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41. 发明授权

US07989207B2 Testing lumenectomy samples for markers of non-vascular diseases 有权
标题翻译：测试非血管疾病标志物的腔内切除术样本
公开(公告)号：US07989207B2
公开(公告)日：2011-08-02
申请号：US11356460
申请日：2006-02-17
申请人： Angela Soito , John B. Simpson
发明人： Angela Soito , John B. Simpson
IPC分类号： G01N33/48 , G01N1/04
CPC分类号： G01N33/68 , A61B10/0233 , A61B17/22 , Y10T436/25
摘要： Lumenectomy material is tested to determine the presence or likelihood of a condition of a patient. The lumenectomy material is in the form of at least one continuous tissue strand collected in vivo from an inner surface of a body lumen of the patient. The presence of at least one marker of a disease is determined. The disease may be hypertension, hyperlipidemia, depression, obesity, metabolic syndrome, insulin resistance, kidney damage, or diabetes. The patient is identified as having or as likely to develop the disease if a marker of the disease is identified in the lumenectomy material of the patient.
摘要翻译：测量肿瘤切除术材料以确定患者状况的存在或可能性。所述内腔切除术材料是从患者体腔的内表面在体内收集的至少一个连续组织线的形式。确定存在至少一种疾病的标志物。该疾病可以是高血压，高脂血症，抑郁症，肥胖，代谢综合征，胰岛素抵抗，肾损伤或糖尿病。如果在患者的内腔切除术材料中鉴定出疾病的标志物，则该患者被鉴定为具有或可能发展该疾病。

42. 发明授权

US07887556B2 Debulking catheters and methods 有权
标题翻译：去污导管和方法
公开(公告)号：US07887556B2
公开(公告)日：2011-02-15
申请号：US10288581
申请日：2002-11-04
申请人： John B. Simpson , Himanshu Patel , Greg Stine
发明人： John B. Simpson , Himanshu Patel , Greg Stine
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B8/12 , A61B17/2202 , A61B17/320725 , A61B17/320783 , A61B2017/00685 , A61B2017/2927 , A61B2017/320032 , A61B2017/320791
摘要： A method of removing material from a blood flow lumen generally includes providing a device having a cutting element and an opening, advancing the device through the blood flow lumen to a site where material is to be removed, forcing the opening toward a wall of the site where material is to be removed, and moving the cutting element and the opening so that material in the blood flow lumen is cut by the cutting element and directed into the opening for removal as the cutting element and opening are moved through the blood flow lumen. In some embodiments, the device may be deflected or bent to force the opening toward a wall to remove material. The cutting element may be rotatable and may have an axis that is movable, that is not parallel to the longitudinal axis of the device, or both. In some embodiments, the cutting element is movable between retracted and deployed positions for advancing the device to a site for treatment and for removing material, respectively.
摘要翻译：从血流腔中去除材料的方法通常包括提供具有切割元件和开口的装置，将装置通过血流腔前进到要除去材料的部位，迫使开口朝向部位的壁其中要去除材料，并且移动切割元件和开口，使得当切割元件和开口移动通过血流腔时，通过切割元件切割血流腔中的材料并将其引导到用于移除的开口中。在一些实施例中，该装置可能被偏转或弯曲以迫使开口朝向壁以移除材料。切割元件可以是可旋转的并且可以具有可移动的轴线，其不平行于装置的纵向轴线或两者。在一些实施例中，切割元件可在缩回和展开位置之间移动，以将装置分别推进到处理场所和用于移除材料。

43. 发明授权

US07699790B2 Debulking catheters and methods 有权
标题翻译：去污导管和方法
公开(公告)号：US07699790B2
公开(公告)日：2010-04-20
申请号：US10896741
申请日：2004-07-21
申请人： John B. Simpson
发明人： John B. Simpson
IPC分类号： A61B10/00 , A61B17/32
CPC分类号： A61B17/320758 , A61B17/320783 , A61B2017/00685 , A61B2017/2927 , A61B2017/320032
摘要： A debulking catheter comprising a tissue debulking assembly for removing a contiguous strand of material from a body lumen. Catheters of the present invention generally include a catheter body having proximal and distal portions and a tissue debulking assembly disposed at least partially within the distal portion. The tissue debulking assembly is radially movable to expose at least a portion of the assembly through a window on the catheter body. The catheter is advanced transluminally through the body lumen to contact material in the body lumen and remove a plane of contiguous material that has a length that is typically longer than a length of the window on the catheter. The contiguous material may be directed into a collection chamber. Thereafter, the material may be removed from the collection chamber and preserved or tested.
摘要翻译：一种减压导管，其包括用于从体腔移除相邻的材料束的组织减积组件。本发明的导管通常包括具有近端部分和远端部分的导管本体和至少部分地设置在远端部分内的组织减灭组件。组织减灭组件可径向移动，以使组件的至少一部分通过导管主体上的窗口露出。导管通过身体腔内腔进行前进以接触体腔内的材料，并移除相邻材料的平面，其长度通常长于导管上的窗口的长度。连续的材料可以被引导到收集室中。此后，材料可以从收集室中取出并保存或测试。

