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41. 发明授权

US5880156A Substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic and medicament containing them 失效
标题翻译：取代的苯甲酰胍，其制备方法，它们作为药物或诊断用途以及含有它们的药物
公开(公告)号：US5880156A
公开(公告)日：1999-03-09
申请号：US898889
申请日：1996-01-30
申请人： Hans-Jochen Lang , Heinz-Werner Kleemann , Wolfgang Scholz , Udo Albus
发明人： Hans-Jochen Lang , Heinz-Werner Kleemann , Wolfgang Scholz , Udo Albus
IPC分类号： A61K31/165 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , C07C277/08 , C07C279/22 , C07C311/15 , C07C317/44 , C07C317/46 , C07C323/62 , C07D241/28 , C07C233/77 , C07C321/24
CPC分类号： C07C279/22 , C07C317/46
摘要： Substituted benzoylguanidines, process for their preparation, their use as a pharmaceutical or diagnostic, and pharmaceutical containing them Benzoylguanidines of the formula I ##STR1## are described in which: R(1), R(2), R(3), R(4) are as defined in the specification, and pharmaceutically tolerated salts thereof.
摘要翻译：描述了其中：R（1），R（2），R（3），R（3），（R） 4）如说明书中所定义，及其药学上可耐受的盐。

42. 发明授权

US5693672A 3,4,5-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic and medicament containing them 失效
标题翻译： 3,4,5-取代苯甲酰胍，其制备方法，它们作为药物或诊断用途以及含有它们的药物
公开(公告)号：US5693672A
公开(公告)日：1997-12-02
申请号：US451309
申请日：1995-05-26
申请人： Andreas Weichert , Hans-Jochen Lang , Wolfgang Scholz , Udo Albus , Florian Lang
发明人： Andreas Weichert , Hans-Jochen Lang , Wolfgang Scholz , Udo Albus , Florian Lang
IPC分类号： A61K31/155 , A61K31/18 , A61K31/33 , A61K31/435 , A61K31/44 , A61P1/16 , A61P3/08 , A61P3/10 , A61P9/00 , A61P9/02 , A61P9/06 , A61P9/10 , A61P11/00 , A61P15/04 , A61P43/00 , C07C277/08 , C07C279/22 , C07C311/37 , C07C315/04 , C07C317/32 , C07C317/44 , C07C323/60 , C07D213/56
CPC分类号： C07C317/44 , C07D213/56 , C07C2101/02 , C07C2101/08 , C07C2101/14 , Y10S514/821
摘要： 3,4,5-Substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic and medicament containing them Benzoylguanidines of the formula I ##STR1## where R(1) is R(4)--SO.sub.m or R(5)R(6)N--SO.sub.2 --, where R(4) and R(5) are alk(en)yl, --C.sub.n H.sub.2n --R(7), and where R(7) is cycloalkyl or phenyl, where R(5) is also H, R(6) is H or C.sub.1 --C.sub.4 --alkyl, R(2) is hydrogen, (cyclo)-alk(en)(yn)yl, aryl and hetaryl, R(3) is defined as R(2) and their pharmaceutically tolerable salts are described.
摘要翻译： 3,4,5-取代的苯甲酰胍，其制备方法，它们用作药物或诊断剂和含有它们的药物。其中R（1）为R（4）-SO m或R 1的式I的苯甲酰胍（5）R（6）N-SO2-，其中R（4）和R（5）是烷（烯）基，-CnH2n-R（7），其中R（7）是环烷基或苯基，其中R （5）也是H，R（6）是H或C 1 -C 4 - 烷基，R（2）是氢，（环）-alk（en）（yn），芳基和杂芳基，R（3）描述了R（2）及其药学上可耐受的盐。

