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41. 发明申请

WO0155306A3 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
公开(公告)号：WO0155306A3
公开(公告)日：2001-12-20
申请号：PCT/US0101304
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： C07K11/00 , C07K14/00 , C12N20060101 , C12N5/00 , C12N5/06 , C12N15/00 , C12N15/63 , C12P21/04 , C12P21/06
CPC分类号： C07K11/00 , C07K14/00 , C12N1/00 , C12N5/00 , C12N5/06 , C12N15/00 , C12N15/63 , C12P21/06
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

42. 发明申请

WO0155387A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
公开(公告)号：WO0155387A8
公开(公告)日：2001-12-06
申请号：PCT/US0101310
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68
CPC分类号： C12N9/6424 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

43. 发明申请

WO0155449A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：WO0155449A8
公开(公告)日：2001-09-07
申请号：PCT/US0101346
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , C07H21/04 , C07K1/00 , C12N1/20 , C12N15/00 , C12N15/12 , C12P21/06 , C12Q1/68
CPC分类号： A61K38/00 , C07H21/04 , C07K1/00 , C12N1/20 , C12N15/00 , C12P21/06 , C12Q1/68
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifiying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新型蛋白质。更具体地，提供编码新型多肽的分离的核酸分子。提供结合这些多肽的新型多肽和抗体。还提供了载体，宿主细胞，以及用于产生人多核苷酸和/或多肽的抗体的重组和合成方法。本发明还涉及用于诊断，治疗，预防和/或预测与这些新型多肽相关的疾病的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制或增强本发明多肽的产生和功能的方法和/或组合物。

44. 发明申请

WO0155368A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
公开(公告)号：WO0155368A8
公开(公告)日：2001-09-07
申请号：PCT/US0101348
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68 , C12N15/11 , A61K38/16 , A61K38/17 , C07K16/00 , C12N15/00 , C12N15/63 , C12P21/02 , G01N33/68
CPC分类号： C12N9/6424 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

45. 发明申请

WO0155350A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：WO0155350A8
公开(公告)日：2001-09-07
申请号：PCT/US0101350
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68 , C12N5/10 , C12N5/16 , C12N15/63 , C12N15/64
CPC分类号： C12N9/6424 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel colorectal cancer related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "colorectal cancer antigens", and the use of such colorectal cancer antigens for detecting disorders of the colon and/or rectum particularly the presence of colorectal cancer and colorectal cancer metastases. More specifically, isolated colorectal cancer associated nucleic acid molecules are provided encoding novel colorectal cancer associated polypeptides. Novel colorectal cancer polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human colorectal cancer associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the colon and/or rectum including colorectal cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新的结直肠癌相关多核苷酸和由本文统称为“结肠直肠癌抗原”的这些多核苷酸编码的多肽，以及此类结肠直肠癌抗原用于检测结肠和/或直肠病症，特别是结肠直肠癌癌症和结直肠癌转移。更具体地说，提供了编码新的结肠直肠癌相关多肽的分离的结直肠癌相关核酸分子。提供了新的结肠直肠癌多肽和结合这些多肽的抗体。还提供了用于产生人结直肠癌相关多核苷酸和/或多肽的载体，宿主细胞以及重组和合成方法。本发明进一步涉及用于诊断，治疗，预防和/或预测与结肠和/或直肠相关的疾病（包括结直肠癌）的诊断和治疗方法，以及治疗这些疾病的治疗方法。本发明进一步涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制本发明多肽的产生和功能的方法和/或组合物。

