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41. 发明授权

US07166696B2 Solid phase synthesis supports and methods 有权
标题翻译：固相合成支持和方法
公开(公告)号：US07166696B2
公开(公告)日：2007-01-23
申请号：US10900240
申请日：2004-07-27
申请人： Jerald K. Rasmussen , Larry R. Krepski
发明人： Jerald K. Rasmussen , Larry R. Krepski
IPC分类号： C07K1/04
CPC分类号： C40B50/14 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00596 , C07B2200/11 , C07H21/04 , C07K1/042
摘要： Functionalized supports and methods for solid phase synthesis. Preferably, the functionalized support is azlactone-functionalized.
摘要翻译：功能化支持和固相合成方法。优选地，功能化载体是吖内酯官能化的。

42. 发明授权

US06841258B2 High density, miniaturized arrays and methods of manufacturing same 有权
标题翻译：高密度，小型化阵列及其制造方法
公开(公告)号：US06841258B2
公开(公告)日：2005-01-11
申请号：US10060799
申请日：2002-01-30
申请人： Kurt J. Halverson , Sanjay L. Patil , Jerald K. Rasmussen
发明人： Kurt J. Halverson , Sanjay L. Patil , Jerald K. Rasmussen
IPC分类号： G01N33/53 , B01J19/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/06 , G01N33/543 , G01N37/00 , B32B13/12
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00664 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , C12Q1/6837 , C40B40/06 , Y10T428/24174 , Y10T428/31667 , Y10T428/31902 , Y10T428/3192 , Y10T428/31938
摘要： High-density, miniaturized arrays including high surface areas. Arrays described include substrate with a coating of linking agents, as well as arrays with reactants affixed to the substrates. Methods of manufacturing high-density arrays of reactants. The methods include the use of oriented, heat shrink films and elastomeric materials. Methods of functionalizing a substrate with linking agents for subsequent affixation of reactants are also disclosed herein.
摘要翻译：高密度，小型化阵列，包括高表面积。所描述的阵列包括具有连接剂涂层的底物，以及附着在基材上的反应物的阵列。制造高密度反应物阵列的方法。这些方法包括使用取向的热收缩膜和弹性体材料。使用连接剂官能化底物的方法用于随后的反应物固定也在本文中公开。

43. 发明授权

US06573338B2 High density, miniaturized arrays and methods of manufacturing same 有权
公开(公告)号：US06573338B2
公开(公告)日：2003-06-03
申请号：US10060794
申请日：2002-01-30
申请人： Kurt J. Halverson , Sanjay L. Patil , Jerald K. Rasmussen
发明人： Kurt J. Halverson , Sanjay L. Patil , Jerald K. Rasmussen
IPC分类号： C08F870
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00664 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , C12Q1/6837 , C40B40/06 , Y10T428/24174 , Y10T428/31667 , Y10T428/31902 , Y10T428/3192 , Y10T428/31938
摘要： High-density, miniaturized arrays including high surface areas. Arrays described include substrate with a coating of linking agents, as well as arrays with reactants affixed to the substrates. Methods of manufacturing high-density arrays of reactants. The methods include the use of oriented, heat shrink films and elastomeric materials. Methods of functionalizing a substrate with linking agents for subsequent affixation of reactants are also disclosed herein.

44. 发明授权

US06379952B1 Method for cell selection utilizing azlactone-functional supports 有权
标题翻译：使用吖内酯功能性支持物的细胞选择方法
公开(公告)号：US06379952B1
公开(公告)日：2002-04-30
申请号：US09240829
申请日：1999-02-01
申请人： Jerald K. Rasmussen , Patrick L. Coleman
发明人： Jerald K. Rasmussen , Patrick L. Coleman
IPC分类号： C12N506
CPC分类号： G01N33/56966 , Y10S530/815 , Y10S530/816 , Y10T442/2525
摘要： Azlactone-functional supports are used to provide cell selection from a mixture such as bone marrow or peripheral blood having a desired target cell population. An azlactone-functional support is derivatized by covalently coupling to the support a biologically active substance that binds the target cells. A mixture containing the target cells is contacted with the derivatized support to bind the target cells to the biologically active substance, and unbound remaining mixture is removed from the support. Bound cells may be eluted from the support to obtain purified target cells. Biologically active substances include antibodies, lectins, proteins, antigens and avidin. The biologically active substance may directly or indirectly bind cells in the mixture. Indirect binding may be through a second, intermediary biologically active substance that is bifunctional. The azlactone-functional support is provided by incorporating an azlactone moiety into a base polymer support that has been selected by prescreening base polymer supports with a cell mixture to identify a base polymer support having minimal nonspecific binding of cells in the mixture.
摘要翻译：氮内酯功能性支持物用于从具有所需靶细胞群体的混合物例如骨髓或外周血提供细胞选择。通过与支持物共价偶联与靶细胞结合的生物活性物质衍生吖内酯功能性支持物。将含有靶细胞的混合物与衍生的载体接触以将靶细胞结合到生物活性物质上，并将未结合的剩余混合物从载体中除去。结合的细胞可以从载体上洗脱以获得纯化的靶细胞。生物活性物质包括抗体，凝集素，蛋白质，抗原和抗生物素蛋白。生物活性物质可以直接或间接地结合混合物中的细胞。间接结合可以通过第二种中间生物活性物质，其是双功能的。通过将吖内酯部分掺入到通过用细胞混合物预筛分基础聚合物载体来选择的基础聚合物载体中来鉴定具有该混合物中细胞的非特异性结合的基础聚合物载体来提供吖内酯官能的载体。

