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41. 发明授权

US5073369A Efomycins as performance promoters in animals 失效
标题翻译：作为动物的性能促销者
公开(公告)号：US5073369A
公开(公告)日：1991-12-17
申请号：US840638
申请日：1986-03-17
申请人： Klaus Frobel , Erwin Bischoff , Hartwig Muller , Olga Salcher , Anno De Jong , Friedrich Berschauer , Martin Scheer
发明人： Klaus Frobel , Erwin Bischoff , Hartwig Muller , Olga Salcher , Anno De Jong , Friedrich Berschauer , Martin Scheer
IPC分类号： A23K20/195 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P15/00 , A61P31/00 , A61P31/12 , C07H7/06 , C07H15/26 , C07H17/04 , C12P1/04 , C12P1/06 , C12P19/58 , C12R1/465
CPC分类号： C07H17/04 , A23K20/195 , C07H15/26 , C07H7/06 , C12P1/06 , Y10S426/807 , Y10S435/886
摘要： The present invention relates to the use of microbiologically prepared compounds and their mixtures, which are called efomycins, as performance promoters in farm animals and processes for their preparation, and furthermore new efomycins and their mixtures as new chemical compounds. The invention also relates to microorganisms which can be used for the preparation of the efomycins and their mixtures.
摘要翻译：本发明涉及微生物制备的化合物及其混合物，其被称为efomycins，作为农场动物中的性能促进剂及其制备方法，此外还涉及新的efomycins及其混合物作为新的化合物。本发明还涉及可用于制备efomycins及其混合物的微生物。

42. 发明授权

US5624897A Cyclic depsipeptides having 18 ring atoms, and their use for combating endoparasites 失效
标题翻译：具有18个环原子的环状缩肽，以及它们用于对抗内寄生虫的用途
公开(公告)号：US5624897A
公开(公告)日：1997-04-29
申请号：US353409
申请日：1994-12-09
申请人： Peter Jeschke , Jurgen Scherkenbeck , Gerhard Bonse , Erwin Bischoff , Norbert Mencke , Achim Harder , Michael Londershausen , Hartwig Muller
发明人： Peter Jeschke , Jurgen Scherkenbeck , Gerhard Bonse , Erwin Bischoff , Norbert Mencke , Achim Harder , Michael Londershausen , Hartwig Muller
IPC分类号： A01N43/72 , A61K31/395 , A61K38/00 , A61P33/00 , A61P33/10 , C07D273/00 , C07K11/02 , A61K38/15
CPC分类号： C07D273/00
摘要： New cyclic depsipeptides having 18 ring atoms, of the general formula (I) ##STR1## in which R represents hydrogen, straight-chain or branched or cyclic alkyl having up to 8 carbon atoms, and their optical isomers and racemates,and their use for combating endoparasites in the field of medicine and veterinary medicine.
摘要翻译：具有18个环原子的具有18个环原子的具有通式（I）的化合物（I）其中R表示氢，具有至多8个碳原子的直链或支链或环状烷基及其旋光异构体和外消旋物，以及它们用于打击医药和兽医领域的内寄生虫。

43. 发明授权

US5463087A Substituted derivatives of deoxymyoinositol, process for their preparation and their use in medicaments 失效
标题翻译：取代的脱氧肌醇衍生物，其制备方法及其在药物中的应用
公开(公告)号：US5463087A
公开(公告)日：1995-10-31
申请号：US372090
申请日：1995-01-13
申请人： Erwin Bischoff , Zhan Gao , Stefan Wohlfeil , Gabriele Hecker , Jeannine Cleophax , Didier Dubreuil , Stephane Gero , Alice Olesker , Catherine Verre-Sebrie , Mauro Vieira de Almeida , Georges Vass
发明人： Erwin Bischoff , Zhan Gao , Stefan Wohlfeil , Gabriele Hecker , Jeannine Cleophax , Didier Dubreuil , Stephane Gero , Alice Olesker , Catherine Verre-Sebrie , Mauro Vieira de Almeida , Georges Vass
IPC分类号： A61K31/66 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P29/00 , A61P37/08 , C07D317/72 , C07F9/117 , C07F9/655
CPC分类号： C07D317/72 , C07F9/117 , C07F9/65517 , Y02P20/55
摘要： A process for the preparation of a compound. That compound is converted to a novel compound of the formula ##STR1## in which R.sup.1, R.sup.2 and R.sup.5 each independently is alkyl of 3 to 14 carbon atoms, which is used to make novel anti-inflammatories.
摘要翻译：一种化合物的制备方法。将该化合物转化成式IMAIm的新化合物，其中R 1，R 2和R 5各自独立地为3至14个碳原子的烷基，其用于制备新的抗炎剂。

