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    • 44. 发明申请
    • Mobilization of hematopoietic cells
    • 动员造血细胞
    • US20050142103A1
    • 2005-06-30
    • US10918328
    • 2004-08-12
    • David WilliamsYi Zheng
    • David WilliamsYi Zheng
    • A61K31/04A61K31/522A61K31/7088A61K35/12A61K35/28A61K38/19A61K38/20C07K14/47C12N5/0775A61K38/10A61K38/08
    • A61K31/522A61K31/04A61K31/7088A61K35/28A61K38/193C07K14/4706C07K2319/01C12N5/0647C12N2500/40C12N2501/125C12N2501/145C12N2501/22C12N2501/23C12N2501/26
    • Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve inhibition of both Rac1 and Rac2 GTPases to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject. The subject's blood can be processed and used to repopulate the destroyed lymphohematopoietic system of a recipient and may in the future be utilized to repair a variety of non-hematopoietic tissues. Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. They can also be used for increasing white blood cell survival and for chemotherapy.
    • 本文提供了改进的方法和药物组合物,用于将造血祖细胞从骨髓移入外周血中,包括单独或组合施用有效量的GTP酶抑制剂,例如Rac1和Rac2。 具体地,公开了将造血干细胞移入受试者的外周血中的方法。 特别地,该方法的实施方案涉及抑制Rac1和Rac2GTP酶以将造血干细胞的数量增加到受试者的受试者的外周血中。 受试者的血液可以被处理并用于重建受体的破坏的淋巴造血系统,并且将来可以用于修复各种非造血组织。 因此,通过本发明的方法动员到受试者的外周血中的造血干细胞可用作骨髓移植中的供体细胞来源,用于治疗各种疾病,包括癌症,贫血,自身免疫和免疫缺陷。 它们也可用于增加白细胞的存活和化疗。
    • 50. 发明申请
    • LASER PATTERNING PROCESS FOR BACK CONTACT THROUGH-HOLES FORMATION PROCESS FOR SOLAR CELL FABRICATION
    • 用于太阳能电池制造的反接触式激光加工方法
    • US20140213015A1
    • 2014-07-31
    • US13750026
    • 2013-01-25
    • Jeffrey L. FranklinYi Zheng
    • Jeffrey L. FranklinYi Zheng
    • H01L31/18
    • H01L31/022425H01L31/068Y02E10/547
    • Embodiments of the invention contemplate formation of a high efficiency solar cell utilizing a laser patterning process to form openings in a passivation layer while maintaining good film properties of the passivation layer on a surface of a solar cell substrate. In one embodiment, a method of forming an opening in a passivation layer on a back surface of a solar cell substrate includes transferring a substrate having a passivation layer formed on a back surface of a substrate into a laser patterning apparatus, the substrate having a first type of doping atom on the back surface of the substrate and a second type of doping atom on a front surface of the substrate, providing laser radiation generated by the laser patterning apparatus from the front surface transmitting through the substrate to the passivation layer disposed on the back surface of the substrate, and forming openings in the passivation layer.
    • 本发明的实施方案考虑使用激光图案化工艺来形成高效率的太阳能电池,以在钝化层中形成开口,同时保持太阳能电池基板的表面上的钝化层的良好的膜特性。 在一个实施例中,在太阳能电池基板的背面上的钝化层中形成开口的方法包括将形成在基板的背面上的钝化层的基板转印到激光图案形成装置中,所述基板具有第一 在衬底的背面上的掺杂原子的类型和在衬底的前表面上的第二类型的掺杂原子,提供由激光图案形成装置产生的激光辐射从透过衬底的前表面到设置在衬底上的钝化层 并且在钝化层中形成开口。