43. 发明授权

US5373024A 3,5-Substituted benzoylguanidines, process for their preparation, their use as a medicament of diagnostic and medicament containing them 失效
标题翻译： 3,5-取代的苯甲酰胍，其制备方法，它们作为含有它们的诊断药物和药物的用途
公开(公告)号：US5373024A
公开(公告)日：1994-12-13
申请号：US15926
申请日：1993-02-10
申请人： Florian Lang , Hans-Jochen Lang , Dieter Mania , Andreas Weichert , Wolfgang Scholz , Udo Albus , Heinrich Englert
发明人： Florian Lang , Hans-Jochen Lang , Dieter Mania , Andreas Weichert , Wolfgang Scholz , Udo Albus , Heinrich Englert
IPC分类号： A61K31/155 , A61K31/18 , A61K31/275 , A61P1/16 , A61P3/08 , A61P3/10 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P13/02 , A61P15/00 , A61P35/00 , A61P35/04 , C07C217/44 , C07C311/16 , C07C311/37 , C07C311/39 , C07C311/47 , C07C317/42 , C07C317/44 , C07C323/65 , C07C279/22
CPC分类号： C07C217/44 , C07C311/16 , Y10S514/821
摘要： Benzoylguanidines of the formula I ##STR1## are described where R(1) is R(4)--SO.sub.m or R(5)R(6)N--SO.sub.z --, where R(4) and R(5) are alk(en)yl or --C.sub.n H.sub.2n --R(7), and where R(7) is a cycloalkyl or phenyl, where R(5) also has the meaning of H, and R(6) is H or C.sub.1 -C.sub.4 -alkyl, R(2) is hydrogen, halogen, alkyl, O--(CH.sub.2).sub.m C.sub.p F.sub.2p+1, --X--R(10), where X is O, S or NR(11), R(10) is H, (cyclo)alkyl(methyl) or --C.sub.n H.sub.2n --R(12) where R(12) is phenyl, and R(3) is defined, inter alia, as R(1), and their pharmaceutically tolerable salts.The compounds I are obtained by reaction of compounds of the formula II ##STR2## with guanidine, in which L is a leaving group which can be easily nucleophilically substituted.Compounds I are outstandingly suitable as antiarrythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment and for the treatment of angina pectoris, where they also preventively inhibit or greatly reduce the pathophysiological processes during the formation of ischemically induced damage. They are moreover distinguished by strong inhibitory action on the proliferation of cells. They can therefore be used as antiatherosclerotics, agents against late-onset diabetic complications, cancers, and fibrotic diseases such as pulmonary fibrosis, fibrosis of the liver or fibrosis of the kidneys.They are effective inhibitors of the cellular sodium/proton antiporter (Na.sup.+ /H.sup.+ exchanger).
摘要翻译：其中R（1）为R（4）-SOm或R（5）R（6）N-SOz-，其中R（4）和R（5）为烷基（烯）或-C n H 2n-R（7），其中R（7）为环烷基或苯基，其中R（5）也为H，R（6）为H或C 1 -C 4 - 烷基，R（2）为氢，卤素，烷基，O-（CH2）mCpF2p + 1，-XR（10）其中X为O，S或NR（11），R（10）为H，（环）烷基（甲基）或-CnH2n-R（12）其中R（12）为苯基，R（3）特别定义为R（1）及其药学上可耐受的盐。化合物I通过式II化合物（II）与胍反应而获得，其中L是可容易地亲核取代的离去基团。化合物I非常适合作为具有用于梗死预防和梗塞治疗的心脏保护组分和用于治疗心绞痛的抗焦虑药物，其中它们还预防性地抑制或大大降低在缺血诱导的损伤形成期间的病理生理过程。此外，它们通过对细胞增殖的强抑制作用而不同。因此，它们可以用作抗动脉粥样硬化，抗晚发性糖尿病并发症，癌症和纤维化疾病如肺纤维化，肝纤维化或肾纤维化的药物。它们是细胞钠/质子反转录酶（Na + / H +交换剂）的有效抑制剂。

