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41. 发明授权

US3987175A Derivatives of phenoxy isobutyric acid having hypolipemizing and hypocholesterolemizing action 失效
标题翻译：具有高效和高脂肪氧化活性的苯氧基异丁酸的衍生物
公开(公告)号：US3987175A
公开(公告)日：1976-10-19
申请号：US577402
申请日：1975-05-14
申请人： Henri Cousse
发明人： Henri Cousse
IPC分类号： C07D213/82 , C07D213/89 , C07D213/56 , A61K31/455 , C07D213/90
CPC分类号： C07D213/82 , C07D213/89
摘要： The present invention relates to new chemical products which are useful as hypolipemizing and hypocholesterolemizing agents.The new compounds are derivatives of phenoxy isobutyric acid of the general formula ##EQU1## wherein: A is a lower-alkylene bridge of 2 to 6 carbon atoms, either linear or branched,X is a halogen atom,R = h or lower-alkyl,The N of the pyridyl ring can be replaced by an N-oxide, or the compounds can be in the form of their pharmaceutically-acceptable acid addition salts.Pharmaceutical compositions containing these active principles are useful for hypolipemizing and hypocholesterolemizing purposes, e.g., in the prevention and treatment of atherosclerosis and its consequences.

42. 发明授权

US5091415A Thioformamidines, their preparation and use as medicaments 失效
标题翻译：噻吗啉胺，他们的制剂和用作药物
公开(公告)号：US5091415A
公开(公告)日：1992-02-25
申请号：US597051
申请日：1990-10-15
申请人： Jean F. Patoiseau , Jean-Marie Autin , Henri Cousse , Veronique Sales , Jacky Tisne-Versailles , Jean-Pierre Bali
发明人： Jean F. Patoiseau , Jean-Marie Autin , Henri Cousse , Veronique Sales , Jacky Tisne-Versailles , Jean-Pierre Bali
IPC分类号： A61K31/155 , A61K31/27 , A61K31/41 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/496 , A61K31/505 , A61P1/04 , A61P43/00 , C07C335/32 , C07D233/42 , C07D233/84 , C07D235/28 , C07D239/10 , C07D239/38 , C07D249/12
CPC分类号： C07D239/10 , C07D233/42 , C07D233/84 , C07D235/28 , C07D239/38 , C07D249/12
摘要： Formamidine compounds of general formula I ##STR1## in which: R.sub.1 represents H or C.sub.1-4 alkyl,R.sub.2 represents benzoyl, benzyl, or alpha-hydroxybenzyl, the aromatic ring being optionally substituted by a halogen atom,R.sub.3 and R.sub.4, which are identical or different, represent hydrogen, lower-alkyl, or lower-alkenyl, or form between them with the formamidine function a heterocycle,R.sub.5 represents hydrogen or C.sub.1-4 lower-alkyl or forms with R.sub.4 a double bond (--N.dbd.R.sub.4) in the case of pseudoaromatic heterocycles,n equals 0 or 1,A represents a linear or branched C.sub.1-4 alkylene chain,X represents hydrogen, halogen, C.sub.1-4 lower-alkyl, C.sub.1-4 lower-alkoxy, or nitro, and pharmaceutically-acceptable salts thereof, are disclosed.The compounds and pharmaceutical compositions thereof are used, optionally in combination with other active principles, as drugs for the treatment of gastrointestinal ailments, especially as gastric antisecretory and antiulcer agents.

