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41. 发明授权

US5779675A Front load pressure jacket system with syringe holder 失效
公开(公告)号：US5779675A
公开(公告)日：1998-07-14
申请号：US519201
申请日：1995-08-25
申请人： David M. Reilly , Arthur E. Uber, III , Alan D. Hirschman
发明人： David M. Reilly , Arthur E. Uber, III , Alan D. Hirschman
IPC分类号： A61M5/142 , A61M5/145 , A61M37/00 , B05C17/01
CPC分类号： B05C17/01 , A61M5/14546 , A61M2005/14553 , A61M5/14566 , Y10S128/01
摘要： The pressure jacket systems of the invention are used to permit the front loading and removal of a syringe from an injector and include a first jacket segment and a second jacket segment surrounding the exterior surface of the syringe, interior surfaces comformable to the exterior surface of the syringe, a mechanism which allows movement of the first jacket segment in relation to the second jacket segment to permit insertion and removal of the syringe from the pressure jacket, and a mechanism for securing the first and second jacket segments in a fixed relationship upon insertion of the syringe.

42. 发明申请

US20100174183A1 MULTIPLE LUMEN DIFFUSION CATHETER 有权
标题翻译：多功能扩散吸管
公开(公告)号：US20100174183A1
公开(公告)日：2010-07-08
申请号：US12515981
申请日：2007-11-28
申请人： Robert S. Schwartz , Robert A. Van Tassel , Eugene A. Gelblum , Alan D. Hirschman , John F. Kalafut , David M. Reilly , Edward J. Rhinehart , Frederick W. Trombley, III , Arthur E. Uber, III
发明人： Robert S. Schwartz , Robert A. Van Tassel , Eugene A. Gelblum , Alan D. Hirschman , John F. Kalafut , David M. Reilly , Edward J. Rhinehart , Frederick W. Trombley, III , Arthur E. Uber, III
IPC分类号： A61B6/00 , A61M25/00
CPC分类号： A61M25/007 , A61M25/003
摘要： A method and device for the simultaneous or sequential introduction of multiple fluids into the bloodstream including a multiple lumen catheter with corresponding multiple hole sets. By introducing a second fluid such as saline, the concentration and bolus of a first fluid, such as a contrast agent, can be controlled and optimized.
摘要翻译：一种用于同时或顺序地将多种流体引入血流中的方法和装置，包括具有相应多孔组的多腔导管。通过引入诸如盐水的第二流体，可以控制和优化第一流体如造影剂的浓度和推注。

43. 发明授权

US07462166B2 Encoding and sensing of syringe information 有权
标题翻译：注射器信息的编码和感测
公开(公告)号：US07462166B2
公开(公告)日：2008-12-09
申请号：US10466418
申请日：2002-01-16
申请人： Kevin P. Cowan , Barry Iddon , Michael J. Yanniello , John A. Brosovich , Alan D. Hirschman
发明人： Kevin P. Cowan , Barry Iddon , Michael J. Yanniello , John A. Brosovich , Alan D. Hirschman
IPC分类号： A61M37/00
CPC分类号： A61M5/14546 , A61M5/14566 , A61M2205/6072
摘要： A syringe for use with a powered injector to inject a fluid into a patient inclides an encoder. The encoder includes at least a first indicator positioned on the encoder. The first indicator is adapted to interact with at least a portion of energy being propagated through or adjacent the encoder in a manner that is detectable. The presence (or absence) of the first indicator provides or corresponds to information about the syringe configuration. The indicator(s) of the present invention can, for example, provide information about syringe configuration by the number and/or position thereof. A plurality or set of such syringes can be provided, with the configuration of each such syringe being represented by the presence or absence of indicator(s) of that syringe.
摘要翻译：用于与动力注射器一起使用以将流体注入患者的注射器包括编码器。编码器至少包括位于编码器上的第一指示器。第一指示符适于与以可检测的方式与正在传播或邻近编码器的能量的至少一部分相互作用。第一个指示器的存在（或不存在）提供或对应于关于注射器配置的信息。例如，本发明的指示器可以通过其数量和/或位置提供关于注射器构造的信息。可以提供多个或一组这样的注射器，每个这样的注射器的构造由该注射器的指示器的存在或不存在表示。

