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41. 发明授权

US4191841A Process for manufacturing 4-hydroxy-3,5-dimethoxy benzoic acid from 3,4,5-trimethoxybenzoic acid 失效
标题翻译：从3,4,5-三甲氧基苯甲酸制备4-羟基-3,5-二甲氧基苯甲酸的方法
公开(公告)号：US4191841A
公开(公告)日：1980-03-04
申请号：US23376
申请日：1979-03-23
申请人： Michel Soreau , Yani Christidis
发明人： Michel Soreau , Yani Christidis
IPC分类号： C07C51/347 , C07C65/04
CPC分类号： C07C51/347
摘要： Demethylation of the 3,4,5-trimethoxybenzoic acid is carried out in the presence of an excess of alkali hydroxide in an amount of ethylene glycol just sufficient to obtain a heterogeneous medium sufficiently fluid in the course of the operation. The ethylene glycol monomethyl ether and the water formed are distilled off progressively with their production and the resulting 4-hydroxy-3,5-dimethoxybenzoic acid is separated by acidification by means of a strong acid and crystallization.
摘要翻译： 3,4,5-三甲氧基苯甲酸的去甲基化在过量碱金属氢氧化物的存在下进行，其量为乙二醇，足以在操作过程中获得足够流体的异质介质。形成的乙二醇单甲醚和形成的水逐渐蒸馏出来，所得到的4-羟基-3,5-二甲氧基苯甲酸通过强酸酸化和结晶分离。

42. 发明授权

US4105690A Process for manufacturing N-acyl derivatives of hydroxy-arylglycines 失效
标题翻译：制备羟基 - 芳基甘氨酸的N-酰基衍生物的方法
公开(公告)号：US4105690A
公开(公告)日：1978-08-08
申请号：US722284
申请日：1976-09-10
申请人： Yani Christidis , Alain Schouteeten
发明人： Yani Christidis , Alain Schouteeten
IPC分类号： C07C231/00 , C07C67/00 , C07C231/08 , C07C231/12 , C07C233/45 , C07C233/47 , C07C233/49 , C07C237/00 , C07D307/77 , C07C102/00 , C07C103/30 , C07C103/46 , C07C103/66
CPC分类号： C07D307/77 , C07C233/45 , C07C237/00
摘要： Condensation of the addition product of glyoxylic acid and amides with hydroxyaryl compounds is effected by a first step, wherein the reaction is carried out hot, at a temperature below 60.degree. C, of an aliphatic amide having at the most 4 carbon atoms selected from the group of acetamide, chloracetamide, propionamide, acrylamide and butyramide, on an aqueous solution of glyoxylic acid. Then in a second step, after the addition of acetic acid and gaseous hydrochloric acid, condensation is effected at a temperature below 35.degree. C of the carboxamidoglycolic acid with an excess reaching 500% of hydroxyaryl compound selected from the group comprising phenol and its alkyl derivatives, their halogen derivatives, polyphenols and their ethers and betanaphthol. After the condensation of said second step, the volatile products are removed by vacuum distillation. When the hydroxyaryl compound is phenol, the crude product resulting from this distillation is taken up in nitromethane or water, which are a non-solvent of the N-acyl derivative of parahydroxyphenylglycine but a solvent of the corresponding ortho derivative; the proportion of the para derivative in the resulting compound is then of the order of 100%.
摘要翻译：乙醛酸和酰胺与羟基芳基化合物的加成产物的缩合是通过第一步进行的，其中反应在低于60℃的温度下进行，所述脂族酰胺选自最多4个碳原子，乙酰胺，氯乙酰胺，丙酰胺，丙烯酰胺和丁酰胺的组合在乙醛酸水溶液中。然后在第二步中，在加入乙酸和气态盐酸后，在羧酰胺聚糖酸的低于35℃的温度下进行冷凝，过量的达到500％的选自苯酚及其烷基衍生物的羟基芳基化合物，它们的卤素衍生物，多酚及其醚和β-萘酚。在所述第二步骤冷凝后，通过真空蒸馏除去挥发性产物。当羟基芳基化合物是苯酚时，由该蒸馏产生的粗产物溶于硝基甲烷或水中，硝基甲烷或水是对羟基苯基甘氨酸的N-酰基衍生物的非溶剂，但是相应的邻位衍生物的溶剂; 所得化合物中对位衍生物的比例为约100％。

43. 发明授权

US4074054A Imidazoles and 2-alkyl imidazoles and method for their manufacture 失效
标题翻译：咪唑和2-烷基咪唑及其制备方法
公开(公告)号：US4074054A
公开(公告)日：1978-02-14
申请号：US672493
申请日：1976-03-31
申请人： Yani Christidis , Dominique Depernet
发明人： Yani Christidis , Dominique Depernet
IPC分类号： C07D233/56 , C07D233/54 , C07D233/58
CPC分类号： C07D233/54
摘要： The method is for manufacturing imidazoles corresponding to the general formula: ##STR1## in which R represents hydrogen or an alkyl radical of 1 to 17 carbon atoms. Glyoxal is condensed with an aliphatic aldehyde and ammonia, in a hydroalcoholic medium at a pH comprised between 6 and 8. The glyoxal is in the form of its bisulfite combination and the ammonia being supplied by an ammonium salt of a weak acid.
摘要翻译：该方法用于制备相应于下列通式的咪唑：其中R表示氢或1至17个碳原子的烷基。乙二醛与脂肪醛和氨在pH为6至8的水醇介质中缩合。乙二醛为亚硫酸氢盐的组合形式，氨由弱酸的铵盐提供。

44. 发明授权

US3954874A Process of manufacture of polyhydric alcohol bromohydrins 失效
标题翻译：多元醇溴代氢化物的制造方法
公开(公告)号：US3954874A
公开(公告)日：1976-05-04
申请号：US497044
申请日：1974-08-13
申请人： Yani Christidis
发明人： Yani Christidis
IPC分类号： C07C31/42 , C07C91/00 , C07C31/34
CPC分类号： C07C31/42
摘要： An improvement to the process for preparing a polyhydric alcohol bromohydrin from the group consisting in the polymethylol-alkanes, penta-erythritols, amino-substituted polyhydric alcohols by the action of hydrobromic acid on the said polyhydric alcohol, consisting of effecting the reaction in an acetic medium with an aqueous solution of hydrobromic acid, eliminating the water during the course of the reaction by distillation of a water-acetic acid mixture rich in water, by means of an apparatus comprising a distillation column adapted to extract vapours at a temperature lower than 103.degree.C, collecting the resultant product, subjecting this latter to a transesterification reaction with a monohydric-alcohol of low molecular weight from the methanol group, and subjecting said product to a purification treatment.
摘要翻译：通过在所述多元醇上的氢溴酸作用，由多羟甲基烷烃，五羟基喹啉，五羟基喹啉，氨基取代的多元醇制备多元醇溴代醇的方法的改进，包括在乙酸中进行反应介质中加入氢溴酸水溶液，通过蒸馏富含水的乙酸 - 乙酸混合物在反应过程中消除水，通过包含蒸馏塔的设备，该蒸馏塔适于在低于103℃的温度下提取蒸气收集所得产物，使其与甲醇基团的低分子量一元醇进行酯交换反应，并对所述产物进行纯化处理。

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