43. 发明授权

US4122199A Amides of pyrrolidinoethylamine which can be used in treatment of coughs 失效
标题翻译：可用于治疗咳嗽的吡咯烷基乙胺的酰胺
公开(公告)号：US4122199A
公开(公告)日：1978-10-24
申请号：US714764
申请日：1976-08-16
申请人： Henri Cousse , Bernard Bonnaud , Jean-Pierre Tarayre , Silvano Casadio
发明人： Henri Cousse , Bernard Bonnaud , Jean-Pierre Tarayre , Silvano Casadio
IPC分类号： C07D279/30 , C07D295/13 , C07D311/12 , C07D311/84 , A61K31/40
CPC分类号： C07D295/13 , C07D279/30 , C07D311/12 , C07D311/84 , Y10S514/849
摘要： New chemical compounds, which are pyrrolidinoethylamine amides, in the form of free bases and salts thereof, which are useful as antitussives, pharmaceutical compositions thereof, and method of treating therewith.In the form of their salts, the compounds have the formula: ##STR1## wherein ##STR2## is an acyl radical of a phenylacetic, 60 -phenyl-.alpha.-(1 to 5 C atoms) acetic, (1 to 5 C atoms) diphenylacetic, benzilic, diphenyl-.alpha.-chloroacetic, .alpha.-lower-alkoxy-.alpha.,.alpha.-diphenylacetic, 3-coumarincarboxylic, 9-xanthenecarboxylic, phenoxyacetic, phenoxyisobutyric, halophenoxyisobutyric, or 9-flourene carboxylic acid, and wherein R'H represents an inorganic or organic acid.Medicaments containing these active principles may be used, inter alia, in the treatment of coughs and respiratory complaints.
摘要翻译：新的化合物，它们是吡咯烷基乙胺酰胺，其形式为游离碱和盐，它们可用作镇咳药，其药物组合物及其处理方法。

44. 发明授权

US5025015A Thioformamidines, and use as medicaments 失效
标题翻译：噻托酰胺，并用作药物
公开(公告)号：US5025015A
公开(公告)日：1991-06-18
申请号：US404337
申请日：1989-09-07
申请人： Jean F. Patoiseau , Jean-Marie Autin , Henri Cousse , Veronique Sales , Jacky Tisne-Versailles , Jean-Pierre Bali
发明人： Jean F. Patoiseau , Jean-Marie Autin , Henri Cousse , Veronique Sales , Jacky Tisne-Versailles , Jean-Pierre Bali
IPC分类号： A61K31/155 , A61K31/27 , A61K31/41 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/496 , A61K31/505 , A61P1/04 , A61P43/00 , C07C335/32 , C07D233/42 , C07D233/84 , C07D235/28 , C07D239/10 , C07D239/38 , C07D249/12
CPC分类号： C07D239/10 , C07D233/42 , C07D233/84 , C07D235/28 , C07D239/38 , C07D249/12
摘要： Formamidine compounds of general formula I ##STR1## in which: R.sub.1 represents H or C.sub.1-4 alkyl,R.sub.2 represents benzoyl, benzyl, or alphahydroxybenzyl, the aromatic ring being optionally substituted by a halogen atom,R.sub.3 and R.sub.4, which are identical or different, represent hydrogen, lower-alkyl, or lower-alkenyl, or form between them with the formamidine function a heterocycle,R.sub.5 represents hydrogen or C.sub.1-4 lower-alkyl or forms with R.sub.4 a double bond (--N.dbd.R.sub.4) in the case of pseudoaromatic heterocycles,n equals 0 or 1,A represents a linear or branched C.sub.1-4 alkylene chain,X represents hydrogen, halogen, C.sub.1-4 lower-alkyl, C.sub.1-4 lower-alkoxy, or nitro, and pharmaceutically-acceptable salts thereof, are disclosed.The compounds and pharmaceutical compositions thereof are used, optionally in combination with other active principles, as drugs for the treatment of gastrointestinal ailments, especially as gastric antisecretory and antiulcer agents.
摘要翻译：通式I的甲脒化合物其中：R 1表示H或C 1-4烷基，R 2表示苯甲酰基，苄基或α-羟基苄基，芳环任选被卤素原子取代，R 3和R 4是相同或不同，代表氢，低级烷基或低级烯基，或在它们与甲脒官能团之间形成杂环，R 5表示氢或C 1-4低级烷基或与R 4形成双键（-N = R 4）在假芳香族杂环的情况下，n表示0或1，A表示直链或支链C 1-4亚烷基链，X表示氢，卤素，C 1-4低级烷基，C 1-4低级烷氧基或硝基，的可接受的盐。所述化合物及其药物组合物，任选地与其它活性成分组合使用，作为用于治疗胃肠道疾病的药物，特别是作为胃抗分泌剂和抗溃疡剂。