44. 再颁专利

USRE33569E Single lumen atherectomy catheter device 失效
标题翻译：单腔粥样斑块切除术导管装置
公开(公告)号：USRE33569E
公开(公告)日：1991-04-09
申请号：US354166
申请日：1989-05-19
申请人： Hanson S. Gifford, III , John B. Simpson
发明人： Hanson S. Gifford, III , John B. Simpson
IPC分类号： A61B17/22
CPC分类号： A61B17/320783 , A61B17/22031 , A61B2017/22038 , A61B2017/22052
摘要： Atherectomy device for removing material from an atheroma in the vascular system. A cutter is mounted in a cylindrical housing having a cutout on one side thereof at the distal end of a catheter. The catheter has a single luminal opening, and a flexible drive cable for operating the cutter passes through this opening. An inflatable balloon is positioned outside the housing opposite the cutout, and a medium for inflating the balloon is introduced through luminal opening of the catheter.

45. 发明授权

US4979951A Atherectomy device and method 失效
标题翻译：动脉粥样硬化切除装置及方法
公开(公告)号：US4979951A
公开(公告)日：1990-12-25
申请号：US298846
申请日：1989-01-18
申请人： John B. Simpson
发明人： John B. Simpson
IPC分类号： A61B10/00 , A61B10/02 , A61B10/04 , A61B17/00 , A61B17/22 , A61B17/32 , A61B19/00 , A61F2/01 , A61F2/958 , A61M29/02
CPC分类号： A61B17/320783 , A61B17/22031 , A61B17/320016 , A61B17/3205 , A61M25/1018 , A61M25/104 , A61B10/0275 , A61B10/04 , A61B2017/00845 , A61B2017/00853 , A61B2017/22038 , A61B2017/22052 , A61B2017/22074 , A61B2017/22075 , A61B2090/064 , A61B2090/3933 , A61B90/06 , A61F2/01 , A61M2025/1093
摘要： Atherectomy device having a generally cylindrical housing formed of a relatively rigid material. The housing has rounded distal and proximal end portions. The housing is formed with a cutout extending longitudinally of the housing on one side of the housing. An atheroma cutter is disposed to the proximal end of the housing and is used for advancing the housing into the arterial passage. A flexible drive cable extends through the flexible guide and is connected to the atheroma cutter for operation of the atheroma cutter.
摘要翻译：动脉粥样硬化切除装置具有由相对刚性材料形成的大致圆柱形壳体。壳体具有圆形的远端和近端部分。壳体形成有在壳体的一侧上沿壳体纵向延伸的切口。动脉粥图切割器设置在壳体的近端，并用于将壳体推进到动脉通道中。柔性驱动电缆延伸穿过柔性引导件，并连接到动脉粥样动脉切割器，用于动脉粥样硬化刀具的操作。

46. 发明授权

US4669469A Single lumen atherectomy catheter device 失效
标题翻译：单腔粥样斑块切除术导管装置
公开(公告)号：US4669469A
公开(公告)日：1987-06-02
申请号：US834950
申请日：1986-02-28
申请人： Hanson S. Gifford, III , John B. Simpson
发明人： Hanson S. Gifford, III , John B. Simpson
IPC分类号： A61B17/32 , A61B17/22
CPC分类号： A61B17/320783 , A61B17/22031 , A61B2017/22038 , A61B2017/22052
摘要： Atherectomy device for removing material from an atheroma in the vascular system. A cutter is mounted in a cylindrical housing having a cutout on one side thereof at the distal end of a catheter. The catheter has a single luminal opening, and a flexible drive cable for operating the cutter passes through this opening. An inflatable balloon is positioned outside the housing opposite the cutout, and a medium for inflating the balloon is introduced through the luminal opening of the catheter.
摘要翻译：用于从血管系统中的动脉粥样化组织中去除材料的动脉粥样硬化切除装置。切割器安装在圆柱形壳体中，在其导管的远端具有在其一侧上的切口。导管具有单个管腔开口，并且用于操作切割器的柔性驱动电缆通过该开口。可充气气球位于外壳的与切口相对的外侧，用于使球囊充气的介质通过导管的管腔开口引入。

47. 发明申请

US20220361743A1 IMAGING CATHETER, IMAGING SYSTEM, AND METHODS OF OPERATION THEREOF 有权
公开(公告)号：US20220361743A1
公开(公告)日：2022-11-17
申请号：US17763527
申请日：2020-09-25
申请人： Kin F Chan , John B. Simpson
发明人： Kin F Chan , John B. Simpson
IPC分类号： A61B1/313 , A61B1/018 , A61B1/00 , A61B5/00
摘要： Imaging apparatus, atherectomy devices, systems, and methods of operation thereof are disclosed. The imaging apparatus further comprises one or more light transmittable windows defined along the dividing layer and a catheter outlet port defined along a ventral side of the catheter body. The catheter outlet port allows the guidewire to advance out of the second catheter lumen and the catheter outlet port is aligned with at least one of the light transmittable windows such that the guidewire is within a field of view of the imaging component when the guidewire extends partially though the catheter outlet port. The atherectomy device can comprise a tubular housing and an inflatable balloon coupled to an exterior side of the tubular housing. The tubular housing includes a cutting window and a rotatable cutter configured to debulk the atherosclerotic material extending into the cutting window. The inflatable balloon can comprise a lumen in fluid communication with the housing lumen such that fluid introduced into the housing lumen via the catheter lumen inflates the inflatable balloon.