44. 发明申请

US20080086050A1 MRI HYPERTHERMIA TREATMENT SYSTEMS, METHODS AND DEVICES, ENDORECTAL COIL 审中-公开
标题翻译： MRI高血压治疗系统，方法和装置，内镜线圈
公开(公告)号：US20080086050A1
公开(公告)日：2008-04-10
申请号：US11868552
申请日：2007-10-08
申请人： George J. Misic , Alan D. Hirschman
发明人： George J. Misic , Alan D. Hirschman
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B18/12 , A61B2018/0016 , A61B2018/183 , A61B2090/374 , G01R33/34084 , G01R33/4804
摘要： Hyperthermia has been applied by, for example, separate ultrasound transducers, RF or microwave transmitters and heated fluids. Imaging by separate MRI imaging coils is usually used to view the anatomical region under treatment. Separate temperature probes (needles, catheters) are often used to monitor tissue temperature. Control of the temperature profile required for effective hyperthermia treatment is usually done by trial and error, involving a human operator. The present invention combines all of these capabilities into a single device, which is MRI compatible and safe. It also allows for automatic control of the RF energy to achieve a prescribed tissue hyperthermia.
摘要翻译：已经通过例如单独的超声换能器，RF或微波发射器和加热流体应用了热疗。单独MRI成像线圈的成像通常用于观察治疗前的解剖区域。单独的温度探针（针，导管）通常用于监测组织温度。控制有效热疗治疗所需的温度曲线通常是通过试验和错误的方式进行的，涉及人类操作者。本发明将所有这些功能组合成单个设备，其是MRI兼容且安全的。它还允许自动控制RF能量以实现规定的组织热疗。

45. 发明授权

US07351221B2 Container for agitating and injecting a multi-component medium 有权
标题翻译：用于搅拌和注射多组分介质的容器
公开(公告)号：US07351221B2
公开(公告)日：2008-04-01
申请号：US11394946
申请日：2006-03-31
申请人： Frederick W. Trombley, III , Arthur E. Uber, III , Edward J. Rhinehart , Rosemary Almon-Martin , Alan D. Hirschman
发明人： Frederick W. Trombley, III , Arthur E. Uber, III , Edward J. Rhinehart , Rosemary Almon-Martin , Alan D. Hirschman
IPC分类号： A61M37/00 , B01F5/00
CPC分类号： A61M5/142 , A61M5/007 , A61M5/14546 , A61M5/14566 , A61M5/445 , A61M2205/3673 , B01F9/103 , B01F13/005
摘要： A system for dispensing a medium includes at least a first container to hold the medium, a pressurizing device, such as a pump, in fluid connection with the container for pressurizing the medium, and an agitation mechanism or device to maintain the components of the medium in a mixed state. The container and the pressurizing device can be separate units, as in the case of an bag or bottle in fluid connection with a peristaltic or other type of pump. The container and the pump can also be combined in a single unit, as in the case of a syringe, wherein the syringe barrel of the syringe acts to contain the medium and the syringe plunger pressurizes the medium within the syringe barrel. A method of injecting a multi-component medium includes the step of agitating the medium (for example, as described above) before or during an injection procedure to maintain the components of the medium in a mixed state.
摘要翻译：用于分配介质的系统至少包括用于保持介质的第一容器，与容器流体连接的用于对介质加压的加压装置，例如泵，以及用于维持介质的组分的搅拌机构或装置处于混合状态。容器和加压装置可以是分离的单元，如在与蠕动或其它类型的泵流体连接的袋或瓶的情况下。容器和泵也可以在单个单元中组合，如在注射器的情况下，其中注射器的注射器筒用于容纳介质，并且注射器柱塞对注射器筒内的介质加压。注射多组分培养基的方法包括在注射过程之前或过程中搅拌培养基（例如，如上所述）以将培养基的组分维持在混合状态的步骤。