45. 发明授权

US5344701A Porous supports having azlactone-functional surfaces 失效
标题翻译：具有吖内酯功能性表面的多孔载体
公开(公告)号：US5344701A
公开(公告)日：1994-09-06
申请号：US896107
申请日：1992-06-09
申请人： David R. Gagnon , Patrick L. Coleman , Gary J. Ortina , Christopher S. Lyons , Dean S. Milbrath , Jerald K. Rasmussen , Julie B. Stahl
发明人： David R. Gagnon , Patrick L. Coleman , Gary J. Ortina , Christopher S. Lyons , Dean S. Milbrath , Jerald K. Rasmussen , Julie B. Stahl
IPC分类号： C08F2/52 , A61L33/00 , B01J20/32 , C07K17/08 , C08F2/00 , C08F8/30 , C08F26/06 , C08F226/06 , C12N11/08 , G01N33/543 , B32B3/26 , B32B5/14 , B32B27/00
CPC分类号： C08F226/06 , A61L33/0011 , B01J20/28023 , B01J20/28033 , B01J20/286 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3255 , B01J20/3274 , B01J20/3276 , B01J20/3278 , B01J20/328 , C07K17/08 , C08F8/30 , C12N11/08 , G01N33/54353 , B01J2220/54 , Y10T428/249953 , Y10T428/249954 , Y10T428/249958 , Y10T428/249959 , Y10T428/249978 , Y10T428/249991
摘要： Supports having azlactone-functional surfaces, adduct supports prepared from such azlactone-functional supports, and methods of preparing both are disclosed. Azlactone functionality is introduced to surfaces of a pre-existing support in a manner which retains useful physical and chemical characteristics of the pre-existing support. One method involves exposing surfaces with high energy radiation to generate free radical reaction sites on the surfaces and causing azlactone-functional moieties to react with the free radical reaction sites. Another method involves coating surfaces with azlactone monomers, crosslinking monomers, and optionally co-monomers and polymerizing the monomers to form a polymerized coating of azlactone-functionality on the surfaces. Another method involves dispersion polymerization of azlactone-functional moieties to produce azlactone-functional particles within pores and interstices of a pre-existing support. Adduct supports are formed by coupling nucleophilic reagents, such as biologically active materials, to azlactone-functional moieties of the support.
摘要翻译：公开了具有吖内酯功能性表面的载体，由这种吖内酯官能载体制备的加合物载体，以及制备两者的方法。将Azlactone功能以保留现有支持物的有用物理和化学特性的方式引入预先存在的载体的表面。一种方法包括用高能量辐射暴露表面以在表面上产生自由基反应位点并使吖内酯官能部分与自由基反应位点反应。另一种方法包括用吖内酯单体，交联单体和任选的共聚单体涂覆表面，并聚合单体以在表面上形成吖内酯官能团的聚合涂层。另一种方法涉及吖内酯功能部分的分散聚合以在预先存在的载体的孔和间隙内产生吖内酯官能团的颗粒。加成载体通过将亲核试剂（例如生物活性物质）偶联到载体的吖内酯官能部分而形成。

46. 发明授权

US5268473A Azlactone Michael adducts 失效
标题翻译：吖内酯迈克尔加合物
公开(公告)号：US5268473A
公开(公告)日：1993-12-07
申请号：US905286
申请日：1992-06-26
申请人： Dean M. Moren , Steven M. Heilmann , Larry R. Krepski , Jerald K. Rasmussen
发明人： Dean M. Moren , Steven M. Heilmann , Larry R. Krepski , Jerald K. Rasmussen
IPC分类号： C07D263/42 , C07D265/06
CPC分类号： C07D263/42 , C07D265/06
摘要： Azlactone-functional Michael adducts are disclosed which are the Michael reaction products of 2-alkenyl azlactones and Michael donors selected from carbon and nitrogen nucleophiles. Reaction products which contain a plurality of azlactone groups are useful as step growth monomers in adhesives, sealants, and coatings.
摘要翻译：公开了作为选自碳和氮亲核试剂的2-烯基吖内酯和迈克尔供体的迈克尔反应产物的吖内酮官能的迈克尔加合物。含有多个吖内酯基团的反应产物可用作粘合剂，密封剂和涂料中的步骤生长单体。