44. 发明授权

US5665739A Substituted benzoylguanidines, process and their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them 失效
标题翻译：取代的苯甲酰胍，方法及其制备，它们作为药物或诊断用途，以及含有它们的药物
公开(公告)号：US5665739A
公开(公告)日：1997-09-09
申请号：US440619
申请日：1995-05-15
申请人： Hans-Jochen Lang , Heinz-Werner Kleeman , Wolfgang Scholz , Udo Albus
发明人： Hans-Jochen Lang , Heinz-Werner Kleeman , Wolfgang Scholz , Udo Albus
IPC分类号： C07D213/64 , C07D213/643 , C07D215/20 , A61K31/44 , C07D213/02
CPC分类号： C07D213/643 , C07D215/20
摘要： Benzoylguanidines of the formula I are described ##STR1## in which R(1)=hydrogen, Hal, --NO.sub.2, --C.tbd.N, --CF.sub.3, R(4)--SO.sub.m or R(5)R(6)N--SO.sub.2 --, R(4) and R(5) are alk(en)yl or CF.sub.3, R(5) also having the meaning of H,R(2)=is heteroaryl or --SR(10), --OR(10), --NR(10)R(11), --CR(10)R(11)R(12); where R(10) is --C.sub.a H.sub.2a -heteroaryl, and R(11) and R(12) are as defined for R(10) and also hydrogen or alkyl,R(3) is as defined for R(1) or is alkyl, --X--R(13) where X is oxygen, S, NR(14), where R(13) is H or (cyclo)alkyl.They are obtained from a compound of the formula II ##STR2## by reacting it with guanidine. The compounds are outstandingly suitable as antiarrhythmic pharmaceuticals with a cardioprotective component for the prophylaxis and treatment of infarctions and for the treatment of angine pectoris, and they also preventively inhibit, or greatly reduce, the pathophysiological processes in the formation of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias.
摘要翻译：其中R（1）=氢，Hal，-NO 2，-CF 3OND N，-CF 3，R（4）-SO m或R（5）R（6）的N-SO 2描述式I的苯甲酰基胍 - ，R（4）和R（5）是烷（烯）基或CF 3，R（5）也具有H的意义，R（2）=是杂芳基或-SR（10），-NR（10）R（11），-CR（10）R（11）R（12）; 其中R（10）是-CaH2a-杂芳基，R（11）和R（12）如对R（10）所定义，并且氢或烷基，R（3）如对R（1）所定义，或者是烷基 -XR（13）其中X是氧，S，NR（14），其中R（13）是H或（环）烷基。它们通过与胍反应从式II的化合物获得。该化合物非常适合作为具有心脏保护成分的抗心律失常药物，用于预防和治疗梗死和治疗心绞痛，并且还预防性地抑制或大大降低缺血诱导的损伤形成中的病理生理过程，特别是引发缺血诱导的心律失常。

45. 发明授权

US5364868A Amino-substituted benzoylguanidines, process for their preparation, their use as a medicament and medicament containing them 失效
标题翻译：氨基取代的苯甲酰胍，其制备方法，它们作为药物的用途和含有它们的药物
公开(公告)号：US5364868A
公开(公告)日：1994-11-15
申请号：US16535
申请日：1993-02-11
申请人： Heinrich Englert , Dieter Mania , Hans-Jochen Lang , Wolfgang Scholz , Wolfgang Linz , Udo Albus
发明人： Heinrich Englert , Dieter Mania , Hans-Jochen Lang , Wolfgang Scholz , Wolfgang Linz , Udo Albus
IPC分类号： A61K31/155 , A61K31/165 , A61K31/445 , A61P1/16 , A61P3/08 , A61P3/10 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P13/02 , A61P15/00 , A61P35/00 , C07C279/22 , C07D213/65 , C07D295/14 , C07D295/155 , C07C279/10 , C07D207/06 , C07D211/28
CPC分类号： C07D295/155 , C07C279/22 , C07D213/65
摘要： Amino-substituted benzoylguanidines, process for their preparation, their use as a medicament and medicament containing themBenzoylguanidines of the formula I ##STR1## are described in which R(1) or R(2) is an amino group --NR(3)R(4), where R(3) and R(4) are H or (cyclo)alkyl or R(3) is phenyl-(CH.sub.2).sub.p -- where p=0, 1, 2, 3 or 4, or phenyl, or R(3) and R(4) can also together be a methylene chain, and in which the other substituent R(1) or R(2) in each case is H, F, Cl, alkyl, alkoxy, CF.sub.3, C.sub.m F.sub.2m+1 --CH.sub.2 --, benzyl or phenoxy, and their pharmaceutically tolerable salts.The compounds according to the invention have very good antiarrhythmic properties, as occur, for example, in the case of oxygen deficiency symptoms. The compounds are used as antiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment as well as for the treatment of angina pectoris, where they also preventively inhibit or greatly decrease the pathophysiological processes in the formation of ischemically induced damage, in particular in the production of ischemically induced cardiac arrhythmias.
摘要翻译：氨基取代的苯甲酰胍，其制备方法，它们作为药物的用途和含有它们的药物描述了其中R（1）或R（2）是氨基-NR（ 3）R（4）其中R（3）和R（4）是H或（环）烷基或R（3）是苯基 - （CH 2）p - ，其中p = 0,1,2,3或4，或苯基或R（3）和R（4）也可以一起为亚甲基链，其中每种情况下其它取代基R（1）或R（2）为H，F，Cl，烷基，烷氧基， CF3，CmF2m + 1-CH2-，苄基或苯氧基，及其药学上可耐受的盐。根据本发明的化合物具有非常好的抗心律失常性质，例如在缺氧症状的情况下发生。该化合物被用作具有用于梗塞预防和梗塞治疗的心脏保护组分以及用于治疗心绞痛的抗心律失常药物，其中它们也预防性地抑制或大大降低缺血诱导的损伤形成中的病理生理过程，特别是在产生缺血诱导的心律失常。