46. 发明授权

US06575930B1 Agitation devices and dispensing systems incorporating such agitation devices 有权
公开(公告)号：US06575930B1
公开(公告)日：2003-06-10
申请号：US09267237
申请日：1999-03-12
申请人： Frederick W. Trombley, III , Arthur E. Uber, III , Edward J. Rhinehart , Rosemary Almon-Martin , Alan D. Hirschman
发明人： Frederick W. Trombley, III , Arthur E. Uber, III , Edward J. Rhinehart , Rosemary Almon-Martin , Alan D. Hirschman
IPC分类号： A61M3700
CPC分类号： A61M5/142 , A61M5/007 , A61M5/14546 , A61M5/14566 , A61M5/445 , A61M2205/3673 , B01F9/103 , B01F13/005
摘要： A system for dispensing a medium includes at least a first container to hold the medium, a pressurizing device, such as a pump, in fluid connection with the container for pressurizing the medium, and an agitation mechanism or device to maintain the components of the medium in a mixed state. The container and the pressurizing device can be separate units, as in the case of an bag or bottle in fluid connection with a peristaltic or other type of pump. The container and the pump can also be combined in a single unit, as in the case of a syringe, wherein the syringe barrel of the syringe acts to contain the medium and the syringe plunger pressurizes the medium within the syringe barrel. A method of injecting a multi-component medium includes the step of agitating the medium (for example, as described above) before or during an injection procedure to maintain the components of the medium in a mixed state.

47. 发明授权

US06440107B1 Fluid delivery system and an aseptic connector for use therewith 有权
标题翻译：流体输送系统和用于其的无菌连接器
公开(公告)号：US06440107B1
公开(公告)日：2002-08-27
申请号：US09507274
申请日：2000-02-18
申请人： Frederick W. Trombley, III , Amy Pomaybo , Alan D. Hirschman , William J. Jaecklein
发明人： Frederick W. Trombley, III , Amy Pomaybo , Alan D. Hirschman , William J. Jaecklein
IPC分类号： A61M500
CPC分类号： A61M39/14 , A61M2039/1033 , A61M2039/1072 , Y10S604/905
摘要： An aseptic connector comprises a first member and a second member. The first member preferably includes a resilient septum, and the second member preferably includes a penetrating member. Preferably, the septum is formed from an elastomeric material such as a silicone elastomer. The penetrating member preferably includes an extending penetrating element to penetrate the resilient septum. The aseptic connector further comprises a resilient sealing element that contacts the penetrating member and one of an inner wall of the first member and an inner wall of the second member to create a seal between the penetrating member and one of the inner wall of the first member and the inner wall of the second member. The seal created is suitable to withstand relatively high pressures (for example, those experienced during the injection of contrast media in CT procedures). A fluid delivery system comprising at least a first aseptic connector as described above is also provided.
摘要翻译：无菌连接器包括第一构件和第二构件。第一构件优选地包括弹性隔膜，并且第二构件优选地包括穿透构件。优选地，隔膜由诸如硅氧烷弹性体的弹性体材料形成。穿透构件优选地包括穿透弹性隔膜的延伸穿透元件。所述无菌连接器还包括弹性密封元件，所述弹性密封元件接触所述穿透构件并且所述第一构件的内壁和所述第二构件的内壁中的一个在所述穿透构件与所述第一构件的内壁中的一个之间形成密封和第二构件的内壁。产生的密封件适合于承受相对高的压力（例如，在CT程序中注射造影剂期间经历的那些）。还提供了至少包括如上所述的第一无菌连接器的流体递送系统。

