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41. 发明授权

US4260842A Isomerization of olefins utilizing heterogeneous dioxyzirconium catalysts 失效
标题翻译：烯烃异构化使用异构二氧锆催化剂
公开(公告)号：US4260842A
公开(公告)日：1981-04-07
申请号：US91963
申请日：1979-11-07
申请人： Jeffrey Schwartz , Michael D. Ward
发明人： Jeffrey Schwartz , Michael D. Ward
IPC分类号： C01B6/24 , C07C5/22 , C07C5/25 , C07C5/23
CPC分类号： C01B6/24 , C07C5/228 , C07C5/2575 , C07C2521/02 , C07C2521/08 , C07C2521/10 , C07C2523/02 , C07C2523/06 , C07C2523/22 , C07C2531/12
摘要： It has been found that catalysts comprising zirconium hydrides, hydride alkyls and dihydrides bonded to metal or metalloid oxides in particular zirconium hydride bonded to silica, when contacted with olefins under mild conditions rapidly cause isomerization to thermodynamic mixtures.
摘要翻译：已经发现，当在温和条件下与烯烃接触时，包含氢化锆，氢化物烷基和二氢化物的催化剂在金属或准金属氧化物，特别是与二氧化硅结合的氢化锆上，与烯烃接触快速导致热力学混合物异构化。

42. 发明授权

US08993117B2 Devices with multiple surface functionality 有权
标题翻译：具有多表面功能的设备
公开(公告)号：US08993117B2
公开(公告)日：2015-03-31
申请号：US13349367
申请日：2012-01-12
申请人： Jeffrey Schwartz , Ellen S. Gawalt , Michael J. Avaltroni
发明人： Jeffrey Schwartz , Ellen S. Gawalt , Michael J. Avaltroni
IPC分类号： B32B15/04 , A61F2/28 , A61F2/02 , A61L27/32 , A61L29/10 , A61L31/08 , B05D1/18 , B82Y30/00 , B82Y40/00 , C03C17/00 , C03C17/23 , C23C14/06 , C23C22/02 , C23C22/48
CPC分类号： A61L27/32 , A61L29/106 , A61L31/086 , B05D1/185 , B82Y30/00 , B82Y40/00 , C03C17/001 , C03C17/23 , C23C14/06 , C23C22/02 , C23C22/48 , Y10T428/12556 , Y10T428/12611 , Y10T428/131 , Y10T428/265
摘要： Phosphorus-based coatings having a plurality of phosphate moieties, a plurality of phosphonate moieties, or both, covalently bonded to an oxide surface of an implantable substrate exhibiting one or more of the following characteristics: (a) the surface phosphorus-containing group density of the coated regions of the substrate is at least about 0.1 nmol/cm2; (b) the phosphorus-based coating has a thickness of less than about 10 nm; or (c) the surface phosphorus-containing group density of the coated regions of the substrate is equal to or greater than the surface hydroxyl group density of the oxide surface of the substrate. Implantable devices embodying the coated substrates are also disclosed.
摘要翻译：具有多个磷酸酯部分，多个膦酸酯部分或两者的基于磷的涂层共价键合到可植入基底的氧化物表面上，其具有一个或多个以下特征：（a）表面含磷组密度衬底的涂覆区域为至少约0.1nmol / cm 2; （b）磷基涂层的厚度小于约10nm; 或者（c）基材的被覆区域的表面含磷组密度等于或大于基板的氧化物表面的表面羟基密度。还公开了体现涂覆的基底的可植入装置。

43. 发明授权

US08092585B2 Enhanced bonding layers on titanium materials 有权
标题翻译：在钛材料上增强粘结层
公开(公告)号：US08092585B2
公开(公告)日：2012-01-10
申请号：US12907823
申请日：2010-10-19
申请人： Jeffrey Schwartz , Michael J. Avaltroni , Kim S. Midwood , Jean E. Schwarzbauer , Ellen Gawalt
发明人： Jeffrey Schwartz , Michael J. Avaltroni , Kim S. Midwood , Jean E. Schwarzbauer , Ellen Gawalt
IPC分类号： C09K17/02
CPC分类号： B05D1/185 , B82Y30/00 , B82Y40/00 , C23C14/06
摘要： The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osteoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.
摘要翻译：本发明提供在材料的天然氧化物表面上的致密覆盖的粘附的磷基涂层。公开的磷基涂层包括磷酸盐和有机膦酸盐涂层。本发明还提供了磷基涂层的进一步衍生化，以在钛材料的天然氧化物表面上产生化学反应性涂层和成骨细胞粘附促进和增殖促进涂层的致密表面覆盖。

