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41. 发明专利

NZ602504A Antiviral vaccines with improved cellular immunogenicity 未知
公开(公告)号：NZ602504A
公开(公告)日：2014-01-31
申请号：NZ60250409
申请日：2009-11-18
申请人： BETH ISRAEL HOSPITAL , LOS ALAMOS NAT SECURITY LLC
发明人： BAROUCH DAN H , KORBER BETTE T , FISCHER WILLIAM M
IPC分类号： A61K39/12 , A61K39/21 , A61K39/385 , A61P31/12 , A61P31/18 , C07K7/06 , C07K7/08 , C07K14/08 , C07K14/155 , C07K14/16 , C07K17/00
摘要： 602504 Disclosed is a vaccine comprising at least two distinct optimized viral HIV-1 polypeptides, wherein said optimized viral polypeptides correspond to the same viral gene product, wherein the viral gene product is selected from the group consisting of gag, pol and env, and wherein the at least two distinct optimized gag polypeptides are selected from any one or more of the groups: (a) SEQ ID NO:3 and 4, (b) SEQ ID NO:3 and 15, (c) SEQ ID NO:4 and 15; wherein the at least two distinct optimized pol polypeptides are selected from any one or more of the groups: (a) SEQ ID NO:12 and 13, (b) SEQ ID NO:12 and 14, (c) SEQ ID NO:13 and 14; and wherein the at least two distinct optimized env polypeptides are selected from any one or more of the groups: (a) SEQ ID NO:9 and 10, (b) SEQ ID NO:9 and 11, (c) SEQ ID NO:10 and 11. >3MGARASVLSGGELDRWEKIRLRPGGKKKYRLKHIVWASRELERFAVNPGLLETSEGCRQILGQLQPSLQTGSEELRSLYNTVATLYCVHQRIEIKDTKEALEKIEEEQNKSKKKAQQAAADTGNSSQVSQNYPIVQNIQGQMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAAEWDRVHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTNNPPIPVGEIYKRWIILGLNKIVRMYSPVSILDIRQGPKEPFRDYVDRFYKTLRAEQASQDVKNWMTETLLVQNANPDCKTILKALGPAATLEEMMTACQGVGGPGHKARVLAEAMSQVTNSATIMMQRGNFRNQRKTVKCFNCGKEGHIAKNCRAPRKKGCWKCGKEGHQMKDCTERQANFLGKIWPSNKGRPGNFLQNRPEPTAPPEESFRFGEETTTPSQKQEPIDKEMYPLASLKSLFGNDPSSQ >4MGARASILRGGKLDKWEKIRLRPGGKKHYMLKHLVWASRELERFALNPGLLETSEGCKQIIKQLQPALQTGTEELRSLFNTVATLYCVHAEIEVRDTKEALDKIEEEQNKSQQKTQQAKEADGKVSQNYPIVQNLQGQMVHQPISPRTLNAWVKVIEEKAFSPEVIPMFTALSEGATPQDLNTMLNTVGGHQAAMQMLKDTINEEAAEWDRLHPVHAGPVAPGQMREPRGSDIAGTTSNLQEQIAWMTSNPPIPVGDIYKRWIILGLNKIVRMYSPTSILDIKQGPKEPFRDYVDRFFKTLRAEQATQDVKNWMTDTLLVQNANPDCKTILRALGPGATLEEMMTACQGVGGPSHKARVLAEAMSQTNSTILMQRSNFKGSKRIVKCFNCGKEGHIARNCRAPRKKGCWKCGKEGHQMKDCTERQANFLGKIWPSHKGRPGNFLQSRPEPTAPPAESFRFEETTPAPKQEPKDREPLTSLRSLFGSDPLSQ >15MGARASVLSGGKLDAWEKIRLRPGGKKKYKLKHIVWASRELDRFALNPGLLETAEGCQQIIEQLQPALQTGSEELKSLYNTVAVLYCVHQRIDVKDTKEALDKIEEIQNKSKQKTQQAAADTGSSSKVSQNYPIVQNAQGQMVHQALSPRTLNAWVKVVEEKGFNPEVIPMFSALAEGATPQDLNMMLNIVGGHQAAMQILKDTINEEAADWDRLHPVHAGPIPPGQMREPRGSDIAGTTSTPQEQIGWMTSNPPVPVGEIYKRWIIMGLNKIVRMYSPVSILDIKQGPKESFRDYVDRFFKVLRAEQATQEVKNWMTETLLIQNANPDCKSILRALGPGASLEEMMTACQGVGGPSHKARILAEAMSQANNTNIMMQRGNFKGQKRIKCFNCGKEGHLARNCRAPRKRGCWKCGREGHQMKDCNERQANFLGKIWPSSKGRPGNFPQSRPEPTAPLEPTAPPAEPTAPPAESFGFGEEITPSPKQEQKDREPLTSLKSLFGSDPLLQ >12MAPISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLAVGDAYFSVPLDEGFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTRILEPFRAKNPEIVIYQYMAALYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKMRTAHTNDVKQLTEAVQKIAMESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTPPLVKLWYQLEKDPIAGVETFYVAGAANRETKLGKAGYVTDRGRQKIVSLTETTNQKTALQAIYLALQDSGSEVNIVTASQYALGIIQAQPDKSESELVNQIIEQLIKKERVYLSWVPAHKGIGGNEQVDKLVSSGIRKVLFLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDQCQLKGEAMHGQVDCSPGIWQLACTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKVIHTANGSNFTSAAVKAACWWAGIQQEFGIPYNPQSQGVVASMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIKDYGKQMAGADCVAGRQDED >13MAPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPIFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLAVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMAALYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWEAWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVAGAANRETKLGKAGYVTDRGRQKVVSLTDTTNQKTALQAIHLALQDSGLEVNIVTASQYALGIIQAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSRGIRKVLFLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGIWQLACTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTANGSNFTSATVKAACWWAGIKQEFGIPYNPQSQGVVASINKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGEYSAGERIVDIIASDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED >14MAPISPIDTVPVTLKPGMDGPKIKQWPLTEEKIKALTEICTEMEKEGKISRIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKRSVTVLAVGDAYFSVPLDKDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRAQNPEIVIYQYVAALYVGSDLEIEQHRTKIEELRAHLLSWGFTTPDKKHQREPPFLWMGYELHPDRWTVQPIELPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGAKALTEVIPLTKEAELELAENREILREPVHGVYYDPSKDLVAEIQKQGQDQWTYQIYQEPYKNLKTGKYARKRSAHTNDVRQLTEAVQKIALESIVIWGKIPKFRLPIQRETWETWWTEYWQATWIPDWEFVNTPPLVKLWYQLEKEPIAGAETFYVAGASNRETKIGKAGYVTDKGRQKVVSLTETTNQKAALQAIQLALQDSGPEVNIVTASQYVLGIIQAQPDRSESELVNQIIEELIKKEKVYLSWVPAHKGIGGNEQVDKLVSAGIRKILFLDGIDKAQEEHERYHSNWRTMASDFNLPPIVAKEIVANCDKCQLKGEAMHGQVDCSPGMWQLACTHLEGKIIIVAVHVASGYMEAEVIPAETGQETAYYILKLAGRWPVKVVHTANGSNFTSTTVKAACWWANVTQEFGIPYNPQSQGVIASMNKELKKIIGQVREQAEHLKTAVQMAVLIHNFKRRGGIGGYSAGERIVDIIATDIQTRELQKQIIKIQNFRVYFRDSRDPVWKGPAKLLWKGEGAVVIQDNSEIKVVPRRKVKIIRDYGKQMAGDDCVAGRQDEDQ >9MRVTGIRKNYQHLWRWGTMLLGILMICSAAGKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEVVLENVTENFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLNCTDDVRNVTNNATNTNSSWGEPMEKGEIKNCSFNITTSIRNKVQKQYALFYKLDVVPIDNDSNNTNYRLISCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNDKKFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSENFTNNAKTIMVQLNVSVEINCTRPNNNTRKSIHIGPGRAFYTAGDIIGDIRQAHCNISRANWNNTLRQIVEKLGKQFGNNKTIVFNHSSGGDPEIVMHSFNCGGEFFYCNSTKLFNSTWTWNNSTWNNTKRSNDTEEHITLPCRIKQIINMWQEVGKAMYAPPIRGQIRCSSNITGLLLTRDGGNDTSGTEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKRRVVQSEKSAVGIGAVFLGFLGAAGSTMGAASMTLTVQARLLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARVLAVERYLKDQQLLGIWGCSGKLICTTTVPWNASWSNKSLDKIWNNMTWMEWEREINNYTSLIYTLIEESQNQQEKNEQELLELDKWASLWNWFDISNWLW >10MRVRGIQRNWPQWWIWGILGFWMIIICRVMGNLWVTVYYGVPVWKEAKTTLFCASDAKAYEKEVHNVWATHACVPTDPNPQEMVLENVTENFNMWKNDMVDQMHEDIIRLWDQSLKPCVKLTPLCVTLECRNVRNVSSNGTYNIIHNETYKEMKNCSFNATTVVEDRKQKVHALFYRLDIVPLDENNSSEKSSENSSEYYRLINCNTSAITQACPKVSFDPIPIHYCAPAGYAILKCNNKTFNGTGPCNNVSTVQCTHGIKPVVSTQLLLNGSLAEEEIIIRSENLTNNAKTIIVHLNETVNITCTRPNNNTRKSIRIGPGQTFYATGDIIGDIRQAHCNLSRDGWNKTLQGVKKKLAEHFPNKTINFTSSSGGDLEITTHSFNCRGEFFYCNTSGLFNGTYMPNGTNSNSSSNITLPCRIKQIINMWQEVGRAMYAPPIAGNITCRSNITGLLLTRDGGSNNGVPNDTETFRPGGGDMRNNWRSELYKYKVVEVKPLGVAPTEAKRRVVESEKSAVGIGAVFLGILGAAGSTMGAASITLTVQARQLLSGIVQQQSNLLRAIEAQQHMLQLTVWGIKQLQTRVLAIERYLQDQQLLGLWGCSGKLICTTAVPWNTSWSNKSQTDIWDNMTWMQWDKEIGNYTGEIYRLLEESQNQQEKNEKDLLALDSWKNLWNWFDITNWLW >11MRVKGIRKNYQHLWKWGTMLLGMLMICSAAEQLWVTVYYGVPVWRDAETTLFCASDAKAYEREVHNIWATHACVPTDPNPQEIVLENVTEEFNMWKNDMVEQMHTDIISLWDESLKPCVKLAPLCVTLNCTNANLNCTNDNCNRTVDKMREEIKNCSFNMTTELRDKKQKVYALFYKLDIVPIEKNSSEYRLINCNTSTITQACPKVTFEPIPIHYCTPAGFAILKCKDKKFNGTGPCKNVSTVQCTHGIKPVISTQLLLNGSLAEGEIIIRSENITNNAKTIIVQLNESVVINCTRPGNNTRKSVRIGPGQAFYATGEIIGDIRQAYCNISRAKWNNTLKQIVTKLKEQFKNKTIVFNQSSGGDPEITTHSFNCGGEFFYCNTTQLFNSTWNSNSTWNDTTGSVTEGNDTITLPCRIKQIVNMWQRVGQAMYAPPIEGNITCKSNITGLLLVRDGGNINRTNETFRPGGGNMKDNWRSELYKYKVVEIKPLGVAPTRAKRRVVESEKSAVGLGAVFLGFLGTAGSTMGAASLTLTVQARQVLSGIVQQQSNLLKAIEAQQHLLKLTVWGIKQLQARILAVERYLRDQQLLGIWGCSGKLICTTNVPWNSSWSNKSQEEIWNNMTWMQWDREISNYTDTIYRLLEDSQNQQEKNEQDLLALDKWASLWNWFSITNWLW

