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41. 发明授权

US07157238B2 Diagnostic and therapeutic use of antibodies against the urokinase receptor 有权
标题翻译：诊断和治疗使用抗尿激酶受体的抗体
公开(公告)号：US07157238B2
公开(公告)日：2007-01-02
申请号：US09926323
申请日：2000-12-13
申请人： Manfred Schmitt , Frank Noack , Henner Graeff , Nadja Harbeck
发明人： Manfred Schmitt , Frank Noack , Henner Graeff , Nadja Harbeck
IPC分类号： G01N33/574
CPC分类号： C07K16/28 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/2896 , C07K2317/565 , C07K2317/622 , G01N33/574 , G01N33/57492 , G01N33/582
摘要： The invention concerns a method and a reagent kit for detecting cells in a biological sample using a double-fluorescence technique and the diagnostic and therapeutic application of amino acid sequence-specific antibodies against the urokinase receptor having a high affinity for tumour cell-expressed receptors.
摘要翻译：本发明涉及一种用于使用双荧光技术检测生物样品中的细胞的方法和试剂盒，以及针对对肿瘤细胞表达受体具有高亲和力的尿激酶受体的氨基酸序列特异性抗体的诊断和治疗应用。

42. 发明申请

US20060070665A1 Volumetric flow regulation valve 审中-公开
标题翻译：体积流量调节阀
公开(公告)号：US20060070665A1
公开(公告)日：2006-04-06
申请号：US10526268
申请日：2003-05-26
申请人： Manfred Schmitt , Karsten Mann , Ulrich Kappenstein
发明人： Manfred Schmitt , Karsten Mann , Ulrich Kappenstein
IPC分类号： F16K17/30 , F16K21/10
CPC分类号： G05D7/0133 , Y10T137/7852 , Y10T137/7869
摘要： The invention starts with a volume flow control valve (36, 38) with a flow restrictor (48, 54) that can be displaced axially in a housing (40, 44), via which the volume flow can be diverted. It is proposed that the flow restrictor (48, 54) have a diverting body (54) and the force generated by the diversion at the diverting body (54) be used to adjust the flow restrictor (48, 54).
摘要翻译：本发明从体积流量控制阀（36,38）开始，其具有可在壳体（40,44）中轴向位移的限流器（48,54），通过该限流器可以转向体积流量。提出限流器（48,54）具有转向主体（54），并且由转向主体（54）上的转向产生的力用于调节限流器（48,54）。

43. 发明授权

US5713332A Method for controlling processes in a motor vehicle 失效
标题翻译：用于控制机动车辆中的过程的方法
公开(公告)号：US5713332A
公开(公告)日：1998-02-03
申请号：US718329
申请日：1996-09-25
申请人： Walter Adler , Manfred Schmitt , Henning Tolle , Thorsten Ullrich
发明人： Walter Adler , Manfred Schmitt , Henning Tolle , Thorsten Ullrich
IPC分类号： F02D43/00 , B60T8/174 , B60T8/175 , F02D29/02 , F02D41/02 , F02D41/14 , F02D41/24 , F02D41/26 , F02D43/04 , F02D45/00 , F02P5/15 , G05B13/02
CPC分类号： F02D41/0215 , B60T8/174 , B60T8/175 , F02D41/2416 , F02D41/2429 , F02D41/2441 , G05B13/0205 , G05B13/024 , G05B13/0265 , B60T2201/14 , F02P5/1502
摘要： A method for controlling processes in a motor vehicle is intended, for example, for open-loop/closed-loop control of combustion processes, transmission switching processes or braking processes. An engine characteristics map is formed by operating quantities of the respective process and is represented by a number of support points. In the corresponding control unit, for each support point a piece of information about the value of the map at the position of the support point is provided. In the open-loop/closed-loop control of the process, for a determined working point of the process at least one map value that is decisive for this working point is determined from the map and taking account of this, at least one control quantity for the emission of a control signal is formed. The map is automatically adapted to a changed process behavior. For the adaptation, a correction value is determined for a certain operating phase of the map. According to the present invention, additionally for each support point a piece of information about the position of the support point within the map is provided so that the support points are enterable independent of a fixed grid into the map. For adaptation of the map, a number of support points of the map lying around the determined correction value is chosen. These support points are then adapted, the support point correction being carried out distance-weighted with reference to the position of the determined correction value within the map.
摘要翻译： PCT No.PCT / DE95 / 00689 371日期1996年9月25日 102（e）1996年9月25日PCT PCT 1995年5月26日PCT公布。出版物WO95 / 33132 日期1995年12月7日一种用于控制机动车辆中的过程的方法例如旨在用于燃烧过程的开环/闭环控制，变速器切换过程或制动过程。发动机特性图是通过对各个过程的操作量进行操作形成的，并由多个支撑点表示。在相应的控制单元中，对于每个支撑点，提供关于在支撑点的位置处的地图的值的一条信息。在该过程的开环/闭环控制中，对于该过程的确定工作点，从该地图确定对该工作点具有决定性的至少一个地图值，并且考虑到这一点，至少一个控制量用于发出控制信号。地图自动适应变更的过程行为。对于适应，对于地图的某个操作阶段确定校正值。根据本发明，另外对于每个支撑点，提供关于地图内的支撑点的位置的一条信息，使得支撑点可独立于图中的固定网格进入。为了适应地图，选择了围绕确定的校正值的地图的若干支持点。然后对这些支撑点进行调整，参考地图内所确定的校正值的位置，进行距离加权的支持点校正。

