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41. 发明授权

US08916035B2 Arrangement and method using microsensors for measuring cell vitalities 有权
标题翻译：微传感器用于测量细胞活力的布置和方法
公开(公告)号：US08916035B2
公开(公告)日：2014-12-23
申请号：US13499376
申请日：2010-09-29
申请人： Alexander Frey , Walter Gumbrecht , Peter Paulicka , Meinrad Schienle , Daniel Sickert , Manfred Stanzel
发明人： Alexander Frey , Walter Gumbrecht , Peter Paulicka , Meinrad Schienle , Daniel Sickert , Manfred Stanzel
IPC分类号： G01N21/41 , C12M1/34 , G01N27/42 , G01N27/416 , G01N27/404
CPC分类号： G01N27/416 , C12M41/38 , C12M41/46 , G01N27/404 , G01N27/423 , G01N33/48735
摘要： An arrangement and a method measures cell vitalities with a sensor array. The sensor array is formed on a surface of a semiconductor chip. The semiconductor chip has integrated circuits and an integrated circuit is associated with each sensor of the sensor array, for processing the measurement signals of the respective sensor. The integrated circuits are formed in the semiconductor chip spatially in each case below the associated sensor and neighboring sensors of the sensor array have a center-to-center in the range of micrometers. The pH and/or pO2 can be measured in the environment of a living cell.
摘要翻译：一种安排和方法用传感器阵列测量细胞活力。传感器阵列形成在半导体芯片的表面上。半导体芯片具有集成电路，并且集成电路与传感器阵列的每个传感器相关联，用于处理相应传感器的测量信号。集成电路在空间上形成在半导体芯片中，在每个情况下在相关传感器下方，并且传感器阵列的相邻传感器具有在微米范围内的中心到中心。 pH和/或pO2可以在活细胞的环境中测量。

42. 发明授权

US08383393B2 Titer plate, reading device therefor and method for detecting an analyte, and use thereof 有权
标题翻译：滴定板，其读取装置和检测分析物的方法及其用途
公开(公告)号：US08383393B2
公开(公告)日：2013-02-26
申请号：US12994906
申请日：2009-05-22
申请人： Walter Gumbrecht , Peter Paulicka
发明人： Walter Gumbrecht , Peter Paulicka
IPC分类号： C12M1/34 , C12Q1/68 , G01N27/00
CPC分类号： B01L3/5025 , B01L7/52 , B01L2200/025 , B01L2200/0689 , B01L2200/10 , B01L2300/0636 , B01L2300/0645 , B01L2300/069 , B01L2300/0829
摘要： A titer plate and a method for detecting an analyte, and the use thereof are disclosed. According to at least one embodiment of the invention, it is proposed that a plurality of depressions and a biochip of the titer plate sposed adjacent thereto be surrounded by a wall in order to effectively prevent sample contamination when there is a high degree of spatial integration.
摘要翻译：公开了滴定板和检测分析物的方法及其用途。根据本发明的至少一个实施方案，提出了与壁相邻的滴定板的多个凹陷和生物芯片被壁包围，以便当存在高度的空间整合时有效地防止样品污染。

43. 发明申请

US20120196318A1 METHOD AND ASSEMBLY FOR DETERMINING CELL VITALITIES 有权
标题翻译：用于确定细胞毒素的方法和装置
公开(公告)号：US20120196318A1
公开(公告)日：2012-08-02
申请号：US13499629
申请日：2010-09-29
申请人： Walter Gumbrecht , Markus Klöpzig , Peter Paulicka , Harald Schmidt , Manfred Stanzel
发明人： Walter Gumbrecht , Markus Klöpzig , Peter Paulicka , Harald Schmidt , Manfred Stanzel
IPC分类号： C12Q1/02 , C12M1/34
摘要： The method includes binding living cells to magnetic particles, adding them to a sensor array, uniformly distributing over the sensor array, magnetically fixing the magnetic particles having the bound cells over the sensor array, and adding substances to maintain and/or improve the cell vitality to the sensory array, and/or adding substances to worsen the cell vitality to the sensor array. The assembly includes a sensor array composed of sensors, which are designed to be in direct fluidic contact with a fluid, and a device for generating a magnetic field over the sensor array. A layer that comprises magnetic particles and living cells is formed on the sensor array.
摘要翻译：该方法包括将活细胞结合到磁性颗粒上，将它们加到传感器阵列上，均匀分布在传感器阵列上，将具有结合细胞的磁性颗粒磁性固定在传感器阵列上，以及添加物质以保持和/或改善细胞活力到感官阵列，和/或添加物质以增加传感器阵列的细胞活力。组件包括由传感器组成的传感器阵列，其被设计成与流体直接流体接触，以及用于在传感器阵列上产生磁场的装置。在传感器阵列上形成包含磁性粒子和活细胞的层。