42. 发明专利

SG10201408784SA ANTIVIRAL VACCINES WITH IMPROVED CELLULAR IMMUNOGENICITY 未知
公开(公告)号：SG10201408784SA
公开(公告)日：2015-02-27
申请号：SG10201408784S
申请日：2009-11-18
申请人： BETH ISRAEL HOSPITAL , LOS ALAMOS NAT SECURITY LLC
发明人： BAROUCH DAN H , KORBER BETTE T , FISCHER WILLIAM M
摘要： The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.

43. 发明专利

NZ593598A Optimized antiviral vaccines with improved cellular immunogenicity 未知
公开(公告)号：NZ593598A
公开(公告)日：2013-02-22
申请号：NZ59359809
申请日：2009-11-18
申请人： BETH ISRAEL HOSPITAL , LOS ALAMOS NAT SECURITY LLC
发明人： BAROUCH DAN H , KORBER BETTE T , FISCHER WILLIAM M
IPC分类号： C07K17/00 , A61K39/12 , A61K39/21 , A61K39/385 , A61P31/12 , A61P31/18 , C07K7/06 , C07K7/08 , C07K14/08 , C07K14/155 , C07K14/16
摘要： 593598 Disclosed is a nucleic acid molecule comprising a nucleotide sequence that encodes at least a first optimized viral polypeptide comprising at least 97% amino acid sequence identity to SEQ ID NO: 9 (MRVTGIRKNYQHLWRWGTMLLGILMICSAAGKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEVVLENVTENFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLNCTDDVRNVTNNATNTNSSWGEPMEKGEIKNCSFNITTSIRNKVQKQYALFYKLDVVPIDNDSNNTNYRLISCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNDKKFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSENFTNNAKTIMVQLNVSVEINCTRPNNNTRKSIHIGPGRAFYTAGDIIGDIRQAHCNISRANWNNTLRQIVEKLGKQFGNNKTIVFNHSSGGDPEIVMHSFNCGGEFFYCNSTKLFNSTWTWNNSTWNNTKRSNDTEEHITLPCRIKQIINMWQEVGKAMYAPPIRGQIRCSSNITGLLLTRDGGNDTSGTEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKRRVVQSEKSAVGIGAVFLGFLGAAGSTMGAASMTLTVQARLLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARVLAVERYLKDQQLLGIWGCSGKLICTTTVPWNASWSNKSLDKIWNNMTWMEWEREINNYTSLIYTLIEESQNQQEKNEQELLELDKWASLWNWFDISNWLW).