44. 发明授权

US5089487A Circulation-active dibenzo[1,5]dioxocin-5-ones 失效
标题翻译：循环活性二苯并（1,5）二氧化物-5-酮
公开(公告)号：US5089487A
公开(公告)日：1992-02-18
申请号：US528667
申请日：1990-05-24
申请人： Klaus Frobel , Jan-Bernd Lenfers , Peter Fey , Andreas Knorr , Johannes-Peter Stasch , Hartwig Muller , Erwin Bischoff , Hans-Georg Dellweg
发明人： Klaus Frobel , Jan-Bernd Lenfers , Peter Fey , Andreas Knorr , Johannes-Peter Stasch , Hartwig Muller , Erwin Bischoff , Hans-Georg Dellweg
IPC分类号： C12N1/14 , A61K31/335 , A61K31/35 , A61K31/357 , A61K31/365 , A61K31/38 , A61K31/40 , A61K31/425 , A61K31/44 , A61K31/443 , A61K31/4433 , A61P3/00 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/12 , C07D321/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D417/04 , C07D493/14 , C07H9/04 , C07H15/26 , C12P17/08 , C12P17/16 , C12R1/80
CPC分类号： C07D405/12 , C07D321/12 , C07D407/04 , C07D407/12 , C07D493/14 , C07H15/26 , C12P17/08 , C12P17/16 , C12R1/80
摘要： Cardioactive compounds of the formula ##STR1## in which R.sup.1 and R.sup.8 and R.sup.14 and R.sup.15 can be hydrogen or various organic radicals.
摘要翻译：其中R 1和R 8以及R 14和R 15可以是氢或各种有机基团的式（Ⅰ）的心脏活性化合物。

45. 发明授权

US4670260A Antibiotic for animal feeds 失效
标题翻译：抗生素用于动物饲料
公开(公告)号：US4670260A
公开(公告)日：1987-06-02
申请号：US802776
申请日：1985-11-27
申请人： Erwin Bischoff , Hartwig Muller , Olga Salcher , Friedrich Berschauer , Martin Scheer , Anno de Jong , Klaus Frobel
发明人： Erwin Bischoff , Hartwig Muller , Olga Salcher , Friedrich Berschauer , Martin Scheer , Anno de Jong , Klaus Frobel
IPC分类号： A23K20/195 , A23K50/30 , A61K35/74 , A61P31/04 , C07G11/00 , C12P1/06 , C12R1/465
CPC分类号： C12P1/06 , A23K20/195 , A23K50/30
摘要： A novel antibiotic for combating bacteria and promoting animal growth is obtained by cultivating Streptomyces strain BA 9.
摘要翻译：通过培养Streptomyces菌株BA 9获得抗菌细菌和促进动物生长的新型抗生素。