48. 发明申请

US20120237942A1 METHODS AFFECTING MARKERS IN PATIENTS HAVING VASCULAR DISEASE 审中-公开
标题翻译：影响血管病患者的方法
公开(公告)号：US20120237942A1
公开(公告)日：2012-09-20
申请号：US13485128
申请日：2012-05-31
申请人： John B. Simpson
发明人： John B. Simpson
IPC分类号： C12Q1/02 , C12Q1/68
CPC分类号： G01N33/6893 , G01N2333/918 , G01N2800/32
摘要： Marker levels and forms can be modulated in patients having vascular disease when sufficient vascular tissue is removed. The markers can be, e.g., from tissue, blood or lymph. The markers are typically involved in molecular pathways which are in turn modulated. Atherectomy catheters are used for accomplishing sufficient removal of vascular tissue to effect the modulations.
摘要翻译：当去除足够的血管组织时，可以在具有血管疾病的患者中调节标记水平和形式。标记物可以是例如组织，血液或淋巴。标记通常参与分子途径，其进而调节。动脉粥样斑块切除术导管用于完成血管组织的充分去除以实现调节。

49. 发明申请

US20120179178A1 METHOD OF EVALUATING A TREATMENT FOR VASCULAR DISEASE 审中-公开
标题翻译：评估血管疾病治疗方法
公开(公告)号：US20120179178A1
公开(公告)日：2012-07-12
申请号：US13177048
申请日：2011-07-06
申请人： John B. Simpson
发明人： John B. Simpson
IPC分类号： A61B17/22
CPC分类号： A61B17/320783 , A61B17/320708 , A61B2017/22084 , A61B2017/320741 , A61B2017/320775 , A61B2017/320791 , G01N33/4833
摘要： Methods of evaluating treatments for vascular disease are described. The treatments can include administration of pharmaceutical, chemical, or biological agents. Vascular tissue is removed from a first site in a vascular lumen and optionally analyzed. A treatment is administered to the patient, followed by removal of a second portion of vascular tissue from a second site. The vascular tissue from both the first and second site are compared to learn the effect of the treatment. Treatments can include placement of prosthetic devices such as stents in the lumen. Whether or not the vascular tissue recurs at a site after removal can be monitored as a measure of the success of a given treatment.
摘要翻译：描述了评估血管疾病治疗方法。治疗可以包括药物，化学或生物制剂的给药。从血管腔中的第一部位移除血管组织，并任选分析。向患者施用治疗，然后从第二部位除去血管组织的第二部分。比较来自第一和第二部位的血管组织以了解治疗的效果。治疗可以包括将假体装置放置在管腔中。可以监测去除后的部位血管组织是否复发，作为给定治疗成功的量度。

50. 发明授权

US07927784B2 Vascular lumen debulking catheters and methods 有权
标题翻译：血管内膜减压导管及方法
公开(公告)号：US07927784B2
公开(公告)日：2011-04-19
申请号：US11328453
申请日：2006-01-10
申请人： John B. Simpson
发明人： John B. Simpson
IPC分类号： A01N1/00
CPC分类号： A61K35/12 , A61B10/0096 , A61B10/02 , A61B10/0266 , A61B10/04 , A61B17/320725 , A61B17/320758 , A61B17/320783 , A61B90/90 , A61B2017/00778 , A61B2017/320791 , G06F19/00 , G16H10/60
摘要： A debulking catheter comprising a tissue debulking assembly for removing a continuous strand of material from a body lumen. Catheters of the present invention generally include a catheter body having proximal and distal portions and a tissue debulking assembly disposed at least partially within the distal portion. The tissue debulking assembly is radially movable to expose at least a portion of the assembly through a window on the catheter body. The catheter is advanced transluminally through the body lumen to contact material in the body lumen and remove a plane of continuous material that has a length that is typically longer than a length of the window on the catheter. The continuous material may be directed into a collection chamber. Thereafter, the material may be removed from the collection chamber and preserved or tested.
摘要翻译：减压导管，其包括用于从体腔移除连续的材料束的组织减积组件。本发明的导管通常包括具有近端部分和远端部分的导管本体和至少部分地设置在远端部分内的组织减灭组件。组织减灭组件可径向移动，以使组件的至少一部分通过导管主体上的窗口露出。导管通过身体腔内腔进行前进以接触体腔中的材料并移除连续材料的平面，其长度通常长于导管上窗口的长度。连续材料可以被引导到收集室中。此后，材料可以从收集室中取出并保存或测试。

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