44. 发明授权

US10625101B2 Method for colouring hair 有权
公开(公告)号：US10625101B2
公开(公告)日：2020-04-21
申请号：US13610232
申请日：2012-09-11
申请人： Annette Elsbeth Klingelmeyer , Thomas Krause , Uwe Mahla , Knut Meinert , Matthias Morand , Manfred Schmitt , Maik Tremel , Elizabeth Ana Diez McCready
发明人： Annette Elsbeth Klingelmeyer , Thomas Krause , Uwe Mahla , Knut Meinert , Matthias Morand , Manfred Schmitt , Maik Tremel , Elizabeth Ana Diez McCready
IPC分类号： A61Q5/06 , A61K8/81 , A61Q5/10 , A61K8/87 , A61K8/03
CPC分类号： A61Q5/06 , A61K8/03 , A61K8/8152 , A61K8/87 , A61Q5/10 , A61K2800/48
摘要： A method for colouring hair, wherein the method comprises: (i) the formation of a first plurality of coated hair fibre portions, wherein the coating comprises a first composition, wherein the first composition comprises a first hair colouring agent, a hydrophobic phase, a hydrophilic phase, a surfactant, and a thickener capable of interacting with the hydrophobic phase and the hydrophilic phase; and subsequently (ii) styling the hair wherein the first plurality of coated hair fibre portions is contacted with a second plurality of hair fibre portions; wherein the method does not comprise the application of a solid barrier means in order to separate the first plurality of coated hair fibre portions from the second plurality of hair fibre portions, and wherein the first composition is substantially free of persulfate.

45. 发明授权

US10053735B2 Markers for the prediction of outcome of anthracycline treatment 有权
公开(公告)号：US10053735B2
公开(公告)日：2018-08-21
申请号：US12067633
申请日：2006-09-21
申请人： John Foekens , John W. Martens , Serenella Eppenberger-Castori , Vincent Vuaroqueaux , Frederique Spyratos , Nadia Harbeck , Manfred Schmitt , Heinz Hoefler , Sabine Maier , Gunter Weiss , Ralf Lesche , Thomas Hildmann , Achim Plum
发明人： John Foekens , John W. Martens , Serenella Eppenberger-Castori , Vincent Vuaroqueaux , Frederique Spyratos , Nadia Harbeck , Manfred Schmitt , Heinz Hoefler , Sabine Maier , Gunter Weiss , Ralf Lesche , Thomas Hildmann , Achim Plum
IPC分类号： C07H21/04 , C12Q1/68 , C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/156 , C12Q2600/16
摘要： The present invention relates to methods for predicting the outcome of anthracycline treatment of cell proliferative disorder patients. This is achieved by determining the expression level of at least one gene selected from the group consisting of PITX2; TFF1 and PLAU. The invention also relates to sequences, oligonucleotides and antibodies which can be used within the described methods.

