group of holes along the length of the tube and is in independent communication with a respective hole or group of holes. The fluid delivery component includes a first conduit connected to the first lumen at the proximal end of the catheter tube as well as a plurality of other conduits which are each connected to a respective other lumen at the proximal end of the catheter tube.
摘要翻译：提供了一种药物输送装置，其使得医疗专业人员能够方便和可控地将药物分布在专利范围内的扩大的目标区域上。该装置包括附接到流体输送部件的导管。导管包括远端，近端，沿着导管管的长度分布的多个孔，未连接到所述多个孔中的任一个的第一腔，并且从第一内腔的近端延伸到远端管，以及多个其它腔，每个腔从导管的近端延伸到沿着管的长度的相应孔或一组孔，并与相应孔或孔组独立连通。流体递送部件包括在导管管的近端处连接到第一腔的第一导管以及多个其它导管，每个导管连接到导管管的近端处的相应的另一个内腔。

48. 发明授权

US06197240B1 Method of device having biostable elastomeric polymers having quaternary carbons 有权
标题翻译：具有具有季碳的生物稳定弹性体聚合物的装置的方法
公开(公告)号：US06197240B1
公开(公告)日：2001-03-06
申请号：US09309007
申请日：1999-05-10
申请人： Leonard Pinchuk
发明人： Leonard Pinchuk
IPC分类号： B29C4108
CPC分类号： B29C41/08 , A61L27/16 , B29L2031/7532 , Y10S623/901 , C08L53/00
摘要： An article of manufacture and method of making and implanting the article made of a polyolefin star or linear copolymer are disclosed in which the polyolefin copolymer is biostable and crack-resistant when implanted in vivo. The polyolefin copolymer is the reaction product of a rubbery component which when homopolymerized produces a polymer having a low level of hardness, and a hardening component which when homopolymerized produces a polymer having a high level of hardness. The polyolefin copolymer is elastomeric, has a hardness intermediate the low and high levels of hardness, and has a backbone in which the majority of polymer linkages along the copolymer chain are alternating quaternary and secondary carbon atoms.
摘要翻译：公开了一种制造和制造由聚烯烃星形或线型共聚物制成的制品的方法，其中聚烯烃共聚物在体内植入时具有生物稳定性和耐裂纹性。聚烯烃共聚物是当均聚产生低硬度聚合物的橡胶组分的反应产物，当均聚时产生具有高硬度水平的聚合物的硬化组分。聚烯烃共聚物是弹性体，具有低和高硬度水平的硬度，并且具有主链，其中沿着共聚物链的大部分聚合物键交替为季碳和次碳原子。

49. 发明授权

US6110142A Balloons for medical devices and fabrication thereof 失效
标题翻译：用于医疗设备的气球及其制造
公开(公告)号：US6110142A
公开(公告)日：2000-08-29
申请号：US33799
申请日：1998-03-03
申请人： Leonard Pinchuk , Robert S. Shonk , Thomas Trotta
发明人： Leonard Pinchuk , Robert S. Shonk , Thomas Trotta
IPC分类号： A61B17/00 , A61L29/06 , A61M25/00 , A61M29/02 , A61M29/00
CPC分类号： A61M25/1029 , A61L29/06 , A61M25/1034 , A61M25/104 , A61B2017/00783 , A61M2025/1086 , A61M25/1038 , A61M29/02
摘要： Dilatation balloons and catheters including same are provided. The balloons are fabricated of a biaxially orientable material such as a nylon or a polyamide material, and they have an inflated, non-distended working profile as well as a stretched inflated profile which is achieved by applying pressure through a dilatation catheter or the like that is in excess of that needed to achieve the inflated, non-distended profile and which is adequate to effect dilatation or the like up to a maximum pre-bursting pressure application. The maximum pre-bursting size of the balloon can be tailored depending upon the needs of the particular balloon within a wide range of possible maximum pre-bursting sizes.
摘要翻译：提供了包括其的扩张气囊和导管。气球由诸如尼龙或聚酰胺材料的双轴取向材料制成，并且它们具有膨胀的，不扩张的加工轮廓以及通过经由膨胀导管等施加压力而实现的拉伸膨胀轮廓，超过了实现膨胀的，不膨胀的轮廓所需要的，并且足以实现扩张等直至最大的预破裂压力施加。可以根据特定气球在可能的最大预爆破尺寸的宽范围内的需要来调整气囊的最大预爆破尺寸。

50. 发明授权

US6102939A Method of implanting biostable elastomeric polymers having quaternary carbons 失效
标题翻译：植入具有季碳的生物稳定弹性体聚合物的方法
公开(公告)号：US6102939A
公开(公告)日：2000-08-15
申请号：US951016
申请日：1997-10-15
申请人： Leonard Pinchuk
发明人： Leonard Pinchuk
IPC分类号： A61L27/00 , A61K6/083 , A61L27/16 , A61L29/00 , A61L31/00 , B29C41/08 , C08F12/08 , C08F20/10 , C08F36/06 , A61F2/06
CPC分类号： B29C41/08 , A61L27/16 , B29L2031/7532 , Y10S623/901
摘要： An article of manufacture and method of making and implanting the article made of a polyolefin star or linear copolymer are disclosed in which the polyolefin copolymer is biostable and crack-resistant when implanted in vivo. The polyolefin copolymer is the reaction product of a rubbery component which when homopolymerized produces a polymer having a low level of hardness, and a hardening component which when homopolymerized produces a polymer having a high level of hardness. The polyolefin copolymer is elastomeric, has a hardness intermediate the low and high levels of hardness, and has a backbone in which the majority of polymer linkages along the copolymer chain are alternating quaternary and secondary carbon atoms.
摘要翻译：公开了一种制造和制造由聚烯烃星形或线型共聚物制成的制品的方法，其中聚烯烃共聚物在体内植入时具有生物稳定性和耐裂纹性。聚烯烃共聚物是当均聚产生低硬度聚合物的橡胶组分的反应产物，当均聚时产生具有高硬度水平的聚合物的硬化组分。聚烯烃共聚物是弹性体，具有低和高硬度水平的硬度，并且具有主链，其中沿着共聚物链的大部分聚合物键交替为季碳和次碳原子。

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