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41. 发明授权

US07777032B2 Quinazoline analogs as receptor tyrosine kinase inhibitors 有权
标题翻译：喹唑啉类似物作为受体酪氨酸激酶抑制剂
公开(公告)号：US07777032B2
公开(公告)日：2010-08-17
申请号：US12496973
申请日：2009-07-02
申请人： Eli Wallace , George Topalov , Joseph Lyssikatos , Alexandre Buckmelter , Qian Zhao
发明人： Eli Wallace , George Topalov , Joseph Lyssikatos , Alexandre Buckmelter , Qian Zhao
IPC分类号： C07D239/00 , C07D239/70 , C07D471/00 , C07D487/00
CPC分类号： C07D498/10 , C04B35/632 , C07D239/94 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04
摘要： This invention concerns quinazoline analogs of Formula I: where an A group is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to three independent R3 groups. The invention also includes methods of using these compounds as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译：本发明涉及式I的喹唑啉类似物：其中A基团与双环的5,6,7或8位上的至少一个碳键合，并且该环被多达三个独立的R 3基团取代。本发明还包括使用这些化合物作为I型受体酪氨酸激酶抑制剂和治疗过度增殖性疾病如癌症的方法。

42. 发明授权

US07501427B2 Quinazoline analogs as receptor tyrosine kinase inhibitors 有权
标题翻译：喹唑啉类似物作为受体酪氨酸激酶抑制剂
公开(公告)号：US07501427B2
公开(公告)日：2009-03-10
申请号：US10642440
申请日：2003-08-14
申请人： Eli Wallace , George Topalov , Joseph Lyssikatos , Alexandre Buckmelter , Qian Zhao
发明人： Eli Wallace , George Topalov , Joseph Lyssikatos , Alexandre Buckmelter , Qian Zhao
IPC分类号： A01N43/54 , A61K31/517 , C07D239/00 , C07D239/70 , C07D471/00 , C07D487/00
CPC分类号： C07D498/10 , C04B35/632 , C07D239/94 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04
摘要： This invention concerns quinazoline analogs of Formula I: where an A group is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to three independent R3 groups. The invention also includes methods of using these compounds as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译：本发明涉及式I的喹唑啉类似物：其中A基团与双环的5,6,7或8位上的至少一个碳键合，并且该环被多达三个独立的R 3基团取代。本发明还包括使用这些化合物作为I型受体酪氨酸激酶抑制剂和治疗过度增殖性疾病如癌症的方法。

43. 发明授权

US07187804B2 Lossless and near-lossless source coding for multiple access networks 有权
标题翻译：多接入网络的无损和近无损源编码
公开(公告)号：US07187804B2
公开(公告)日：2007-03-06
申请号：US10066339
申请日：2002-01-30
申请人： Qian Zhao , Michelle Effros
发明人： Qian Zhao , Michelle Effros
IPC分类号： G06K9/00
CPC分类号： H03M7/40 , H03M7/30
摘要： Embodiments of the invention present implementations for multiple access source coding (MASC). One embodiment presents an implementation directed at the lossless side-information case of MASC. Another embodiment gives an implementation of the general case MASC. One embodiment is a near-lossless implementation of MASC. In a two dimensional example, the invention provides a way to decode data pairs (x,y) from encoded individual data streams x and y. The present invention provides a solution that partitions the source code into optimal partitions and then finds a matched code that is optimal for the given partition. Embodiments of the present invention use Optimal Shannon, Huffman and Arithmetic Codes for the matched codes. Another embodiment of the present invention gives a method of finding near-lossless multiple access source coding.
摘要翻译：本发明的实施例提出了用于多址存取源编码（MASC）的实现。一个实施例提出了针对MASC的无损侧信息情况的实现。另一个实施例给出了一般情况MASC的实现。一个实施例是MASC的近无损实现。在二维示例中，本发明提供了一种从编码的单独数据流x和y解码数据对（x，y）的方法。本发明提供了一种将源代码划分成最佳分区然后找到对于给定分区是最佳的匹配代码的解决方案。本发明的实施例使用用于匹配码的Optimal Shannon，Huffman和算术码。本发明的另一个实施例给出了一种找到近无损多址接入源编码的方法。