46. 发明授权

US09156942B2 Method and device for cleaning an absorptive polyester 有权
标题翻译：清洗吸收性聚酯的方法和装置
公开(公告)号：US09156942B2
公开(公告)日：2015-10-13
申请号：US13032198
申请日：2011-02-22
申请人： Anja Enderle , Manfred Schmitt
发明人： Anja Enderle , Manfred Schmitt
IPC分类号： C08G63/08 , C08G63/00 , C08G63/90 , B01D11/00 , F26B11/02
CPC分类号： C08G63/90 , C08G63/08
摘要： In a method for cleaning an absorptive polyester, the polymer is dissolved in a first solvent (12) and subsequently the polymer solution is brought into tight contact with a second solvent (41) in a turbulent shear field under the influence of strong shear forces. Here, the second solvent (41) represents a non-solvent for the absorptive polyester and is mixable with the first solvent (12) to an unlimited extent. Subsequently, the polymer suspension resulting from the addition of the second solvent (41) is conveyed onto or into a rotating, cylindrical screen body (71) of a drum shear screen (70) and then the moist polymer mass is removed from the screen body (71) and subsequently dried. The method is suitable for the production of absorptive polyester with a high degree of quality and may be performed in a cost-effective fashion on an industrial scale as well.
摘要翻译：在清洗吸收性聚酯的方法中，将聚合物溶解在第一溶剂（12）中，随后在强剪切力的影响下，在湍流剪切场中使聚合物溶液与第二溶剂（41）紧密接触。这里，第二溶剂（41）表示用于吸收性聚酯的非溶剂，并且与第一溶剂（12）混合无限制。随后，将由第二溶剂（41）加入产生的聚合物悬浮液输送到滚筒筛网（70）的旋转的圆柱形筛网（71）上，然后将湿的聚合物物质从筛体（71），随后干燥。该方法适用于生产具有高质量的吸收性聚酯，并且可以在工业规模上以成本有效的方式进行。

47. 发明授权

US08398724B2 Methods for preparing hair coloring compositions 有权
标题翻译：染发组合物的制备方法
公开(公告)号：US08398724B2
公开(公告)日：2013-03-19
申请号：US13352552
申请日：2012-01-18
申请人： Juergen Schmenger , Manfred Schmitt
发明人： Juergen Schmenger , Manfred Schmitt
IPC分类号： A61Q5/10
CPC分类号： A61K8/41 , A61K2800/88 , A61Q5/08 , A61Q5/10
摘要： Methods for providing, at the discretion of the user, at least two different oxidative hair coloring compositions providing different level of lift based on a single tint component. The methods involve the use of a tint component, an oxidizing component and a third component comprising a non-ammonia alkalizing agent. The compositions may comprise little or no ammonia.
摘要翻译：根据使用者的判断提供至少两种不同氧化性着色组合物的方法，所述组合物基于单色调组分提供不同程度的提升。所述方法包括使用着色组分，氧化组分和包含非氨碱化剂的第三组分。组合物可以包含很少或不含氨。

48. 发明授权

US08281589B2 Device and method for operating an internal combustion engine, computer program, computer program product 有权
标题翻译：用于操作内燃机，计算机程序，计算机程序产品的装置和方法
公开(公告)号：US08281589B2
公开(公告)日：2012-10-09
申请号：US12437032
申请日：2009-05-07
申请人： Guillaume Huard , Juergen Stegmaier , Henrick Brandes , Martin Cichon , Manfred Schmitt , Lutz Rauchfuss , Oliver Tschismar
发明人： Guillaume Huard , Juergen Stegmaier , Henrick Brandes , Martin Cichon , Manfred Schmitt , Lutz Rauchfuss , Oliver Tschismar
IPC分类号： F01K23/10 , F02G3/00 , B60K6/20 , F01N3/02 , F01N5/02 , F02M25/07
CPC分类号： F01N5/02 , F01K23/065 , F01K23/101 , F02G5/02 , Y02T10/16 , Y02T10/166
摘要： For operating an internal combustion engine having a throttle situated in an exhaust line or exhaust return line, in which a heat engine is driven by a quantity of heat produced by the internal combustion engine, in a first non-heating operating mode of the internal combustion engine, a first setpoint value is preset, a first operating parameter that characterizes a temperature of the internal combustion engine is detected, a first triggering value is determined for the triggering of the at least one throttle as a function of the first setpoint value and the first operating parameter, the at least one throttle is triggered in accordance with the first triggering value, and the at least one heat engine is driven by the resulting quantity of heat.
摘要翻译：为了操作具有位于排气管线或排气返回管路中的节气门的内燃机，其中热内燃机由内燃机产生的一定量的热量驱动，内燃机的第一非加热运行模式发动机，预先设定第一设定值，检测表征内燃机的温度的第一操作参数，确定作为第一设定值的函数的至少一个节气门的触发的第一触发值，以及第一操作参数，根据第一触发值触发至少一个节气门，并且由所得到的热量驱动至少一个热机。