46. 发明授权

US07135474B2 Derivatives of 2-(1-benzyl-1H-pyrazolo(3,4-B)pyridine-3-yl)-5(-4-pyridinyl)l-4-pyrimidinamines and the use thereof as quanylate cyclase stimulators 有权
标题翻译： 2-（1-苄基-1H-吡唑并（3,4-B）吡啶-3-基）-5（-4-吡啶基）-1- [4-嘧啶胺]的衍生物及其作为苯甲酸酯环化酶刺激剂的用途
公开(公告)号：US07135474B2
公开(公告)日：2006-11-14
申请号：US10514909
申请日：2003-05-05
申请人： Stefan Weigand , Erwin Bischoff , Klaus Münter , Johannes-Peter Stasch , Elke Stahl
发明人： Stefan Weigand , Erwin Bischoff , Klaus Münter , Johannes-Peter Stasch , Elke Stahl
IPC分类号： C07D471/04 , A61K31/505 , C07D231/38
CPC分类号： C07D471/04
摘要： This application relates to compounds of the formula (I) in which R1 is chlorine, cyano, trifluoromethyl or methoxy and R2 is hydrogen or flurorine; or R1 and R2 are both fluorine; and to pharmaceutically acceptable salts of these materials. Pharmaceutical compositions containing these materials, and methods of using them in treatment of hypertension and sexual dysfunction are also disclosed and claimed.
摘要翻译：本申请涉及式（I）化合物，其中R 1是氯，氰基，三氟甲基或甲氧基，R 2是氢或氟磺酰; 或R 1和R 2均为氟; 以及这些材料的药学上可接受的盐。还公开并要求保护含有这些材料的药物组合物和使用它们治疗高血压和性功能障碍的方法。

47. 发明申请

US20060052397A1 Carbamate-substituted pyrazolopyridines 有权
标题翻译：氨基甲酸酯取代的吡唑并吡啶
公开(公告)号：US20060052397A1
公开(公告)日：2006-03-09
申请号：US10513869
申请日：2003-04-25
申请人： Cristina Alonso-Alija , Erwin Bischoff , Klaus Munter , Johannes-Peter Stasch , Elke Stahl , Stefan Weigand , Achim Feurer
发明人： Cristina Alonso-Alija , Erwin Bischoff , Klaus Munter , Johannes-Peter Stasch , Elke Stahl , Stefan Weigand , Achim Feurer
IPC分类号： A61K31/506 , C07D471/02
CPC分类号： C07D471/04 , A61K31/506 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compounds which stimulate soluble guanylate cyclase, to the preparation thereof and to the use thereof as medicaments, in particular as medicaments for the treatment of cardiovascular disorders and/or sexual dysfunction.
摘要翻译：本发明涉及刺激可溶性鸟苷酸环化酶，其制备及其作为药物的用途，特别是作为用于治疗心血管疾病和/或性功能障碍的药物的化合物。

48. 发明授权

US06291515B1 Use of efomycins 失效
标题翻译：使用efomycins
公开(公告)号：US06291515B1
公开(公告)日：2001-09-18
申请号：US09267322
申请日：1999-03-12
申请人： Horst-Peter Antonicek , Erwin Bischoff , Daniel Gondol , Oliver Gutbrod , Thomas Krahn , Maria-Luisa Rodriguez , Helmuth Schütz
发明人： Horst-Peter Antonicek , Erwin Bischoff , Daniel Gondol , Oliver Gutbrod , Thomas Krahn , Maria-Luisa Rodriguez , Helmuth Schütz
IPC分类号： A61K31365
CPC分类号： C07H7/06 , C07D321/00
摘要： The present invention relates to the use of known efomycins and elaiophylins for the treatment of autoimmune disorders, to new natural substances efomycins M and T, and processes for their preparation; in particular to their use as medicaments in psoriasis therapy.
摘要翻译：本发明涉及已知的efomycins和elaiophylin用于治疗自身免疫性疾病，新型天然物质efomycins M和T的用途及其制备方法; 特别是其作为牛皮癣治疗药物的用途。