44. 发明授权

US09354664B2 Electronic device and input method 有权
标题翻译：电子设备和输入法
公开(公告)号：US09354664B2
公开(公告)日：2016-05-31
申请号：US13638529
申请日：2011-03-29
申请人： Qian Zhao
发明人： Qian Zhao
IPC分类号： G06F13/00 , G06F1/16 , G06F3/14 , G09G5/00
CPC分类号： G06F1/1654 , G06F1/1616 , G06F1/1626 , G06F3/1423 , G06F3/1454 , G09G5/006 , G09G2370/04 , G09G2370/06 , G09G2370/22
摘要： An electronic device and an input method are provided. The electronic device comprises a first system and a second system; the first system comprises a first hardware system on which a first Operation System (OS) runs, and the first hardware system comprises a first interface and a second interface; the second system comprises a second hardware system, an input device and a display device, a second OS runs on the second hardware system, and the second hardware system comprises a third interface and a fourth interface; the first interface and the third interface support a first data transmission protocol, and the second interface and the fourth interface support a second data transmission protocol; the electronic device has a first connection state and a second connection state; the first connection state is the state in which the first system is connected to the third interface of the second system through the first interface, the display device is used for displaying the running status of the first OS, the input device is used for generating a first operating instruction, and the first OS is used for responding to the first operating instruction; and the second connection state is the state in which the first system is connected to the fourth interface of the second system through the second interface, the input device is used for generating a second operating instruction which is processed by the second OS and transmitted to the first OS after being processed, and the processed second operating instruction is responded to by the first OS. Because the two parts of the electronic device are combined arbitrarily and the respective skilled functions of the two systems are fully used after being combined, user can take full use of all parts of a detachable computer by applying this technical solution.
摘要翻译：提供电子设备和输入方法。电子设备包括第一系统和第二系统; 第一系统包括运行第一操作系统（OS）的第一硬件系统，并且第一硬件系统包括第一接口和第二接口; 第二系统包括第二硬件系统，输入设备和显示设备，第二OS在第二硬件系统上运行，第二硬件系统包括第三接口和第四接口; 第一接口和第三接口支持第一数据传输协议，第二接口和第四接口支持第二数据传输协议; 电子设备具有第一连接状态和第二连接状态; 第一连接状态是第一系统通过第一接口连接到第二系统的第三接口的状态，显示设备用于显示第一OS的运行状态，输入设备用于生成第一操作指令，第一操作系统用于响应第一操作指令; 并且第二连接状态是第一系统通过第二接口连接到第二系统的第四接口的状态，输入设备用于产生由第二OS处理并发送到第二系统的第二操作指令处理后的第一OS，并且处理的第二操作指令由第一OS响应。由于电子设备的两个部分被任意组合，并且两个系统的各个熟练功能在组合之后被完全使用，所以通过应用该技术方案，用户可以充分利用可拆卸计算机的所有部件。

45. 发明授权

US09174981B2 Substituted N-(1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide compounds as type III receptor tyrosine kinase inhibitors 有权
标题翻译：取代的N-（1H-吲唑-4-基）咪唑并[1,2-a]吡啶-3-甲酰胺化合物作为III型受体酪氨酸激酶抑制剂
公开(公告)号：US09174981B2
公开(公告)日：2015-11-03
申请号：US13994048
申请日：2011-12-13
申请人： Mark Laurence Boys , Robert Kirk DeLisle , Erik James Hicken , April L. Kennedy , David A. Mareska , Fredrik P. Marmsater , Mark C. Munson , Brad Newhouse , Bryson Rast , James P. Rizzi , Martha E. Rodriguez , George T. Topalov , Qian Zhao
发明人： Mark Laurence Boys , Robert Kirk DeLisle , Erik James Hicken , April L. Kennedy , David A. Mareska , Fredrik P. Marmsater , Mark C. Munson , Brad Newhouse , Bryson Rast , James P. Rizzi , Martha E. Rodriguez , George T. Topalov , Qian Zhao
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/496 , A61K45/06
摘要： Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.
摘要翻译：式I化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义，是cFMS的抑制剂，可用于治疗纤维化，骨相关疾病，癌症，自身免疫性疾病，炎性疾病，心血管疾病，哺乳动物的疼痛和灼伤。