47. 再颁专利

USRE34348E Fluorinated polymers derived from acrylamide-functional monomers 失效
公开(公告)号：USRE34348E
公开(公告)日：1993-08-17
申请号：US969462
申请日：1992-10-30
申请人： Steven M. Heilmann , Larry R. Krepski , Dean M. Moren , Jerald K. Rasmussen , Howell K. Smith, II
发明人： Steven M. Heilmann , Larry R. Krepski , Dean M. Moren , Jerald K. Rasmussen , Howell K. Smith, II
IPC分类号： C07C233/49 , C08F20/58
CPC分类号： C07C233/49 , C08F20/58
摘要： Novel fluorinated, acrylamide monomers are prepared from 2-alkenyl azlactones reacted with fluorinated alcohols. The novel monomers have the formula ##STR1## wherein R.sup.1 and R.sup.6 are independently hydrogen or methyl; R.sup.2 and R.sup.3 independently can be an alkyl, cycloalkyl, or aryl group, or R.sup.2 and R.sup.3 taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms;R.sup.4 and R.sup.5 are independently hydrogen or lower alkyl;a is 0 or 1;b is 1 or 2;X is a single bond, CH.sub.2, CH.sub.2 OCH.sub.2, and CH.sub.2 CH.sub.2 OCH.sub.2 ; andR.sub.f is a substantially perfluorinated alkyl, cycloalkyl, or aryl group when b is 1 and perfluorinated alkylene when b is 2.Novel polymers and copolymers can be prepared from the monomers of the invention.

48. 发明授权

US5157108A Thermally sensitive linkages 失效
标题翻译：热敏感联系
公开(公告)号：US5157108A
公开(公告)日：1992-10-20
申请号：US449719
申请日：1989-12-12
申请人： Larry R. Krepski , Steven M. Heilmann , Dean M. Moren , Jerald K. Rasmussen
发明人： Larry R. Krepski , Steven M. Heilmann , Dean M. Moren , Jerald K. Rasmussen
IPC分类号： C07D263/42 , C07D263/52 , C07D265/06 , C07D265/10 , C07D265/12 , C08F8/00 , C08G59/40 , C08G59/50 , C08G73/00
CPC分类号： C07D265/10 , C07D263/42 , C08G59/4014 , C08G59/5046 , C08G73/00
摘要： Compounds containing alpha-amidoacetyle linkages are described that are thermally labile and yield nucleophilic and azlactone products. Nucleophiles are useful as curing agents for epoxy resin sealants and adhesives and azlactones are useful in crosslinking systems for polymers.

49. 发明授权

US5149806A Azlactone Michael adducts 失效
标题翻译： AZLACTONE MICHAEL ADDUCTS
公开(公告)号：US5149806A
公开(公告)日：1992-09-22
申请号：US500768
申请日：1990-03-28
申请人： Dean M. Moren , Steven M. Heilmann , Larry R. Krepski , Jerald K. Rasmussen
发明人： Dean M. Moren , Steven M. Heilmann , Larry R. Krepski , Jerald K. Rasmussen
IPC分类号： C07D263/42 , C07D265/06 , C07D413/12 , C08G18/30 , C08G73/06 , C09D7/12 , C09D11/06 , C09J11/06
CPC分类号： C07D265/06 , C07D263/42
摘要： Azlactone-functional Michael adducts are disclosed which are the Michael reaction products of 2-alkenyl azlactones and Michael donors selected from carbon and nitrogen nucleophiles. Reaction products which contain a plurality of azlactone groups are useful as step growth monomers in adhesives, sealants, and coatings.

50. 发明授权

US5081197A Oligo(2-alkenyl azlactones) 失效
标题翻译：低聚（2-链烯基吖内酯）
公开(公告)号：US5081197A
公开(公告)日：1992-01-14
申请号：US602100
申请日：1990-10-23
申请人： Steven M. Heilmann , Dean M. Moren , Jerald K. Rasmussen , Larry R. Krepski , Sadanand V. Pathre
发明人： Steven M. Heilmann , Dean M. Moren , Jerald K. Rasmussen , Larry R. Krepski , Sadanand V. Pathre
IPC分类号： C07D263/42 , C07D265/10 , C07D498/04 , C07D498/14 , C08F26/06 , C08F26/10 , C08F34/00 , C08F126/06
CPC分类号： C07D263/42
摘要： This invention provides novel azlactone-functional oligomers of 2-alkenyl azlactones in which oligomerization has occurred predominantly via the 2-alkenyl group. Oligomerization of the 2-alkenyl group provides oligomers having 2 to 15 mer units with predominantly carbon-carbon backbone segments. Oligomerized in this fashion, the novel compositions possess azlactone groups which can be reacted with nucleophiles in the normal ring-opening sense. The oligomers are prepared by a novel process in which both Lewis and Bronsted acidic catalysts are effective. The reactive oligomers find utility as crosslinking agents for polymers containing azlactone-reactable nucleophilic groups.
摘要翻译：本发明提供2-链烯基吖内酯的新型吖内酯官能低聚物，其中低聚主要通过2-链烯基发生。 2-烯基的低聚提供了具有主要为碳 - 碳骨架链段的2至15个mer单元的低聚物。以这种方式低聚，新型组合物具有吖内酯基团，其可以以正常的开环方式与亲核试剂反应。低聚物通过其中Lewis和Bronsted酸性催化剂都有效的新方法制备。反应性低聚物可用作用于含有吖内酯可反应的亲核基团的聚合物的交联剂。

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