49. 发明授权

US5565561A Natural substance cyclamenol and chemical derivatives 失效
标题翻译：天然物质仙客来醇和化学衍生物
公开(公告)号：US5565561A
公开(公告)日：1996-10-15
申请号：US397208
申请日：1995-04-27
申请人： Hartwig M uller , Erwin Bischoff , Volker-Bernd Fiedler , Karlheinz Weber , Burkhard Fugmann , Bruno Rosen
发明人： Hartwig M uller , Erwin Bischoff , Volker-Bernd Fiedler , Karlheinz Weber , Burkhard Fugmann , Bruno Rosen
IPC分类号： A61K31/395 , A61P29/00 , C07D225/02 , C07F7/18 , C12P17/10 , C12R1/465
CPC分类号： C12P17/10 , C07D225/02 , C07F7/1856
摘要： The invention relates to the natural substance cyclamenol of the formula ##STR1## a process for its preparation from microorganisms of the order of the Actinomycetales, in particular from the Streptomyces strain MHW 846, chemical derivatives thereof, and its use as a medicament, in particular for acute and chronic inflammatory disorders in human and veterinary medicine.
摘要翻译： PCT No.PCT / EP93 / 02472 Sec。 371日期：1995年04月27日 102（e）日期1995年4月27日PCT提交1993年9月13日PCT公布。出版物WO94 / 06774 日期：1994年3月31日本发明涉及式为“IMAGE”的天然物质仙客来醇，其由放线菌纲，特别是来自链霉菌属菌株MHW 846的微生物制备的方法，其化学衍生物及其作为一种药物，特别是用于人和兽医学中的急性和慢性炎症性疾病。

50. 发明申请

US20090221570A1 Uses of 2-Phenyl-Substituted Imidazotriazinone Derivatives for Treating Pulmonary Hypertension 审中-公开
标题翻译：用于治疗肺动脉高压的2-苯基取代的咪唑并三嗪酮衍生物的用途
公开(公告)号：US20090221570A1
公开(公告)日：2009-09-03
申请号：US11918312
申请日：2006-03-27
申请人： Helmut Haning , Peter Serno , Erwin Bischoff , Ernst Ulbrich
发明人： Helmut Haning , Peter Serno , Erwin Bischoff , Ernst Ulbrich
IPC分类号： A61K31/53 , A61K31/5377 , A61K31/519 , A61K31/4985
CPC分类号： A61K31/53 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the use of PDE 5 inhibitors generally and in particular of known 2-phenyl-substituted imidazotriazinone derivatives for manufacturing medicaments for the treatment of pathological states which can be treated by raising cGMP levels in certain tissues, such as, for example, of, for example: primary pulmonary hypertension, secondary pulmonary hypertension, pulmonary arterial hypertension, portopulmonary hypertension, hepatopulmonary syndrome, pulmonary hypertension caused by medicaments (amphetamines), interstitial lung disease, pulmonary hypertension occurring with HIV, thromboembolic pulmonary hypertension, pulmonary hypertension in children and neonates, pulmonary hypertension induced by atmospheric hypoxia (altitude sickness), COPD, emphysema, chronic bronchial asthma, mucoviscidosis-related pulmonary hypertension, right heart failure, left heart failure and global failure, and which can be treated by raising cGMP levels in certain tissues, such as, for example, isolated systiolic hypertension (ISH) and hardening of blood vessels, specifically of arterial blood vessels, and combination of PDE 5 inhibitors generally and in particular of known 2-phenyl-substituted imidazotriazinone derivatives with further therapeutic agents in the said indications.
摘要翻译：本发明涉及PDE5抑制剂的用途，通常，特别是已知的2-苯基取代的咪唑并三嗪酮衍生物用于制备用于治疗可通过提高某些组织中的cGMP水平治疗的病理状态的药物，例如，例如：原发性肺动脉高压，继发性肺动脉高压，肺动脉高压，肺动脉高压，肝肺综合征，药物引起的肺动脉高压（苯丙胺），间质性肺病，HIV发生的肺动脉高压，血栓栓塞性肺动脉高压，肺动脉高压儿童和新生儿，大气缺氧引起的肺动脉高压（高原病），COPD，肺气肿，慢性支气管哮喘，粘膜相关性肺动脉高压，右心衰竭，左心衰竭和全身性衰竭，以及可通过提高cGMP水平进行治疗某些组织，如，例如，分离的囊性高血压（ISH）和血管的硬化，特别是动脉血管的硬化，以及PDE5抑制剂的组合，通常特别是已知的2-苯基取代的咪唑并三嗪酮衍生物与所述适应症中的其它治疗剂。

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