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41. 发明授权

US07306598B2 Polymer matrix devices for treatment of vascular malformations 有权
标题翻译：用于治疗血管畸形的聚合物基质装置
公开(公告)号：US07306598B2
公开(公告)日：2007-12-11
申请号：US10456113
申请日：2003-06-05
申请人： Csaba Truckai , John H. Shadduck
发明人： Csaba Truckai , John H. Shadduck
IPC分类号： A61B18/18 , A61B5/04
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12118 , A61B17/12145 , A61B17/12168 , A61B17/12172 , A61B17/12181 , A61B2017/12068 , A61F2/07 , A61F2/848 , A61F2/90 , A61F2220/0016
摘要： A system for treating a wide-neck aneurysm comprising a mesh-like sleeve fabricated from a class of polymer filaments that carry conductive particles therein to provide the filaments with a specified resistivity. The releasable mesh-like sleeve is introduced to the site of a targeted vascular malformation by the working end of a catheter that carries an electrode arrangement at its distal terminus. The system further provides an electrical source and controller (i) that modulates power delivery to the polymer matrix which can then fuse the sleeve to the wall of a blood vessel to span across the vascular malformation.
摘要翻译：一种用于治疗宽颈动脉瘤的系统，包括由一类聚合物长丝制成的网状套筒，所述聚合物细丝在其中携带导电颗粒以提供具有指定电阻率的细丝。可释放的网状套筒通过导管的工作端引导到目标血管畸形部位，该导管在其远端具有电极装置。该系统还提供一种电源和控制器（i），其调节向聚合物基质的功率传递，然后可将该套管熔合到血管的壁以横跨血管畸形。

42. 发明授权

US07186253B2 Electrosurgical jaw structure for controlled energy delivery 有权
标题翻译：用于受控能量输送的电外科钳口结构
公开(公告)号：US07186253B2
公开(公告)日：2007-03-06
申请号：US11118881
申请日：2005-04-29
申请人： Csaba Truckai , James Baker , Bruno Strul , John H. Shadduck
发明人： Csaba Truckai , James Baker , Bruno Strul , John H. Shadduck
IPC分类号： A61B18/14 , A61B18/12
CPC分类号： A61B18/1442 , A61B2018/00077 , A61B2018/00083 , A61B2018/00148 , A61B2018/0063 , A61B2018/00809
摘要： A working end of a surgical instrument that carries first and second jaws for delivering energy to tissue. In a preferred embodiment, at least one jaw of the working end defines a tissue-engagement plane that contacts the targeted tissue. The cross-section of the engagement plane reveals that it defines a surface conductive portion that overlies a variably resistive matrix of a temperature-sensitive resistive material or a pressure-sensitive resistive material. An interior of the jaw carries a conductive material or electrode that is coupled to an Rf source and controller. In an exemplary embodiment, the variably resistive matrix can comprise a positive temperature coefficient (PTC) material, such as a ceramic, that is engineered to exhibit a dramatically increasing resistance (i.e., several orders of magnitude) above a specific temperature of the material.
摘要翻译：手术器械的工作端，其携带用于将能量递送至组织的第一和第二钳口。在优选实施例中，工作端的至少一个钳口限定了接触目标组织的组织接合平面。接合平面的横截面显示它限定了覆盖在温度敏感电阻材料或压敏电阻材料的可变电阻矩阵上的表面导电部分。钳口的内部承载耦合到Rf源和控制器的导电材料或电极。在示例性实施例中，可变电阻矩阵可以包括正温度系数（PTC）材料，例如陶瓷，其被工程化以显示高于材料的特定温度的显着增加的电阻（即几个数量级）。