46. 发明授权

US5733934A Antiarrythmic and cardioprotective substituted indenoylguanidines 失效
标题翻译：抗焦虑和心脏保护取代茚酰基胍
公开(公告)号：US5733934A
公开(公告)日：1998-03-31
申请号：US633223
申请日：1996-04-16
申请人： Nigrogi Venkata Satya Ramakrishna , Tulsidas Sitaram More , Anagha Suhas Kulkarni , Bansi Lal , Rao Venkata Satya Veerabhadra Vadlamudi , Anil Vasantrao Ghate , Ravindra Dattatraya Gupte , Wolfgang Scholz , Hans Jochen Lang
发明人： Nigrogi Venkata Satya Ramakrishna , Tulsidas Sitaram More , Anagha Suhas Kulkarni , Bansi Lal , Rao Venkata Satya Veerabhadra Vadlamudi , Anil Vasantrao Ghate , Ravindra Dattatraya Gupte , Wolfgang Scholz , Hans Jochen Lang
IPC分类号： A61K31/155 , A61K20060101 , A61K31/16 , A61K31/185 , A61K31/205 , A61K31/435 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , C07C20060101 , C07C277/08 , C07C279/22 , C07C279/26 , C07C327/50 , C07C327/54 , C07D20060101 , C07D295/26 , A01N33/02 , A01N37/30
CPC分类号： C07C279/22 , C07C2102/08
摘要： Indenoylguanidines of formula I and formula II, the process for their preparation, their use as medicaments, medicaments containing them, their use as diagnostic agents and medicaments containing them are described. Compounds I are useful for treating cardiac arrhythmias. Further they are useful as cardioprotective agents in mammals, which comprises administering the compound of formula-I or II with the above properties in combination with pharmaceutically accepted carrier to said mammal. ##STR1##
摘要翻译：描述式I和式II的茚烯酰基胍，其制备方法，它们作为药物的用途，含有它们的药物，它们作为诊断剂的用途和含有它们的药物。化合物I可用于治疗心律失常。此外，它们可用作哺乳动物的心脏保护剂，其包括将具有上述性质的式I或II化合物与药学上可接受的载体组合施用于所述哺乳动物。 II。图像II

47. 发明授权

US5091394A Benzoylguanidines, a process for their preparation, their use as medicaments and medicaments containing them 失效
标题翻译：苯甲酰胺，其制备方法，它们作为含有它们的药物和药物使用
公开(公告)号：US5091394A
公开(公告)日：1992-02-25
申请号：US576937
申请日：1990-09-04
申请人： Heinrich C. Englert , Hans-Jochen Lang , Wolfgang Linz , Bernward Scholkens , Wolfgang Scholz
发明人： Heinrich C. Englert , Hans-Jochen Lang , Wolfgang Linz , Bernward Scholkens , Wolfgang Scholz
IPC分类号： C07C279/22 , A61K31/155 , A61K31/18 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/445 , A61K31/455 , A61K31/535 , A61K31/5375 , A61P9/06 , A61P9/08 , A61P9/10 , C07C277/00 , C07C279/10 , C07C311/15 , C07C311/47 , C07C317/42 , C07C317/44 , C07C323/60 , C07C323/62 , C07C323/65 , C07C323/67 , C07D209/08 , C07D211/28 , C07D295/14 , C07D295/155 , C07D295/195 , C07D295/22 , C07D295/26
CPC分类号： C07D295/26 , C07C311/47 , C07C317/42 , C07C323/67 , C07D209/08 , C07D295/155 , C07C2101/06 , C07C2101/14
摘要： Benzoylguanidines of the formula I ##STR1## where R(1) or R(2) is equal to R(6)--S(O).sub.n -- or R(7)R(8)N--O.sub.2 S--and the other substituent R(1) or R(2) is in each case equal to H, F, Cl, Br, I, alkyl, alkoxy or phenoxy, R(6)--S(O).sub.n or R(7)R(8)N--and R(6) is equal to alkyl, cycloalkyl, cyclopentylmethyl, cyclohexylmethyl or phenyl,R(7) and R(8) are equal to alkyl or phenylakyl or phenyl,and in which R(7) and R(8) may also together be a C.sub.4 -C.sub.7 chain, and in which R(7) and R(8), together with the nitrogen atom to which they are bonded, may be dihydroindole, tetrahydroquinoline or tetrahydroisoquinoline system,and where R(3), R(4) and R(5) are equal to hydrogen or alkyl, or R(3) and R(4) are together an alkylene chain or R(4) and R(5) are together an alkylene chain,and where n is equal to zero, 1 or 2 and their pharmaceutically tolerable salts are outstanding antiarrhythmics.
摘要翻译：其中R（1）或R（2）等于R（6）-S（O）n - 或R（7）R（8）N-O 2 S-的式I的苯甲酰基胍（I）其中R（1）或R（2）各自为H，F，Cl，Br，I，烷基，烷氧基或苯氧基，R（6）-S（O）n或R（7） 8）N-和R（6）等于烷基，环烷基，环戊基甲基，环己基甲基或苯基，R（7）和R（8）等于烷基或苯基烷基或苯基，其中R（7）和R 8）也可以一起是C4-C7链，其中R（7）和R（8）与它们所键合的氮原子一起可以是二氢吲哚，四氢喹啉或四氢异喹啉体系，其中R（3 ），R（4）和R（5）等于氢或烷基，或R（3）和R（4）一起是亚烷基链或R（4）和R（5）一起是亚烷基链，其中n等于零，1或2及其药学上可耐受的盐是出色的抗心律失常药。

