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41. 发明授权

US07181284B2 Apparatus and methods of energy efficient, atrial-based Bi-ventricular fusion-pacing 有权
标题翻译：节能，基于心房的双心室融合起搏的装置和方法
公开(公告)号：US07181284B2
公开(公告)日：2007-02-20
申请号：US10803570
申请日：2004-03-17
申请人： John E. Burnes , Thomas J. Mullen
发明人： John E. Burnes , Thomas J. Mullen
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： The bi-ventricular implantable pulse generator described and depicted herein enables hemodynamic efficiencies for patients suffering from intraventricular conduction delays or conduction blockage. The pulse generator effectively overcomes such conduction delay or block (e.g., left bundle branch block, “LBBB,” or right bundle branch block, “RBBB”) by delivering a novel form of cardiac resynchronization therapy (CRT). Specifically, a single ventricular pre-excitation pacing stimulus is triggered from an atrial event (e.g., intrinsic or evoked depolarization). The triggering event may emanate from the right atrium (RA) or the left atrium (LA). A single ventricular pre-excitation pacing stimulus is delivered prior to the intrinsic depolarization of the other ventricle and thus promotes intraventricular electromechanical synchrony during CRT delivery.
摘要翻译：本文描述和描述的双心室可植入脉冲发生器能够对患有心室内传导延迟或传导阻塞的患者进行血液动力学效率。通过递送心脏再同步治疗（CRT）的新形式，脉冲发生器有效地克服了这种传导延迟或阻滞（例如左束支传导阻滞“LBBB”或右束支传导阻滞“RBBB”）。具体来说，从心房事件（例如内在或诱发的去极化）触发单个心室预激发起搏刺激。触发事件可能从右心房（RA）或左心房（LA）发出。在另一个心室的内在去极化之前输送单个心室预激励起搏刺激，从而在CRT输送期间促进脑室内机电同步。

42. 发明授权

US07027871B2 Aggregation of data from external data sources within an implantable medical device 有权
公开(公告)号：US07027871B2
公开(公告)日：2006-04-11
申请号：US10284923
申请日：2002-10-31
申请人： John E. Burnes , Luc R. Mongeon
发明人： John E. Burnes , Luc R. Mongeon
IPC分类号： A61N1/00
CPC分类号： A61B5/0031 , G06F19/00
摘要： An implantable device is described that collects and aggregates data from non-implanted medical devices external from a body of a patient. The device may also collect and aggregate data from medical devices implanted within the body. The implantable device includes a wireless transceiver to acquire physiological data from the external medical devices, and a storage medium to store the physiological data. A processor retrieves the physiological data and communicates the physiological data to a remote patient management system. The device may collect the physiologic data from the various external data sources, possibly over an extended period of time, and stores the data for subsequent upload to a common patient management system. In addition, the implantable device may collect physiological data from other medical devices implanted within the patient. In this manner, the device provides a central point for collection and aggregation of physiological data relating to the patient.

43. 发明授权

US09597505B2 Implantable medical device crosstalk evaluation and mitigation 有权
公开(公告)号：US09597505B2
公开(公告)日：2017-03-21
申请号：US12362781
申请日：2009-01-30
申请人： William T. Donofrio , John E. Burnes , Paul G. Krause , Xiaohong Zhou , Gerald P. Arne , David J. Peichel , James D. Reinke
发明人： William T. Donofrio , John E. Burnes , Paul G. Krause , Xiaohong Zhou , Gerald P. Arne , David J. Peichel , James D. Reinke
IPC分类号： A61N1/36 , A61N1/37 , A61N1/372 , A61N1/39 , A61N1/365 , A61N1/08 , A61B5/00 , A61B5/0428 , A61N1/362 , A61N1/368
CPC分类号： A61N1/36114 , A61B5/04288 , A61B5/7217 , A61N1/3621 , A61N1/36521 , A61N1/3688 , A61N1/3702 , A61N1/37247 , A61N1/37282 , A61N1/3962 , A61N2001/083
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

44. 发明授权

US09042982B2 Algorithm for the automatic determination of optimal AV and VV intervals 有权
公开(公告)号：US09042982B2
公开(公告)日：2015-05-26
申请号：US13400381
申请日：2012-02-20
申请人： John E. Burnes , Yong K. Cho , David Igel , Luc R. Mongeon , John C. Rueter , Harry Stone , Jodi Zilinski
发明人： John E. Burnes , Yong K. Cho , David Igel , Luc R. Mongeon , John C. Rueter , Harry Stone , Jodi Zilinski
IPC分类号： A61N1/00 , A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： Methods and devices for determining optimal Atrial to Ventricular (AV) pacing intervals and Ventricular to Ventricular (VV) delay intervals in order to optimize cardiac output. Impedance, preferably sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change.