44. 发明授权

US08088576B2 Method and assembly for DNA isolation with dry reagents 有权
标题翻译：用干试剂进行DNA分离的方法和装配
公开(公告)号：US08088576B2
公开(公告)日：2012-01-03
申请号：US11587581
申请日：2005-04-28
申请人： Walter Gumbrecht , Peter Paulicka , Manfred Stanzel
发明人： Walter Gumbrecht , Peter Paulicka , Manfred Stanzel
IPC分类号： C12Q1/68
CPC分类号： B01L3/502761 , B01J2219/00286 , B01J2219/00459 , B01J2219/005 , B01J2219/00648 , B01J2219/00722 , B01L7/52 , B01L2200/0668 , B01L2200/082 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2400/0406 , B01L2400/0487 , C12N15/1013 , C12Q1/6806 , C12Q2563/143 , C12Q2531/113
摘要： A DNA isolation method by removal of constituents, interfering with a subsequent PCR is disclosed. According to an embodiment of the method, all substances and method steps are fully integrated into a closed unit (cartridge) for single use, which allows entry of a DNA-containing sample and DNA-binding substrates are used for isolating the released DNA. In particular, when the method is applied to DNA isolation from whole blood by disruption of white blood cells, the reagents, required for carrying out the cell disruption and other reactions, are stored in a form which is stable at room temperature. For disrupting the white blood cells and for DNA isolation, a dry stored lysis reagent is dissolved in an aqueous solution and brought into contact with the white blood cells. The corresponding assembly includes a unit, for housing DNA-containing biological containers and/or reagents, whereby at least one microchannel is provided to contain reagents, whereby the reagent is present in the microchannel as a dry mixture with a negligible vapor pressure, which forms a stable substance at room temperature.
摘要翻译：公开了通过去除组分，干扰后续PCR的DNA分离方法。根据该方法的一个实施方案，所有物质和方法步骤完全整合到用于单次使用的封闭单元（盒）中，其允许含DNA样品的进入和DNA结合底物用于分离释放的DNA。特别是，当将该方法应用于通过破坏白血细胞从全血中分离DNA时，进行细胞破碎和其它反应所需的试剂以在室温下稳定的形式储存。为了破坏白细胞和进行DNA分离，将干燥储存的裂解试剂溶解在水溶液中并与白细胞接触。相应的组件包括用于容纳含有DNA的生物容器和/或试剂的单元，由此提供至少一个微通道以容纳试剂，由此所述试剂作为干燥的混合物存在于微通道中，所述干燥混合物具有可忽略的蒸气压，其形成在室温下稳定的物质。

45. 发明申请

US20080193926A1 Device and method for extracting a smear sample 有权
标题翻译：用于提取涂片样品的装置和方法
公开(公告)号：US20080193926A1
公开(公告)日：2008-08-14
申请号：US11599424
申请日：2006-11-15
申请人： Klaus Abraham-Fuchs , Thomas Ehben , Walter Gumbrecht , Peter Paulicka , Sebastian Schmidt , Manfred Stanzel , Christian Zilch
发明人： Klaus Abraham-Fuchs , Thomas Ehben , Walter Gumbrecht , Peter Paulicka , Sebastian Schmidt , Manfred Stanzel , Christian Zilch
IPC分类号： C12M1/26 , C12Q1/68
CPC分类号： B01L3/502715 , A61B10/0051 , A61B10/0096 , B01L3/502738 , B01L3/502761 , B01L3/5029 , B01L2200/027 , B01L2300/042 , B01L2400/0478 , B01L2400/0633 , G01N2001/028
摘要： A device is disclosed for extracting a smear sample. The device includes a cavity, into which a sample carrier carrying a smear sample can be introduced. Liquid can be introduced into the cavity through at least one liquid feed connected to the cavity, and the liquid can be removed from the cavity through at least one liquid discharge connected to the cavity.
摘要翻译：公开了一种用于提取涂片样品的装置。该装置包括可以引入携带涂片样品的样品载体的空腔。可以通过连接到空腔的至少一个液体进料将液体引入空腔中，并且可以通过连接到空腔的至少一个液体排出物从腔中去除液体。