43. 发明申请

US20060122625A1 Bone treatment systems and methods 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US20060122625A1
公开(公告)日：2006-06-08
申请号：US11209035
申请日：2005-08-22
申请人： Csaba Truckai , John Shadduck
发明人： Csaba Truckai , John Shadduck
IPC分类号： A61F2/34
CPC分类号： A61B17/8805 , A61B17/70 , A61B17/8822 , A61B17/8827 , A61B17/8836 , A61B2017/00022 , A61B2017/00026 , A61B2017/00084 , A61B2017/564 , A61F2/44
摘要： The present invention relates in certain embodiments to medical devices for treating vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the flow of bone cement into the interior of a vertebra and the application of forces causes by the cement flow. An exemplary system utilizes Rf energy in combination a conductive bone cement for selectively polymerizing the inflow plume to increase the viscosity of the cement. In one aspect of the invention, the system utilizes a controller to control bone cement flow parameters to either allow or disallow cement interdigitation into cancellous bone. A method of the invention includes pulsing the flows of bone cement wherein high acceleration of the flow pulses can apply expansion forces across the surface of the cement plume to reduce a vertebral fracture.
摘要翻译：本发明在某些实施例中涉及用于治疗脊椎压缩性骨折的医疗装置。更具体地，本发明的实施例涉及通过控制骨水泥进入椎骨内部并且由水泥流引起的力的施加来可控地恢复椎体高度的仪器和方法。示例性系统利用结合导电骨水泥的Rf能量来选择性聚合流入羽流以增加水泥的粘度。在本发明的一个方面，该系统利用控制器来控制骨水泥流动参数以允许或不允许水泥交叉指向松质骨。本发明的方法包括脉动骨粘固剂的流动，其中流动脉冲的高加速度可以施加穿过水泥羽流表面的膨胀力，以减少椎骨骨折。

44. 发明申请

US20060106459A1 Bone treatment systems and methods 审中-公开
标题翻译：骨治疗系统和方法
公开(公告)号：US20060106459A1
公开(公告)日：2006-05-18
申请号：US11215730
申请日：2005-08-30
申请人： Csaba Truckai , John Shadduck
发明人： Csaba Truckai , John Shadduck
IPC分类号： A61F2/44
CPC分类号： A61B17/8836 , A61B17/7095 , A61B17/7098
摘要： A system for treating an abnormal vertebral body such as a compression fracture. In an exemplary embodiment, the system includes a biocompatible flow-through implant structure configured with a three-dimensional interior web that defines flow openings therein for cooperating with a two-part hardenable bone cement. The flow-through structure is capable of compacted and extended shapes and in one embodiment provides a gradient in flow openings for controlling flow parameters of a bone cement injected under high pressure into the interior thereof. The flow-through implant structure is configured for transducing cement injection forces into a selected direction for moving apart cortical endplates of a vertebra to reduce a fracture. In one embodiment, the flow-through implant structure is coupled to an Rf source for applying Rf energy to a two-part bone cement to accelerate curing of the cement to thereby allow on-demand alterations of cement viscosity. The Rf system allows for control of bone cement polymerization globally or regionally to prevent cement extravasion and to direct forces applied to a vertebra to reduce a fracture.
摘要翻译：用于治疗异常椎体的系统，例如压缩性骨折。在一个示例性实施例中，该系统包括生物相容性流通植入结构，该植入结构被构造成具有限定其中的流动开口的三维内部腹板，用于与两部分可硬化骨粘固剂配合。流通结构能够压实和延伸形状，并且在一个实施例中提供流动开口中的梯度，用于控制在高压下注入其内部的骨粘固剂的流动参数。流通植入结构被配置为将水泥注射力转换到选定的方向以移动分开的椎骨的皮层终板以减少骨折。在一个实施例中，流过植入结构耦合到Rf源，以将Rf能量施加到两部分骨水泥以加速水泥的固化，从而允许水泥粘度的按需改变。 Rf系统允许全局或区域地控制骨水泥聚合，以防止水泥外渗，并引导施加到椎骨上的力以减少骨折。

45. 发明申请

US20050267464A1 Electrosurgical instrument and method of use 审中-公开
标题翻译：电外科仪器及使用方法
公开(公告)号：US20050267464A1
公开(公告)日：2005-12-01
申请号：US10973818
申请日：2004-10-25
申请人： Csaba Truckai , John Shadduck , Bruno Strul , James Baker
发明人： Csaba Truckai , John Shadduck , Bruno Strul , James Baker
IPC分类号： A61B18/14
CPC分类号： A61B18/1442 , A61B2018/00619
摘要： An embodiment of a method of the invention provides a method for welding tissue comprising providing a tissue welding device having first and second tissue engaging surfaces with at least one surface including an electrode surface that defines a plurality of surface portions having different resistances to electrical current flow therethrough. A target tissue volume is engaged with the tissue engaging surfaces. Rf energy is delivered to the target volume to create a substantially even temperature distribution across at least a portion of the target tissue volume to substantially uniformly weld at least a portion of the target tissue volume.
摘要翻译：本发明的方法的一个实施例提供了一种焊接组织的方法，包括提供具有第一和第二组织接合表面的组织焊接装置，其中至少一个表面包括限定对电流流动具有不同电阻的多个表面部分的电极表面通过。目标组织体积与组织接合表面接合。将Rf能量传递到目标体积以在目标组织体积的至少一部分上产生基本均匀的温度分布，以基本均匀地焊接目标组织体积的至少一部分。