45. 发明授权

US08532779B2 Implantable medical device crosstalk evaluation and mitigation 有权
标题翻译：植入式医疗器械串扰评估和缓解
公开(公告)号：US08532779B2
公开(公告)日：2013-09-10
申请号：US12362814
申请日：2009-01-30
申请人： Paul G. Krause , John E. Burnes , William T. Donofrio , David J. Peichel , Gerald P. Arne , Xiaohong Zhou , James D. Reinke
发明人： Paul G. Krause , John E. Burnes , William T. Donofrio , David J. Peichel , Gerald P. Arne , Xiaohong Zhou , James D. Reinke
IPC分类号： A61N1/02
CPC分类号： A61N1/08 , A61N1/36114 , A61N1/37 , A61N1/37258 , A61N1/37288
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.
摘要翻译：可以评估两个可植入医疗装置或两个不同的可植入医疗装置的不同治疗模块之间的电串扰，并且在一些示例中可以减轻。在一些示例中，可植入医疗装置或治疗模块之一将电刺激递送至非心肌组织部位或非血管心脏组织部位，而另一种可植入医疗装置或治疗组件将心律管理治疗递送至患者的心脏。

46. 发明申请

US20120290030A1 AV NODAL STIMULATION DURING ATRIAL TACHYARRHYTHMIA TO PREVENT INAPPROPRIATE THERAPY DELIVERY 有权
标题翻译：急性心肌梗塞期间的AV NODAL刺激，以防止不准确的治疗方案
公开(公告)号：US20120290030A1
公开(公告)日：2012-11-15
申请号：US13105689
申请日：2011-05-11
申请人： Eduardo N. Warman , John E. Burnes , Koen J. Michels , Paul D. Ziegler , Lilian Kornet
发明人： Eduardo N. Warman , John E. Burnes , Koen J. Michels , Paul D. Ziegler , Lilian Kornet
IPC分类号： A61N1/365
CPC分类号： A61N1/3622 , A61N1/36053 , A61N1/36114 , A61N1/3621 , A61N1/3624
摘要： The disclosure describes techniques for delivering electrical stimulation to decrease the ventricular rate response during an atrial tachyarrhythmia, such as atrial fibrillation. AV nodal stimulation is employed during an atrial tachyarrhythmia episode with rapid ventricular conduction to distinguish ventricular tachyarrhythmia from supraventricular tachycardia and thereby prevent delivering inappropriate therapy to a patient.
摘要翻译：本公开描述了用于递送电刺激以降低心房速发性心律失常（例如心房颤动）期间的心室率反应的技术。在房性快速性心律失常发作期间采用AV淋巴结刺激，其具有快速的心室传导以区分室上性快速性心律失常与室上性心动过速，从而阻止对患者传递不适当的治疗。

47. 发明授权

US08290593B2 Implantable medical device including a plurality of lead connection assemblies 有权
标题翻译：可植入医疗装置，包括多个引线连接组件
公开(公告)号：US08290593B2
公开(公告)日：2012-10-16
申请号：US12610157
申请日：2009-10-30
申请人： Robert W. Libbey , William T. Donofrio , John E. Burnes , Paul G. Krause , Michael K. Berquist , Olivier Blandin , Michael Hudziak , William L. Johnson , John E. Nicholson , George Patras , Andrew J. Ries , Jeffrey Swanson , Paul Vahle , Thomas J. Olson , William K. Wenger , Michael R. Klardie , Samira Tahvildari
发明人： Robert W. Libbey , William T. Donofrio , John E. Burnes , Paul G. Krause , Michael K. Berquist , Olivier Blandin , Michael Hudziak , William L. Johnson , John E. Nicholson , George Patras , Andrew J. Ries , Jeffrey Swanson , Paul Vahle , Thomas J. Olson , William K. Wenger , Michael R. Klardie , Samira Tahvildari
IPC分类号： A61N1/375
CPC分类号： A61N1/3752
摘要： An implantable medical device (IMD) may include at least two separate lead connection assemblies, each with electrical connectors for connecting implantable leads to the IMD. In some examples, a IMD may include a first therapy module configured to generate a first electrical stimulation therapy and a second therapy module configured to generate a second electrical stimulation therapy for delivery to the patient. The IMD may include a first lead connection assembly including a first electrical connector electrically coupled to the first therapy module and a second lead connection assembly including a second electrical connector electrically coupled to the second therapy module. In some examples, the first and second lead connection assemblies are distributed around the outer perimeter of the IMD housing.
摘要翻译：可植入医疗装置（IMD）可以包括至少两个单独的引线连接组件，每个具有用于将可植入引线连接到IMD的电连接器。在一些示例中，IMD可以包括被配置为产生第一电刺激治疗的第一治疗模块和被配置为产生用于递送给患者的第二电刺激治疗的第二治疗模块。 IMD可以包括第一引线连接组件，其包括电耦合到第一治疗模块的第一电连接器和包括电耦合到第二治疗模块的第二电连接器的第二引线连接组件。在一些示例中，第一和第二引线连接组件围绕IMD外壳的外周分布。