44. 发明申请

US20080166470A1 Enhanced Bonding Layers on Native Oxide Surfaces 有权
标题翻译：天然氧化物表面上增强的粘结层
公开(公告)号：US20080166470A1
公开(公告)日：2008-07-10
申请号：US11855847
申请日：2007-09-14
申请人： Jeffrey Schwartz , Michael Danahy , Michael Avaltroni , Jing Guo
发明人： Jeffrey Schwartz , Michael Danahy , Michael Avaltroni , Jing Guo
IPC分类号： A61L27/06
CPC分类号： B82Y30/00 , B05D1/185 , B82Y40/00 , C23C14/06
摘要： Process for forming a coated article by (a) depositing a layer of an omega functionalized organophosphorous compound on an oxide substrate; (b) heating the substrate of step (a) to a temperature sufficient to bond the omega functionalized organophosphorous compound to the oxide substrate; (c) depositing a separate layer onto the layer produced by step (b); and (d) bonding the layers produced by steps (b) and (c) through the omega functional group.
摘要翻译：通过（a）在氧化物基底上沉积Ω官能化的有机磷化合物层来形成涂覆制品的方法; （b）将步骤（a）的基底加热到足以将ω官能化的有机磷化合物键合到氧化物基底上的温度; （c）在由步骤（b）制备的层上沉积单独的层; 和（d）通过步骤（b）和（c）产生的层通过ω官能团键合。

45. 发明申请

US20080102918A1 System and method for playing a game of chance having a base game and a bonus game 审中-公开
标题翻译：用于玩基本游戏和奖励游戏的机会游戏的系统和方法
公开(公告)号：US20080102918A1
公开(公告)日：2008-05-01
申请号：US11976704
申请日：2007-10-26
申请人： Michael Campagno , Jeffrey Schwartz
发明人： Michael Campagno , Jeffrey Schwartz
IPC分类号： A63F9/24
CPC分类号： G07F17/3258 , G07F17/32
摘要： Embodiments of the invention include method and system for providing a bonus game of chance in conjunction with a plurality of base games of chance over a plurality of gaming locations. The bonus game is associated with a vault including a bonus prize and a secret combination of discrete elements. A player is qualified to participate in the bonus game upon meeting at least one winning criterion on the base game of chance. An input device is provided to be presented to the player, wherein the player inputs a guess at the secret combination. The player guess at the secret combination is then received through the input device and a determination is won as to whether the bonus prize is won based on the secret combination, the player guess, and a matching criteria associated with the secret combination.
摘要翻译：本发明的实施例包括用于在多个游戏位置结合多个机会的基本游戏提供机会的奖励游戏的方法和系统。奖金游戏与包括奖金奖金和离散元素的秘密组合的保险库相关联。一名玩家有资格参加奖金游戏，符合基本游戏机会的至少一项获胜标准。提供输入设备以呈现给玩家，其中玩家输入秘密组合的猜测。然后，通过输入装置接收玩家对秘密组合的猜测，并且基于秘密组合，玩家猜测以及与秘密组合相关联的匹配标准，赢得奖金奖金是否获胜。

46. 发明授权

US5132111A CRF analog conjugates 失效
标题翻译： CRF类似物共轭物
公开(公告)号：US5132111A
公开(公告)日：1992-07-21
申请号：US508258
申请日：1990-04-11
申请人： Wylie W. Vale, Jr. , Jean E. F. Rivier , Jeffrey Schwartz
发明人： Wylie W. Vale, Jr. , Jean E. F. Rivier , Jeffrey Schwartz
IPC分类号： C07K14/575
CPC分类号： C07K14/57509 , Y10S514/805 , Y10S530/807 , Y10S930/28
摘要： Agonists and antagonists of rCRF are disclosed that exhibit good binding affinity to CRF receptors. One exemplary agonist is: H-Ser-Gln-Glu-Pro-Pro-Ile-Ser- Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met- Ala-Arg-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg- Leu-Leu-Leu-Glu-Glu-Ala-NH.sub.2. In the agonists, one or more of the first five N-terminal residues may be deleted or may be substituted by a peptide up to 10 amino acids long. A number of other substitutions may also be made throughout the chain. Similar peptides which function as CRF antagonists are created by deleting the first 7, 8 or 9 N-terminal residues. These analogs are coupled to a cytotoxin, such as gelonin, by a dialdehyde or the like, e.g., glutaraldehyde. The conjugates may be used to eliminate CRF Target Cells, and thus to regulate secretion of ACTH, .beta.-lipotropin and the like. Such conjugates can also be administered to alleviate conditions associated with hyperactivity of the hypothalamus-pituitary adrenal axis as well as neoplastic diseases associated with tumors that express CRF receptor.
摘要翻译：公开了rCRF的激动剂和拮抗剂，其表现出对CRF受体的良好结合亲和力。一个示例性的激动剂是：H-Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met- -Arg-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2。在激动剂中，前5个N-末端残基中的一个或多个可以被缺失，或者可被长达10个氨基酸的肽取代。还可以在整个链中进行许多其它取代。作为CRF拮抗剂起作用的相似肽通过缺失第7,8或9个N-末端残基而产生。这些类似物通过二醛或类似物例如戊二醛与细胞毒素（例如gelonin）偶联。缀合物可用于消除CRF靶细胞，并因此调节ACTH，β-Lipotropin等的分泌。也可以施用这样的缀合物以减轻与下丘脑 - 垂体肾上腺轴的多动症相关的病症以及与表达CRF受体的肿瘤相关的肿瘤疾病。

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