46. 发明申请

US20050192568A1 Electrosurgical jaw structure for controlled energy delivery 有权
标题翻译：用于受控能量输送的电外科钳口结构
公开(公告)号：US20050192568A1
公开(公告)日：2005-09-01
申请号：US11118881
申请日：2005-04-29
申请人： Csaba Truckai , James Baker , Bruno Strul , John Shadduck
发明人： Csaba Truckai , James Baker , Bruno Strul , John Shadduck
IPC分类号： A61B18/14
CPC分类号： A61B18/1442 , A61B2018/00077 , A61B2018/00083 , A61B2018/00148 , A61B2018/0063 , A61B2018/00809
摘要： A working end of a surgical instrument that carries first and second jaws for delivering energy to tissue. In a preferred embodiment, at least one jaw of the working end defines a tissue-engagement plane that contacts the targeted tissue. The cross-section of the engagement plane reveals that it defines a surface conductive portion that overlies a variably resistive matrix of a temperature-sensitive resistive material or a pressure-sensitive resistive material. An interior of the jaw carries a conductive material or electrode that is coupled to an Rf source and controller. In an exemplary embodiment, the variably resistive matrix can comprise a positive temperature coefficient (PTC) material, such as a ceramic, that is engineered to exhibit a dramatically increasing resistance (i.e., several orders of magnitude) above a specific temperature of the material.
摘要翻译：手术器械的工作端，其携带用于将能量递送至组织的第一和第二钳口。在优选实施例中，工作端的至少一个钳口限定了接触目标组织的组织接合平面。接合平面的横截面显示它限定了覆盖在温度敏感电阻材料或压敏电阻材料的可变电阻矩阵上的表面导电部分。钳口的内部承载耦合到Rf源和控制器的导电材料或电极。在示例性实施例中，可变电阻矩阵可以包括正温度系数（PTC）材料，例如陶瓷，其被工程化以显示高于材料的特定温度的显着增加的电阻（即几个数量级）。

47. 发明授权

US5487757A Multicurve deflectable catheter 失效
标题翻译： Multicurve可偏导管
公开(公告)号：US5487757A
公开(公告)日：1996-01-30
申请号：US391333
申请日：1995-02-21
申请人： Csaba Truckai , Richard S. Jaraczewski , Frank Nguyen , Scott H. West
发明人： Csaba Truckai , Richard S. Jaraczewski , Frank Nguyen , Scott H. West
IPC分类号： A61B18/14 , A61M25/01 , A61N1/05
CPC分类号： A61M25/0144 , A61B18/1492 , A61M25/0136 , A61M25/0147 , A61N1/056 , A61B2017/003 , A61B2018/00065 , A61B2018/00357 , A61B2018/00392 , A61B2018/00577 , A61B2018/00839 , A61B2018/0091 , A61B2018/00946 , A61B2018/00952 , A61B2018/126 , A61B2018/1435 , A61B2018/1472 , A61B2218/002 , A61M2025/0063 , A61M2025/015 , A61M25/0141
摘要： An electrophysiology catheter (20) comprises a shaft (22) having a first bending stiffness and a deflectable tip (28) secured to the distal end (24) of the shaft with a second bending stiffness less than the first bending stiffness. At least one electrode (34, 36) is mounted to the tip for delivering current to or monitoring electrical activity of tissue. A manipulator wire (58) is coupled to the distal end of the deflectable tip, whereby the deflectable tip may be deflected by axial force applied to the manipulator wire. A stiffener member (66) is axially slidable relative to the tip so as to adjust the tip curvature without removing the catheter from the body. The catheter may further include a core wire (72) configured to rotate the deflectable tip about a longitudinal axis (2) without rotating the proximal end (26) of the catheter shaft, wherein the distal end of the deflectable tip remains in a substantially constant axial position, preferably in a plane perpendicular to the longitudinal axis.
摘要翻译：电生理学导管（20）包括具有第一弯曲刚度的轴（22）和固定到所述轴的远端（24）的可偏转尖端（28），其具有小于所述第一弯曲刚度的第二弯曲刚度。至少一个电极（34,36）安装到尖端以将电流传送到或监测组织的电活动。操纵杆（58）联接到可偏转尖端的远端，由此通过施加到机械手线的轴向力，可偏转尖端可能被偏转。加强件（66）相对于尖端可轴向滑动，以便调节尖端曲率而不从体内移除导管。该导管还可以包括芯线（72），该芯线被构造成围绕纵向轴线（2）旋转可偏转尖端，而不旋转导管轴的近端（26），其中可偏转尖端的远端保持基本上恒定优选地在垂直于纵向轴线的平面中。