49. 发明申请

US20120198840A1 DEVICE FOR UTILIZING WASTE HEAT 有权
标题翻译：废物处理装置
公开(公告)号：US20120198840A1
公开(公告)日：2012-08-09
申请号：US13390082
申请日：2010-06-22
申请人： Juergen Stegmaier , Martin Cichon , Manfred Schmitt , Achim Schmidt
发明人： Juergen Stegmaier , Martin Cichon , Manfred Schmitt , Achim Schmidt
IPC分类号： F01N5/02 , F02B37/00
CPC分类号： F02B33/34 , F01K9/003 , F01K23/065 , F01N5/02 , F01P2005/105 , F01P2060/08 , F02B39/08 , F02G5/02 , Y02T10/16 , Y02T10/166
摘要： A device for utilizing waste heat of an internal combustion engine. A heat exchanger of a circuit of a working medium is provided in its exhaust system. A pump is connected upstream from the heat exchanger, the circuit containing an expansion machine. A coupling heat exchanger is located in the circuit of the working medium, the working medium of the circuit and the cooling medium of the internal combustion engine flowing through the coupling heat exchanger.
摘要翻译：一种利用内燃机废热的装置。在其排气系统中设置工作介质回路的热交换器。泵从热交换器的上游连接，电路包含一台膨胀机。耦合热交换器位于工作介质的回路中，电路的工作介质和内燃机的冷却介质流经耦合热交换器。

50. 发明申请

US20110311465A1 Oxidizing Composition for the Treatment of Keratin Fibers 有权
标题翻译：用于治疗角蛋白纤维的氧化组合物
公开(公告)号：US20110311465A1
公开(公告)日：2011-12-22
申请号：US13111603
申请日：2011-05-19
申请人： Wilfried BURG , Matthias Morand , Anette Sallwey , Manfred Schmitt
发明人： Wilfried BURG , Matthias Morand , Anette Sallwey , Manfred Schmitt
IPC分类号： A61K8/81 , B65D71/00 , A61Q5/08
CPC分类号： A61Q5/10 , A61K8/8152 , A61K2800/548 , A61K2800/594 , A61Q5/04 , A61Q5/08
摘要： The present invention relates to an oxidizing composition for treatment of keratin fibers comprising a combination of; (a) at least one anionic associative copolymer, (b) at least one anionic non associative copolymer; (c) at least one peroxide agent; (d) at least one persulfate agent; (e) at least on alkalizing agent; and (f) a carrier medium suitable for hair treatment.The oxidizing composition described is suitable for composition used in conventional hair treatments such as dyeing, bleaching, and permanent waving or relaxing/straightening of the keratinous fibers, particularly human hair, requiring an oxidizing composition.
摘要翻译：本发明涉及一种用于治疗角蛋白纤维的氧化组合物，其包含以下组合：（a）至少一种阴离子缔合共聚物，（b）至少一种阴离子非缔合共聚物; （c）至少一种过氧化物; （d）至少一种过硫酸盐剂; （e）至少碱性剂; 和（f）适于头发处理的载体介质。所述的氧化组合物适合用于需要氧化组合物的常规头发处理如染色，漂白，永久挥发或松弛/矫直角质纤维，特别是人发的组合物。

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