46. 发明授权

US08957068B2 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH 有权
标题翻译： 3-嘧啶-4-基 - 恶唑烷-2-酮作为突变体IDH的抑制剂
公开(公告)号：US08957068B2
公开(公告)日：2015-02-17
申请号：US14347481
申请日：2012-09-26
申请人： Thomas Raymond Caferro , Young Shin Cho , Abran Q. Costales , Huangshu Lei , Francois Lenoir , Julian Roy Levell , Gang Liu , Mark G. Palermo , Keith Bruce Pfister , Martin Sendzik , Cynthia Shafer , Michael David Shultz , Troy Smith , James Clifford Sutton , Bakary-Barry Toure , Fan Yang , Qian Zhao
发明人： Thomas Raymond Caferro , Young Shin Cho , Abran Q. Costales , Huangshu Lei , Francois Lenoir , Julian Roy Levell , Gang Liu , Mark G. Palermo , Keith Bruce Pfister , Martin Sendzik , Cynthia Shafer , Michael David Shultz , Troy Smith , James Clifford Sutton , Bakary-Barry Toure , Fan Yang , Qian Zhao
IPC分类号： C07D413/04 , C07D413/14 , A61K31/506 , C07D487/04 , C07D471/04 , C07D487/08 , C07D417/14 , C07D498/10
CPC分类号： C07D413/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D498/10 , C07D513/04
摘要： The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中R 1 -R 6在本文中定义。本发明还涉及含有式（I）化合物的组合物以及这些化合物在抑制具有新形态活性的突变体IDH蛋白质中的用途。本发明还涉及式（I）化合物在治疗与这种突变体IDH蛋白相关的疾病或病症中的用途，包括但不限于细胞增殖病症如癌症。

47. 发明授权

US08940864B2 Stabilized therapeutic small helical antiviral peptides 有权
标题翻译：稳定的治疗性小螺旋抗病毒肽
公开(公告)号：US08940864B2
公开(公告)日：2015-01-27
申请号：US12438414
申请日：2007-10-02
申请人： Asim Kumar Debnath , Hongtao Zhang , Qian Zhao
发明人： Asim Kumar Debnath , Hongtao Zhang , Qian Zhao
IPC分类号： C07K7/08 , A61K38/00 , A61K38/04 , C07K7/00
CPC分类号： C07K7/08 , A61K38/00
摘要： Provided are constrained peptides that inhibit HIV assembly. Pharmaceutical compositions comprising the above peptides are also provided. Additionally provided are methods of inhibiting replication of a capsid-containing virus in a cell. Also provided are methods of treating a mammal infected with a capsid-containing virus. Further provided are methods of treating a mammal at risk for infection with a capsid-containing virus. Methods of making the above peptides are additionally provided, as are uses of the above peptides and pharmaceutical compositions.
摘要翻译：提供抑制HIV组装的约束肽。还提供了包含上述肽的药物组合物。另外提供了抑制细胞中含壳衣病毒复制的方法。还提供了治疗感染了含有衣壳的病毒的哺乳动物的方法。还提供了治疗感染包含衣壳病毒风险的哺乳动物的方法。另外提供制备上述肽的方法，以及上述肽和药物组合物的用途。