48. 发明授权

US5416094A Antiarrhythmic and cardioprotective substituted -1(2H)isoquinolines, medicament containing them, and their use for combating heart failures 失效
标题翻译：抗心律失常和心脏保护性取代的-1（2H）异喹啉，含有它们的药物及其对抗心力衰竭的用途
公开(公告)号：US5416094A
公开(公告)日：1995-05-16
申请号：US126200
申请日：1993-09-24
申请人： Bansi Lal , Ramesh Gidwani , Ramanujam Rajagopalan , Radha Panicker , Chinnakulandai Sankar , Hans-Jochen Lang , Heinrich Englert , Wolfgang Scholz
发明人： Bansi Lal , Ramesh Gidwani , Ramanujam Rajagopalan , Radha Panicker , Chinnakulandai Sankar , Hans-Jochen Lang , Heinrich Englert , Wolfgang Scholz
IPC分类号： A61K31/47 , A61K31/472 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , C07D217/26 , C07D401/04 , C07D401/12 , C07D413/04 , C07D413/12 , C07D217/12
CPC分类号： C07D401/04 , C07D217/26 , C07D413/04
摘要： Described are guanidinocarbonyl isoquinolines of the formula I, ##STR1## wherein R(1) is hydrogen, (amino) (cyclo) (aryl)alk(en)yl (heteroaryl); R(2) is hydrogen, halogen, alkyl, or aryl; G is a radical of the formula VII: ##STR2## X(2), X(3) and X(4) are hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono) (di) (lower alkyl) (amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also a process for their preparation, their use as medicaments, and medicaments containing them for treating congestive heart failure, and arrhythmic conditions as well as cardioprotective agents in mammals.
摘要翻译：描述了式I，其中R（1）是氢，（氨基）（环）（芳基）烷基（烯）基（杂芳基））的胍基羰基异喹啉。 R（2）是氢，卤素，烷基或芳基; G是式VII的基团：X（2），X（3）和X（4）是氢，卤素，硝基，氨基，烷基，磺酰胺，（单）（二）（低级烷基）（氨基），苄氧基，羟基; X（1）氢，氧，硫和NR（7）R（8）及其药学上可接受的盐; 也描述了它们的制备方法，它们作为药物的用途，以及含有它们用于治疗充血性心力衰竭的药物，以及心律失常病症以及哺乳动物的心脏保护剂。