48. 发明授权

US09662163B2 Endometrial ablation devices and systems 有权
公开(公告)号：US09662163B2
公开(公告)日：2017-05-30
申请号：US13236471
申请日：2011-09-19
申请人： Akos Toth , Dominique J. Filloux , Csaba Truckai
发明人： Akos Toth , Dominique J. Filloux , Csaba Truckai
IPC分类号： A61B18/18 , A61B18/04 , A61B18/14 , A61B18/00 , A61B18/12 , A61B90/00
CPC分类号： A61B18/042 , A61B18/1492 , A61B2018/00214 , A61B2018/00559 , A61B2018/00577 , A61B2018/00642 , A61B2018/00797 , A61B2018/00821 , A61B2018/00898 , A61B2018/122 , A61B2018/147 , A61B2090/3983
摘要： Systems and methods for endometrial ablation. The systems include a handle and elongated introducer sleeve extending to an expandable working end having a fluid-tight interior chamber. A thin dielectric wall surrounds at least a portion of the interior chamber and has an external surface for contacting endometrial tissue. The thin dielectric wall surrounds a collapsible-expandable frame and receives an electrically non-conductive gas. First and second polarity electrodes are exposed to the interior and exterior of the chamber, respectively. A radiofrequency power source operatively connects to the electrode arrangement to apply a radiofrequency voltage across the first and second electrodes, wherein the voltage is sufficient to initiate ionization of the neutral gas into a conductive plasma within the interior chamber, and to capacitively couple the current in the plasma across the thin dielectric wall to ablate endometrial tissue engaged by the external surface of the dielectric structure.

49. 发明授权

US09597118B2 Bone anchor apparatus and method 有权
公开(公告)号：US09597118B2
公开(公告)日：2017-03-21
申请号：US12683358
申请日：2010-01-06
申请人： Csaba Truckai , John H. Shadduck
发明人： Csaba Truckai , John H. Shadduck
IPC分类号： A61B17/04 , A61B17/70 , A61B17/86
CPC分类号： A61B17/70 , A61B17/7001 , A61B17/8685
摘要： A bone anchor can include an elongated body and a plurality of separate elements. The bone anchor can be configured to be insertable into bone. The bone anchor can be coupleable to a spine treatment apparatus. The bone anchor can be revisable so that after a treatment interval attached to a spine treatment apparatus, the spine treatment apparatus can be detached and the bone anchor revised by removing the plurality of separate elements from the bone thus allowing a new anchor to be implanted in the bone.

50. 发明授权

US09510922B2 Systems and methods for treatment of sleep apnea 有权
标题翻译：用于治疗睡眠呼吸暂停的系统和方法
公开(公告)号：US09510922B2
公开(公告)日：2016-12-06
申请号：US13113946
申请日：2011-05-23
申请人： Edward M. Gillis , John H. Shadduck , Csaba Truckai , Andrew Poutiatine , Paul J. Buscemi
发明人： Edward M. Gillis , John H. Shadduck , Csaba Truckai , Andrew Poutiatine , Paul J. Buscemi
IPC分类号： A61F2/00 , A61F5/56
CPC分类号： A61F2/00 , A61F5/566 , A61F2210/0004
摘要： An implant for treating an obstructive airway disorder includes an elongate implant body configured for implanting in airway-interface tissue. At least a portion of the elongate body carries a light transmission material for permitting light transmission therein. Systems and methods of treating an airway disorder including implanting an implant in an airway-interface tissue are also provided.
摘要翻译：用于治疗阻塞性气道障碍的植入物包括构造成用于植入气道界面组织中的细长植入体。细长体的至少一部分携带用于允许光透射的透光材料。还提供了治疗气道障碍的系统和方法，包括将植入物植入气道界面组织中。

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