48. 发明授权

US06385483B1 Patient specific dosing contrast delivery systems and methods 有权
标题翻译：患者特异性给药对比剂输送系统和方法
公开(公告)号：US06385483B1
公开(公告)日：2002-05-07
申请号：US09197773
申请日：1998-11-23
申请人： Arthur E. Uber, III , Alan D. Hirschman , Thomas R. Welch , Rosemary Almon-Martin
发明人： Arthur E. Uber, III , Alan D. Hirschman , Thomas R. Welch , Rosemary Almon-Martin
IPC分类号： A61B600
CPC分类号： A61B8/06 , A61B8/481 , A61M5/007 , A61M5/1723 , A61M2205/581 , A61M2205/80 , G06F19/00 , G06F19/321 , G06F19/3468 , Y10S128/12 , Y10S128/13
摘要： This invention relates generally to the field of medical devices for delivering contrast media during medical diagnostic and therapeutic imaging procedures and more particularly, this invention relates to improved contrast media delivery systems and methods of use which allow adjustment of contrast media concentration and injection parameters either before or during an injection procedure to provide patient specific dosing of contrast media, thus decreasing the waste and cost of these procedures while increasing their efficiency.
摘要翻译：本发明一般涉及在医疗诊断和治疗成像过程中用于输送造影剂的医疗装置领域，更具体地说，本发明涉及改进的造影剂递送系统和使用方法，其允许在之前调节造影剂浓度和注射参数或在注射过程期间以提供患者特异性剂量的造影剂，从而降低这些程序的浪费和成本，同时提高其效率。

49. 发明授权

US06371938B1 Front load pressure jacket system with syringe holder 有权
公开(公告)号：US06371938B1
公开(公告)日：2002-04-16
申请号：US09304934
申请日：1999-05-04
申请人： David M. Reilly , Arthur E. Uber, III , Alan D. Hirschman , Eugene A. Gelblum
发明人： David M. Reilly , Arthur E. Uber, III , Alan D. Hirschman , Eugene A. Gelblum
IPC分类号： A61M3700
CPC分类号： B05C17/01 , A61M5/14546 , A61M5/14566 , A61M2005/14553 , Y10S128/01
摘要： The pressure jacket systems of the invention are used to permit the front loading and removal of a syringe from an injector and include a first jacket segment and a second jacket segment surrounding the exterior surface of the syringe, interior surfaces comformable to the exterior surface of the syringe, a mechanism which allows movement of the first jacket segment in relation to the second jacket segment to permit insertion and removal of the syringe from the pressure jacket, and a mechanism for securing the first and second jacket segments in a fixed relationship upon insertion of the syringe.

50. 再颁专利

USRE37487E1 Front load pressure jacket system with syringe holder 有权
标题翻译：带有注射器支架的前负载压力护套系统
公开(公告)号：USRE37487E1
公开(公告)日：2001-12-25
申请号：US09612539
申请日：2000-07-07
申请人： David M. Reilly , Arthur E. Uber, III , Alan D. Hirschman
发明人： David M. Reilly , Arthur E. Uber, III , Alan D. Hirschman
IPC分类号： A61M3700
CPC分类号： B05C17/01 , A61M5/14546 , A61M5/14566 , A61M2005/14553 , Y10S128/01
摘要： The pressure jacket systems of the invention are used to permit the front loading and removal of a syringe from an injector and include a first jacket segment and a second jacket segment surrounding the exterior surface of the syringe, interior surfaces conformable to the exterior surface of the syringe, a mechanism which allows movement of the first jacket segment in relation to the second jacket segment to permit insertion and removal of the syringe from the pressure jacket, and a mechanism for securing the first and second jacket segments in a fixed relationship upon insertion of the syringe.
摘要翻译：本发明的压力护套系统用于允许从注射器前部装载和取出注射器，并且包括第一护套区段和围绕注射器外表面的第二护套区段，内表面适合于注射器的外表面注射器，允许第一护套片段相对于第二护套片段移动以允许将注射器从压力护套插入和移除的机构，以及用于在插入时将固定关系固定在第一和第二夹套片段上的机构，注射器。

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