44. 发明专利

AP2011005767A0 Antiviral vaccines with improved cellular immunogenicity. 未知
公开(公告)号：AP2011005767A0
公开(公告)日：2011-06-30
申请号：AP2011005767
申请日：2009-11-18
申请人： LOS ALAMOS NAT SECURITY LLC , BETH ISRAEL HOSPITAL
发明人： BAROUCH DAN H , KORBER BETTE T , FISHER WILLIAM M
IPC分类号： C07K17/00
摘要： The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.

45. 发明专利

AP201105767A0 Antiviral vaccines with improved cellular immunogenicity. 未知
公开(公告)号：AP201105767A0
公开(公告)日：2011-06-30
申请号：AP201105767
申请日：2009-11-18
申请人： LOS ALAMOS NAT SECURITY LLC , BETH ISRAEL HOSPITAL
发明人： BAROUCH DAN H , KORBER BETTE T , FISHER WILLIAM M
IPC分类号： C07K17/00
CPC分类号： A61K39/21 , A61K39/12 , A61K39/235 , A61K39/275 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2710/10043 , C12N2710/10343 , C12N2710/24043 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12N2740/16222 , C12N2740/16234 , C12N2740/16271 , C12N2740/16322 , C12N2740/16334 , Y02A50/467
摘要： The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent (e.g., 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.

46. 发明专利

JP2014079250A Consensus/ancestral immunogens 有权
标题翻译：共同体/免疫系统免疫
公开(公告)号：JP2014079250A
公开(公告)日：2014-05-08
申请号：JP2013253689
申请日：2013-12-06
申请人： Univ Duke , デュークユニバーシティ , Univ Of Alabama At Birmingham Research Foundation , ザ・ユニバーシティー・オブ・アラバマ・アット・バーミンガム・リサーチ・ファウンデーション , Regents Of The Univ Of California , ザ・リージェンツ・オブ・ザ・ユニバーシティー・オブ・カリフォルニアThe Regents Of The University Of California
发明人： HAYNES BARTON F , GAO FENG , KORBER BETTE T , HAHN BEATRICE H , SHAW GEORGE M , KOTHE DENISE , LI YING YING , DECKER JULIE , LIAO HUA-XIN
IPC分类号： C12N15/09 , A61K39/00 , A61K39/21 , A61K48/00 , A61P31/18 , C07H21/04 , C07K14/16 , C12N20060101 , C12N5/02 , C12N15/74
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K16/4225 , C12N2740/15022 , C12N2740/15034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16322
摘要： PROBLEM TO BE SOLVED: To provide antibodies that neutralize a variety of human immunodeficiency virus (HIV) primary isolates.SOLUTION: The present invention relates to a method of inducing anti-HIV antibodies and/or a T cell immune response, using an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates and/or a T cell immune response.
摘要翻译：要解决的问题：提供中和多种人类免疫缺陷病毒（HIV）初级分离物的抗体。解决方案：本发明涉及一种诱导抗HIV抗体和/或T细胞免疫应答的方法，使用免疫原诱导中和大量HIV原代分离物和/或T细胞免疫应答的抗体。

47. 发明公开

EP1917040A4 POLYVALENT VACCINE 审中-公开
标题翻译：价疫苗
公开(公告)号：EP1917040A4
公开(公告)日：2012-12-12
申请号：EP06802155
申请日：2006-08-23
申请人： UNIV CALIFORNIA , BETH ISRAEL HOSPITAL , UNIV DUKE , UNIV ALABAMA RES FOUND
发明人： KORBER BETTE T , PERKINS SIMON , BHATTACHARYA TANMOY , FISCHER WILLIAM M , THEILER JAMES , LETVIN NORMAN , HAYNES BARTON F , HAHN BEATRICE H , YUSIM KARINA , KUIKEN CARLA
IPC分类号： A61K39/21 , A61K38/00 , A61K39/00 , A61K39/12
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , C12N2740/16034