46. 发明授权

US08518343B2 Method for the production of a solution, associated arrangement and uses of the method and arrangement 有权
标题翻译：解决方案的生产方法，相关安排和使用方法和安排
公开(公告)号：US08518343B2
公开(公告)日：2013-08-27
申请号：US11587572
申请日：2005-04-26
申请人： Walter Gumbrecht , Peter Paulicka , Manfred Stanzel
发明人： Walter Gumbrecht , Peter Paulicka , Manfred Stanzel
IPC分类号： G01N21/75
CPC分类号： B01F15/0205 , B01F1/00 , B01F13/0059 , B01F15/021 , Y10T436/25
摘要： Solid matter in a cavity is used to produce a solution of at least one solid matter in a solvent. The solid matter which is soluble in the solvent in initially covered and/or surrounded in the cavity by a medium which is insoluble in a solvent, such that dissolving of the solid matter is prevented. Subsequently the solvent is guided to the cavity and the medium which is insoluble in the solvent is treated in such a manner that contact is made between the solvent and the soluble solid matter, enabling the solid matter to dissolve in the solvent. Solutions including two or more solid matter can be produced in an advantageous manner.
摘要翻译：空腔中的固体物质用于在溶剂中产生至少一种固体物质的溶液。首先被溶解在溶剂中的固体物质通过不溶于溶剂的介质在空腔中被包覆和/或包围，从而防止固体物质的溶解。随后将溶剂引导到空腔中，并且不溶于溶剂的介质以在溶剂和可溶性固体物质之间接触使得固体物质溶解在溶剂中的方式被处理。可以以有利的方式制备包含两种或更多种固体物质的溶液。

47. 发明申请

US20120108456A1 DEVICE SIMILAR TO AN ELECTROMECHANICAL CAMERA AND METHOD FOR THE PRODUCTION AND USE OF THE DEVICE 有权
标题翻译：类似于机电相机的装置及其制造和使用的方法
公开(公告)号：US20120108456A1
公开(公告)日：2012-05-03
申请号：US13262578
申请日：2010-03-02
申请人： Alexander Frey , Walter Gumbrecht , Peter Paulicka , Meinrad Schienle , Manfred Stanzel
发明人： Alexander Frey , Walter Gumbrecht , Peter Paulicka , Meinrad Schienle , Manfred Stanzel
IPC分类号： C40B30/04 , C40B50/18 , C40B60/12
CPC分类号： G01N27/3277 , G01N33/5438
摘要： A device for detecting chemical or biochemical substances in fluids includes a first carrier having a sensor array with a plurality of electrochemical sensors. A second carrier includes a porous layer having at least one functional region, in which specifically binding capturing molecules are immobilized. The at least one functional region is arranged directly adjacent to at least one non-functionalized region. Assigned to the at least one functional region and the at least one non-functionalized region are several sensors of the sensor array, for use as an electrochemical camera.
摘要翻译：用于检测流体中的化学或生化物质的装置包括具有传感器阵列的多个电化学传感器的第一载体。第二载体包括具有至少一个功能区的多孔层，其中固定有特异性结合的捕获分子。所述至少一个功能区域直接邻近至少一个非功能化区域布置。分配给至少一个功能区域和至少一个非功能化区域是传感器阵列的几个传感器，用作电化学照相机。

48. 发明授权

US07851227B2 Method for carrying out an electrochemical measurement on a liquid measuring sample in a measuring chamber that can be accessed by lines, and corresponding arrangement 有权
标题翻译：在可以通过线路访问的测量室中的液体测量样品上进行电化学测量的方法和相应的布置
公开(公告)号：US07851227B2
公开(公告)日：2010-12-14
申请号：US11665331
申请日：2005-10-17
申请人： Heike Barlag , Siegfried Birkle , Walter Gumbrecht , Daniela Kühn , Peter Paulicka , Manfred Stanzel
发明人： Heike Barlag , Siegfried Birkle , Walter Gumbrecht , Daniela Kühn , Peter Paulicka , Manfred Stanzel
IPC分类号： G01N1/10 , G01N35/00
CPC分类号： B01L3/5027 , B01L3/502707 , B01L3/502723 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： Especially in order to carry out the so-called enzyme-coupled DNA hybridization test in a closed cartridge including a microfluid system, using stored dry reagents, the reagents must be dissolved in the microfluid system and transported into the measuring chamber directly before the measurement. During the dissolution of the reagents in water, air cushions that cannot reach the measuring chamber must absolutely be prevented from forming upstream of the reagent liquid. According to an embodiment of the invention, the liquid measuring sample and the liquid reagents are transported in such a way that the air cushion is directed into the waste line and the measuring sample and the reagents are then introduced into the measuring chamber without any air bubbles. In this way, measuring errors can be avoided.
摘要翻译：特别是为了在包含微流体系统的封闭筒中进行所谓的酶偶联DNA杂交试验，使用储存的干试剂，试剂必须溶解在微流体系统中，并在测量前直接运送到测量室中。在将试剂溶解在水中时，必须绝对防止不能到达测量室的气垫在试剂液体的上游形成。根据本发明的一个实施例，液体测量样品和液体试剂以这样一种方式运输，使得气垫被引导到废液管线中，然后将测量样品和试剂引入测量室，而没有任何气泡。这样可以避免测量误差。