46. 发明申请

WO0155343A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：WO0155343A8
公开(公告)日：2001-09-07
申请号：PCT/US0101322
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68 , C07K14/00 , C12N5/10 , C12N15/11 , C12N15/63
CPC分类号： C12N9/6424 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel connective tissue related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "connective tissue antigens", and the use of such connective tissue antigens for detecting disorders of connective tissue(s), particularly the presence of cancer and cancer metastases. More specifically, isolated connective tissue associated nucleic acid molecules are provided encoding novel connective tissue associated polypeptides. Novel connective tissue polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human connective tissue associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to connective tissue(s), including cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonsits of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新的结缔组织相关多核苷酸和由本文统称为“结缔组织抗原”的这些多核苷酸编码的多肽，以及此类结缔组织抗原用于检测结缔组织病症，特别是癌症的存在和癌症转移。更具体而言，提供了编码新型结缔组织相关多肽的分离的结缔组织相关核酸分子。提供了新颖的结缔组织多肽和结合这些多肽的抗体。还提供了载体，宿主细胞以及用于产生人结缔组织相关多核苷酸和/或多肽的重组和合成方法。本发明还涉及用于诊断，治疗，预防和/或预测与结缔组织相关的疾病（包括癌症）的诊断和治疗方法，以及用于治疗这些疾病的治疗方法。本发明进一步涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制本发明多肽的产生和功能的方法和/或组合物。

47. 发明申请

WO0155315A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：WO0155315A8
公开(公告)日：2001-09-07
申请号：PCT/US0101326
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68 , C12N
CPC分类号： C12N9/6424 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新蛋白质。更具体而言，提供了编码新多肽的分离的核酸分子。提供了与这些多肽结合的新多肽和抗体。还提供了载体，宿主细胞，以及用于生产人多核苷酸和/或多肽以及抗体的重组和合成方法。本发明进一步涉及用于诊断，治疗，预防和/或预测与这些新多肽有关的病症的诊断和治疗方法。本发明进一步涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明进一步涉及用于抑制或增强本发明多肽的产生和功能的方法和/或组合物。

48. 发明申请

WO0155307A8 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：WO0155307A8
公开(公告)日：2001-09-07
申请号：PCT/US0101306
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68 , C12N
CPC分类号： C12N9/6424 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosis, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新型蛋白质。更具体地，提供编码新型多肽的分离的核酸分子。提供结合这些多肽的新型多肽和抗体。还提供了载体，宿主细胞，以及用于产生人多核苷酸和/或多肽的抗体的重组和合成方法。本发明还涉及可用于诊断，治疗，预防和/或预后与这些新型多肽相关的疾病的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制或增强本发明多肽的产生和功能的方法和/或组合物。

49. 发明申请

WO0155305A2 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
公开(公告)号：WO0155305A2
公开(公告)日：2001-08-02
申请号：PCT/US0101303
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： C07H21/02 , C07H21/04 , C12N20060101 , C12N1/20 , C12N15/00 , C12N15/09 , C12N15/12 , C12N15/63 , C12N15/70 , C12N15/74 , C12N
CPC分类号： C07H21/02 , C07H21/04 , C12N1/00 , C12N1/20 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

50. 发明申请

WO2005105841A3 HUMAN G-PROTEIN CHEMOKINE RECEPTOR (CCR5) HDGNR10 审中-公开
标题翻译：人类G蛋白激素受体（CCR5）HDGNR10
公开(公告)号：WO2005105841A3
公开(公告)日：2006-04-20
申请号：PCT/US2005008377
申请日：2005-03-11
申请人： HUMAN GENOME SCIENCES INC , ROSCHKE VICTOR , ROSEN CRAIG A , RUBEN STEVEN M
发明人： ROSCHKE VICTOR , ROSEN CRAIG A , RUBEN STEVEN M
IPC分类号： C07K14/705 , C07K14/715 , C07K16/28 , C12N15/13
CPC分类号： C07K16/2866 , C07K14/7158 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N2333/715
摘要： The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this novel human protein and these novel human antibodies.
摘要翻译：本发明涉及一种称为人G蛋白趋化因子受体（CCR5）HDGNR10的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。本发明还涉及结合人G蛋白趋化因子受体（CCR5）HDGNR10的人抗体和编码这些抗体的多核苷酸。还提供了用于产生人G蛋白趋化因子受体（CCR5）HDGNR10和人类抗人G蛋白趋化因子受体（CCR5）HDGNR10抗体的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与该新型人蛋白质和这些新型人抗体相关的疾病，病症和/或病症的诊断和治疗方法。

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