48. 发明申请

WO2004075850A3 POLYVALENT IMMUNOGEN 审中-公开
标题翻译：多价免疫
公开(公告)号：WO2004075850A3
公开(公告)日：2007-06-28
申请号：PCT/US2004005497
申请日：2004-02-26
申请人： UNIV DUKE , UNIV CALIFORNIA , HAYNES BARTON F , KORBER BETTE T , DE LORIMIER ROBERT M , LIAO HUA-XIN
发明人： HAYNES BARTON F , KORBER BETTE T , DE LORIMIER ROBERT M , LIAO HUA-XIN
IPC分类号： A61K39/00 , A01N37/18 , A61K20060101 , A61K6/00 , A61K31/7088 , A61K38/00 , A61K39/12 , A61K39/21 , A61K39/38 , A61P31/18 , C07K14/155 , C07K14/16 , C12N15/48
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/54 , A61K2039/543 , A61K2039/545 , A61K2039/55544 , A61K2039/55566 , A61K2039/57 , C07K2319/00 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , Y10S530/826
摘要： The present invention relates, generally, to a polyvalent immunogen and, more particularly, to a method of inducing neutralizing antibodies against HIV and to a polyvalent immunogen suitable for use in such a method.
摘要翻译：本发明一般涉及多价免疫原，更特别地涉及诱导中和抗HIV的抗体的方法以及适用于这种方法的多价免疫原。

49. 发明申请

WO2005028625A2 CONSENSUS/ANCESTRAL IMMUNOGENS 审中-公开
标题翻译：一致/反应原免疫
公开(公告)号：WO2005028625A2
公开(公告)日：2005-03-31
申请号：PCT/US2004030397
申请日：2004-09-17
申请人： UNIV DUKE , HAYNES BARTON F , GAO FENG , KORBER BETTE T , HAHN BEATRICE H , SHAW GEORGE M , KOTHE DENISE , LI YING YING , DECKER JULIE , LIAO HUA-XIN
发明人： HAYNES BARTON F , GAO FENG , KORBER BETTE T , HAHN BEATRICE H , SHAW GEORGE M , KOTHE DENISE , LI YING YING , DECKER JULIE , LIAO HUA-XIN
IPC分类号： A61K39/21 , C07H21/04 , C12N20060101 , C12N5/02 , C12N15/74 , C12N
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K16/4225 , C12N2740/15022 , C12N2740/15034 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16322
摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
摘要翻译：本发明一般涉及免疫原，特别涉及用于诱导中和广谱HIV原发分离株和/或诱导T细胞免疫应答的免疫原的抗体的免疫原。本发明还涉及使用这种免疫原诱导抗HIV抗体的方法，和/或诱导T细胞免疫应答的方法。本发明还涉及编码本发明免疫原的核酸序列。

50. 发明申请

WO2007024941A3 POLYVALENT VACCINE 审中-公开
标题翻译：多价疫苗
公开(公告)号：WO2007024941A3
公开(公告)日：2010-01-28
申请号：PCT/US2006032907
申请日：2006-08-23
申请人： UNIV CALIFORNIA , BETH ISRAEL DEACONNESS MEDICAL , UNIV DUKE , UNIV ALABAMA RES FOUND , KORBER BETTE T , PERKINS SIMON , BHATTACHARYA TANMOY , FISCHER WILLIAM M , THEILER JAMES , LETVIN NORMAN , HAYNES BARTON F , HAHN BEATRICE H , YUSIM KARINA , KUIKEN CARLA
发明人： KORBER BETTE T , PERKINS SIMON , BHATTACHARYA TANMOY , FISCHER WILLIAM M , THEILER JAMES , LETVIN NORMAN , HAYNES BARTON F , HAHN BEATRICE H , YUSIM KARINA , KUIKEN CARLA
IPC分类号： A61K39/21 , A61K38/00 , A61K39/00 , A61K39/12
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , C12N2740/16034
摘要： The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
摘要翻译：本发明通常涉及免疫原性组合物（例如疫苗），并且特别涉及多价免疫原性组合物，例如多价HIV疫苗，以及使用其的方法。本发明进一步涉及使用遗传算法来产生适用于例如疫苗接种策略的多价抗原组的方法。

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