49. 发明申请

US20100248242A1 PROCESS FOR CONCENTRATING NUCLEIC ACID MOLECULES 有权
标题翻译：浓缩核酸分子的方法
公开(公告)号：US20100248242A1
公开(公告)日：2010-09-30
申请号：US12734934
申请日：2008-11-03
申请人： Walter Gumbrecht , Peter Paulicka , Manfred Stanzel
发明人： Walter Gumbrecht , Peter Paulicka , Manfred Stanzel
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/6825 , C12Q1/6834 , C12Q1/6837 , Y10T436/143333 , C12Q2527/107 , C12Q2537/125 , C12Q2565/543
摘要： A process concentrates nucleic acid molecules to be detected of a sample on a surface, with capture molecules that specifically bind the nucleic acid molecules. A support material has a capture probe that can specifically be linked to the nucleic acid molecules to be detected to give complexes. The support material and the nucleic acid molecules of the sample are incubated to form the complexes. The complexes are moved to the surface. At least one portion of the complexes becomes bound to the capture molecules via the capture probe.
摘要翻译：一种方法将待检测的样品的核酸分子浓缩在表面上，其中捕获分子特异性结合核酸分子。载体材料具有捕获探针，其可以特异性地连接到待检测的核酸分子以得到复合物。将样品的载体材料和核酸分子孵育以形成复合物。络合物移动到表面。复合物的至少一部分经由捕获探针与捕获分子结合。

50. 发明申请

US20090136922A1 Method for carrying out an electrochemical measurement on a liquid measuring sample in a measuring chamber that can be accessed by lines, and corresponding arrangement 有权
标题翻译：在可以通过线路访问的测量室中的液体测量样品上进行电化学测量的方法和相应的布置
公开(公告)号：US20090136922A1
公开(公告)日：2009-05-28
申请号：US11665331
申请日：2005-10-17
申请人： Heike Barlag , Siegfried Birkle , Walter Gumbrecht , Daniela Kuhn , Peter Paulicka , Manfred Stanzel
发明人： Heike Barlag , Siegfried Birkle , Walter Gumbrecht , Daniela Kuhn , Peter Paulicka , Manfred Stanzel
IPC分类号： C12Q1/68 , C12M1/00
CPC分类号： B01L3/5027 , B01L3/502707 , B01L3/502723 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： Especially in order to carry out the so-called enzyme-coupled DNA hybridisation test in a closed cartridge including a microfluid system, using stored dry reagents, the reagents must be dissolved in the microfluid system and transported into the measuring chamber directly before the measurement. During the dissolution of the reagents in water, air cushions that cannot reach the measuring chamber must absolutely be prevented from forming upstream of the reagent liquid. According to an embodiment of the invention, the liquid measuring sample and the liquid reagents are transported in such a way that the air cushion is directed into the waste line and the measuring sample and the reagents are then introduced into the measuring chamber without any air bubbles. In this way, measuring errors can be avoided.
摘要翻译：特别是为了在包括微流体系统的封闭式筒体中进行所谓的酶偶联DNA杂交试验，使用储存的干试剂，试剂必须溶解在微流体系统中，并在测量前直接输送到测量室中。在将试剂溶解在水中时，必须绝对防止不能到达测量室的气垫在试剂液体的上游形成。根据本发明的一个实施例，液体测量样品和液体试剂以这样一种方式运输，使得气垫被引导到废液管线中，然后将测量样品和试剂引入测量室，而没有任何气泡。这样可以避免测量误差。

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