48. 发明授权

US08937154B2 Stabilized therapeutic small helical antiviral peptides 有权
标题翻译：稳定的治疗性小螺旋抗病毒肽
公开(公告)号：US08937154B2
公开(公告)日：2015-01-20
申请号：US13364667
申请日：2012-02-02
申请人： Asim Kumar Debnath , Hongtao Zhang , Qian Zhao
发明人： Asim Kumar Debnath , Hongtao Zhang , Qian Zhao
IPC分类号： C07K7/06 , A61K38/00 , A61K38/04 , C07K7/00
CPC分类号： C07K7/06 , A61K38/00
摘要： Provided are constrained peptides that inhibit HIV assembly. Pharmaceutical compositions comprising the above peptides are also provided. Additionally provided are methods of inhibiting replication of a capsid-containing virus.
摘要翻译：提供抑制HIV组装的约束肽。还提供了包含上述肽的药物组合物。另外提供了抑制含衣壳病毒复制的方法。

49. 发明授权

US08660585B2 Method and device for controlling wireless communication terminal service based on positional area 有权
标题翻译：基于位置区域控制无线通信终端服务的方法和装置
公开(公告)号：US08660585B2
公开(公告)日：2014-02-25
申请号：US13581324
申请日：2010-09-21
申请人： Qian Zhao , Zhenzhuo Zeng , Chenxi Li
发明人： Qian Zhao , Zhenzhuo Zeng , Chenxi Li
IPC分类号： H04W24/00
CPC分类号： H04W48/04 , H04M1/72572 , H04M1/72577
摘要： A method for controlling wireless communication terminals based on location areas is disclosed, including: a wireless communication terminal obtaining its own current location information (101); using a service and function control table to deactivate services and functions that need to be restricted according to the obtained location information, and storing the location information and the deactivated services and functions (102); the wireless communication terminal re-obtaining the location information, activating restriction-cancelled services and functions or deactivating restricted services and functions according to the re-obtained location information, the stored location information and/or the deactivated services and functions; a device for controlling wireless communication terminals based on location areas is also disclosed, and the method and device can be used to control all the services and functions of the wireless communication terminal at the terminal side, so that controlling the wireless communication terminal is more flexibly and more targeted.
摘要翻译：公开了一种基于位置区域控制无线通信终端的方法，包括：无线通信终端获取其自己的当前位置信息（101）; 使用服务和功能控制表来根据所获得的位置信息去激活需要限制的服务和功能，并存储位置信息和停用的服务和功能（102）; 无线通信终端根据重新获得的位置信息，存储的位置信息和/或停用的服务和功能，重新获取位置信息，激活限制取消的服务和功能或停用受限服务和功能; 还公开了一种基于位置区域来控制无线通信终端的装置，并且该方法和装置可用于控制终端侧无线通信终端的所有业务和功能，从而更灵活地控制无线通信终端更具针对性。

50. 发明授权

US08648087B2 N4-phenyl-quinazoline-4-amine derivatives and related compounds as ErbB type I receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases 有权
标题翻译： N4-苯基 - 喹唑啉-4-胺衍生物和相关化合物作为用于治疗过度增殖性疾病的ErbB I型受体酪氨酸激酶抑制剂
公开(公告)号：US08648087B2
公开(公告)日：2014-02-11
申请号：US12085048
申请日：2006-11-15
申请人： Joseph P. Lyssikatos , Julie Marie Greschuk , Fredrik P. Marmsäter , Qian Zhao , D. David Hennings , Weidong Liu
发明人： Joseph P. Lyssikatos , Julie Marie Greschuk , Fredrik P. Marmsäter , Qian Zhao , D. David Hennings , Weidong Liu
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号： A61K31/337 , A61K31/513 , A61K31/517 , A61K39/3955 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D519/00
摘要： This invention provides compounds of Formula I wherein B, G, A, E, R1, R2, R3, m and n are as defined herein, which are useful as type I receptor tyrosine kinase inhibitors, and methods of use thereof in the treatment of hyperproliferative disorders in mammals.
摘要翻译：本发明提供式I化合物，其中B，G，A，E，R 1，R 2，R 3，m和n如本文所定义，其可用作I型受体酪氨酸激酶抑制剂，及其用于治疗哺乳动物过度增生性疾病。

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