45. 发明授权

US06599540B1 Use of a Serenoa repens extract for the production of a medicament to treat prostate cancer 有权
标题翻译：使用Serenoa repens提取物生产用于治疗前列腺癌的药物
公开(公告)号：US06599540B1
公开(公告)日：2003-07-29
申请号：US09937676
申请日：2001-09-28
申请人： Pierre Fabre , Jean-Pierre Raynaud , Henri Cousse
发明人： Pierre Fabre , Jean-Pierre Raynaud , Henri Cousse
IPC分类号： A61K3578
CPC分类号： A61K36/889 , A61K2300/00
摘要： The invention relates to the use of a lipido-sterolic Serenoa repens extract for the production of a medicament which is administered in an isolated manner or in an associated manner, in a simultaneous, separated or staggered manner, with prostatectomy, radiotherapy and/or hormonotherapy in order to prevent and/or treat prostate cancer.
摘要翻译：本发明涉及使用脂质 - 甾体Serenoa repens提取物来生产药物，其以前列腺切除术，放射治疗和/或激素治疗以同时，分离或交错的方式以孤立的方式或以相关联的方式施用以预防和/或治疗前列腺癌。

46. 发明授权

US4192883A Amides of pyrrolidinoethylamine which can be used in lung therapy 失效
标题翻译：可用于肺部治疗的吡咯烷基乙胺的酰胺
公开(公告)号：US4192883A
公开(公告)日：1980-03-11
申请号：US931489
申请日：1978-08-07
申请人： Henri Cousse , Bernard Bonnaud , Jean-Pierre Tarayre , Silvano Casadio
发明人： Henri Cousse , Bernard Bonnaud , Jean-Pierre Tarayre , Silvano Casadio
IPC分类号： C07D279/30 , C07D295/13 , C07D311/12 , C07D311/84 , A61K31/40 , C07D295/14
CPC分类号： C07D295/13 , C07D279/30 , C07D311/12 , C07D311/84
摘要： New chemical compounds, which are pyrrolidinoethylamine amides, in the form of free bases and salts thereof, which are useful as antitussives, pharmaceutical compositions thereof, and method of treating therewith.In the form of their salts, the compounds have the formula: ##STR1## wherein ##STR2## is an acyl radical of a phenylacetic,.alpha.-phenyl-.alpha.-ethylacetic, diphenylacetic, benzilic, .alpha.-lower-alkoxy-.alpha.,.alpha.-diphenylacetic, 10-phenothiazinecarboxylic, benzoic, halobenzoic, 3-coumarincarboxylic, 9-xanthenecarboxylic, salicylic, cresotic, halocresotic, lower-alkoxybenzoic, phenoxyacetic, phenoxyisobutyric, halophenoxyisobutyric, cinnamic, or 9-fluorene carboxylic acid, and wherein R'H represents an inorganic or organic acid, and wherein R may be, for example, a substituted aromatic ring of the formula: ##STR3## wherein R.sub.1 and R.sub.2 may independently be lower-alkyl, lower-alkoxy, hydrogen, lower-alkenyloxy, or lower-alkynyloxy, and X may be hydrogen or halogen.Medicaments containing these active principles may be used, inter alia, in the treatment of coughs and respiratory complaints.
摘要翻译：新的化合物，它们是吡咯烷基乙胺酰胺，其形式为游离碱和盐，它们可用作镇咳药，其药物组合物及其处理方法。以它们的盐的形式，化合物具有下式：其中是苯乙酸，α-苯基-α-乙基乙酸，二苯基乙酸，苯偶酰，α-低级烷氧基-α，α 二苯乙酸，10-吩噻嗪羧酸，苯甲酸，卤代苯甲酸，3-香豆素羧酸，9-呫吨羧酸，水杨酸，间歇，卤代，低级烷氧基苯甲酸，苯氧基乙酸，苯氧基异丁酰，卤代苯氧基异丁酸，肉桂酸或9-芴羧酸，其中R'H代表无机或有机酸，其中R可以是例如下式的取代芳环：其中R 1和R 2可以独立地为低级烷基，低级烷氧基，氢，低级烯氧基或低级 - 炔氧基，X可以是氢或卤素。含有这些积极原则的药物，除其他外，可用于治疗咳嗽和呼吸道疾病。

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