48. 发明申请

US20120259389A1 TREATMENT OF POSTPRANDIAL HYPERGLYCEMIA BY GASTRIC ELECTRICAL STIMULATION 审中-公开
标题翻译：通过胃电刺激治疗高血压患者
公开(公告)号：US20120259389A1
公开(公告)日：2012-10-11
申请号：US13445718
申请日：2012-04-12
申请人： Warren Starkebaum , John E. Burnes , Roland C. Maude-Griffin
发明人： Warren Starkebaum , John E. Burnes , Roland C. Maude-Griffin
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61B5/0006 , A61B5/14532 , A61B5/686 , A61N1/36085 , A61N1/36171 , A61N1/36175
摘要： In some examples, the disclosure relates to a systems, devices, and techniques for delivering electrical stimulation therapy to a patient. In some example, the disclosure relates to systems and methods of treating hyperglycemia in a patient including delivering gastric electrical stimulation (GES) to the patient. Devices, systems and methods according to the disclosure may comprise an implantable stimulator, a blood glucose monitor and/or a food intake sensor. In some examples, a blood glucose level and/or food intake of a patient is detected and GES is delivered to the patient in response to the detection.
摘要翻译：在一些示例中，本公开涉及用于向患者递送电刺激治疗的系统，装置和技术。在一些实例中，本公开涉及治疗患者的高血糖症的系统和方法，包括向患者输送胃电刺激（GES）。根据本公开的装置，系统和方法可以包括可植入刺激器，血糖监测器和/或食物摄取传感器。在一些示例中，检测到患者的血糖水平和/或食物摄取，并且响应于检测将GES递送给患者。

49. 发明申请

US20120150253A1 ALGORITHM FOR THE AUTOMATIC DETERMINATION OF OPTIMAL AV AND VV INTERVALS 有权
标题翻译：用于自动确定最佳AV和VV间隔的算法
公开(公告)号：US20120150253A1
公开(公告)日：2012-06-14
申请号：US13400381
申请日：2012-02-20
申请人： John E. Burnes , Yong K. Cho , David Igel , Luc R. Mongeon , John C. Rueter , Harry Stone , Jodi Zilinski
发明人： John E. Burnes , Yong K. Cho , David Igel , Luc R. Mongeon , John C. Rueter , Harry Stone , Jodi Zilinski
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： Methods and devices for determining optimal Atrial to Ventricular (AV) pacing intervals and Ventricular to Ventricular (VV) delay intervals in order to optimize cardiac output. Impedance, preferably sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change.
摘要翻译：用于确定最佳心房与心室（AV）起搏间隔和心室间室（VV）延迟间隔的方法和装置，以优化心输出量。在选择的心脏周期时间内，跨心脏测量阻抗，优选亚阈值阻抗，作为腔室扩张或收缩的量度。为了设定AV间隔，一个实施例测量长AV间隔上的阻抗以获得指示最大心室扩张的最小阻抗。另一个实施例测量一个周期的阻抗变化，并且改变二进制搜索中的AV步速间隔以收敛于AV间隔，从而引起指示最大心室输出的最大阻抗变化。另一种方法将右心室改变为左心室（VV）间隔，以收敛于指示最终心脏收缩最小心脏容积的阻抗最大值。另一实施例改变VV间隔以最大化阻抗变化。

50. 发明申请

US20100114215A1 IMPLANTABLE MEDICAL DEVICE INCLUDING TWO POWER SOURCES 有权
标题翻译：可植入医疗器械，包括两个电源
公开(公告)号：US20100114215A1
公开(公告)日：2010-05-06
申请号：US12609637
申请日：2009-10-30
申请人： John E. Burnes , Paul G. Krause , William T. Donofrio
发明人： John E. Burnes , Paul G. Krause , William T. Donofrio
IPC分类号： A61N1/378 , A61N1/39
CPC分类号： A61N1/378 , A61N1/36114 , A61N1/3962 , A61N1/3975
摘要： An implantable medical device (IMD) may include a battery dedicated to providing cardiac stimulation therapy and a separate power source that provides power for electrical stimulation therapy. Such a configuration preserves the battery dedicated for providing cardiac stimulation therapy even if the second power source is depleted. As an example, the IMD may comprise a cardiac stimulation module configured to deliver at least one stimulation therapy selected from a group consisting of pacing, cardioversion and defibrillation. The IMD further comprises a electrical stimulation module configured to deliver electrical stimulation therapy, a first power source including a battery, wherein the first power source is configured to supply power to the cardiac stimulation module and not to the electrical stimulation module, and a second power source. The second power source is configured to supply power to at least the electrical stimulation module.
摘要翻译：可植入医疗装置（IMD）可以包括专用于提供心脏刺激治疗的电池和为电刺激治疗提供电力的单独电源。这样的配置即使在第二电源耗尽的情况下也保留专用于提供心脏刺激治疗的电池。作为示例，IMD可以包括心脏刺激模块，该心脏刺激模块被配置为递送至少一种选自起搏，心脏复律和除颤的刺激疗法。 IMD还包括被配置为递送电刺激治疗的电刺激模块，包括电池的第一电源，其中第一电源被配置为向心脏刺激模块而不是电刺激模块供电，以及第二电源资源。第二电源被配置为向至少电刺激模块供电。

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