49. 发明授权

US5292755A USPA benzolyguanidines 失效
标题翻译： USPA苯并胍
公开(公告)号：US5292755A
公开(公告)日：1994-03-08
申请号：US830355
申请日：1992-01-31
申请人： Heinrich C. Englert , Hans-Jochen Lang , Wolfgang Linz , Bernward Scholkens , Wolfgang Scholz
发明人： Heinrich C. Englert , Hans-Jochen Lang , Wolfgang Linz , Bernward Scholkens , Wolfgang Scholz
IPC分类号： C07C279/22 , A61K31/155 , A61K31/18 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/445 , A61K31/455 , A61K31/535 , A61K31/5375 , A61P9/06 , A61P9/08 , A61P9/10 , C07C277/00 , C07C279/10 , C07C311/15 , C07C311/47 , C07C317/42 , C07C317/44 , C07C323/60 , C07C323/62 , C07C323/65 , C07C323/67 , C07D209/08 , C07D211/28 , C07D295/14 , C07D295/155 , C07D295/195 , C07D295/22 , C07D295/26
CPC分类号： C07D295/26 , C07C311/47 , C07C317/42 , C07C323/67 , C07D209/08 , C07D295/155 , C07C2101/06 , C07C2101/14
摘要： Benzoylguanidines of the formula I ##STR1## where R(1) or R(2) is equal to R(6)--S(O).sub.n -- or R(7)R(8)N--O.sub.2 S--and the other substituent R(1) or R(2) is in each case equal to H, F, Cl, Br, I, alkyl, alkoxy or phenoxy, R(6)--S(O).sub.n or R(7)R(8)N--and R(6) is equal to alkyl, cycloalkyl, cyclopentylmethyl, cyclohexylmethyl or phenyl,R(7) and R(8) are equal to alkyl or phenylalkyl or phenyl,and in which R(7) and R(8) may also together be a C.sub.4 --C.sub.7 chain, and in which R(7) and R(8), together with the nitrogen atom to which they are bonded, may be a dihydroindole, tetrahydroquinoline or tetrahydroisoquinoline system,and where R(3), R(4) and R(5) are equal to hydrogen or alkyl, or R(3) and R(4) are together an alkylene chain or R(4) and R(4) are together an alkylene chain,and where n is equal to zero, 1 or 2and their pharmaceutically tolerable salts are outstanding antiarrhythmics.
摘要翻译：其中R（1）或R（2）等于R（6）-S（O）n - 或R（7）R（8）N-O 2 S-的式I的苯甲酰基胍（I）其中R（1）或R（2）各自为H，F，Cl，Br，I，烷基，烷氧基或苯氧基，R（6）-S（O）n或R（7） 8）N-和R（6）等于烷基，环烷基，环戊基甲基，环己基甲基或苯基，R（7）和R（8）等于烷基或苯基烷基或苯基，其中R（7）和R（ 8）也可以一起是C4-C7链，其中R（7）和R（8）与它们所键合的氮原子一起可以是二氢吲哚，四氢喹啉或四氢异喹啉体系，其中R（ 3）中，R（4）和R（5）等于氢或烷基，或R（3）和R（4）一起是亚烷基链或R（4）和R（4）并且其中n等于零，1或2及其药学上可耐受的盐是杰出的抗心律失常药。

50. 发明授权

US06348476B1 Pharmaceutical combination preparation of an inhibitor of the sodium/hydrogen exchanger and a medicament for the treatment of cardiovascular diseases 有权
标题翻译：钠/氢交换剂的抑制剂的药物组合制剂和用于治疗心血管疾病的药物
公开(公告)号：US06348476B1
公开(公告)日：2002-02-19
申请号：US09610425
申请日：2000-07-05
申请人： Wolfgang Scholz , Udo Albus
发明人： Wolfgang Scholz , Udo Albus
IPC分类号： A61K31445
CPC分类号： A61K45/06
摘要： Pharmaceutical combination preparation of an inhibitor of the sodium/hydrogen exchanger and a medicament for the treatment of cardiovascular diseases. These combinations of an NHE inhibitor can comprise one or more therapeutically active compounds having cardiovascular activity. The combination of the cardioprotective properties with known therapies of cardiovascular diseases leads on the one hand to an improvement of the quality of the treatment and on the other hand in a large number of combinations to an additive or potentiated increase of the cardiovascular effects of the individual active compounds alone.
摘要翻译：钠/氢交换剂的抑制剂的药物组合制剂和用于治疗心血管疾病的药物。这些NHE抑制剂的组合可以包含一种或多种具有心血管活性的治疗活性化合物。心脏保护性质与已知的心血管疾病疗法的组合一方面导致治疗质量的改善，另一方面导致大量与添加剂的组合或个体的心血管效应的增强的增加活性化合物。

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